Osteocyte lacunar properties and cortical microstructure in human iliac crest as a function of age and sex.

abstract：:Glucocorticoids act on the osteoblasts to up-regulate the expression of RANKL, which is very important in the etiology of glucocorticoid-induced osteoclast differentiation and bone resorption. The mechanisms of this process are still not completely understood. Recent studies have shown that glucocorticoids mediate ost...

journal_title：Bone

authors： Shi C,Qi J,Huang P,Jiang M,Zhou Q,Zhou H,Kang H,Qian N,Yang Q,Guo L,Deng L

更新日期：2014-11-01 00:00:00

abstract：:Bisphosphonates are widely used to treat children with osteogenesis imperfecta (OI), a bone fragility disorder that is most often caused by mutations in COL1A1 or COL1A2. However, it is unclear whether this treatment decreases the risk of developing scoliosis. We retrospectively evaluated spine radiographs and charts ...

journal_title：Bone

authors： Sato A,Ouellet J,Muneta T,Glorieux FH,Rauch F

更新日期：2016-05-01 00:00:00

abstract：:Osteoporosis is a common complex disorder with reduced bone mineral density (BMD) and increased susceptibility to fracture. Peak BMD is one of the primary determinants of osteoporotic fracture risk, and is under substantial genetic control. Extracellular matrix, a major component of the bone, influences BMD by regulat...

journal_title：Bone

authors： Alam I,Padgett LR,Ichikawa S,Alkhouli M,Koller DL,Lai D,Peacock M,Xuei X,Foroud T,Edenberg HJ,Econs MJ

更新日期：2014-07-01 00:00:00

abstract：:The effects of basic fibroblasts growth factor (bFGF) administered intravenously at dosages of 0.1 and 0.3 mg/kg per day for 7 days to growing rats are reported. Static and dynamic histomorphometry techniques were applied to the microradiographs and undecalcified ground sections of the proximal tibiae and tibial shaft...

journal_title：Bone

authors： Nagai H,Tsukuda R,Mayahara H

更新日期：1995-03-01 00:00:00

abstract：:Spinal cord injury (SCI) results in a dramatic loss of bone mineral and a marked increase in fracture incidence in the femur; however, its effect on the femur's geometric structure and strength is poorly studied. The primary purpose of the present study was to assess the geometric structure, composition, and strength ...

journal_title：Bone

authors： Modlesky CM,Slade JM,Bickel CS,Meyer RA,Dudley GA

更新日期：2005-02-01 00:00:00

abstract：:Ronacaleret is an orally-active calcium-sensing receptor (CaSR) antagonist that has the potential for therapeutic utility in the stimulation of PTH release, notably as a bone anabolic agent comparable to recombinant human PTH(1-34) (rhPTH(1-34)). A recent study has shown that, despite the ability to increase circulati...

journal_title：Bone

authors： Caltabiano S,Dollery CT,Hossain M,Kurtinecz MT,Desjardins JP,Favus MJ,Kumar R,Fitzpatrick LA

更新日期：2013-09-01 00:00:00

abstract：:Parathyroid hormone (PTH) is used clinically in osteoporotic patients to increase bone mass by enhancing bone formation. PTH therapy is not uniformly effective at all skeletal sites and "life-style" factors may modulate the skeletal response to PTH. Alcohol may represent one of these factors. Chronic alcohol abuse is ...

journal_title：Bone

authors： Iwaniec UT,Trevisiol CH,Maddalozzo GF,Rosen CJ,Turner RT

更新日期：2008-04-01 00:00:00

abstract：:The eValuation of IBandronate Efficacy (VIBE) head-to-head database fracture study compared fracture rates between patients treated with monthly ibandronate and weekly oral bisphosphonates (BPs). This large study included women >/=45 years old, newly prescribed monthly oral ibandronate or weekly oral alendronate or ri...

journal_title：Bone

authors： Harris ST,Reginster JY,Harley C,Blumentals WA,Poston SA,Barr CE,Silverman SL

更新日期：2009-05-01 00:00:00

abstract：:Sclerosteosis and van Buchem disease are two rare bone sclerosing dysplasias caused by genetic defects in the synthesis of sclerostin. In this article we review the demographic, clinical, biochemical, radiological, and histological characteristics of patients with sclerosteosis and van Buchem disease that led to a bet...

journal_title：Bone

authors： van Lierop AH,Appelman-Dijkstra NM,Papapoulos SE

更新日期：2017-03-01 00:00:00

abstract：:Nearly all bone fractures in humans can deteriorate into a non-union fracture, often due to formation of fibrotic tissue. Cranial allogeneic bone grafts present a striking example: although seemingly attractive for craniofacial reconstructions, they often fail due to fibrosis at the host-graft junction, which physical...

journal_title：Bone

authors： Cohn Yakubovich D,Eliav U,Yalon E,Schary Y,Sheyn D,Cook-Wiens G,Sun S,McKenna CE,Lev S,Binshtok AM,Pelled G,Navon G,Gazit D,Gazit Z

