Platelets can neutralize hydrogen peroxide in an acute toxicity model with cells involved in granulation tissue formation.

abstract：:The SIBLINGs are a subfamily of the secreted calcium-binding phosphoproteins and comprise five small integrin-binding ligand N-linked glycoproteins [dentin matrix protein-1 (DMP1), secreted phosphoprotein-1 (SPP1) also called osteopontin (OPN), integrin-binding sialoprotein (IBSP) also called bone sialoprotein (BSP), ...

journal_title：Bone

authors： Whyte MP,Amalnath SD,McAlister WH,McKee MD,Veis DJ,Huskey M,Duan S,Bijanki VN,Alur S,Mumm S

更新日期：2020-03-01 00:00:00

abstract：:Although much is known about hip fracture epidemiology, there are relatively little data regarding fractures at other peripheral sites. Epidemiological differences between fractures are important, since they imply that an understanding of the consequences and clinical expression of osteoporosis requires the study of m...

journal_title：Bone

authors： Baron JA,Barrett JA,Karagas MR

更新日期：1996-03-01 00:00:00

abstract：:The purpose of this study is twofold: (a) to investigate the application of transosseous low-intensity pulsed ultrasound (LiUS) on the enhancement of fracture healing and (b) to demonstrate the ability of transosseous ultrasound propagation to monitor the healing process. A midshaft tibial osteotomy model was used on ...

journal_title：Bone

authors： Malizos KN,Papachristos AA,Protopappas VC,Fotiadis DI

更新日期：2006-04-01 00:00:00

abstract：BACKGROUND:Genesis of a cartilaginous scaffold is an obligate precursor to bone formation in heterotopic endochondral ossification (HEO). We tested the hypothesis that cartilage-derived retinoic acid-sensitive protein (CD-RAP) can serve as a plasma biomarker for the pre-osseous cartilaginous stage of HEO. Palovarotene,...

journal_title：Bone

authors： Lindborg CM,Brennan TA,Wang H,Kaplan FS,Pignolo RJ

更新日期：2018-04-01 00:00:00

abstract：:Epigenetic regulatory proteins support mammalian development, cancer, aging and tissue repair by controlling many cellular processes including stem cell self-renewal, lineage-commitment and senescence in both skeletal and non-skeletal tissues. We review here our knowledge of epigenetic regulatory protein complexes tha...

journal_title：Bone

authors： van Wijnen AJ,Bagheri L,Badreldin AA,Larson AN,Dudakovic A,Thaler R,Paradise CR,Wu Z

更新日期：2021-02-01 00:00:00

abstract：:The effects of tumor-conditioned media (TCM) derived from cultured cells from an oncogenic hypophosphatemic osteomalacia (OHO) tumor on transformed human kidney cells were investigated. Dose-dependent cell detachment and aggregation occurred in kidney cells cultured in serum-free medium supplemented with TCM, but not ...

journal_title：Bone

authors： Rowe PS,Ong AC,Cockerill FJ,Goulding JN,Hewison M

更新日期：1996-02-01 00:00:00

abstract：:Cyclic mechanical loading augments trabecular bone mass, mainly by increasing trabecular thickness. For this reason, we hypothesized that an in silico thickening algorithm using open-loop control would be sufficient to reliably predict the response of trabecular bone to cyclic mechanical loading. This would also mean ...

journal_title：Bone

authors： Schulte FA,Lambers FM,Webster DJ,Kuhn G,Müller R

更新日期：2011-12-01 00:00:00

abstract：:The present work was designed to investigate the effects of oscillating fluid flow on gap junctional intercellular communication (GJIC) and the gap junction protein connexin (Cx) 43 in osteocyte-like MLOY-4 cells. Cells were exposed for 1 h to oscillating fluid flow at a shear stress of +/-10 dyn/cm(2) and a frequency...

journal_title：Bone

authors： Alford AI,Jacobs CR,Donahue HJ

更新日期：2003-07-01 00:00:00

abstract：:Chronic alcohol abuse is a risk factor for osteoporosis in men. Human recombinant parathyroid hormone (1-34) (PTH) therapy increases bone mass in patients with osteoporosis. The purpose of the present study was to determine whether PTH is effective in increasing bone formation and bone mass in a rat model for establis...

journal_title：Bone

authors： Sibonga JD,Iwaniec UT,Shogren KL,Rosen CJ,Turner RT

更新日期：2007-04-01 00:00:00

abstract：:The relationships of bone size, bone strength, and bone formation were investigated in two strains of mice, NZB/B1NJ and RF/J. Measurement of the femur midshaft size by peripheral quantitative computed tomography (pQCT) showed that the RF/J mice had a 32% greater cross-sectional area than NZB/B1NJ mice at 10 weeks of ...

