Abstract:
:The purpose of this in vitro biomechanical study is to determine the force attenuation capacity of four different hip protectors (KPH1, KPH2, Safehip, and Safetypants) in falling simulations in elderly subjects (falls to the side). The simulated falling conditions were created by a biomechanical testing system, which consisted of an impact pendulum, surrogate pelvis and femur, and two load cells. Three series of impact experiments were conducted in an ascending order (low, moderate-, and high-force experiments), each exceeding the literature-provided average (+/- 1 SD) fracture threshold (3100 +/- 1200 N) of the proximal femur of elderly women with a mean age of 71 years. Using a low impact force of 4330 N, the trochanteric soft tissue (20-mm-thick polyethylene foam) attenuated the peak femoral impact force to 3740 N and, accordingly, the KPH1 protector to 590 N, KPH2 to 510 N, Safehip to 1080 N, and Safetypants to 790 N. Thus, in this low force experiment, all tested protectors could reduce the peak impact force entered into the proximal femur below the aforementioned average fracture threshold area (3100 +/-1200 N) of the proximal femur of elderly women. With a moderate impact force of 7230 N, the soft tissue attenuated the peak femoral impact force to 6130 N, and the protectors to 780 N, 760 N, 2240 N, and 2760 N, respectively. Thus, with this impact force, only the KPH hip protectors could reduce the impact force clearly below the fracture threshold area. In the final series of the experiment, the peak femoral impact force was set to be so high (10,840 N) that the protector, if effective, should prevent the hip fracture in almost all cases and situations. The trochanteric soft tissue attenuated this peak impact force to 9190 N, and the tested protectors to 1360 N, 1170 N, 4640 N, and 5770 N. Thus, with the KPH protectors the force received by the proximal femur remained below the average force required to fracture the proximal femur of elderly women, whereas with the two other protectors the impact force entered into the proximal femur clearly exceeded this threshold value. In conclusion, the test results showed that, of the four tested hip protectors, the anatomically designed energy-shunting and energy-absorbing KPH protectors can provide an effective impact force attenuation in a sideways-fall simulation in the elderly, whereas the force attenuation capacity of the two other protectors seems more limited. However, the true efficacy of any protector in the prevention of hip fractures can only be evaluated in randomized clinical trials.
journal_name
Bonejournal_title
Boneauthors
Kannus P,Parkkari J,Poutala Jdoi
10.1016/s8756-3282(99)00154-4subject
Has Abstractpub_date
1999-08-01 00:00:00pages
229-35issue
2eissn
8756-3282issn
1873-2763pii
S8756-3282(99)00154-4journal_volume
25pub_type
杂志文章相关文献
BONE文献大全abstract::The present study describes the biological effects of risedronate, a pyridinyl bisphosphonate, on bone and assesses the safety and tolerability of risedronate when given at high doses, with or without calcium, to postmenopausal women with spinal osteoporosis. This single-center descriptive, double-blind, placebo-contr...
journal_title:Bone
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s8756-3282(00)00410-5
更新日期:2001-01-01 00:00:00
abstract::Embryonic/neonatal bones in culture are commonly used for the study of osteoclastic resorption in vitro. For this purpose, the release of 45calcium (45Ca) from prelabeled bones is measured as an index of resorption. We studied 45Ca release from two types of long bone explants after different preparation methods: 17-da...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(95)00135-z
更新日期:1995-07-01 00:00:00
abstract::One main problem associated with alveolar bone augmentation in implant dentistry is resorption of grafted bone, which may be further compromised by systemic skeletal disorders such as osteoporosis. Zoledronate acid (ZOL) is the most potent bisphosphonate to treat osteoporosis and therefore it is hypothesized to be abl...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2011.10.011
更新日期:2012-01-01 00:00:00
abstract::SOST encodes sclerostin, an inhibitor of bone formation that antagonizes canonical Wnt signaling. Variations of SOST expression have an impact on bone mineral density (BMD) and bone strength. We hypothesized that genetic and epigenetic DNA modifications have an impact on SOST gene expression. By analyzing 43 bone samp...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2016.08.004
更新日期:2016-11-01 00:00:00
abstract::Depending on populations, 15 to 40% of patients have a familial form of Paget's disease of bone (PDB), which is transmitted in an autosomal-dominant mode of inheritance with incomplete penetrance. To date, only SQSTM1 gene mutations have been linked to the disease. Several single nucleotide polymorphisms (SNPs) have b...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2016.01.007
更新日期:2016-03-01 00:00:00