更新日期：2017-04-01 00:00:00

abstract：:This study describes the early interface reaction of cancellous bone to a nanocrystalline hydroxyapatite cement containing type I collagen (HA/Coll) and its modifications with sodium citrate (CI), calcium carbonate (CA), phosphoserine (P) and phosphoserine plus RGD-peptide (RGD). Cylindrical implants of HA/Coll and it...

journal_title：Bone

authors： Schneiders W,Reinstorf A,Pompe W,Grass R,Biewener A,Holch M,Zwipp H,Rammelt S

更新日期：2007-04-01 00:00:00

abstract：:Bone strength in adulthood is known to be affected by health at birth and early childhood. Habitual bone loading is a primary determinant of bone strength in later childhood and adulthood. However, the effects of physical activity in early childhood (e.g. crawling, standing and walking) on bone strength are unknown. F...

journal_title：Bone

authors： Ireland A,Rittweger J,Schönau E,Lamberg-Allardt C,Viljakainen H

更新日期：2014-11-01 00:00:00

abstract：:This is a cross-sectional study of spine and hip bone density (BMD) in 124 female athletes, aged 16-68 years, who trained for at least 3 hs/week. The aim was to document the effects of competitive running on BMD in women over a broad age range. Thirty-three subjects, aged <35 years, were currently oligo- or amenorrhei...

journal_title：Bone

authors： Gibson JH,Harries M,Mitchell A,Godfrey R,Lunt M,Reeve J

更新日期：2000-06-01 00:00:00

abstract：BACKGROUND:Periostin (POSTN) regulates multiple biological behaviors of tumor cells. We studied the association of serum POSTN with mortality in home-dwelling men. METHODS:POSTN was measured at baseline using immunoassay (USCN life science, China) in 815 home-dwelling men aged 60-87 followed-up for 8 years. RESULTS:I...

journal_title：Bone

authors： Rousseau JC,Bertholon C,Chapurlat R,Szulc P

更新日期：2020-03-01 00:00:00

abstract：:Bone morphogenetic proteins (BMPs) were first described over 50 years ago as potent inducers of ectopic bone formation when administrated subcutaneously. Preclinical studies have extensively examined the osteoinductive properties of BMPs in vitro and new bone formation in vivo. BMPs (BMP-2, BMP-7) have been used in or...

journal_title：Bone

authors： Kamiya N,Atsawasuwan P,Joiner DM,Waldorff EI,Goldstein S,Yamauchi M,Mishina Y

更新日期：2020-09-01 00:00:00

abstract：:Human osteoclast formation from mononuclear phagocyte precursors involves interactions between lectins and their receptors. A type-2 ribosome inactivating protein consists of an A chain and a B chain. The glycosylated B chain binds specifically to galactose moieties of sugar molecules. In this study we showed that the...

journal_title：Bone

authors： Wang YM,Lu TL,Hsu PN,Tang CH,Chen JH,Liu KC,Kao JT,Tzen JT,Wu YY

更新日期：2011-06-01 00:00:00

abstract：:It was the aim of this retrospective analysis to examine the influence of low-dose monophasic oral contraceptives (OCs) on bone mineral density (BMD) of the femoral neck and of the spine in young female endurance athletes. Data on training intensity, dietary intake, menarche, menstrual cycle disorders, years of OC use...

journal_title：Bone

authors： Hartard M,Kleinmond C,Kirchbichler A,Jeschke D,Wiseman M,Weissenbacher ER,Felsenberg D,Erben RG

更新日期：2004-10-01 00:00:00

abstract：:Tooth eruption involves the movement of a tooth from its site of development within the alveolar bone to its functional position in the oral cavity. Because this process is dependent upon monocytes and formation of osteoclasts, it represents an excellent model for examination of these processes under developmental reg...

journal_title：Bone

authors： Graves DT,Alsulaimani F,Ding Y,Marks SC Jr

更新日期：2002-08-01 00:00:00

abstract：:Old age-associated osteoporosis is related to diminished bone blood flow and impaired nitric oxide (NO)-mediated vasodilation of the bone vasculature. Endurance exercise training restores the age-associated reduction of vasodilation in numerous vascular beds, as well as improving bone properties. The purpose of this s...

journal_title：Bone

authors： Dominguez JM 2nd,Prisby RD,Muller-Delp JM,Allen MR,Delp MD

更新日期：2010-03-01 00:00:00

abstract：OBJECTIVE:To estimate the cost-effectiveness of strontium ranelate in the treatment of postmenopausal osteoporotic women aged over 75 years. MATERIALS AND METHODS:A validated Markov microsimulation model with a Belgian payer's perspective estimated the cost per quality-adjusted life-year (QALY) of a 3-year strontium r...

