Abstract：
:The effects of basic fibroblasts growth factor (bFGF) administered intravenously at dosages of 0.1 and 0.3 mg/kg per day for 7 days to growing rats are reported. Static and dynamic histomorphometry techniques were applied to the microradiographs and undecalcified ground sections of the proximal tibiae and tibial shafts. The bone histomorphometric analyses in the proximal tibia revealed that 0.1 mg/kg per day of bFGF increased longitudinal growth rate, cartilage cell production rate, and metaphyseal bone area. In the tibial shaft, the endocortical mineral apposition and bone formation rates, total bone area, total osteoid area, and medullary bone area were increased, but the periosteal mineral apposition and bone formation rates were depressed. Two weeks after the cessation of treatment, the increased osteoid bone on the endocortical surface and in the marrow cavity was completely calcified, and the total mineralized area in the tibial shaft was significantly increased. The rats given 0.3 mg of bFGF/kg per day showed retarded weight gain, defective calcification at the growth plate metaphyseal junction, and on the endocortical surface. The growth plate width was increased, and the longitudinal growth rate, cartilage cell production rate, endocortical labeled surface, and bone formation rate were decreased. Two weeks after the cessation of treatment, these changes were almost reversed, and the longitudinal growth rate and cartilage cell production rate were increased as rebound phenomena. These results suggest that a low dose (0.1 mg/kg per day) of bFGF stimulates endosteal and endochondral bone formation and depresses periosteal bone formation in growing rats.
journal_name
Bonejournal_title
Boneauthors
Nagai H,Tsukuda R,Mayahara Hdoi
10.1016/8756-3282(94)00049-2subject
Has Abstractpub_date
1995-03-01 00:00:00pages
367-73issue
3eissn
8756-3282issn
1873-2763pii
8756328294000492journal_volume
16pub_type
杂志文章相关文献
BONE文献大全abstract：:High-resolution peripheral quantitative computed tomography (HR-pQCT) is clinically available today and provides a non-invasive measure of 3D bone geometry and micro-architecture with unprecedented detail. In combination with microarchitectural finite element (μFE) models it can be used to determine bone strength usin...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2011.02.022
更新日期：2011-06-01 00:00:00
abstract：:To facilitate an understanding of the dependence of ultrasound velocity and attenuation upon the material and structural properties of cancellous bone, several theoretical concepts for ultrasound propagation have been adapted or developed, including the Biot theory and several scattering theories. Biot theory consider...
journal_title：Bone
pub_type： 杂志文章,评审
doi：10.1016/s8756-3282(99)00011-3
更新日期：1999-04-01 00:00:00
abstract：:Hypophosphatasia (HPP) is an inherited disorder characterized by defective bone mineralization caused by mutations in the alkaline phosphatase gene (ALPL). Clinically, the disease spans a great continuum of disease severity and six forms can be distinguished according to the age of onset. The most severe is the autoso...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2013.12.009
更新日期：2014-03-01 00:00:00
abstract：:End plate chondrocyte degeneration is a major cause of intervertebral disc degeneration. Mechanical biophysical forces, including intermittent cyclic mechanical tension (ICMT), exacerbate end plate chondrocyte degeneration. However, the underlying molecular mechanism of mechanical stretch-induced end plate chondrocyte...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2019.115052
更新日期：2019-11-01 00:00:00
abstract：:The Mediterranean osteoporosis (MEDOS) study was carried out in 14 centres from six countries in Southern Europe to determine the incidence rates and risk factors associated with hip fracture over the age of 50 years. This paper discusses both the validity and relevance of the data, that is, whether the number of coll...
journal_title：Bone
pub_type： 杂志文章,多中心研究
doi：10.1016/8756-3282(93)90349-f
更新日期：1993-01-01 00:00:00
abstract：:The Microphthalmia-associated transcription factor (Mitf) is required for the proper development of several cell lineages including osteoclasts, melanocytes, retinal pigment epithelial cells, mast cells and natural killer cells. Mutations in Mitf in multiple organisms result in osteopetrosis due to defective osteoclas...
