Abstract：
:Hypercalcemia results from an imbalance between the fluxes of calcium (Ca) entering and leaving the extracellular space. The two most important influxes are the net intestinal Ca absorption and the net skeletal Ca resorption, whereas the renal excretion represents the main route of elimination. When produced in excess, various factors, particularly calciotropic hormones and cytokines, can disturb the Ca fluxes at intestinal, skeletal and renal tubular sites. If the excessive production of these substances cannot be controlled by surgical or pharmacological means, the next most rational therapeutic strategy should be aimed at correcting those Ca fluxes which are abnormally increased. In hypercalcemia of malignancy (HM), an augmentation in net bone resorption (BR) is observed in most patients. However, a sustained stimulation in tubular Ca reabsorption (TRCa), despite correction of volume depletion by saline infusions, may not only contribute to the hypercalcemia, but in some cases it appears to be the prevailing disturbance. In these patients the effects of the antiresorbing agent clodronate (500 mg/8 h iv in one single infusion) is incomplete, despite the normalisation of BR. Thus, administration of an antiresorbing agent, such as clodronate, is the treatment of choice in HM with elevated BR and normal TRCa. It should be given with other therapeutic agents when a sustained increase in TRCa is the prevailing mechanism for hypercalcemia. In this regard, experimental studies suggest that the agent WR-2721, which specifically inhibits TRCa could be an effective drug for rapidly lowering plasma Ca in HM with high TRCa.
journal_name
Bonejournal_title
Boneauthors
Bonjour JP,Rizzoli R,Hirschel-Scholz S,Caverzasio Jsubject
Has Abstractpub_date
1987-01-01 00:00:00pages
S29-33eissn
8756-3282issn
1873-2763journal_volume
8 Suppl 1pub_type
杂志文章,评审相关文献
BONE文献大全abstract：:The R51Q mutation in sorting nexin 10 (SNX10) was shown to cause a lethal genetic disease in humans, namely autosomal recessive osteopetrosis (ARO). We describe here the first R51Q SNX10 knock-in mouse model and show that mice homozygous for this mutation exhibit massive, early-onset, and widespread osteopetrosis. The...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2020.115360
更新日期：2020-07-01 00:00:00
abstract：:How estrogen therapy influences bone metabolism in postmenopausal women has previously been studied using several approaches, including bone densitometry, measurement of biochemical markers of bone turnover, and histomorphometry. Taken together, these investigations suggest that conventional doses of estrogen protect ...
journal_title：Bone
pub_type： 杂志文章,评审
doi：10.1016/s8756-3282(98)00156-2
更新日期：1999-02-01 00:00:00
abstract：:Chondrocyte proliferation and differentiation are crucial for endochondral ossification and strictly regulated by numerous signaling molecules and transcription factors, but the hierarchical regulatory network remains to be deciphered. The present study emphasized the interplay of Activin A, Foxa, Notch and Shh signal...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2019.03.036
更新日期：2019-06-01 00:00:00
abstract：BACKGROUND:Bone scintigraphy used as a diagnostic technique frequently yields non-specific intense uptake by vertebrae. Bone biopsy may therefore be required to establish a diagnosis in cases of Paget's disease of bone. The aim of the study was to ascertain the sensitivity and specificity of two new images-heart sign a...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2003.10.014
更新日期：2004-04-01 00:00:00
abstract：:The traditional view of osteoporotic fractures is that they result from a reduction in bone mass combined with alterations in the micro-architecture. Apart from the effects of bone remodeling, the material properties of the remaining bone are thought to be unaffected. To test this, we compared the degree of matrix min...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2004.05.025
更新日期：2004-10-01 00:00:00
abstract：:Bisphosphonates (BPs), bone targeted drugs that disrupt osteoclast function, are routinely used to treat complications of bone metastasis. Studies in preclinical models of cancer have shown that BPs reduce skeletal tumor burden and increase survival. Similarly, we observed in the present study that administration of t...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2009.01.010
更新日期：2009-05-01 00:00:00
