Treatment of a recurrent aneurysmal bone cyst with bioactive glass in a child allows for good bone remodelling and growth.

abstract：:Treatment with parathyroid hormone 1-84 (PTH) or teriparatide increases osteonal remodeling and decreases bone mineral density (BMD) at cortical (Ct) bone sites but may also increase bone size. Decreases in BMD and increases in size exert opposing effects on bone strength. In adult ovariectomized (OVX) rhesus monkeys,...

journal_title：Bone

authors： Fox J,Miller MA,Newman MK,Recker RR,Turner CH,Smith SY

更新日期：2007-09-01 00:00:00

abstract：:Recent studies have established that generalized loss of trabecular bone occurs in the growing rat following day-to-day inflammatory irritation for a period of 3 wk. We can now demonstrate that there are similar effects on bone in milder but more prolonged chronic inflammation (14 wk). Thus, there were significant dec...

journal_title：Bone

authors： Pfeilschifter J,Minne HW,Enzmann E,Krempien B,Ziegler R

更新日期：1985-01-01 00:00:00

abstract：:Parathyroid hormone (PTH) is used clinically in osteoporotic patients to increase bone mass by enhancing bone formation. PTH therapy is not uniformly effective at all skeletal sites and "life-style" factors may modulate the skeletal response to PTH. Alcohol may represent one of these factors. Chronic alcohol abuse is ...

journal_title：Bone

authors： Iwaniec UT,Trevisiol CH,Maddalozzo GF,Rosen CJ,Turner RT

更新日期：2008-04-01 00:00:00

abstract：:It is known that marrow fat content increases in a variety of osteoporoses. This study sought to clarify this phenomenon by combining bone and marrow histomorphometry, and to determine (1) whether the marrow fat increase follows or precedes diminishment of bone volume, and (2) whether the increase in fat volume is due...

journal_title：Bone

authors： Martin RB,Zissimos SL

更新日期：1991-01-01 00:00:00

abstract：:Strontium ranelate (S12911) has previously been shown to stimulate bone formation and inhibit bone resorption in rats. To determine whether strontium ranelate affects normal bone remodeling, we studied the effect of strontium ranelate on alveolar bone in monkeys. Strontium ranelate, at dosages of 100, 275, and 750 mg/...

journal_title：Bone

authors： Buehler J,Chappuis P,Saffar JL,Tsouderos Y,Vignery A

更新日期：2001-08-01 00:00:00

abstract：:The effects of basic fibroblasts growth factor (bFGF) administered intravenously at dosages of 0.1 and 0.3 mg/kg per day for 7 days to growing rats are reported. Static and dynamic histomorphometry techniques were applied to the microradiographs and undecalcified ground sections of the proximal tibiae and tibial shaft...

journal_title：Bone

authors： Nagai H,Tsukuda R,Mayahara H

更新日期：1995-03-01 00:00:00

abstract：:Osteoblast-like cells express receptors for various hormones and neurotransmitters that induce widespread actions in the bone to which intercellular communication and its modulation may contribute. Therefore, we examined the effects of the osteotropic hormones vitamin D3 (vitD3) and 17beta-estradiol (17beta-E2) as wel...

journal_title：Bone

authors： Schirrmacher K,Bingmann D

更新日期：1998-12-01 00:00:00

abstract：:Loss of bone and muscle mass are two major clinical complications among the growing list of chronic diseases that primarily affect elderly individuals. Persistent low-grade inflammation, one of the major drivers of aging, is also associated with both bone and muscle dysfunction in aging. Particularly, chronic activati...

journal_title：Bone

authors： Davis HM,Essex AL,Valdez S,Deosthale PJ,Aref MW,Allen MR,Bonetto A,Plotkin LI

更新日期：2019-07-01 00:00:00

abstract：:Sulfate conjugation is an important pathway in the metabolism of many drugs, xenobiotic compounds, and hormones. Sulfotransferases (SULTs) catalyze these reactions and have been detected and characterized in various human tissues including the liver and small intestine. Substrates for SULTs that include estrogen and t...

journal_title：Bone

authors： Dubin RL,Hall CM,Pileri CL,Kudlacek PE,Li XY,Yee JA,Johnson ML,Anderson RJ

更新日期：2001-06-01 00:00:00

abstract：:A more accurate understanding of the molecular mechanisms and signaling pathways underpinning human mesenchymal stem cell (MSC) plasticity and differentiation properties is pivotal for accomplishing solid and diligent translation of MSC-based experimental therapeutics and clinical trials to broad clinical practice. In...

