Abstract:
:A 57 year old white male with oncogenous osteomalacia due to a mixed mesenchymal tumor was evaluated by sequential histologic and metabolic studies over a period of 33 mos prior to identifying the location of the tumor. On the basis of these studies we conclude: (i) disorders of the enterohepatic circulation and/or acceleration of metabolism of calcitriol are not responsible for its diminished level in oncogenous osteomalacia, (ii) the Von Kossa stain is preferred to the modified Masson in evaluating osteomalacia, (iii) avascular necrosis of the femoral head may be part of the syndrome, (iv) heterogeneity may be the hallmark of the responsible mesenchymal tumor and account for the different histological interpretations in the literature, (v) in compliant patients with oncogenous osteomalacia, calcitriol and Pi therapy may be effective.
journal_name
Bonejournal_title
Boneauthors
Taylor HC,Santa-Cruz D,Teitelbaum SL,Bergfeld MA,Whyte MPdoi
10.1016/8756-3282(88)90025-7subject
Has Abstractpub_date
1988-01-01 00:00:00pages
37-43issue
1eissn
8756-3282issn
1873-2763pii
8756-3282(88)90025-7journal_volume
9pub_type
杂志文章相关文献
BONE文献大全abstract::The relative bioavailability of enteric-coated sodium fluoride (NaF) tablets (10 mg F-) has been assessed following administration with a standard calcium-rich breakfast or calcium-poor lunch, and 2 h before or simultaneously with antacid administration (2.4 g aluminum-magnesium hydroxide), versus intake on an empty s...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(89)90070-7
更新日期:1989-01-01 00:00:00
abstract::The relationship between serum 25-hydroxyvitamin D and quantitative ultrasound bone mineral density in young children remains unclear. In addition, consensus has not been reached with regard to the concentration of 25(OH)D to define vitamin D deficiency for infants and children. In the present study, 203 children 0-6 ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2012.12.012
更新日期:2013-03-01 00:00:00
abstract::Ecto-nucleotide pyrophosphatase/phosphodiesterases (NPPs) hydrolyse nucleotide triphosphates to the corresponding nucleotide monophosphates and the mineralisation inhibitor, pyrophosphate (PPi). This study examined the role of NPP1 in osteocytes, osteoclasts and cortical bone, using a mouse model lacking NPP1 (Enpp1(-...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2014.09.016
更新日期:2014-12-01 00:00:00
abstract::It is well known that physical inactivity leads to loss of muscle mass, but it also causes bone loss. Mechanistically, osteoclastogenesis and bone resorption have recently been shown to be regulated by vibration. However, the underlying mechanism behind the inhibition of osteoclast formation is yet unknown. Therefore,...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2013.08.020
更新日期:2013-12-01 00:00:00
abstract::The distribution of hyaluronan was investigated in the proximal tibiotarsal bones of normal (vitamin D-treated) chicks, and chicks with rachitic lesions induced by vitamin D deficiency. Localization studies using a biotinylated hyaluronan-binding probe revealed that in vitamin D-treated chicks, a high level of hyaluro...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(96)00046-4
更新日期:1996-05-01 00:00:00
abstract::Osteoclast differentiation and activation is controlled, at least in part, by the counterbalancing influences of osteoprotegerin ligand (OPGL) and osteoprotegerin (OPG). Nonsteroidal anti-inflammatory drugs have been shown to inhibit bone loss in vivo and bone resorption in vitro, and this is associated with a loss of...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(00)00431-2
更新日期:2001-02-01 00:00:00
abstract::Endochondral ossification in the growth plate of long bones involves cartilage mineralization, bone formation and the budding vasculature. Many of these processes take place in a complex and dynamic zone, the provisional ossification zone, of the growth plate. Here we investigate aspects of mineralization in 2D and 3D...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2019.115086
更新日期:2020-01-01 00:00:00
abstract:UNLABELLED:We identified regions inside the proximal femur that are most strongly associated with hip fracture. Bone densitometry based on such fracture-critical regions showed improved power in discriminating fracture patients from controls. INTRODUCTION:Hip fractures typically occur in lateral falls, with focal mech...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2008.12.008
更新日期:2009-04-01 00:00:00
abstract:BACKGROUND:Radiation treatment results in a severe diminution of osseous vascularity. Intermittent parathyroid hormone (PTH) has been shown to have an anabolic effect on osteogenesis, though its impact on angiogenesis remains unknown. In this murine model of distraction osteogenesis, we hypothesize that radiation treat...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2013.04.022
