COMP-Ang1, a chimeric form of Angiopoietin 1, enhances BMP2-induced osteoblast differentiation and bone formation.

abstract：:Skeletal problems and osteoporosis occur in up to 50% affected neurofibromatosis type 1 (NF1) humans. Inactivation of neurofibromin results in deregulation of Ras signal transduction. Little is known of bone biology in humans with NF1. The goal of our work was to determine if loss-of-function of Nf1 gene was associate...

journal_title：Bone

authors： Yu X,Chen S,Potter OL,Murthy SM,Li J,Pulcini JM,Ohashi N,Winata T,Everett ET,Ingram D,Clapp WD,Hock JM

更新日期：2005-05-01 00:00:00

abstract：:There are increasing evidences suggesting bone marrow adiposity tissue (MAT) plays a critical role in affecting both bone quantity and quality. However, very limited studies that have investigated the association between the composition of MAT and bone mineral density (BMD). The goal of this study was to quantify MAT ...

journal_title：Bone

authors： Li X,Shet K,Xu K,Rodríguez JP,Pino AM,Kurhanewicz J,Schwartz A,Rosen CJ

更新日期：2017-12-01 00:00:00

abstract：:Aging is associated with gradual bone loss in men and premenopausal women, with an accelerated rate of loss after menopause in women. Although many studies have investigated bone loss due to surgically induced estrogen depletion, little is known regarding normal age-related changes in bone mass in animal models. We us...

journal_title：Bone

authors： Black A,Tilmont EM,Handy AM,Scott WW,Shapses SA,Ingram DK,Roth GS,Lane MA

更新日期：2001-03-01 00:00:00

abstract：:Paramagnetic manganese can be employed as a calcium surrogate to sensitize the magnetic resonance imaging (MRI) technique to the processing of calcium during the bone formation process. At low doses, after just 48h of exposure, osteoblasts take up sufficient quantities of manganese to cause marked reductions in the wa...

journal_title：Bone

authors： Chesnick IE,Centeno JA,Todorov TI,Koenig AE,Potter K

更新日期：2011-05-01 00:00:00

abstract：:Bisphosphonates play an important role in the treatment of metabolic bone diseases such as osteoporosis. In addition to their anti-resorptive activity by triggering osteoclast apoptosis, nitrogen-containing bisphosphonates (N-BP) may also influence osteogenic differentiation, which might rely on their capacity to inhi...

journal_title：Bone

authors： Adam C,Glück L,Ebert R,Goebeler M,Jakob F,Schmidt M

更新日期：2018-06-01 00:00:00

abstract：:Within-bone variation in mineral density could be functional. A heterogeneous mineral-density distribution might serve to maintain habitual amplitudes of bone strain within a non-harmful, i.e., physiological range. Regions of a bone that would be strained the most on the basis of architecture alone might have a higher...

journal_title：Bone

authors： de Jong WC,van Ruijven LJ,Brugman P,Langenbach GE

更新日期：2013-08-01 00:00:00

abstract：:X-linked hypophosphatemia (XLH) is characterized by rickets and osteomalacia and arises from mutations in the Phex and PHEX genes in mice (Hyp) and humans, respectively. The present study was undertaken to examine the effect of gene dose on the skeletal phenotype using a histomorphometric approach. Metrical traits (ve...

journal_title：Bone

authors： Qiu ZQ,Travers R,Rauch F,Glorieux FH,Scriver CR,Tenenhouse HS

更新日期：2004-01-01 00:00:00

abstract：:To determine the ability of bone turnover to predict the response in bone mass during treatment with Tibolone, two biochemical markers of bone metabolism were evaluated [CrossLaps corrected for urinary creatinine (CrossLaps/Cr.) and serum osteocalcin measured in a newly developed assay (N-Mid)]. Data from a 2-year dou...

journal_title：Bone

authors： Bjarnason NH,Bjarnason K,Hassager C,Christiansen C

更新日期：1997-02-01 00:00:00

abstract：:High-resolution peripheral quantitative computed tomography (HR-pQCT) is clinically available today and provides a non-invasive measure of 3D bone geometry and micro-architecture with unprecedented detail. In combination with microarchitectural finite element (μFE) models it can be used to determine bone strength usin...

journal_title：Bone

authors： Mueller TL,Christen D,Sandercott S,Boyd SK,van Rietbergen B,Eckstein F,Lochmüller EM,Müller R,van Lenthe GH

更新日期：2011-06-01 00:00:00

abstract：:Cylindrical trabecular bone specimens (d = 7 mm) were drilled in a vertical direction from the central part of the third vertebral body (L3) from 23 normal individuals aged 15-87 years (10 males and 13 females). The bone samples were embedded in methylmetacrylate and sawn in 400 microns thick sections with an arbitrar...