journal_title：Bone

authors： Wergedal JE,Sheng MH,Ackert-Bicknell CL,Beamer WG,Baylink DJ

更新日期：2002-12-01 00:00:00

abstract：:The loss of trabecular bone in the ovariectomized (OVX) rat provides a useful experimental model of postmenopausal osteoporosis. In this study, two bone-modulating compounds, an NSAID (flurbiprofen: FBP) and a chemically modified nonantimicrobial tetracycline (CMT), were tested either individually or in combination in...

journal_title：Bone

authors： Aoyagi M,Sasaki T,Ramamurthy NS,Golub LM

更新日期：1996-12-01 00:00:00

abstract：:A previously developed in vivo X-ray fluorescence (IVXRF) I-125 based system was used to measure bone strontium levels non-invasively in an osteoporotic female volunteer. The volunteer was recruited in December 2008, as part of the Ryerson and McMaster University Strontium in Bone Research Study and measured at twice ...

journal_title：Bone

authors： Moise H,Adachi JD,Chettle DR,Pejović-Milić A

更新日期：2012-07-01 00:00:00

abstract：:Bone morphogenetic proteins (BMPs) were first described over 50 years ago as potent inducers of ectopic bone formation when administrated subcutaneously. Preclinical studies have extensively examined the osteoinductive properties of BMPs in vitro and new bone formation in vivo. BMPs (BMP-2, BMP-7) have been used in or...

journal_title：Bone

authors： Kamiya N,Atsawasuwan P,Joiner DM,Waldorff EI,Goldstein S,Yamauchi M,Mishina Y

更新日期：2020-09-01 00:00:00

abstract：:Bisphosphonates play an important role in the treatment of metabolic bone diseases such as osteoporosis. In addition to their anti-resorptive activity by triggering osteoclast apoptosis, nitrogen-containing bisphosphonates (N-BP) may also influence osteogenic differentiation, which might rely on their capacity to inhi...

journal_title：Bone

authors： Adam C,Glück L,Ebert R,Goebeler M,Jakob F,Schmidt M

更新日期：2018-06-01 00:00:00

abstract：:Six women, aged 24-67 years, had osteopenia and insufficiency fractures, which suggested a diagnosis of osteomalacia. The insufficiency fractures occurred at traditional sites for Looser zones, were multiple in number, were symmetrically distributed in three patients, and did not heal promptly. Bone mass was low, as a...

journal_title：Bone

authors： McKenna MJ,Kleerekoper M,Ellis BI,Rao DS,Parfitt AM,Frame B

更新日期：1987-01-01 00:00:00

abstract：:Skeleton is the most common organ targeted by breast cancer cells, especially from estrogen receptor alpha (ER)-positive neoplasms. Metastatic cells can stimulate directly or indirectly osteoclast-mediated bone resorption. Tumor-induced osteolysis is often extensive and leads to the release of large quantities of calc...

journal_title：Bone

authors： Journé F,Dumon JC,Kheddoumi N,Fox J,Laïos I,Leclercq G,Body JJ

更新日期：2004-08-01 00:00:00

abstract：:Glucocorticoids act on the osteoblasts to up-regulate the expression of RANKL, which is very important in the etiology of glucocorticoid-induced osteoclast differentiation and bone resorption. The mechanisms of this process are still not completely understood. Recent studies have shown that glucocorticoids mediate ost...

journal_title：Bone

authors： Shi C,Qi J,Huang P,Jiang M,Zhou Q,Zhou H,Kang H,Qian N,Yang Q,Guo L,Deng L

更新日期：2014-11-01 00:00:00

abstract：:This study reports the effects of a recreational team handball exercise programme (randomised controlled trial, RCT) on bone health, postural balance and body composition in inactive postmenopausal women without previous experience of the sport. Sixty-seven postmenopausal women (68.3 ± 6.2 years, stature 156.9 ± 5.8 c...

journal_title：Bone

authors： Pereira R,Krustrup P,Castagna C,Coelho E,Santos R,Helge EW,Jørgensen NR,Magalhães J,Póvoas S

更新日期：2021-01-13 00:00:00

abstract：:The correlation between bone mineral density and vertebral strength is not based on mechanical principles and thus the method cannot reflect the effects of subtle geometric features and densitometric inhomogeneities that may substantially affect vertebral strength. Finite element models derived from quantitative compu...

journal_title：Bone

authors： Crawford RP,Cann CE,Keaveny TM

更新日期：2003-10-01 00:00:00

abstract：:Active vitamin D is a major therapeutic agent for bone disease. Although some studies have reported that vitamin D ameliorates bone disease related to diabetes, the mechanism remains unclear. Our study investigated the effect of the vitamin D receptor activator 22-oxacalcitriol (OCT) on bone disease in a rat model of ...

journal_title：Bone

authors： Goto S,Fujii H,Kono K,Nakai K,Awata R,Yonekura Y,Hirata M,Shinohara M,Nishi S,Fukagawa M

