Abstract：
:Chronic inflammatory diseases are associated with bone loss. While the occurrence of systemic bone loss is well described in chronic inflammatory diseases, the impact of these conditions on articular bone has not been systematically investigated. Recent refinements in high-resolution CT assessment of the joints now allow the accurate measure of articular bone composition. In this study 476 subjects comprising healthy individuals and patients with anticitrullinated protein antibody (ACPA)-positive rheumatoid arthritis (RA), ACPA-negative RA, Crohn's disease (CD), ulcerative colitis (UC), psoriasis (PsO) and psoriatic arthritis (PsA) were subjected to high-resolution quantitative computed tomography (HR-pQCT) of the hand. Metacarpal heads were assessed for total, trabecular and cortical volumetric bone mineral density (vBMD). Only ACPA+RA, but not the remaining inflammatory diseases (ACPA-RA, CD, UC, PsO, PsA) showed significant (p < 0.001) loss of articular bone affecting both the trabecular and the cortical compartments. Age and body mass index were also associated with articular bone changes, the former with lower, the latter with higher articular bone mass. In multivariate models, presence of ACPA+RA was an independent factor for articular bone loss. Among chronic inflammatory diseases ACPA+RA is the most potent precipitator for articular bone loss pointing out the role of autoimmunity in the development of articular bone disease in the context of chronic inflammatory disease.
journal_name
Bonejournal_title
Boneauthors
Simon D,Kleyer A,Englbrecht M,Stemmler F,Simon C,Berlin A,Kocijan R,Haschka J,Hirschmann S,Atreya R,Neurath MF,Sticherling M,Rech J,Hueber AJ,Engelke K,Schett Gdoi
10.1016/j.bone.2018.07.017subject
Has Abstractpub_date
2018-11-01 00:00:00pages
87-93eissn
8756-3282issn
1873-2763pii
S8756-3282(18)30285-0journal_volume
116pub_type
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