journal_title：Bone

authors： Mosekilde L

更新日期：1988-01-01 00:00:00

abstract：:Recent studies have established that generalized loss of trabecular bone occurs in the growing rat following day-to-day inflammatory irritation for a period of 3 wk. We can now demonstrate that there are similar effects on bone in milder but more prolonged chronic inflammation (14 wk). Thus, there were significant dec...

journal_title：Bone

authors： Pfeilschifter J,Minne HW,Enzmann E,Krempien B,Ziegler R

更新日期：1985-01-01 00:00:00

abstract：:Eldecalcitol (ELD), a 2β-hydroxypropyloxy derivative of 1α,25 (OH) 2D3, inhibits bone resorption more potently than alfacalcidol (ALF) while maintaining osteoblastic function in an ovariectomized (OVX) osteoporosis rat model. Alendronate (ALN), which is the most common bisphosphonate used for the treatment of osteopor...

journal_title：Bone

authors： Sugimoto M,Futaki N,Harada M,Kaku S

更新日期：2013-01-01 00:00:00

abstract：:Fracture risk and mechanical competence of bone are functions of bone mass and tissue quality, which in turn are dependent on the bone's mechanical environment. Male mice have a greater response to non-weight-bearing exercise than females, resulting in larger, stronger bones compared with control animals. The aim of t...

journal_title：Bone

authors： Wallace JM,Rajachar RM,Allen MR,Bloomfield SA,Robey PG,Young MF,Kohn DH

更新日期：2007-04-01 00:00:00

abstract：:A computerised technique is described for the quantitative assessment of resorption cavities in iliac trabecular bone. Using an Ibas II image analyser, the original bone surface, eroded by bone resorbing cells, is reconstructed using a curve fitting technique that maintains a smooth continuity with the trabecular bone...

journal_title：Bone

authors： Garrahan NJ,Croucher PI,Compston JE

更新日期：1990-01-01 00:00:00

abstract：:Background and Purpose Radiotherapy is known to produce long-term skeletal complications. We aim to evaluate the biomechanical effect on femoral neck bone from hypothetical eccentric loads on pre- and post-radiotherapy CT-images for patients treated for rectal cancer. MATERIAL AND METHODS:Pre- and post-radiotherapy C...

journal_title：Bone

authors： Almendros-Abellán VM,Castro-García M,Canales-Vázquez J,Berenguel-Herraiz P,Sabater S

更新日期：2021-01-26 00:00:00

abstract：:In order to evaluate the effects of uremia and low levels of dietary phosphorus on bone, male Sprague-Dawley rats weighing 320 +/- 20 g (12 weeks old) were subjected to either a two-step, subtotal nephrectomy or sham-operation (SO), and then fed a custom diet with either normal calcium (0.5%) and normal phosphorus (0....

journal_title：Bone

authors： Lieuallen WG,Weisbrode SE,Horst RL,Nagode LA

更新日期：1990-01-01 00:00:00

abstract：:The objective of the study was to assess the short- and long-term effects of adhesive capsulitis (frozen shoulder) on the bone mineral density (BMD) of the affected extremity. BMD and clinical status of 22 patients (group A) with active-phase unilateral adhesive capsulitis and 31 patients (group B) with a previous adh...

journal_title：Bone

authors： Leppälä J,Kannus P,Sievänen H,Järvinen M,Vuori I

更新日期：1998-06-01 00:00:00

abstract：:Identification of a reliable marker of skeletal precursor cells within calcified and soft tissues remains a major challenge for the field. To address this, we used a transgenic model in which osteoblasts can be eliminated by pharmacological treatment. Following osteoblast ablation a dramatic increase in a population o...

journal_title：Bone

authors： Kalajzic Z,Li H,Wang LP,Jiang X,Lamothe K,Adams DJ,Aguila HL,Rowe DW,Kalajzic I

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:Bone allografts carry a risk of infection, so terminal sterilization by gamma irradiation at 25kGy is recommended; but is deleterious to bone quality. Contemporary bone banking significantly reduces initial allograft bioburden, questioning the need to sterilize at 25kGy. METHODS:We inoculated allograft bone...

journal_title：Bone

authors： Nguyen H,Cassady AI,Bennett MB,Gineyts E,Wu A,Morgan DA,Forwood MR

更新日期：2013-11-01 00:00:00

abstract：:Peroxisome proliferator activated receptors (PPARs) are DNA-binding nuclear hormone receptors that are upregulated in response to high fat diets. PPARs are structurally related to the type II nuclear receptors, including the thyroid hormone receptors (TRs). To investigate if PPARs modulate TR-mediated terminal differe...

