Abstract:
:Eldecalcitol (ELD), a 2β-hydroxypropyloxy derivative of 1α,25 (OH) 2D3, inhibits bone resorption more potently than alfacalcidol (ALF) while maintaining osteoblastic function in an ovariectomized (OVX) osteoporosis rat model. Alendronate (ALN), which is the most common bisphosphonate used for the treatment of osteoporosis, increases the bone mineral density (BMD) by suppressing bone resorption. In this study, we investigated the effects of combination treatments with ELD and ALN or with ALF and ALN on bone mass and strength in OVX rats. Seventy female rats, 32 weeks old, were assigned to seven groups: (1) a sham-operated control group; (2) an OVX-control group; (3) an ELD group; (4) an ALF group; (5) an ALN group; (6) an ELD+ALN group; and (7) an ALF+ALN group. OVX rats were orally treated with ELD (0.015 μg/kg), ALF (0.0375 μg/kg), or ALN (0.2mg/kg) daily for 12 weeks. In both the lumbar spine and the femur, ELD and ALF monotherapy significantly increased the BMD, and ELD+ALN and ALF+ALN significantly increased the BMD, compared with ALN monotherapy, as an additive effect. In particular, ELD+ALN resulted in a significantly higher BMD than ALF+ALN in the femur. On mechanical testing of the lumbar spine, ELD and ALF monotherapy significantly increased the ultimate load, and ELD+ALN and ALF+ALN significantly increased the ultimate load compared with ALN monotherapy. In the femur, ELD, ELD+ALN, and ALF+ALN treatment significantly increased the ultimate load, compared with the OVX-control group, and ELD+ALN resulted in a significantly higher ultimate load than ALN monotherapy. A histomorphometric analysis showed that ELD monotherapy and ELD+ALN combination therapy had a potent inhibitory effect on bone resorption parameters (osteoclast surface and eroded surface), while maintaining bone formation parameters (osteoblast surface and osteoid surface). By contrast, ALF and ALF+ALN significantly lowered the histological parameters of both bone resorption and formation. These results suggested that ELD or ALF used in combination with ALN has therapeutic advantages over ALN monotherapy, with ELD+ALN combination treatment producing an especially beneficial anti-osteoporotic effect by inhibiting osteoclastic bone resorption and maintaining osteoblastic function, compared with ALF+ALN combination treatment.
journal_name
Bonejournal_title
Boneauthors
Sugimoto M,Futaki N,Harada M,Kaku Sdoi
10.1016/j.bone.2012.09.031subject
Has Abstractpub_date
2013-01-01 00:00:00pages
181-8issue
1eissn
8756-3282issn
1873-2763pii
S8756-3282(12)01293-8journal_volume
52pub_type
杂志文章相关文献
BONE文献大全abstract::The present study describes the biological effects of risedronate, a pyridinyl bisphosphonate, on bone and assesses the safety and tolerability of risedronate when given at high doses, with or without calcium, to postmenopausal women with spinal osteoporosis. This single-center descriptive, double-blind, placebo-contr...
journal_title:Bone
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s8756-3282(00)00410-5
更新日期:2001-01-01 00:00:00
abstract::Whilst exercise is recommended for optimum bone health in adult women, there are few systematic reviews of the efficacy of walking as singular exercise therapy for postmenopausal bone loss. The aim of this study was to assess the effects of prescribed walking programmes on bone mineral density (BMD) at the hip and spi...