journal_title：Bone

authors： Ishiy FAA,Fanganiello RD,Kobayashi GS,Kague E,Kuriki PS,Passos-Bueno MR

更新日期：2018-01-01 00:00:00

abstract：:Various substitution mutations in ALK2, a transmembrane serine/threonine kinase receptor for bone morphogenetic proteins (BMPs), have been identified in patients with genetic disorders such as fibrodysplasia ossificans progressiva (FOP), diffuse intrinsic pontine glioma (DIPG) and heart defects. In this study, we char...

journal_title：Bone

authors： Machiya A,Tsukamoto S,Ohte S,Kuratani M,Fujimoto M,Kumagai K,Osawa K,Suda N,Bullock AN,Katagiri T

更新日期：2018-06-01 00:00:00

abstract：:Postmenopausal fractures are associated with low bone mass; however, the role of low peak bone mass in young adults in determining subsequent osteoporosis suggests that premenopausal fractures may also be relevant. We therefore sought to determine whether a self-reported previous history of premenopausal wrist and non...

journal_title：Bone

authors： Fiorano-Charlier C,Ostertag A,Aquino JP,de Vernejoul MC,Baudoin C

更新日期：2002-07-01 00:00:00

abstract：INTRODUCTION:High plasma homocysteine (Hcy) levels have been associated with increased risk of fracture. Since Hcy has been shown to induce apoptosis in many cell types, including vascular endothelial cells, we hypothesized that Hcy would have a similar apoptotic effect on osteoblasts, leading to osteoporosis by reduci...

journal_title：Bone

authors： Kim DJ,Koh JM,Lee O,Kim NJ,Lee YS,Kim YS,Park JY,Lee KU,Kim GS

更新日期：2006-09-01 00:00:00

abstract：:The formation of cartilage prior to bone in an endochondral bone formation process suggests that some osteogenic factors exist in the cartilage. This osteogenic activity of cartilage or cartilage cells was examined by implanting ribs and costal cartilage zone into a subcutaneous pocket of abdominal wall, or the growth...

journal_title：Bone

authors： Okihana H,Shimomura Y

更新日期：1992-01-01 00:00:00

abstract：:The present work was designed to investigate the effects of oscillating fluid flow on gap junctional intercellular communication (GJIC) and the gap junction protein connexin (Cx) 43 in osteocyte-like MLOY-4 cells. Cells were exposed for 1 h to oscillating fluid flow at a shear stress of +/-10 dyn/cm(2) and a frequency...

journal_title：Bone

authors： Alford AI,Jacobs CR,Donahue HJ

更新日期：2003-07-01 00:00:00

abstract：:Alterations in bone strength and structure were found in knockout (KO) mouse strains with deletion of several acetylcholine receptors. Interestingly, the expression of the nicotinic acetylcholine receptors (nAChR) subunit α10 was down-regulated in osteogenic differentiated mesenchymal stem cells of patients with osteo...

journal_title：Bone

authors： Baumann L,Kauschke V,Vikman A,Dürselen L,Krasteva-Christ G,Kampschulte M,Heiss C,Yee KT,Vetter DE,Lips KS

更新日期：2019-03-01 00:00:00

abstract：:Levels of HtrA1 protein in cartilage have been reported to elevate in joints of human osteoarthritis patients. To understand roles of HtrA1 in normal osteogenesis as well as in pathogenesis of arthritis, we examine HtrA1 expression pattern during bone and cartilage development and in articular cartilage affected by ex...

journal_title：Bone

authors： Tsuchiya A,Yano M,Tocharus J,Kojima H,Fukumoto M,Kawaichi M,Oka C

更新日期：2005-09-01 00:00:00

abstract：:Fracture risk and mechanical competence of bone are functions of bone mass and tissue quality, which in turn are dependent on the bone's mechanical environment. Male mice have a greater response to non-weight-bearing exercise than females, resulting in larger, stronger bones compared with control animals. The aim of t...

journal_title：Bone

authors： Wallace JM,Rajachar RM,Allen MR,Bloomfield SA,Robey PG,Young MF,Kohn DH

更新日期：2007-04-01 00:00:00

abstract：:Odontoblasts and osteoblasts are two among the myriads of cell types present in the craniofacial complex. Both have a common ectomesenchymal origin and secrete macromolecules that are necessary for the formation of dentin and alveolar bone via matrix-mediated mechanisms. The mineralized matrices of bone and dentin dif...

journal_title：Bone

authors： Hao J,He G,Narayanan K,Zou B,Lin L,Muni T,Ramachandran A,George A

更新日期：2005-10-01 00:00:00

abstract：:Bisphosphonates are widely used to treat children with osteogenesis imperfecta (OI), a bone fragility disorder that is most often caused by mutations in COL1A1 or COL1A2. However, it is unclear whether this treatment decreases the risk of developing scoliosis. We retrospectively evaluated spine radiographs and charts ...

