Abstract:
:Paget's disease is the most exaggerated example of bone remodeling in which abnormal osteoclastic bone resorption remains coupled to new bone formation. There are abnormalities in the stages of osteoclast development, and studies in Paget's disease have suggested a major role for IL-6 in human osteoclast activity. The pathophysiologic basis for these abnormalities is not clearly defined, except that the primary cellular abnormality resides in the osteoclast. Many important questions about the pathophysiology of Paget's disease still remain to be answered, including: (1) What is the identity of the virus in pagetic osteoclasts?; (2) Are Paget's patients in different geographical locales harboring a similar virus in their osteoclasts, or can different paramyxoviruses induce Paget's disease?; (3) How is the virus maintained and propagated for many years, so that it can be expressed in the osteoclast, a cell with a finite lifespan?; and (4) Since Paget's disease has a very high familial tendency, with up to 40% of patients having an affected relative, what is the genetic locus associated with Paget's disease, and does this genotype result in an increased propensity for hematopoietic cells such as the osteoclast to harbor paramyxoviruses? The application of the techniques of molecular and cell biology to Paget's disease should provide answers to some of these questions and give important insights into the normal bone remodeling process.
journal_name
Bonejournal_title
Boneauthors
Roodman GDdoi
10.1016/8756-3282(96)00211-6subject
Has Abstractpub_date
1996-09-01 00:00:00pages
209-12issue
3eissn
8756-3282issn
1873-2763pii
8756328296002116journal_volume
19pub_type
杂志文章,评审相关文献
BONE文献大全abstract::We examined the mode of action of bisphosphonates on osteoclastic cell recruitment using mouse marrow cultures with or without osteoblastic cells. Tartrate-resistant acid phosphatase-positive multinucleated cells [TRAP(+)MNC] formed in cultures were determined to be osteoclastic cells. In marrow cultures, TRAP(+) MNC ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(95)00426-2
更新日期:1996-01-01 00:00:00
abstract::The use of combined antiretroviral agents during pregnancy is important to prevent mother-to-child transmission of human immunodeficiency virus (HIV). Antiretroviral treatment (ARV) is associated with reduced bone mass and altered bone metabolism in HIV-infected patients. There are no data regarding the effect of ARV ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2011.10.030
更新日期:2012-01-01 00:00:00
abstract::A macro-micro-nano-multi-level study was conducted to explore age-related structural and mechanical properties of bone, as well as the effects of aging on bone properties. A total of 70 male Wistar rats were used, ranging in the ages of 1, 3, 5, 7, 9, 11, 14, 15, 16, and 17 months (n = 7/age group). After micro-comput...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2015.03.022
更新日期:2015-07-01 00:00:00
abstract::Several studies have documented that diabetes impairs bone healing clinically and experimentally. Systemic insulin treatment has been shown to ameliorate impaired diabetic bone healing. However, these studies failed to distinguish between a direct and a systemic effect of insulin upon bone healing. A novel intramedull...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2005.04.039
更新日期:2005-10-01 00:00:00
abstract::The propensity of individual trabeculae to fracture (microfracture) may be important clinically since it could be indicative of bone fragility. Whether or not an overloaded trabecula fractures is determined in part by its structural ductility, a mechanical property that describes how much deformation a trabecula can s...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2005.07.019
更新日期:2005-12-01 00:00:00
abstract::Five strains of inbred mice were found to have variations in bone mass although they were similar in body weight. Two of these strains, C57BL/6J and A/J, were studied in greater detail and the former had more bone in both femur and tibia. The increased bone mass was associated with larger quadriceps muscles in the C57...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(00)00164-2
更新日期:1995-08-01 00:00:00
abstract::Trabecular bone fracture represents a major health problem, therefore the improvement of its assessment is mandatory for the reduction of the economic and social burden. The micro-structure of the trabecular bone was found to have an important effect on trabecular mechanical behavior. Nonetheless, the high variability...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2013.12.007
更新日期:2014-03-01 00:00:00
abstract::We previously reported that a type II sodium phosphate (Na(+)-Pi) cotransporter (Npt2) protein is expressed in osteoclasts and that Pi limitation decreases osteoclast-mediated bone resorption in vitro. We also demonstrated that mice homozygous for the disrupted Npt2 gene (Npt2-/-) exhibit a unique age-dependent bone p...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(01)00601-9
更新日期:2001-11-01 00:00:00
abstract::Iliac crest bone biopsies from 62 patients (42 women, 20 men; median age 59 years; range 17-79 years) with primary hyperparathyroidism (PHP) were examined. Static and structural parameters were compared with 30 age- and sex-matched normal controls. Eighteen sex-matched younger controls were used for evaluation of the ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(93)90207-q