journal_title:Bone
pub_type: 杂志文章,meta分析
doi:10.1016/j.bone.2008.05.012
更新日期:2008-09-01 00:00:00
abstract::There is increasing evidence that osteogenic cells are present not only in bone marrow (BM) but also in peripheral blood (PB). Since staining for alkaline phosphatase (AP) identifies osteoprogenitor cells in BM, we sought to further characterize BM versus PB hematopoietic lineage negative (lin-)/AP+ cells and to compa...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2010.03.018
更新日期:2010-07-01 00:00:00
abstract::Levels of circulating cytokines are elevated in inflammatory diseases. Previously, it was shown that interleukin (IL-)17A, in synergism with 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] and tumor necrosis factor α (TNFα), induces the release of granulocyte-macrophage colony-stimulating factor (GM-CSF) by murine osteoblasts ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2017.01.036
更新日期:2017-04-01 00:00:00
abstract::FGF23 is an O-glycosylated circulating peptide hormone with a critical role in phosphate homeostasis; it is inactivated by cellular proprotein convertases in a pre-release degradative pathway. We have here examined the metabolism of FGF23 in a model bone cell line, IDG-SW3, prior to and following differentiation, as w...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2015.12.055
更新日期:2016-03-01 00:00:00
abstract::The effects of glucocorticoid (GC) excess, thyrotoxicosis, and hypothyroidism on linear growth indicate that growth plate chondrocytes are exquisitely sensitive to GC and thyroid hormone (T(3)). Murine ATDC5 cells undergo chondrogenesis in vitro and were used to evaluate the effects of dexamethasone (Dex) and T(3) on ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(02)00855-4
更新日期:2002-10-01 00:00:00
abstract::Administration of perioperative antibiotic prophylaxis is a routine procedure in orthopedic surgery. Besides systemic prophylaxis, only few techniques are established for local application of antibiotics to reduce infection related to orthopedic implants. The aim of this study was to evaluate the efficacy of locally v...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2005.01.008
更新日期:2005-05-01 00:00:00
abstract::Due to the increasing number of osteoporotic fractures of hip, spine, and wrist there is a growing need for methods to track down the subjects with inferior bone structure and to monitor the effects of therapeutic measures. This study aims at a noninvasive diagnostic tool, deriving architectural properties of trabecul...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(97)00233-0
更新日期:1998-02-01 00:00:00
abstract::The skeletal consequences of streptozotocin-induced (STZ) diabetes in the rat are characterized by decreased bone formation and, consequently, reductions in bone mass. Given the ability of tetracyclines to inhibit the breakdown of connective tissue collagen in experimental diabetes (and in other diseases), we examined...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(97)00104-x
更新日期:1997-08-01 00:00:00
abstract::The striking predilection of temporomandibular disorders (TMD) in women, especially during gonad-intact puberty or reproductive years, indicates that oestrogen plays an important role in the progression of TMD, but the underlying mechanism remains unclear. In this study, unilateral anterior crossbite (UAC) was used to...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2018.03.008
更新日期:2018-06-01 00:00:00
abstract::Growing evidence suggests that positive associations between fat mass (FM) and bone mineral density (BMD) are mediated by not only biomechanical but also biochemical factors. Adiponectin is a novel adipocyte-derived hormone that regulates energy homeostasis and has anti-inflammatory and anti-atherogenic effects. Unlik...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(03)00237-0
更新日期:2003-10-01 00:00:00
abstract:BACKGROUND:Epimedium-derived flavonoids (EFs) have a potential to treat established osteoporosis in postmenopausal women. However, one of the main disadvantages of the compound is the high volume and dosage during long-term administration period. Meanwhile, the beneficial effect of EFs on osteoporotic bone depends grea...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2013.02.012
更新日期:2013-07-01 00:00:00
abstract::A mildly elevated homocysteine (Hcy) level is a novel and potentially modifiable risk factor for age-related osteoporotic fractures. Elevated Hcy levels can have a nutritional cause, such as inadequate intake of folate, riboflavin, pyridoxine or cobalamin, which serve as cofactors or substrates for the enzymes involve...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2007.08.021
更新日期:2007-12-01 00:00:00
abstract::Eldecalcitol (ED-71), a 2β-hydroxypropyloxy derivative of 1α,25(OH)(2)D(3), inhibits bone resorption more potently than does alfacalcidol while maintaining osteoblastic function in an estrogen-deficient, high-turnover osteoporosis rat model. Alendronate (ALN) has been reported to increase bone mass by suppressing bone...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2012.02.005
更新日期:2012-05-01 00:00:00
abstract::Given the adaptation of bone to prevalent loading, bone loss should follow, but lag behind, the decline in physical performance during aging. Furthermore, bone responsiveness to load-induced strains is believed to decrease with aging. However, the relationship between bone and lean body ( approximately muscle) mass ap...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2009.07.014
更新日期:2009-11-01 00:00:00
abstract::X-linked hypophosphatemia (XLH) is characterized by rickets and osteomalacia and arises from mutations in the Phex and PHEX genes in mice (Hyp) and humans, respectively. The present study was undertaken to examine the effect of gene dose on the skeletal phenotype using a histomorphometric approach. Metrical traits (ve...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2003.09.004
更新日期:2004-01-01 00:00:00
abstract::Depending on populations, 15 to 40% of patients have a familial form of Paget's disease of bone (PDB), which is transmitted in an autosomal-dominant mode of inheritance with incomplete penetrance. To date, only SQSTM1 gene mutations have been linked to the disease. Several single nucleotide polymorphisms (SNPs) have b...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2016.01.007
更新日期:2016-03-01 00:00:00
abstract::Trabecular bone fracture represents a major health problem, therefore the improvement of its assessment is mandatory for the reduction of the economic and social burden. The micro-structure of the trabecular bone was found to have an important effect on trabecular mechanical behavior. Nonetheless, the high variability...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2013.12.007
更新日期:2014-03-01 00:00:00
abstract::The responses of bone cells to skeletal loading are clearly an important factor in bone biology, but much remains to be learned about the role of these responses in skeletal development, maintenance, and tissue repair. Bone morphogenetic proteins (BMPs) are key regulators of bone formation. We examined the effect of B...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(02)00865-7
更新日期:2002-11-01 00:00:00
abstract::The present review summarizes the pathogenic mechanisms leading to hip fracture based on epidemiological, experimental, and controlled clinical studies. The estimated lifetime risk of hip fracture is about 14% in postmenopausal women and 6% in men. The incidence of hip fractures increases exponentially with aging, but...
