Co-deteriorations of anisotropic extracellular matrix arrangement and intrinsic mechanical property in c-src deficient osteopetrotic mouse femur.

abstract：PURPOSE:Bone acquisition in childhood impacts adult bone mass, and can be influenced by childhood socioeconomic conditions. Socioeconomic status is also associated with body weight which affects the load that bone is exposed to in a fall. We hypothesized that socioeconomic advantage in childhood is associated with grea...

journal_title：Bone

authors： Karlamangla AS,Mori T,Merkin SS,Seeman TE,Greendale GA,Binkley N,Crandall CJ

更新日期：2013-10-01 00:00:00

abstract：:Weekly administration of teriparatide has been shown to reduce the risk of vertebral and non-vertebral fractures in patients with osteoporosis at higher fracture risk in Japan. However, its efficacy for hip fracture has not been established. To gain insight into the effect of weekly teriparatide on the hip, hip struct...

journal_title：Bone

authors： Sone T,Ito M,Fukunaga M,Tomomitsu T,Sugimoto T,Shiraki M,Yoshimura T,Nakamura T

更新日期：2014-07-01 00:00:00

abstract：:Eldecalcitol (ED-71), a 2β-hydroxypropyloxy derivative of 1α,25(OH)(2)D(3), inhibits bone resorption more potently than does alfacalcidol while maintaining osteoblastic function in an estrogen-deficient, high-turnover osteoporosis rat model. Alendronate (ALN) has been reported to increase bone mass by suppressing bone...

journal_title：Bone

authors： Sakai S,Endo K,Takeda S,Mihara M,Shiraishi A

更新日期：2012-05-01 00:00:00

abstract：:We examined the mode of action of bisphosphonates on osteoclastic cell recruitment using mouse marrow cultures with or without osteoblastic cells. Tartrate-resistant acid phosphatase-positive multinucleated cells [TRAP(+)MNC] formed in cultures were determined to be osteoclastic cells. In marrow cultures, TRAP(+) MNC ...

journal_title：Bone

authors： Nishikawa M,Akatsu T,Katayama Y,Yasutomo Y,Kado S,Kugal N,Yamamoto M,Nagata N

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND:WNT signaling plays a major role in bone and cartilage metabolism. Impaired WNT/β-catenin signaling leads to early-onset osteoporosis, but specific features in bone and other tissues remain inadequately characterized. We have identified two large Finnish families with early-onset osteoporosis due to a hetero...

journal_title：Bone

authors： Mäkitie RE,Niinimäki T,Nieminen MT,Schalin-Jäntti C,Niinimäki J,Mäkitie O

更新日期：2017-08-01 00:00:00

abstract：:There are conflicting reports on the influence of lean and fat mass on bone accrual during childhood. No infant's studies have been reported that describe the influence of changes in body composition with changes in bone accrual during the first year of life. The objective of this research was to test the hypothesis t...

journal_title：Bone

authors： Sudhagoni RG,Wey HE,Djira GD,Specker BL

更新日期：2012-03-01 00:00:00

abstract：:Although much is known about hip fracture epidemiology, there are relatively little data regarding fractures at other peripheral sites. Epidemiological differences between fractures are important, since they imply that an understanding of the consequences and clinical expression of osteoporosis requires the study of m...

journal_title：Bone

authors： Baron JA,Barrett JA,Karagas MR

更新日期：1996-03-01 00:00:00

abstract：:Whether glucocorticoids directly enhance or interrupt osteoclastogenesis is still a controversial subject. In this study, we ascertained the dose-dependent positive effects of glucocorticoids on osteoclastogenesis in vivo and in vitro as well as investigated the mechanism in vitro. As the dose of glucocorticoids incre...

journal_title：Bone

authors： Shi J,Wang L,Zhang H,Jie Q,Li X,Shi Q,Huang Q,Gao B,Han Y,Guo K,Liu J,Yang L,Luo Z

更新日期：2015-10-01 00:00:00

abstract：:We investigated the effect of 2-beta-(3-hydroxypropoxy)-1alpha,25-dihydroxyvitamin D3 (ED-71) on the modeling of bone in distraction osteogenesis. The tibiae of 30 rabbits were lengthened by 10 mm in 10 days. Following osteotomy, ED-71 (0.05 microg/kg) was administered subcutaneously twice a week to the ED-71 group un...

journal_title：Bone

authors： Yamane K,Okano T,Kishimoto H,Hagino H

更新日期：1999-03-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Fibroblast growth factor 23 (FGF23) participates in phosphate, calcium and vitamin D metabolism. In children these interactions and modifying factors are largely unknown. PARTICIPANTS AND METHODS:This study evaluates temporal changes and modifiers of FGF23 concentrations from 12 to 24 months,...

journal_title：Bone

authors： Enlund-Cerullo M,Hauta-Alus H,Valkama S,Rosendahl J,Andersson S,Mäkitie O,Holmlund-Suila E

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:Good bone and joint health is essential for the physical tasks of daily living and poorer indicators of physical capability in older adults have been associated with increased mortality rates. Genetic variants of indicators of bone and joint health may be associated with measures of physical capability. MET...

journal_title：Bone

authors： Alfred T,Ben-Shlomo Y,Cooper R,Hardy R,Cooper C,Deary IJ,Gunnell D,Harris SE,Kumari M,Martin RM,Sayer AA,Starr JM,Kuh D,Day IN,HALCyon study team.