abstract：:Fibrillin-containing microfibrils are structural components of extracellular matrices of a diverse range of tissues, including bone. Their importance in bone biology is illustrated by the skeletal abnormalities manifest in the congenital disorder, Marfan syndrome, which results from mutations in the fibrillin-1 gene. ...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/s8756-3282(00)00292-1
更新日期：2000-07-01 00:00:00
abstract：:Alagille syndrome (ALGS) is an autosomal dominant disorder attributed to mutations in the Notch signaling pathway. Children with ALGS are at increased risk for fragility fracture of unknown etiology. Our objective was to characterize bone mass, geometry, and microarchitecture in children with ALGS. This was a cross-se...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2020.115576
更新日期：2020-12-01 00:00:00
abstract：:Osteocytes, the most abundant cells in the cortical bone matrix, are thought to have mechanosensory and chemosensory regulatory roles. Marotti theorized that osteocytes signal to osteoblasts to recruit them into the osteocyte lineage. Martin extended this theory, assuming that osteocytes display a general inhibitory e...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/s8756-3282(03)00245-x
更新日期：2003-11-01 00:00:00
abstract：:The relationships of bone size, bone strength, and bone formation were investigated in two strains of mice, NZB/B1NJ and RF/J. Measurement of the femur midshaft size by peripheral quantitative computed tomography (pQCT) showed that the RF/J mice had a 32% greater cross-sectional area than NZB/B1NJ mice at 10 weeks of ...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/s8756-3282(02)00908-0
更新日期：2002-12-01 00:00:00
abstract：:We examined the effect of nicotine on cellular proliferation, as measured by [3H]thymidine (TdR) incorporation and cell count, and on alkaline phosphatase activity in UMR 106-01 rat osteoblastic osteosarcoma cells. The cells were cultured with varying concentrations of nicotine in serum-free medium for 2 to 72 hours. ...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/8756-3282(91)90077-v
更新日期：1991-01-01 00:00:00
abstract：:The striking predilection of temporomandibular disorders (TMD) in women, especially during gonad-intact puberty or reproductive years, indicates that oestrogen plays an important role in the progression of TMD, but the underlying mechanism remains unclear. In this study, unilateral anterior crossbite (UAC) was used to...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2018.03.008
更新日期：2018-06-01 00:00:00
abstract：:Understanding the cellular basis of osteoblastic cell-biomaterial interaction is crucial to the analysis of the mechanism of osseointegration, a requirement of long-term orthopedic implant stability. Clinically, the amount of bone ingrowth is variable, and cellular parameters that influence ingrowth have yet to be cle...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/s8756-3282(99)00077-0
更新日期：1999-05-01 00:00:00
abstract：INTRODUCTION:The structure of trabecular bone represents an aspect of bone properties that affects vertebral bone strength independently of bone mineral density [M. Kleerekoper, A. Villanueva, J. Stanciu, D. Rao, and A. Parfitt. The role of three-dimensional trabecular microstructure in the pathogenesis of vertebral co...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2008.08.131
更新日期：2009-01-01 00:00:00
abstract：:There is a lot of interest for how and how much osteoclasts resorb bone. However, little is known about the mechanism which controls the orientation and the duration of a resorptive event, thereby determining the specific geometry of a cavitation. Here we show that the relative rate of collagenolysis vs. demineralizat...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2013.06.007
更新日期：2013-09-01 00:00:00
abstract：BACKGROUND:Although 25-hydroxyvitamin D (25[OH]D) is commonly used to define vitamin D status, there is no consensus on the cutoff levels for vitamin D deficiency and insufficiency. In this study, we aimed to identify the 25(OH)D threshold that maximally suppressed parathyroid hormone (PTH) in Hong Kong Chinese populat...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2017.01.030
更新日期：2017-04-01 00:00:00
abstract：:To investigate whether exercise training can produce increases in bone mass in spinal cord-injured (SCI) individuals with established disuse osteopenia, nine subjects (age 28.2 years, time since injury 6.0 years, level of injury C5-T7) were recruited for a 9-month training program using functional electrical stimulati...