journal_title：Bone

authors： Sato A,Ouellet J,Muneta T,Glorieux FH,Rauch F

更新日期：2016-05-01 00:00:00

abstract：:Bone structure is an important determinant of osteoporotic fracture. In women, bone structure is highly heritable, and several quantitative trait loci (QTL) have been reported. There are few comparable data in men. This study in men aimed at establishing the heritability of bone structure at the proximal femur, identi...

journal_title：Bone

authors： Peacock M,Koller DL,Lai D,Hui S,Foroud T,Econs MJ

更新日期：2005-10-01 00:00:00

abstract：:Genetic heterogeneity, high burden and the paucity of genetic testing for rare diseases challenge genomic healthcare for these disorders in India. Here we report our experience over the past decade, of establishing the genomic evaluation of skeletal dysplasia at a tertiary university hospital in India. Research or cli...

journal_title：Bone

authors： Uttarilli A,Shah H,Bhavani GS,Upadhyai P,Shukla A,Girisha KM

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND AND AIM:The safety of bisphosphonates in human pregnancy has not been well established. To characterize pregnancy outcome in women receiving bisphosphonates, we conducted a multi-centre, prospective cohort study with a comparison group. METHODS:Patients were recruited through 3 teratogen information centres...

journal_title：Bone

authors： Levy S,Fayez I,Taguchi N,Han JY,Aiello J,Matsui D,Moretti M,Koren G,Ito S

更新日期：2009-03-01 00:00:00

abstract：:Giant osteoclasts and other cells were isolated from Pagetic bone tissue using 0.5 mM ethylene diamine tetraacetic acid on bone samples from 8 patients with Paget's disease. The cell suspension contained osteoclasts and osteoblasts as well as some mononuclear cells such as monocytes. The number of nuclei in isolated o...

journal_title：Bone

authors： Basle MF,Mazaud P,Malkani K,Chretien MF,Moreau MF,Rebel A

更新日期：1988-01-01 00:00:00

abstract：:Aldehyde dehydrogenase 2 (ALDH2) is the enzyme that oxidizes the acetaldehyde produced by alcohol metabolism. This variant not only affects the response to alcohol but is also associated with several diseases, such as esophageal cancer, myocardial infarction, and particularly osteoporosis. In our previous study, we re...

journal_title：Bone

authors： Kosugi K,Tajima T,Menuki K,Okuma KF,Tokuda K,Fukuda H,Okada Y,Tsukamoto M,Yamanaka Y,Zenke Y,Sakai A

更新日期：2020-07-01 00:00:00

abstract：:In order to assess the ability of six potential bone graft substitutes to support the growth of human osteoblasts, these cells were grown in culture and then plated onto fragments of the six materials and cultured for a further period of 15 days. Tests to confirm the osteoblastic phenotype of the cells included spectr...

journal_title：Bone

authors： Begley CT,Doherty MJ,Hankey DP,Wilson DJ

更新日期：1993-07-01 00:00:00

abstract：INTRODUCTION:The RANKL-OPG axis is a key regulator of osteoclastogenesis and bone turnover activity. Its contribution to bone resorption under altered mechanical states, however, has not been fully elucidated. Here we examined the role of OPG in regulating mechanically induced bone modeling in a rat model of orthodonti...

journal_title：Bone

authors： Dunn MD,Park CH,Kostenuik PJ,Kapila S,Giannobile WV

更新日期：2007-09-01 00:00:00

abstract：:One year of treatment with bisphosphonates at 5x the dose used for post-menopausal osteoporosis significantly increases failure load and microdamage, and decreases toughness at multiple skeletal sites in intact female beagles. The goal of this study was to determine if similar changes occur with doses equivalent to th...

journal_title：Bone

authors： Allen MR,Iwata K,Phipps R,Burr DB

更新日期：2006-10-01 00:00:00

abstract：:Because the extracellular matrices of dentin and bone are composed mainly of type I collagen, their characteristics are determined by the nature of noncollagenous proteins (NCPs). Among these NCPs, some proteoglycans (PGs) belong to the small leucine-rich proteoglycans (SLRPs). Recently, osteoadherin (OSAD) has been d...

journal_title：Bone

authors： Buchaille R,Couble ML,Magloire H,Bleicher F

更新日期：2000-08-01 00:00:00

abstract：:Dynamic mechanical loading increases bone density and strength and promotes osteoblast proliferation, differentiation and matrix production, by acting at the gene expression level. Molecular mechanisms through which mechanical forces are conversed into biochemical signalling in bone are still poorly understood. A grow...

journal_title：Bone

authors： Costessi A,Pines A,D'Andrea P,Romanello M,Damante G,Cesaratto L,Quadrifoglio F,Moro L,Tell G

更新日期：2005-03-01 00:00:00