更新日期：2015-05-01 00:00:00

abstract：:Recent studies have shown that treatment with bisphosphonates could be effective against the myelomatous skeletal deterioration. However, the mechanisms of action of these drugs in multiple myeloma (MM) have been poorly studied. In the present study, 11 patients with MM and bone lesions were treated orally with 30 mg/...

journal_title：Bone

authors： Roux C,Ravaud P,Cohen-Solal M,de Vernejoul MC,Guillemant S,Cherruau B,Delmas P,Dougados M,Amor B

更新日期：1994-01-01 00:00:00

abstract：:The osteoprotegerin (OPG)/receptor activator of NF-kappaB ligand (RANKL) axis is thought to be involved in the upregulation of bone turnover following sex steroid deficiency. Here, we investigated the effects of orchiectomy (ORX) on bone turnover and free soluble RANKL (sRANKL) in aged rats. Free, bioactive sRANKL is ...

journal_title：Bone

authors： Proell V,Xu H,Schüler C,Weber K,Hofbauer LC,Erben RG

更新日期：2009-10-01 00:00:00

abstract：:While the role of T cells in the regulation of bone homeostasis is well defined, little is known about the role of innate lymphoid cells (ILCs) on bone. ILCs are innate immune cells that share cytokine expression patterns with T cells but lack the T cell receptor. In this study we show that type 2 ILCs (ILC2) potently...

journal_title：Bone

authors： Omata Y,Frech M,Lucas S,Primbs T,Knipfer L,Wirtz S,Kadono Y,Saito T,Tanaka S,Sarter K,Schett G,Zaiss MM

更新日期：2020-07-01 00:00:00

abstract：OBJECTIVES:This study sought to identify the clinical and biochemical characteristics that would help distinguish hypophosphatasia (HPP) from other metabolic bone diseases in adult patients attending a metabolic bone clinic by comparing patients who have genetically confirmed HPP with a group of patients with low bone ...

journal_title：Bone

authors： Desborough R,Nicklin P,Gossiel F,Balasubramanian M,Walsh JS,Petryk A,Teynor M,Eastell R

更新日期：2021-03-01 00:00:00

abstract：:Diabetes increases the risk of fracture, impairs fracture healing and causes rapid loss of the fracture callus cartilage, which was linked to increased FOXO1 expression in chondrocytes. We recently demonstrated that deletion of FOXO1 in chondrocytes blocked the premature removal of cartilage associated with endochondr...

journal_title：Bone

authors： Lu Y,Alharbi M,Zhang C,O'Connor JP,Graves DT

更新日期：2019-06-01 00:00:00

abstract：:CCN2/connective tissue growth factor (CCN2/CTGF) is known to promote both the proliferation and differentiation of chondrocytes, which actions are mediated by ERK and p38 MAPK, respectively. In this study, we first re-evaluated the involvement of multiple MAPKs therein and found that JNK also mediated such CCN2 signal...

journal_title：Bone

authors： Yosimichi G,Kubota S,Nishida T,Kondo S,Yanagita T,Nakao K,Takano-Yamamoto T,Takigawa M

更新日期：2006-06-01 00:00:00

abstract：BACKGROUND AND AIM:Bone mineral density (BMD) is under strong genetic regulation, but it is not clear which genes are involved in the regulation, particularly in Asian populations. This study sought to determine the association between 29 genes discovered by Caucasian-based genome-wide association studies and BMD in a ...

journal_title：Bone

authors： Ho-Pham LT,Nguyen SC,Tran B,Nguyen TV

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:Radiation treatment results in a severe diminution of osseous vascularity. Intermittent parathyroid hormone (PTH) has been shown to have an anabolic effect on osteogenesis, though its impact on angiogenesis remains unknown. In this murine model of distraction osteogenesis, we hypothesize that radiation treat...

journal_title：Bone

authors： Kang SY,Deshpande SS,Donneys A,Rodriguez JJ,Nelson NS,Felice PA,Chepeha DB,Buchman SR

更新日期：2013-09-01 00:00:00

abstract：:Although it is generally acknowledged that matrix vesicles and alkaline phosphatase are required for cartilage calcification, their precise role in initiation or propagation of mineralization remains controversial. We have investigated this problem in a neoplastic model of chondrogenesis, the Swarm rat chondrosarcoma....

journal_title：Bone

authors： Miller GJ,DeMarzo AM

更新日期：1988-01-01 00:00:00

abstract：:The last step of the osteoclast differentiation process is cell fusion. Most efforts to understand the fusion mechanism have focused on the identification of molecules involved in the fusion process. Surprisingly, the basic fusion modalities, which are well known for fusion of other cell types, are not known for the o...

journal_title：Bone

authors： Søe K,Hobolt-Pedersen AS,Delaisse JM

更新日期：2015-04-01 00:00:00