更新日期：2013-01-01 00:00:00

abstract：:Cortical bone, the dominant component of the human skeleton by volume, plays a key role in protecting bones from fracture. We analyzed the cortical bone effects of teriparatide treatment in postmenopausal women with osteoporosis who had previously received long-term alendronate (ALN) therapy or were treatment naïve (T...

journal_title：Bone

authors： Ma YL,Zeng QQ,Chiang AY,Burr D,Li J,Dobnig H,Fahrleitner-Pammer A,Michalská D,Marin F,Pavo I,Stepan JJ

更新日期：2014-02-01 00:00:00

abstract：:Cementum, a mineralized tissue lining the surface of the tooth root, is required for formation of a functional periodontal ligament attachment during development. Additionally, during regeneration of tissues after disease, cementum is thought to play a critical role in the reparative process. Research efforts aimed to...

journal_title：Bone

authors： D'Errico JA,Ouyang H,Berry JE,MacNeil RL,Strayhorn C,Imperiale MJ,Harris NL,Goldberg H,Somerman MJ

更新日期：1999-07-01 00:00:00

abstract：:Rough-surfaced substrates made by a variety of methods have been shown to influence osteoblast proliferation and differentiation. The purpose of this study is to confirm the role of surface roughness in promoting osteoblastic differentiation using tissue culture polystyrene as substrate, by excluding factors other tha...

journal_title：Bone

authors： Hatano K,Inoue H,Kojo T,Matsunaga T,Tsujisawa T,Uchiyama C,Uchida Y

更新日期：1999-10-01 00:00:00

abstract：:Oral glucocorticoids (GC) preserve muscle strength and prolong walking in boys with Duchenne muscular dystrophy (DMD). Although vertebral fractures have been reported in boys taking GC, fracture rates for different GC regimes have not been investigated. The aim of this pragmatic longitudinal study was to compare growt...

journal_title：Bone

authors： Crabtree NJ,Adams JE,Padidela R,Shaw NJ,Högler W,Roper H,Hughes I,Daniel A,Mughal MZ

更新日期：2018-11-01 00:00:00

abstract：:Six women, aged 24-67 years, had osteopenia and insufficiency fractures, which suggested a diagnosis of osteomalacia. The insufficiency fractures occurred at traditional sites for Looser zones, were multiple in number, were symmetrically distributed in three patients, and did not heal promptly. Bone mass was low, as a...

journal_title：Bone

authors： McKenna MJ,Kleerekoper M,Ellis BI,Rao DS,Parfitt AM,Frame B

更新日期：1987-01-01 00:00:00

abstract：INTRODUCTION:The elderly population is growing fast worldwide, and therefore, investigation of health outcomes peculiar to these individuals is a public health priority nowadays. The decade between 2000 and 2010 is denominated as the Bone and Joint Decade, and researchers are encouraged to quantity the burden of muscul...

journal_title：Bone

authors： Siqueira FV,Facchini LA,Hallal PC

更新日期：2005-08-01 00:00:00

abstract：:Osteopontin (OPN) gene expression and alkaline phosphatase activity were evaluated in the epiphyseal growth plates of normal chickens and in diet-induced tibial dyschdroplasia (TD)-afflicted chickens. In the normal growth plate, OPN gene was expressed by a) cells of the subperichondrial zone surrounding the articular ...

journal_title：Bone

authors： Knopov V,Leach RM,Barak-Shalom T,Hurwitz S,Pines M

更新日期：1995-04-01 00:00:00

abstract：:Due to the rising life expectancy, bone diseases (e.g. osteoporosis, osteoarthritis) and trauma (e.g. fracture) have become an important socio-economic burden. Accurate visualization and quantification of the bone microstructure in vivo is seen as an important step to enhance diagnosis and treatment. Micro-computed to...

journal_title：Bone

authors： Mys K,Stockmans F,Vereecke E,van Lenthe GH

更新日期：2018-09-01 00:00:00

abstract：:With age, alterations occurring in bone quality, quantity, and microarchitecture affect the resistance of trabecular bone to local failure. The clinical implications of these changes are evident by the observed exponential increase in fracture incidence with age. Although age-related development of skeletal fragility ...