更新日期:1993-09-01 00:00:00
abstract:BACKGROUND:U.S. Army Basic Combat Training (BCT) is a physically-demanding program at the start of military service. Whereas animal studies have shown that increased mechanical loading rapidly alters bone structure, there is limited evidence of changes in bone density and structure in humans exposed to a brief period o...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2018.04.021
更新日期:2018-08-01 00:00:00
abstract::There is a lot of interest for how and how much osteoclasts resorb bone. However, little is known about the mechanism which controls the orientation and the duration of a resorptive event, thereby determining the specific geometry of a cavitation. Here we show that the relative rate of collagenolysis vs. demineralizat...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2013.06.007
更新日期:2013-09-01 00:00:00
abstract::In order to investigate the effect of fluoride on bone mineral crystals, we gave groups of female rats 8 mM NaF/L water and distilled water to control groups. The rats were sacrificed at six weeks, three months, and six months. The fluor content of the bone was determined by neutron activation. X-ray diffraction showe...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(92)90085-b
更新日期:1992-01-01 00:00:00
abstract::Although extensive studies have done much to clarify the molecular mechanisms of osteoclastogenesis during the last ten years, there may still be unknown molecules associated with osteoclast differentiation. Thus, we used fluorescent differential display to screen for genes whose expression is induced by receptor acti...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2011.10.028
更新日期:2012-01-01 00:00:00
abstract:CASE REPORT:A female patient with consanguineous parents presented with severe symptomatic hypocalcemia (1.62mmol/l) at the age of 4 months. Treatment with oral 1,25-(OH)2-vitamin D and calcium carbonate was started and serum calcium concentrations were stabilized at the lower end of the normal range. Subsequently she ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2012.06.009
更新日期:2012-09-01 00:00:00
abstract::Among vertebrates, urodele amphibians (e.g., axolotls) have the unique ability to perfectly regenerate complex body parts after amputation. The limb has been the most widely studied due to the presence of three defined axes and its ease of manipulation. Hence, the limb has been chosen as a model to study the process o...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2006.07.005
更新日期:2007-01-01 00:00:00
abstract::Bone matrix, mainly composed of type I collagen and apatite, is constantly modified during the bone remodeling process, which exposes bone cells to various proportions of mineralized collagen within bone structural units. Collagen-mineralized substrates have been shown to increase osteoblast activities. We hypothesize...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2010.03.010
更新日期:2010-07-01 00:00:00
abstract::Bone fragility is a complication of chronic kidney disease (CKD). Patients on dialysis have higher risk of fracture than the general population, but the reason remains obscure. Bone strength is determined by bone mass and bone quality. Although factors affecting bone quality include microarchitecture, remodeling activ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2011.03.672
更新日期:2011-06-01 00:00:00
abstract::Bone morphogenetic protein 2 (BMP2), a very potent bone-inducing agent, promotes the differentiation of bone marrow stem cells (BMSCs) to osteoblasts. However, the potency of BMP2 action is variable and its perturbed dynamic signaling pathways in human BMSCs has not been fully elucidated. In this study, we used a comb...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2010.02.013
更新日期:2010-06-01 00:00:00
abstract::Women with prevalent fractures have an increased risk of developing additional, incident fractures. This article examines the relation between the location of prevalent fractures within the spine and the risk of subsequent vertebral fractures. The subjects were 721 Japanese-American women of mean age 69.5 +/- 5.3 (SD)...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(98)00176-8
更新日期:1999-03-01 00:00:00
abstract::Osteoblast-like cells express receptors for various hormones and neurotransmitters that induce widespread actions in the bone to which intercellular communication and its modulation may contribute. Therefore, we examined the effects of the osteotropic hormones vitamin D3 (vitD3) and 17beta-estradiol (17beta-E2) as wel...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(98)00142-2
更新日期:1998-12-01 00:00:00
abstract::Conventional methods used to image and quantify microdamage accumulation in bone are limited to histological sections, which are inherently invasive, destructive, two-dimensional, and tedious. These limitations inhibit investigation of microdamage accumulation with respect to volumetric spatial variation in mechanical...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2010.10.160
更新日期:2011-03-01 00:00:00
abstract::Trabecular bone score (TBS) is a recently-developed analytical tool that performs novel grey-level texture measurements on lumbar spine dual X-ray absorptiometry (DXA) images, and thereby captures information relating to trabecular microarchitecture. In order for TBS to usefully add to bone mineral density (BMD) and c...
