Adaptive changes in trabecular architecture in relation to functional strain patterns and disuse.

abstract：:On the basis of previous investigations indicating that the distribution of osteonic and interstitial lamellae in a normal femur depends on its mechanical properties, a procedure has been devised to provide information on the distribution of lamellae in human femora diaphyses deformed by bending. To achieve this, exac...

journal_title：Bone

authors： Ascenzi A,Improta S,Portigliatti Barbos M,Carando S,Boyde A

更新日期：1987-01-01 00:00:00

abstract：:Among vertebrates, urodele amphibians (e.g., axolotls) have the unique ability to perfectly regenerate complex body parts after amputation. The limb has been the most widely studied due to the presence of three defined axes and its ease of manipulation. Hence, the limb has been chosen as a model to study the process o...

journal_title：Bone

authors： Hutchison C,Pilote M,Roy S

更新日期：2007-01-01 00:00:00

abstract：:Mineralocorticoid receptor (MR) antagonism may affect bone turnover via direct and indirect pathways involving parathyroid hormone, but randomized controlled trials are lacking. In a pre-specified analysis of the "Eplerenone in primary hyperparathyroidism" placebo-controlled, randomized trial (ISRCTN 33941607), effect...

journal_title：Bone

authors： Verheyen N,Grübler MR,Meinitzer A,Trummer C,Schwetz V,Amrein K,Dimai HP,März W,Catena C,von Lewinski D,Voelkl J,Alesutan I,Fahrleitner-Pammer A,Brussee H,Pilz S,Tomaschitz A

更新日期：2017-12-01 00:00:00

abstract：OBJECTIVE:The aim was to analyse risk of forearm fractures in first- and second-generation immigrants to Sweden. METHODS:A nationwide study of individuals 20 years of age and older was conducted. Forearm fractures were defined as at least one registered diagnosis in the National Patient Register between January 1, 199...

journal_title：Bone

authors： Wändell P,Li X,Carlsson AC,Sundquist J,Sundquist K

更新日期：2020-09-01 00:00:00

abstract：:How estrogen therapy influences bone metabolism in postmenopausal women has previously been studied using several approaches, including bone densitometry, measurement of biochemical markers of bone turnover, and histomorphometry. Taken together, these investigations suggest that conventional doses of estrogen protect ...

journal_title：Bone

authors： Tobias JH,Compston JE

更新日期：1999-02-01 00:00:00

abstract：:Regulation of osteoclast differentiation and function is a central element in bone homeostasis. While the role of soluble factors, such as cytokines, hormones and growth factors, in controlling osteoclast differentiation has been intensively characterized, the function of surface receptors is less well understood. Sia...

journal_title：Bone

authors： Andes FT,Adam S,Hahn M,Aust O,Frey S,Grueneboom A,Nitschke L,Schett G,Steffen U

更新日期：2021-02-01 00:00:00

abstract：:Although much is known about hip fracture epidemiology, there are relatively little data regarding fractures at other peripheral sites. Epidemiological differences between fractures are important, since they imply that an understanding of the consequences and clinical expression of osteoporosis requires the study of m...

journal_title：Bone

authors： Baron JA,Barrett JA,Karagas MR

更新日期：1996-03-01 00:00:00

abstract：:Osteocytes can participate in systemic mineral homeostasis through perilacunar maintenance and remodeling, where changes to osteocyte lacunar morphology may affect bone structural integrity, tissue strains, and osteocyte mechanosensitivity. Though aging is associated with both decreased bone quality and altered minera...

journal_title：Bone

authors： Heveran CM,Rauff A,King KB,Carpenter RD,Ferguson VL

更新日期：2018-05-01 00:00:00

abstract：:Spinal cord injury (SCI) results in a dramatic loss of bone mineral and a marked increase in fracture incidence in the femur; however, its effect on the femur's geometric structure and strength is poorly studied. The primary purpose of the present study was to assess the geometric structure, composition, and strength ...

journal_title：Bone

authors： Modlesky CM,Slade JM,Bickel CS,Meyer RA,Dudley GA

更新日期：2005-02-01 00:00:00

abstract：INTRODUCTION:Spinal mobilization is commonly used in the treatment of patients with back pain, including individuals with osteoporosis. Previous data indicated that traditional predictors of skeletal failure-lateral or anteroposterior bone mineral density (BMD) by dual energy X-ray absorptiometry (DXA) or geometry of t...

journal_title：Bone

authors： Sran MM,Boyd SK,Cooper DM,Khan KM,Zernicke RF,Oxland TR

更新日期：2007-03-01 00:00:00

abstract：:Mutations in the SCN8A gene encoding the neuronal voltage-gated sodium channel Nav1.6 are known to be associated with epileptic encephalopathy type 13. We identified a novel de novo SCN8A mutation (p.Phe360Ala, c.1078_1079delTTinsGC, Exon 9) in a 6-year-old girl with epileptic encephalopathy accompanied by severe juve...