abstract::The prevalence of vertebral deformity, estimated in lateral spine radiographs (Th4-L4) using quantitative morphometry, in 64 men and 132 women with hip fractures was compared with the prevalence of vertebral deformity in individuals in two population-based studies. A vertebral deformity of a specific vertebra was defi...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(02)00951-1
更新日期:2003-02-01 00:00:00
abstract::Osteopetrotic bone shows dissociation between bone mineral density (BMD) and bone strength. In this study, volumetric BMD; preferential orientation of the extracellular matrix (ECM), which is composed of collagen fibers and apatite crystals as bone material quality; and mechanical properties of the src-/- osteopetroti...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2017.06.023
更新日期:2017-10-01 00:00:00
abstract::Hypertension and osteoporosis are two major chronic diseases affecting the elderly. A cross-sectional study of 3887 Chinese men (n = 1958) and women (n = 1929) was used to explore the association between angiotensin converting enzyme inhibitor (ACEI) use and bone mineral density (BMD). The participants were aged 65 ye...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2005.09.011
更新日期:2006-04-01 00:00:00
abstract::Amelogenin is the major enamel protein produced by ameloblasts. Its expression has been shown to be down-regulated in ameloblasts of vitamin-D-deficient (-D) rats. The potential expression and localization of amelogenin in odontoblasts and its regulation by vitamin D were investigated in this study. RT-PCR and semi-qu...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(02)00978-x
更新日期:2003-03-01 00:00:00
abstract::Bisphosphonates are widely used in the treatment of osteoporosis and contribute to the reduction of bone fractures. Ibandronate (IBN) is a highly potent, nitrogen-containing bisphosphonate, which is administered orally or intravenously at extended dosing intervals. Vitamin D or active vitamin D3 derivatives are also u...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2015.08.004
更新日期:2015-12-01 00:00:00
abstract::A theory is developed to resolve several inconsistencies between current concepts and observations about bone remodeling. For example, the observation that remodeling increases both when mechanical loading is excessively low, that is, in a disuse state, and when it is excessively high, producing substantial fatigue da...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(99)00241-0
更新日期:2000-01-01 00:00:00
abstract::This study reports the elastic material properties of cortical bone in the mandible of juvenile Alligator mississippiensis obtained by using an ultrasonic wave technique. The elastic modulus, the shear modulus, and Poisson's ratio were measured on 42 cylindrical Alligator bone specimens obtained from the lingual and f...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2009.11.010
更新日期:2010-03-01 00:00:00
abstract::A 57 year old white male with oncogenous osteomalacia due to a mixed mesenchymal tumor was evaluated by sequential histologic and metabolic studies over a period of 33 mos prior to identifying the location of the tumor. On the basis of these studies we conclude: (i) disorders of the enterohepatic circulation and/or ac...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(88)90025-7
更新日期:1988-01-01 00:00:00
abstract::Compounds, like beta-aminopropionitrile (bAPN) and homocysteine (hcys), are known to inhibit a stable matrix formation. Osteoblast-synthesized collagen matrix regulates the differentiation of precursor cells into mature osteoblasts. They express lysyl oxidase, an enzyme involved in the collagen cross-linking process. ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2009.10.038
更新日期:2010-03-01 00:00:00
abstract::The study reports a theranostic nature of rno-miR-300 (miR300) in the osteoblast functioning, by influencing the signaling pathway(s), associated with osteoblast differentiation. Excessive expression of miR300 suppresses osteoblast functions. Smad3 served as a validated target for miR300, on homology-based computation...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2020.115603
更新日期:2021-02-01 00:00:00
abstract::The present study was designed to evaluate the relationships between ultrasonic backscatter, density, and microarchitecture of cancellous bone. The slopes of the frequency-dependent attenuation coefficient (nBUA), ultrasound bone velocity (UBV), the frequency-averaged backscatter coefficient (BUB) were measured in 25 ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(01)00650-0
更新日期:2002-01-01 00:00:00
abstract::Clinical bone sonometers applied at the calcaneus measure broadband ultrasound attenuation and speed of sound. However, the relation of ultrasound measurements to bone strength is not well-characterized. Addressing this issue, we assessed the extent to which ultrasonic measurements convey in vitro mechanical propertie...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2017.06.021
更新日期:2017-10-01 00:00:00
abstract::Recent studies have identified that Interleukin (IL)-23/IL-17 axis plays crucial role in pathogenesis of inflammation and bone destruction. IL-23 is thought to promote joint destruction in arthritis by stimulating Th17 cells. IL-23 directly mediates bone loss by inducing osteoclastogenesis and receptor activator of ka...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2018.01.027