journal_title：Bone
pub_type： 杂志文章,评审
doi：10.1016/j.bone.2003.08.014
更新日期：2004-04-01 00:00:00
abstract：:Nearly all bone fractures in humans can deteriorate into a non-union fracture, often due to formation of fibrotic tissue. Cranial allogeneic bone grafts present a striking example: although seemingly attractive for craniofacial reconstructions, they often fail due to fibrosis at the host-graft junction, which physical...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2017.01.020
更新日期：2017-04-01 00:00:00
abstract：:Achondroplasia (ACH), the most common form of human dwarfism is caused by a mutation in the Fibroblast Growth Factor Receptor 3 (FGFR3) gene, resulting in constitutive activation of the receptor. Typical radiological features include shortening of the tubular bones and macrocephaly, due to disruption of endochondral o...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2010.07.020
更新日期：2010-11-01 00:00:00
abstract：:Osteoblasts are believed to differentiate into osteocytes, becoming embedded in bone, or to undergo apoptosis after the bone formation phase. The regulation of this terminal differentiation seems to be critical for bone homeostasis. However the mechanism remains unclear and there is no assay system currently available...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2012.09.001
更新日期：2013-01-01 00:00:00
abstract：:The present study describes the biological effects of risedronate, a pyridinyl bisphosphonate, on bone and assesses the safety and tolerability of risedronate when given at high doses, with or without calcium, to postmenopausal women with spinal osteoporosis. This single-center descriptive, double-blind, placebo-contr...
journal_title：Bone
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s8756-3282(00)00410-5
更新日期：2001-01-01 00:00:00
abstract：INTRODUCTION:Because osteoporotic patients are prone to fractures, it must be considered whether or not patients undergoing drug therapies should discontinue treatment after sustaining a non-vertebral fracture. This study has tested the effect of novel active vitamin D3 analog, 1alpha,25-dihydroxy-2beta(3-hydroxypropox...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2006.07.023
更新日期：2007-01-01 00:00:00
abstract：OBJECTIVES:Progression of an incomplete atypical femoral fracture (IF) to a complete fracture in patients on long term bisphosphonate (BP) therapy can be catastrophic. We aimed to determine the frequency and imaging features of IF in asymptomatic patients on long-term BP therapy and to identify distinguishing clinical ...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2013.03.018
更新日期：2013-07-01 00:00:00
abstract：:Mammalian bone sialoprotein (BSP) is a mineralized tissue-specific protein containing an RGD (arginine-glycine-aspartic acid) cell-attachment sequence and two distinct glutamic acid (glu)-rich regions, with each containing one contiguous glu sequence. These regions have been proposed to contribute to the attachment of...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/s8756-3282(00)00392-6
更新日期：2000-12-01 00:00:00
abstract：:Regulation of calcium release from mouse calvariae by glycosaminoglycans and known modulators of bone resorption has been examined. Anticoagulant and nonanticoagulant fragments of heparin were combined with parathyroid hormone (PTH) and interleukin-1, beta (IL1), and calcium release from radiolabeled bone was determin...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/8756-3282(88)90018-x
更新日期：1988-01-01 00:00:00
abstract：OBJECTIVE:While the importance of cortical structure quantification is increasingly underscored by recent literature, conventional analysis techniques obscure potentially important regional variations in cortical structure. The objective of this study was to characterize the spatial variability in cortical geometry and...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2012.10.031
更新日期：2013-02-01 00:00:00
abstract：:With the increased burden of low back pain (LBP) in our globally aging population there is a need to develop preclinical models of LBP that capture clinically relevant features of physiological aging, degeneration, and disability. Here we assess the validity of using a mouse model system for age-related LBP by charact...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2019.03.037
更新日期：2019-06-01 00:00:00
abstract：:Transiliac bone biopsies, while widely considered to be the standard for the analysis of bone microstructure, are typically restricted to specialized centers. The benefit of Trabecular Bone Score (TBS) in addition to areal bone mineral density (aBMD) for fracture risk assessment has been documented in cross-sectional ...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2015.06.007
更新日期：2015-10-01 00:00:00
abstract：:Platelets play a key role in the replacement of the blood clot with granulation tissue during the early steps of bone regeneration. We hypothesized that activated platelets can neutralize locally produced reactive oxygen species, thereby protecting cells involved in granulation tissue formation. The potential of plate...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2005.01.015