journal_title：Bone

authors： Rolvien T,Butscheidt S,Jeschke A,Neu A,Denecke J,Kubisch C,Meisler MH,Pueschel K,Barvencik F,Yorgan T,Oheim R,Schinke T,Amling M

更新日期：2017-10-01 00:00:00

abstract：:Collagen sponge disks (6 mm diameter, 1 mm thickness) were impregnated with recombinant human bone morphogenetic protein-2 (rhBMP-2) (5 microg/disk) and implanted onto the back muscles of mice. Ten or 20 mg/kg per day of Rolipram, a selective inhibitory agent to phosphodiesterase type 4 (PDE-4), or vehicle, was inject...

journal_title：Bone

authors： Horiuchi H,Saito N,Kinoshita T,Wakabayashi S,Yotsumoto N,Takaoka K

更新日期：2002-04-01 00:00:00

abstract：:Chronic inflammatory diseases are associated with bone loss. While the occurrence of systemic bone loss is well described in chronic inflammatory diseases, the impact of these conditions on articular bone has not been systematically investigated. Recent refinements in high-resolution CT assessment of the joints now al...

journal_title：Bone

authors： Simon D,Kleyer A,Englbrecht M,Stemmler F,Simon C,Berlin A,Kocijan R,Haschka J,Hirschmann S,Atreya R,Neurath MF,Sticherling M,Rech J,Hueber AJ,Engelke K,Schett G

更新日期：2018-11-01 00:00:00

abstract：:Vitamin K is a cofactor for γ-glutamyl carboxylase, which is an essential enzyme for the γ-carboxylation of vitamin K-dependent proteins such as osteocalcin and matrix Gla protein. Although it has been suggested that vitamin K plays an important role in the improvement of bone metabolism, the relationship between diet...

journal_title：Bone

authors： Sogabe N,Maruyama R,Baba O,Hosoi T,Goseki-Sone M

更新日期：2011-05-01 00:00:00

abstract：OBJECTIVES:This study aimed to evaluate the involvement of Angiotensin II (Ang II) in joint lesions associated with osteoarthritis (OA) in vitro and in vivo. METHODS:Chondrocyte cultures were obtained from knee joints of neonatal rats and stimulated with Ang II/MIA/ACE inhibitors. In vivo, rats treated or not with the...

journal_title：Bone

authors： de Sá GA,Dos Santos ACPM,Nogueira JM,Dos Santos DM,Amaral FA,Jorge EC,Caliari MV,Queiroz-Junior CM,Ferreira AJ

更新日期：2021-01-07 00:00:00

abstract：:During normal aging and menopause, cancellous bone is lost at all skeletal sites due to remodeling-related factors: negative formation balance; temporarily increased remodeling space; and osteoclastic perforations. The relative importance of the various factors in inducing bone mass loss and perforations is still cont...

journal_title：Bone

authors： Thomsen JS,Mosekilde L,Mosekilde E

更新日期：1996-11-01 00:00:00

abstract：:A more accurate understanding of the molecular mechanisms and signaling pathways underpinning human mesenchymal stem cell (MSC) plasticity and differentiation properties is pivotal for accomplishing solid and diligent translation of MSC-based experimental therapeutics and clinical trials to broad clinical practice. In...

journal_title：Bone

authors： Ishiy FAA,Fanganiello RD,Kobayashi GS,Kague E,Kuriki PS,Passos-Bueno MR

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Vertebral fracture (VF) is the most common osteoporotic fracture in postmenopausal women, although most VFs are subclinical. Prevalent VFs are a significant predictor of subsequent fracture and therefore, identification of VF improves the identification of those with high fracture risk. The aim of present st...

journal_title：Bone

authors： Yang J,Mao Y,Nieves JW

更新日期：2020-07-01 00:00:00

abstract：:Sulfate conjugation is an important pathway in the metabolism of many drugs, xenobiotic compounds, and hormones. Sulfotransferases (SULTs) catalyze these reactions and have been detected and characterized in various human tissues including the liver and small intestine. Substrates for SULTs that include estrogen and t...

journal_title：Bone

authors： Dubin RL,Hall CM,Pileri CL,Kudlacek PE,Li XY,Yee JA,Johnson ML,Anderson RJ

更新日期：2001-06-01 00:00:00

abstract：:Hypophosphatasia (HPP) is an inherited disorder characterized by defective bone mineralization caused by mutations in the alkaline phosphatase gene (ALPL). Clinically, the disease spans a great continuum of disease severity and six forms can be distinguished according to the age of onset. The most severe is the autoso...

