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Examining the causal role of leptin in bone mineral density: A Mendelian randomization study.

Abstract：

:Leptin, a small polypeptide hormone secreted by the adipocytes, controls body weight and gonadal function by binding to a special receptor located in the hypothalamus. Observational studies have demonstrated a controversial association between leptin and bone mineral density (BMD), and functional studies of the relationship between leptin and BMD still largely vary by different studies. Using SNPs strongly associated with leptin levels in 52,140 individuals, we conducted a two-sample Mendelian randomization study to identify whether genetically lowered leptin levels were associated with BMD by using an inverse-variance weighted method, a weighted median method, MR-Egger and Robust Adjusted Profile Score. We found that circulating leptin levels may causally decrease lumbar spine BMD (effect size = -0.45, 95% CI: -0.82, -0.083; p value = 0.016). The association estimates of circulating leptin levels on femoral neck, forearm and total body BMD were not significant. Our study suggests that genetically predicted higher circulating leptin was associated with lower LS-BMD.

journal_name

Bone

journal_title

Bone

authors

Meng XH,Tan LJ,Xiao HM,Tang BS,Deng HW

doi

10.1016/j.bone.2019.05.006

subject

Has Abstract

pub_date

2019-08-01 00:00:00

pages

25-29

eissn

8756-3282

issn

1873-2763

pii

S8756-3282(19)30171-1

journal_volume

125

pub_type

杂志文章

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