journal_title：Bone

authors： Hiligsmann M,Bruyère O,Reginster JY

更新日期：2010-02-01 00:00:00

abstract：OBJECTIVE:The pathogenesis of osteonecrosis of the femoral head (ONFH) probably reflects multiple etiologies. Recent studies have explored associations between genetic mutations and/or polymorphisms and ONFH. Annexins (ANXs) have been implicated in many physiological functions, including blood coagulation, inflammation...

journal_title：Bone

authors： Kim TH,Hong JM,Shin ES,Kim HJ,Cho YS,Lee JY,Lee SH,Park EK,Kim SY

更新日期：2009-07-01 00:00:00

abstract：:The conventional stereologic procedure for estimating bone surface densities in iliac crest biopsies gives biased estimates because bone substructure is anisotropic and the sectioning of the biopsies is intended to be parallel to the cylindrical axis of the iliac crest biopsy. It has recently been shown that random an...

journal_title：Bone

authors： Vesterby A,Kragstrup J,Gundersen HJ,Melsen F

更新日期：1987-01-01 00:00:00

abstract：:Progressive osseous heteroplasia (POH) is a rare autosomal dominant disorder of mesenchymal differentiation characterized by progressive heterotopic ossification (HO) of dermis, deep connective tissues and skeletal muscle. Usually, initial bone formation occurs during infancy as primary osteoma cutis (OC) then progres...

journal_title：Bone

authors： Elli FM,Barbieri AM,Bordogna P,Ferrari P,Bufo R,Ferrante E,Giardino E,Beck-Peccoz P,Spada A,Mantovani G

更新日期：2013-10-01 00:00:00

abstract：:Avian tibial dyschondroplasia is a disorder of endochondral ossification which results in the accumulation of noncalcified, avascular cartilage. We have investigated the changes in cell proliferation and enzyme activities within specific cell types in the growth plate of chickens with differing severity of the disease...

journal_title：Bone

authors： Farquharson C,Whitehead C,Rennie S,Thorp B,Loveridge N

更新日期：1992-01-01 00:00:00

abstract：:Leptin, a small polypeptide hormone secreted by the adipocytes, controls body weight and gonadal function by binding to a special receptor located in the hypothalamus. Observational studies have demonstrated a controversial association between leptin and bone mineral density (BMD), and functional studies of the relati...

journal_title：Bone

authors： Meng XH,Tan LJ,Xiao HM,Tang BS,Deng HW

更新日期：2019-08-01 00:00:00

abstract：:Osteocalcin, the gamma-carboxyglutamic acid-containing protein, which in most species is the predominant noncollagenous protein of bone and dentin, has been postulated to play roles in bone formation and remodeling. Recently, genetic studies showed that osteocalcin acts as an inhibitor of osteoblast function. Based on...

journal_title：Bone

authors： Boskey AL,Gadaleta S,Gundberg C,Doty SB,Ducy P,Karsenty G

更新日期：1998-09-01 00:00:00

abstract：:Deficiency of Sirtuin 6 (SIRT6), a chromatin-related deacetylase, in mice reveals severe premature aging phenotypes including osteopenia. However, the underlying molecular mechanisms of SIRT6 in bone metabolism are unknown. Here we show that SIRT6 deficiency in mice produces low-turnover osteopenia caused by impaired ...

journal_title：Bone

authors： Sugatani T,Agapova O,Malluche HH,Hruska KA

更新日期：2015-12-01 00:00:00

abstract：:Skeletal problems and osteoporosis occur in up to 50% affected neurofibromatosis type 1 (NF1) humans. Inactivation of neurofibromin results in deregulation of Ras signal transduction. Little is known of bone biology in humans with NF1. The goal of our work was to determine if loss-of-function of Nf1 gene was associate...

journal_title：Bone

authors： Yu X,Chen S,Potter OL,Murthy SM,Li J,Pulcini JM,Ohashi N,Winata T,Everett ET,Ingram D,Clapp WD,Hock JM

更新日期：2005-05-01 00:00:00

abstract：:1,25-Dihydroxyvitamin D [1,25(OH)(2)D] insufficiency appears to be associated with several age-related diseases. Insufficient levels of serum 25-hydroxyvitamin D has been shown to lead to the progression of osteoarthritis (OA) while underlying biological mechanisms remain largely unknown. In this study, we sought to d...

journal_title：Bone

authors： Shen M,Luo Y,Niu Y,Chen L,Yuan X,Goltzman D,Chen N,Miao D

更新日期：2013-08-01 00:00:00

abstract：INTRODUCTION:The GH-IGF axis has profound effects on bone metabolism and may be important in the etiology of idiopathic osteoporosis. Serum IGF-I is often low in men with osteoporosis, which may be attributable to GH hypo-secretion or hepatic GH insensitivity. We studied the GH-IGF axis in depth to look for evidence to...

journal_title：Bone

authors： Patel MB,Arden NK,Masterson LM,Phillips DI,Swaminathan R,Syddall HE,Byrne CD,Wood PJ,Cooper C,Holt RI,Hertfordshire Cohort Study Group.

更新日期：2005-12-01 00:00:00