journal_title:Bone
pub_type: 杂志文章,评审
doi:10.1016/8756-3282(95)00382-7
更新日期:1996-01-01 00:00:00
abstract:PURPOSE:Clinical and in vitro studies suggest that subchondral bone sclerosis due to abnormal osteoblasts is involved in the progression of osteoarthritis (OA). Human osteoblasts isolated from sclerotic subchondral OA bone tissue show an altered phenotype, a decreased canonical Wnt/ß-catenin pathway, and a reduced mine...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2015.02.001
更新日期:2015-06-01 00:00:00
abstract::Ronacaleret is an orally-active calcium-sensing receptor (CaSR) antagonist that has the potential for therapeutic utility in the stimulation of PTH release, notably as a bone anabolic agent comparable to recombinant human PTH(1-34) (rhPTH(1-34)). A recent study has shown that, despite the ability to increase circulati...
journal_title:Bone
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.bone.2013.05.021
更新日期:2013-09-01 00:00:00
abstract:BACKGROUND:Lipotoxicity is defined as cellular toxicity observed in the presence of an abnormal accumulation of fat and adipocyte-derived factors in non-fat tissues. Palmitic acid (PA), an abundant fatty acid in the bone marrow and particularly in osteoporotic bones, affects osteoblastogenesis and osteoblast function, ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2019.06.016
更新日期:2019-10-01 00:00:00
abstract::High bone mass (HBM), detected in 0.2% of DXA scans, is characterised by a mild skeletal dysplasia largely unexplained by known genetic mutations. We conducted the first systematic assessment of the skeletal phenotype in unexplained HBM using pQCT in our unique HBM population identified from screening routine UK NHS D...
journal_title:Bone
pub_type: 杂志文章,多中心研究
doi:10.1016/j.bone.2012.10.021
更新日期:2013-01-01 00:00:00
abstract::Bone marrow mesenchymal stem cells (BMMSCs) provide the biological basis for bone reconstruction. Mechanical tension stimulation as a potent modulator is able to promote osteogenic capability of BMMSCs. Long non-coding RNAs (LncRNAs) as competing endogenous RNAs (ceRNAs) for microRNAs, are postulated to regulate the o...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2017.12.013
更新日期:2018-03-01 00:00:00
abstract::In some types of low-trauma fractures of older adults the number and incidence of fractures are stabilizing or even decreasing. However, very little population-based information is available concerning the nationwide numbers, incidences and especially secular trends of low-trauma fractures of the distal humerus. There...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2009.11.025
更新日期:2010-05-01 00:00:00
abstract::Although ovariectomized cynomolgus monkeys are used extensively for studies examining perimenopausal changes in the skeleton, very little is known about the changes that occur naturally during growth and aging in these animals. To evaluate the changes in bone during growth and aging in female cynomolgus monkeys, 29 mo...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(98)00149-5
更新日期:1999-01-01 00:00:00
abstract::The amount of bone turnover in the skeleton has been identified as a predictor of fracture risk independent of areal bone mineral density (aBMD) and is increasingly cited as an explanation for discrepancies between areal bone mineral density and fracture risk. A number of mechanisms have been proposed to explain how b...
journal_title:Bone
pub_type: 杂志文章,评审
doi:10.1016/j.bone.2008.02.001
更新日期:2008-06-01 00:00:00
abstract::Cancellous microanatomy, bone remodelling, and hematopoietic tissue were studied in iliac crest and femoral neck biopsies taken intraoperatively in 102 consecutive patients with displaced intracapsular fractures. About half of the femoral biopsies had osteopenia, and most showed replacement of hematopoietic tissue by ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(91)90047-m
更新日期:1991-01-01 00:00:00
abstract::Recently, there have been remarkable advances in medical techniques for regenerating bone defects. To determine the degree of bone regeneration, it is essential to develop a new method that can analyze microstructure and related mechanical function. Here, quantitative analysis of the orientation distribution of biolog...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2012.07.003
更新日期:2012-10-01 00:00:00