journal_title：Bone

authors： Wang L,Shao YY,Ballock RT

更新日期：2005-09-01 00:00:00

abstract：:Bone geometry plays a prominent role in bone strength. Cross-sectional studies have shown that advancing age is associated with increasing diameter of long bones, related to both periostal apposition and endosteal resorption. However, there are few data provided by prospective studies, especially concerning the change...

journal_title：Bone

authors： Briot K,Kolta S,Fechtenbaum J,Said-Nahal R,Benhamou CL,Roux C

更新日期：2010-08-01 00:00:00

abstract：:Ronacaleret is an orally-active calcium-sensing receptor (CaSR) antagonist that has the potential for therapeutic utility in the stimulation of PTH release, notably as a bone anabolic agent comparable to recombinant human PTH(1-34) (rhPTH(1-34)). A recent study has shown that, despite the ability to increase circulati...

journal_title：Bone

authors： Caltabiano S,Dollery CT,Hossain M,Kurtinecz MT,Desjardins JP,Favus MJ,Kumar R,Fitzpatrick LA

更新日期：2013-09-01 00:00:00

abstract：:Three siblings, aged 12, 4 and 2 years, presented at a Gambian clinic with bone deformities. Radiographs of knees and wrists confirmed the presence of florid rickets. The family (including 2 unaffected siblings and the mother) were investigated for hereditary rickets. The three affected siblings had biochemical featur...

journal_title：Bone

authors： Braithwaite V,Pettifor JM,Prentice A

更新日期：2013-03-01 00:00:00

abstract：:Mechanical signal transduction in bone tissue begins with load-induced activation of several cellular pathways in the osteocyte population. A key pathway that participates in mechanotransduction is Wnt/Lrp5 signaling. A putative downstream mediator of activated Lrp5 is the nucleocytoplasmic shuttling protein β-catenin...

journal_title：Bone

authors： Kang KS,Hong JM,Robling AG

更新日期：2016-07-01 00:00:00

abstract：:Subject motion during high-resolution peripheral quantitative computed tomography (HR-pQCT) causes image artifacts that affect morphological analysis of bone quality. The aim of our study was to determine effectiveness of techniques for quality control in the presence of motion in vivo including automated and manual a...

journal_title：Bone

authors： Pauchard Y,Liphardt AM,Macdonald HM,Hanley DA,Boyd SK

更新日期：2012-06-01 00:00:00

abstract：:Low body weight is associated with an increased risk for osteoporosis and fractures, but the contribution of other lifestyle related factors have not been previously studied within lean elderly women. The present study evaluated the association between lifelong lifestyle factors and bone density, falls and postmenopau...

journal_title：Bone

authors： Korpelainen R,Korpelainen J,Heikkinen J,Väänänen K,Keinänen-Kiukaanniemi S

更新日期：2006-08-01 00:00:00

abstract：:Weekly administration of teriparatide has been shown to reduce the risk of vertebral and non-vertebral fractures in patients with osteoporosis at higher fracture risk in Japan. However, its efficacy for hip fracture has not been established. To gain insight into the effect of weekly teriparatide on the hip, hip struct...

journal_title：Bone

authors： Sone T,Ito M,Fukunaga M,Tomomitsu T,Sugimoto T,Shiraki M,Yoshimura T,Nakamura T

更新日期：2014-07-01 00:00:00

abstract：:Given the adaptation of bone to prevalent loading, bone loss should follow, but lag behind, the decline in physical performance during aging. Furthermore, bone responsiveness to load-induced strains is believed to decrease with aging. However, the relationship between bone and lean body ( approximately muscle) mass ap...

journal_title：Bone

authors： Rantalainen T,Sievänen H,Linnamo V,Hoffrén M,Ishikawa M,Kyröläinen H,Avela J,Selänne H,Komi PV,Heinonen A

更新日期：2009-11-01 00:00:00

abstract：:Bone tissue undergoes permanent and lifelong remodeling with a concerted action of bone-building osteoblasts and bone-resorbing osteoclasts. A precise cooperation between those two cell types is critical in the complex process of bone renewal. Galectin-3 is a member of the β-galactoside-binding lectin family playing m...

journal_title：Bone

authors： Simon D,Derer A,Andes FT,Lezuo P,Bozec A,Schett G,Herrmann M,Harre U

更新日期：2017-12-01 00:00:00

abstract：:A predictable animal model with skeletal remodeling characteristics similar to those of humans is needed to facilitate the understanding of the mechanism of postmenopausal osteoporosis. We have utilized the ovariohysterectomized (Ovh) dog to examine cellular and biochemical responses to estrogen depletion and PTH stim...

journal_title：Bone

authors： Shen V,Dempster DW,Birchman R,Mellish RW,Church E,Kohn D,Lindsay R

更新日期：1992-01-01 00:00:00