journal_title：Bone

authors： Watanabe A,Satoh S,Fujita A,Naing BT,Orimo H,Shimada T

更新日期：2014-03-01 00:00:00

abstract：:Although a critical role of COX-2 in bone repair has been established, the mechanism involved remains unclear. During early inflammatory phase of bone healing, COX-2 is produced by the surrounding inflammatory cells as well as bone/cartilage progenitors. Based on the temporal and spatial expression of COX-2 during the...

journal_title：Bone

authors： Xie C,Ming X,Wang Q,Schwarz EM,Guldberg RE,O'Keefe RJ,Zhang X

更新日期：2008-12-01 00:00:00

abstract：:Giant osteoclasts and other cells were isolated from Pagetic bone tissue using 0.5 mM ethylene diamine tetraacetic acid on bone samples from 8 patients with Paget's disease. The cell suspension contained osteoclasts and osteoblasts as well as some mononuclear cells such as monocytes. The number of nuclei in isolated o...

journal_title：Bone

authors： Basle MF,Mazaud P,Malkani K,Chretien MF,Moreau MF,Rebel A

更新日期：1988-01-01 00:00:00

abstract：:Ordinary measurements of the wall thickness (the end result of the osteoblastic work) of trabecular bone packets (completed remodeling sites) describe the average thickness of walls formed during the previous two to three years. If the bone biopsy is obtained shortly after onset of disease or initiation of treatment, ...

journal_title：Bone

authors： Steiniche T,Eriksen EF,Kudsk H,Mosekilde L,Melsen F

更新日期：1992-01-01 00:00:00

abstract：:The present study was designed to evaluate the relationships between ultrasonic backscatter, density, and microarchitecture of cancellous bone. The slopes of the frequency-dependent attenuation coefficient (nBUA), ultrasound bone velocity (UBV), the frequency-averaged backscatter coefficient (BUB) were measured in 25 ...

journal_title：Bone

authors： Chaffaî S,Peyrin F,Nuzzo S,Porcher R,Berger G,Laugier P

更新日期：2002-01-01 00:00:00

abstract：:The effect of homologous recombinant porcine growth hormone (r-pGH) on secondary fracture healing was investigated in a diaphyseal defect of the tibia in Yucatan micropigs. A 1 cm defect of the tibia was created surgically and stabilized with an AO 3.5 mm DCP plate. The treatment group (12 animals) received 100 microg...

journal_title：Bone

authors： Raschke M,Kolbeck S,Bail H,Schmidmaier G,Flyvbjerg A,Lindner T,Dahne M,Roenne IA,Haas N

更新日期：2001-10-01 00:00:00

abstract：:This is a cross-sectional study of spine and hip bone density (BMD) in 124 female athletes, aged 16-68 years, who trained for at least 3 hs/week. The aim was to document the effects of competitive running on BMD in women over a broad age range. Thirty-three subjects, aged <35 years, were currently oligo- or amenorrhei...

journal_title：Bone

authors： Gibson JH,Harries M,Mitchell A,Godfrey R,Lunt M,Reeve J

更新日期：2000-06-01 00:00:00

abstract：INTRODUCTION:Spinal cord injury (SCI) is characterized by rapid bone loss and an increased risk of fragility fracture around regions of the knee. Our purpose was to quantify changes in torsional stiffness K and strength Tult at the proximal tibia due to actual bone loss and simulated bone recovery in acute SCI. METHOD...

journal_title：Bone

authors： Edwards WB,Schnitzer TJ,Troy KL

更新日期：2014-03-01 00:00:00

abstract：:The transcription factor nuclear factor E2 p45-related factor 2 (Nrf2) forms heterodimers with small musculoaponeurotic fibrosarcoma (Maf) proteins for the selective recognition of the antioxidant responsive element on target genes, followed by the regulation of gene expression of phase II detoxifying enzymes as well ...

journal_title：Bone

authors： Hinoi E,Takarada T,Fujimori S,Wang L,Iemata M,Uno K,Yoneda Y

更新日期：2007-02-01 00:00:00

abstract：BACKGROUND:NF-κB essential modulator (NEMO), encoded by IKBKG, is necessary for activation of the ubiquitous transcription factor nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB). Animal studies suggest NEMO is required for NF-κB mediated bone homeostasis, but this has not been thoroughly studied ...

journal_title：Bone

authors： Frost M,Tencerova M,Andreasen CM,Andersen TL,Ejersted C,Svaneby D,Qui W,Kassem M,Zarei A,McAlister WH,Veis DJ,Whyte MP,Frederiksen AL

更新日期：2019-04-01 00:00:00

abstract：:Short-term changes in biochemical markers of bone turnover (bone markers) have been suggested as predictors of long-term response in bone mass during antiresorptive treatment. In the Danish cohort (n = 306) of the Early Postmenopausal Intervention Cohort (EPIC) Study (n = 1609) of oral alendronate (ALN) for prevention...

journal_title：Bone

authors： Ravn P,Thompson DE,Ross PD,Christiansen C

更新日期：2003-07-01 00:00:00