更新日期:2013-09-01 00:00:00
abstract::Recent studies suggest that whole-body vibration (WBV) can improve measures of bone health for certain clinical conditions and ages. In the elderly, there also is particular interest in assessing the ability of physical interventions such as WBV to improve coordination, strength, and movement speed, which help prevent...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2010.07.014
更新日期:2010-10-01 00:00:00
abstract::Fracture risk and mechanical competence of bone are functions of bone mass and tissue quality, which in turn are dependent on the bone's mechanical environment. Male mice have a greater response to non-weight-bearing exercise than females, resulting in larger, stronger bones compared with control animals. The aim of t...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2006.12.002
更新日期:2007-04-01 00:00:00
abstract::Recently, there have been remarkable advances in medical techniques for regenerating bone defects. To determine the degree of bone regeneration, it is essential to develop a new method that can analyze microstructure and related mechanical function. Here, quantitative analysis of the orientation distribution of biolog...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2012.07.003
更新日期:2012-10-01 00:00:00
abstract::Nearly all bone fractures in humans can deteriorate into a non-union fracture, often due to formation of fibrotic tissue. Cranial allogeneic bone grafts present a striking example: although seemingly attractive for craniofacial reconstructions, they often fail due to fibrosis at the host-graft junction, which physical...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2017.01.020
更新日期:2017-04-01 00:00:00
abstract::This paper reviews the mechanisms of action of the bisphosphonates, a new class of recently developed drugs. The geminal bisphosphonates are characterized by a P-C-P bond and are thus analogs of pyrophosphate. They bind strongly to hydroxyapatite crystals and in vitro inhibit both crystal formation and dissolution. In...
journal_title:Bone
pub_type: 历史文章,杂志文章,评审
doi:
更新日期:1987-01-01 00:00:00
abstract:CONTEXT:Low energy availability causes disruption of hypothalamic gonadotropin-releasing hormone secretion leading to functional hypothalamic amenorrhea (FHA) and hypoestrogenism, which in turn contributes to decreased bone mineral density (BMD) and increased bone marrow adipose tissue (MAT). Transdermal estradiol admi...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2021.115841
更新日期:2021-01-06 00:00:00
abstract::Recent proton magnetic resonance (MR) spectroscopy studies have shown that cortical bone exists as different components which have distinct transverse relaxation times (T2s). However, cortical bone shows zero or near zero signal with all conventional MR sequences on clinical scanners and the different water components...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2011.11.029
更新日期:2012-03-01 00:00:00
abstract::Bone remodeling is required for healthy calcium homeostasis and for repair of damage occurring with stress and age. Osteoclasts resorb bone and osteoblasts form bone. These processes normally occur in a tightly regulated sequence of events, where the amount of formed bone equals the amount of resorbed bone, thereby re...
journal_title:Bone
pub_type: 杂志文章,评审
doi:10.1016/j.bone.2009.03.671
更新日期:2009-06-01 00:00:00
abstract:INTRODUCTION:Angiogenesis is closely associated with bone formation, especially endochondral ossification. Angiopoietin 1 (Ang1) is a specific growth factor functioning to generate a stable and matured vasculature through the Tie2 receptor/PI3K/AKT pathway. Recently cartilage oligomeric matrix protein (COMP)-Ang1, an A...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2009.09.019
更新日期:2010-02-01 00:00:00
abstract::Fibroblast growth factor 23 (FGF23) circulates as active protein and inactive fragments. Low iron status increases FGF23 gene expression, and iron deficiency is common. We hypothesized that in healthy premenopausal women, serum iron influences C-terminal and intact FGF23 concentrations, and that iron and FGF23 associa...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2016.03.005
更新日期:2016-05-01 00:00:00
abstract::CD200 is a transmembrane protein that belongs to the immunoglobulin family of proteins and is ubiquitously expressed on a variety of cell types. Upon interaction with its receptors (CD200Rs) expressed on myeloid-derived cells and T lymphocytes, an immunoregulatory signal is delivered to receptor-expressing cells. Prev...