journal_title：Bone

authors： Nagaraja S,Lin AS,Guldberg RE

更新日期：2007-04-01 00:00:00

abstract：:Bone is a complex endocrine organ that facilitates structural support, protection to vital organs, sites for hematopoiesis, and calcium homeostasis. The bone marrow microenvironment is a heterogeneous niche consisting of multipotent musculoskeletal and hematopoietic progenitors and their derivative terminal cell types...

journal_title：Bone

authors： Pierce JL,Begun DL,Westendorf JJ,McGee-Lawrence ME

更新日期：2019-01-01 00:00:00

abstract：:There is no adequate animal model to mimic the difficult clinical situation of infected non-union of the tibia after intramedullary stabilization. The purpose was to establish an animal model of implant-related infected non-unions of the tibia in rats. Furthermore, it was evaluated if detection of bacteria by fluoresc...

journal_title：Bone

authors： Alt V,Lips KS,Henkenbehrens C,Muhrer D,Oliveira Cavalcanti MC,Sommer U,Thormann U,Szalay G,Heiss C,Pavlidis T,Domann E,Schnettler R

更新日期：2011-05-01 00:00:00

abstract：:One of the side effects associated with glucocorticoid therapy is glucocorticoid-induced bone loss. Glucocorticoids partly detain bone formation via the inhibition of osteoblastic function, however, the exact mechanism of this inhibition remains elusive. In this study, we examined the effect of dexamethasone, an activ...

journal_title：Bone

authors： Kósa JP,Kis A,Bácsi K,Balla B,Nagy Z,Takács I,Speer G,Lakatos P

更新日期：2011-05-01 00:00:00

abstract：INTRODUCTION:The RANKL-OPG axis is a key regulator of osteoclastogenesis and bone turnover activity. Its contribution to bone resorption under altered mechanical states, however, has not been fully elucidated. Here we examined the role of OPG in regulating mechanically induced bone modeling in a rat model of orthodonti...

journal_title：Bone

authors： Dunn MD,Park CH,Kostenuik PJ,Kapila S,Giannobile WV

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND:Like osteonecrosis of the femoral head (ONFH), subchondral insufficiency fracture of the femoral head (SIF) causes femoral head collapse. However, little is known about the differences between the two diseases regarding the morphological features of the collapsed lesion. We tested the hypothesis that the mor...

journal_title：Bone

authors： Kawano K,Motomura G,Ikemura S,Yamaguchi R,Baba S,Xu M,Nakashima Y

更新日期：2020-12-01 00:00:00

abstract：:Bisphosphonates are widely used to treat children with osteogenesis imperfecta (OI), a bone fragility disorder that is most often caused by mutations in COL1A1 or COL1A2. However, it is unclear whether this treatment decreases the risk of developing scoliosis. We retrospectively evaluated spine radiographs and charts ...

journal_title：Bone

authors： Sato A,Ouellet J,Muneta T,Glorieux FH,Rauch F

更新日期：2016-05-01 00:00:00

abstract：OBJECTIVES:The present study was motivated by the fact that bone regeneration in the compromised vascular microenvironment of T2DM is challenging and the factors that determine the adverse bone regeneration outcomes are poorly understood. For this purpose the effect of T2DM on osteogenic and angiogenic healing potentia...

journal_title：Bone

authors： Caliaperoumal G,Souyet M,Bensidhoum M,Petite H,Anagnostou F

更新日期：2018-07-01 00:00:00

abstract：:Investigators and clinicians use bone histomorphometry data from iliac bone biopsies to study bone abnormalities in diseased patients, and to understand the safety and effectiveness of pharmaceutical interventions. This requires access to a high quality normal data-set to be used for comparisons, a resource that has n...

journal_title：Bone

authors： Recker RR,Akhter MP,Lappe JM,Watson P

更新日期：2018-06-01 00:00:00

abstract：AIMS:Hip fracture patients have severe deterioration of their quality of life and function after their injury. Markers of malnutrition such as low albumin and low body mass index (BMI) have been shown to increase mortality and complication rates but their effect on recovery of quality of life and function after hip fra...

journal_title：Bone

authors： Sim SD,Sim YE,Tay K,Howe TS,Png MA,Chang CCP,Abdullah HR,Koh JSB

更新日期：2021-02-01 00:00:00

abstract：:Trauma-induced heterotopic ossification is an intriguing phenomenon involving the inappropriate ossification of soft tissues within the body such as the muscle and ligaments. This inappropriate formation of bone is highly prevalent in those affected by blast injuries. Here, we developed a simplified cell culture model...

journal_title：Bone

authors： Logan NJ,Camman M,Williams G,Higgins CA

更新日期：2018-12-01 00:00:00