journal_title:Bone
pub_type: 杂志文章,评审
doi:10.1016/j.bone.2015.05.016
更新日期:2015-09-01 00:00:00
abstract::Mutations in the SCN8A gene encoding the neuronal voltage-gated sodium channel Nav1.6 are known to be associated with epileptic encephalopathy type 13. We identified a novel de novo SCN8A mutation (p.Phe360Ala, c.1078_1079delTTinsGC, Exon 9) in a 6-year-old girl with epileptic encephalopathy accompanied by severe juve...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2017.06.025
更新日期:2017-10-01 00:00:00
abstract::LMP1 is an intracellular scaffold protein that contains a PDZ domain and three LIM domains. LMP1 has multiple functions including regulating mesenchymal stem cell (MSC) osteogenesis. Gene delivery of LMP1 induces bone formation in vivo in heterotopic and orthotopic sites. However, little is known about the physiologic...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2010.03.013
更新日期:2010-07-01 00:00:00
abstract::A recurrent aneurysmal bone cyst of the proximal phalanx of the index finger of a three-year-old child, treated with bioactive glass, is presented. Over a two-year follow-up, the treated area appeared dense on X-rays. At two years, no cavity was observed and the homogenous region resembled normal trabecular bone. The ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2009.04.195
更新日期:2009-08-01 00:00:00
abstract:BACKGROUND:Periostin (POSTN) regulates multiple biological behaviors of tumor cells. We studied the association of serum POSTN with mortality in home-dwelling men. METHODS:POSTN was measured at baseline using immunoassay (USCN life science, China) in 815 home-dwelling men aged 60-87 followed-up for 8 years. RESULTS:I...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2019.115184
更新日期:2020-03-01 00:00:00
abstract::There is a persuasive rationale from the use of hormone replacement therapy (HRT) at the time of the menopause, but there are a number of factors which limit its widespread application for osteoporosis. These relate partly to the long-term efficacy of HRT when given for a finite duration at the time of the menopause, ...
journal_title:Bone
pub_type: 杂志文章,评审
doi:10.1016/s8756-3282(96)90163-5
更新日期:1996-11-01 00:00:00
abstract::The effect of low-dose 1 alpha-hydroxyvitamin D3 [1 alpha(OH)D3] on experimental osteoporosis in rats induced by a combination of hemicordotomy and ovariectomy was evaluated. 1 alpha(OH)D3 (0.1 microgram/kg 1 alpha(OH)D3 three times a week) increased the femur score and photo-density. The administration of 1 alpha(OH)...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(87)90066-4
更新日期:1987-01-01 00:00:00
abstract::The multi-domain neutral endopeptidase, ADAMTS-1 (a disintegrin and metalloprotease with thrombospondin repeats) is induced by parathyroid hormone (PTH) in rat osteoblasts and has therefore been suggested to be involved in initiation of bone remodeling. However, its function(s) in bone cells have not been studied. Her...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2007.04.187
更新日期:2007-08-01 00:00:00
abstract::One of the side effects associated with glucocorticoid therapy is glucocorticoid-induced bone loss. Glucocorticoids partly detain bone formation via the inhibition of osteoblastic function, however, the exact mechanism of this inhibition remains elusive. In this study, we examined the effect of dexamethasone, an activ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2011.01.017
更新日期:2011-05-01 00:00:00