journal_title：Bone
pub_type： 临床试验,杂志文章
doi：10.1016/8756-3282(96)00109-3
更新日期：1996-07-01 00:00:00
abstract：:To study the osteoinductive action of hyaluronic acid (HA), we examined the effects of applying an elastoviscous high-molecular HA preparation on bone wound healing after bone marrow ablation. The middiaphyses of cortical bones from rat femurs were perforated with a round bar, and excavated marrow cavities were filled...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/s8756-3282(94)00001-8
更新日期：1995-01-01 00:00:00
abstract：INTRODUCTION:Spinal cord injury (SCI) is characterized by rapid bone loss and an increased risk of fragility fracture around regions of the knee. Our purpose was to quantify changes in torsional stiffness K and strength Tult at the proximal tibia due to actual bone loss and simulated bone recovery in acute SCI. METHOD...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2013.12.012
更新日期：2014-03-01 00:00:00
abstract：:Due to the increasing number of osteoporotic fractures of hip, spine, and wrist there is a growing need for methods to track down the subjects with inferior bone structure and to monitor the effects of therapeutic measures. This study aims at a noninvasive diagnostic tool, deriving architectural properties of trabecul...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/s8756-3282(97)00233-0
更新日期：1998-02-01 00:00:00
abstract：:G protein-coupled receptors (GPCRs) require G proteins for intracellular signaling to regulate a variety of growth and maintenance processes, including osteogenesis and bone turnover. Bone maintenance events may be altered by changes in the activity or level of G proteins, which then modify signaling in bone cells suc...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2013.11.021
更新日期：2014-02-01 00:00:00
abstract：:The objective of the study was to assess the short- and long-term effects of adhesive capsulitis (frozen shoulder) on the bone mineral density (BMD) of the affected extremity. BMD and clinical status of 22 patients (group A) with active-phase unilateral adhesive capsulitis and 31 patients (group B) with a previous adh...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/s8756-3282(98)00049-0
更新日期：1998-06-01 00:00:00
abstract：:Solute transport in the lacunar-canalicular system (LCS) is essential for bone metabolism and mechanotransduction. Using the technique of fluorescence recovery after photobleaching (FRAP) we have been quantifying solute transport in the LCS of murine long bone as a function of loading parameters and molecular size. Ho...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2009.06.026
更新日期：2009-10-01 00:00:00
abstract：:X-linked hypophosphatemia (XLH) is characterized by rickets and osteomalacia and arises from mutations in the Phex and PHEX genes in mice (Hyp) and humans, respectively. The present study was undertaken to examine the effect of gene dose on the skeletal phenotype using a histomorphometric approach. Metrical traits (ve...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2003.09.004
更新日期：2004-01-01 00:00:00
abstract：:The effect of vitamin D supplementation on growth of fetal bones during pregnancy is unclear. The aim of this study was to assess the effect of low dose vitamin D supplementation during pregnancy on bony anthropometric aspects of the fetus. In this prospective randomized trial, 140 patients were divided into two equal...
journal_title：Bone
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.bone.2019.02.022
更新日期：2019-05-01 00:00:00
abstract：:Percutaneous vertebroplasty consists of injecting polymethylmethacrylate cement into the cancellous bone of vertebral bodies for the treatment of various lesions of the spine, including osteoporotic compression fractures. Clinicians practicing vertebroplasty commonly alter the mixture of monomer-to-powder recommended ...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/s8756-3282(99)00129-5
更新日期：1999-08-01 00:00:00
abstract：:Low-intensity pulsed ultrasound (LIPUS) has distinct effects on biologic mineralization at intensities of <100 mW/cm2. Intensity-dependent differences in the pattern of accelerated mineralization may be due to different alterations in regulation of collagenous matrix formation. However, little is known about the influ...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2004.04.024
更新日期：2004-09-01 00:00:00
abstract：:A previously developed in vivo X-ray fluorescence (IVXRF) I-125 based system was used to measure bone strontium levels non-invasively in an osteoporotic female volunteer. The volunteer was recruited in December 2008, as part of the Ryerson and McMaster University Strontium in Bone Research Study and measured at twice ...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2012.04.008
更新日期：2012-07-01 00:00:00
abstract：OBJECTIVES:Osteoarthritis (OA) is a disease of the whole joint characterized by cartilage loss and subchondral bone remodeling. The role of microcracks in cartilage integrity and subchondral bone homeostasis is not fully understood. The main goal of this work was to evaluate microcrack density in both calcified cartila...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2019.03.011
更新日期：2019-06-01 00:00:00
abstract：:The gamma-carboxy glutamic acid (Gla)-containing protein of mammalian bone (BGP, also called osteocalcin) is a 49 amino acid polypeptide containing two to three residues of gamma-carboxyglutamic acid. BGP is synthesized by osteoblastlike cells, and plasma BGP in laboratory animals is derived principally from recently ...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/8756-3282(85)90400-4
更新日期：1985-01-01 00:00:00