journal_title:Bone
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.bone.2013.12.004
更新日期:2014-03-01 00:00:00
abstract::Glucocorticoids have marked effects on bone metabolism, and continued exposure of skeletal tissue to excessive amounts of these steroids results in osteoporosis. Therefore, in the present proteomic study, we characterized the potential effects of glucocorticoids on protein expression in human osteoblastic cells. Using...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2003.09.010
更新日期:2004-02-01 00:00:00
abstract:PURPOSE:To evaluate the effects of different definitions of glucocorticoid (GC) exposure on the magnitude and pattern of fracture risk using the same dataset. METHODS:Data from patients with rheumatoid arthritis (RA) were extracted from the Clinical Practice Research Datalink, a primary care database with electronic h...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2018.09.004
更新日期:2018-12-01 00:00:00
abstract::Bone fragility is a complication of chronic kidney disease (CKD). Patients on dialysis have higher risk of fracture than the general population, but the reason remains obscure. Bone strength is determined by bone mass and bone quality. Although factors affecting bone quality include microarchitecture, remodeling activ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2011.03.672
更新日期:2011-06-01 00:00:00
abstract::The magnetic resonance-guided focused ultrasound (MRgFUS) system uses MR imaging for real-time aiming of thermal ablation of bone and soft tissue tumors. Past clinical studies showed no increase in fracture rate after MRgFUS treatment. The purpose of this study was to determine the effect of MRgFUS treatment on mechan...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2013.06.032
更新日期:2013-11-01 00:00:00
abstract::Numerous studies have investigated the effects of physical activity on bone health; however, little is known about the effects of isokinetic strength training on bone. While bone mineral density (BMD) is widely used to assess bone health and fracture risk, there are several limitations of this measure that warrant new...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2007.07.004
更新日期:2007-10-01 00:00:00
abstract::Global gene expression profiling has been used to study the molecular mechanisms of increased bone remodeling caused by PHPT. This disease is a model for chronic over-stimulation of target organs by PTH due to an inappropriate overproduction of the hormone. Hyperactivity of osteoblasts and osteoclasts lead to increase...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2005.12.020
更新日期:2006-07-01 00:00:00
abstract:PURPOSE:The positive effects of denosumab (DMAb) on bone mineral density (BMD) are quickly reversible after its discontinuation. We investigated whether this rebound was associated with dysregulation of the Wnt canonical pathway and/or by the increase in the receptor-activator of nuclear factor-kappa B ligand (RANKL) s...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2019.03.019
更新日期:2019-06-01 00:00:00
abstract::We believe that the assembled data are consistent with the presence of mRNA species and/or proteins in pagetic bone that are recognized by some paramyxovirus antibodies and nucleic acid probes. The evidence presented so far is insufficient to substantiate claims for the "unequivocal" presence of paramyxovirus sequence...
journal_title:Bone
pub_type: 杂志文章,评审
doi:10.1016/s8756-3282(99)00032-0
更新日期:1999-05-01 00:00:00
abstract::Fatigue behavior of compact bone at physiological strain ranges was examined in vitro. Standardized specimens of bovine compact bone were cyclically loaded in uniaxial tension of 0-1200 or 0-1500 microstrain for up to 13-37 million cycles to study the long-term fatigue properties. All specimens exhibited fatigue durin...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(90)90087-f
更新日期:1990-01-01 00:00:00
abstract::Osteogenesis imperfecta (OI) is a heritable collagen-related bone dysplasia, characterized by brittle bones with increased fracture risk that presents most severely in children. Anti-resorptive bisphosphonates are frequently used to treat pediatric OI and controlled clinical trials have shown that bisphosphonate thera...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2014.10.012
更新日期:2015-02-01 00:00:00