更新日期：2005-04-01 00:00:00
abstract：:Parathyroid hormone (PTH) and tumor necrosis factoralpha (TNFalpha) are bone resorptive agents that upregulate interleukin-6 (IL-6) and RANKL production by osteoblasts. IL-6 mRNA expression induced by PTH is rapid and transient in osteoblasts both in vitro and in vivo. This study found that IL-6 secretion induced by P...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2005.10.007
更新日期：2006-04-01 00:00:00
abstract：:Osteocyte apoptosis precedes osteoclast resorption, and may act as a critical signal to trigger bone remodeling. While osteoclast precursors are known to travel via the circulation, the specific mechanisms by which they accumulate at remodeling sites are unclear. We hypothesized that osteocyte apoptosis mediates osteo...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2011.09.052
更新日期：2012-01-01 00:00:00
abstract：:Investigators and clinicians use bone histomorphometry data from iliac bone biopsies to study bone abnormalities in diseased patients, and to understand the safety and effectiveness of pharmaceutical interventions. This requires access to a high quality normal data-set to be used for comparisons, a resource that has n...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2018.03.019
更新日期：2018-06-01 00:00:00
abstract：:The purpose of this in vitro biomechanical study is to determine the force attenuation capacity of four different hip protectors (KPH1, KPH2, Safehip, and Safetypants) in falling simulations in elderly subjects (falls to the side). The simulated falling conditions were created by a biomechanical testing system, which ...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/s8756-3282(99)00154-4
更新日期：1999-08-01 00:00:00
abstract：:Mechanical signal transduction in bone tissue begins with load-induced activation of several cellular pathways in the osteocyte population. A key pathway that participates in mechanotransduction is Wnt/Lrp5 signaling. A putative downstream mediator of activated Lrp5 is the nucleocytoplasmic shuttling protein β-catenin...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2016.04.028
更新日期：2016-07-01 00:00:00
abstract：BACKGROUND:Since July 1, 2006 bone mineral density (BMD) testing has been reimbursed for osteoporosis screening under specific clinical conditions in France. Concurrently, drug coverage has been extended to all anti-osteoporotic treatments in women with low BMD. It was thus expected that the utilisation of BMD testing ...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2010.06.026
更新日期：2010-10-01 00:00:00
abstract：:Although extensive studies have done much to clarify the molecular mechanisms of osteoclastogenesis during the last ten years, there may still be unknown molecules associated with osteoclast differentiation. Thus, we used fluorescent differential display to screen for genes whose expression is induced by receptor acti...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2011.10.028
更新日期：2012-01-01 00:00:00
abstract：:Gap junctional intercellular communication (GJIC) may contribute to cellular differentiation. To examine this possibility in bone cells we examined markers of cellular differentiation, including alkaline phosphatase, osteocalcin, and osteopontin, in ROS17/2.8 cells (ROS), a rat osteoblastic cell line expressing phenot...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/s8756-3282(99)00227-6
更新日期：1999-12-01 00:00:00
abstract：:The conventional stereologic procedure for estimating bone surface densities in iliac crest biopsies gives biased estimates because bone substructure is anisotropic and the sectioning of the biopsies is intended to be parallel to the cylindrical axis of the iliac crest biopsy. It has recently been shown that random an...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/8756-3282(87)90126-8
更新日期：1987-01-01 00:00:00
abstract：:A more accurate understanding of the molecular mechanisms and signaling pathways underpinning human mesenchymal stem cell (MSC) plasticity and differentiation properties is pivotal for accomplishing solid and diligent translation of MSC-based experimental therapeutics and clinical trials to broad clinical practice. In...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2017.10.014
更新日期：2018-01-01 00:00:00
abstract：:Physician recommendation for prophylactic surgical fixation of a femur with metastatic bone disease (MBD) is usually based on Mirels' criteria and clinical experience, both of which suffer from poor specificity. This may result in a significant number of these health compromised patients undergoing unnecessary surgery...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2018.02.011
更新日期：2018-05-01 00:00:00
abstract：:We have previously found BMD and fracture risk to be significantly associated with the MTHFR (C677T) polymorphism in healthy postmenopausal women in the first years after menopause. Since then, other cohort studies have suggested that sufficient intake of riboflavin and/or folate may have the potential to prevent deve...
journal_title：Bone
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1016/j.bone.2004.12.014
更新日期：2005-03-01 00:00:00