更新日期:2018-05-01 00:00:00
abstract::The process of bone turnover displays variations over 24 h, with C-terminal cross-linked telopeptide of type 1 collagen (CTX) and osteocalcin exhibiting a nadir in the afternoon and a peak in the night. In contrast, N-terminal propeptide of type 1 procollagen (P1NP) did not display an apparent 24-hour rhythm. Other em...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2018.10.002
更新日期:2019-03-01 00:00:00
abstract::Mammalian bone sialoprotein (BSP) is a mineralized tissue-specific protein containing an RGD (arginine-glycine-aspartic acid) cell-attachment sequence and two distinct glutamic acid (glu)-rich regions, with each containing one contiguous glu sequence. These regions have been proposed to contribute to the attachment of...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(00)00392-6
更新日期:2000-12-01 00:00:00
abstract::The correlation between bone mineral density and vertebral strength is not based on mechanical principles and thus the method cannot reflect the effects of subtle geometric features and densitometric inhomogeneities that may substantially affect vertebral strength. Finite element models derived from quantitative compu...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(03)00210-2
更新日期:2003-10-01 00:00:00
abstract::How estrogen therapy influences bone metabolism in postmenopausal women has previously been studied using several approaches, including bone densitometry, measurement of biochemical markers of bone turnover, and histomorphometry. Taken together, these investigations suggest that conventional doses of estrogen protect ...
journal_title:Bone
pub_type: 杂志文章,评审
doi:10.1016/s8756-3282(98)00156-2
更新日期:1999-02-01 00:00:00
abstract::Recently, the involvement of immune responses in metabolic bone disease and/or local bone destruction has received much attention. Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4), a member of the immunoglobulin (Ig) superfamily, negatively regulates T cell activation. The deficiency of CTLA-4 induces profound ost...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2004.06.018
更新日期:2004-11-01 00:00:00
abstract::Significant decreases in ovine compact bone viscoelastic properties (specifically, stress-rate sensitivity, and damping efficiency) are associated with three years of ovariectomy and are particularly evident at higher frequencies [Proc. Orthop. Res. Soc. 27 (2002) 89]. It is unclear what materials or architectural fea...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2004.04.006
更新日期:2004-09-01 00:00:00
abstract::Ginsenoside Rh2 is one of the most active components of red ginseng, controlling cancer and other metabolic diseases including osteoclast differentiation. However, the molecular mechanism underlying the inhibition of osteoclast differentiation by ginsenoside Rh2 remains poorly understood. In the present study, it was ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2012.03.022
更新日期:2012-06-01 00:00:00
abstract::Interstitial bone fluid flow (IBFF) is suggested as a communication medium that bridges external physical signals and internal cellular activities in the bone, which thus regulates bone remodeling. Intramedullary pressure (ImP) is one main regulatory factor of IBFF and bone adaptation related mechanotransduction. Our ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2014.05.018
更新日期:2014-09-01 00:00:00
abstract:PURPOSE:Bone acquisition in childhood impacts adult bone mass, and can be influenced by childhood socioeconomic conditions. Socioeconomic status is also associated with body weight which affects the load that bone is exposed to in a fall. We hypothesized that socioeconomic advantage in childhood is associated with grea...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2013.06.021
更新日期:2013-10-01 00:00:00
abstract:BACKGROUND:The association between beta-blockers (BB) and fracture risk is controversial, due largely to conflicting findings from previous studies. The present study sought to evaluate the effect of BB on fracture risk by using a Bayesian meta-analysis approach. METHODS AND RESULTS:We systematically retrieved 13 obse...
journal_title:Bone
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.bone.2012.07.013
更新日期:2012-11-01 00:00:00
abstract::This multicenter study assessed the safety and efficacy of teriparatide 20 microg/day in Japanese men and women with osteoporosis at high risk of fracture during a 12-month, randomized, double-blind, placebo-controlled treatment period followed by second and third treatment periods (to 18 and 24 months, respectively,)...
journal_title:Bone
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.bone.2010.05.022
更新日期:2010-09-01 00:00:00
abstract::Many clinical and experimental investigations address the influence of statins on bone formation and fracture healing. Simvastatin was shown to increase the expression of Bone morphogenetic protein (BMP-2), which is one of the most potent growth factors targeting bone formation. In this study, the effect of simvastati...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2009.05.010
更新日期:2009-09-01 00:00:00