Histomorphometry and bone biomarkers in cynomolgus females: a study in young, mature, and old monkeys.

abstract：:The Mediterranean osteoporosis (MEDOS) study was carried out in 14 centres from six countries in Southern Europe to determine the incidence rates and risk factors associated with hip fracture over the age of 50 years. This paper discusses both the validity and relevance of the data, that is, whether the number of coll...

journal_title：Bone

authors： Elffors L,Gullberg B,Allander E,Johnell O,Kanis JA

更新日期：1993-01-01 00:00:00

abstract：:Appositional and longitudinal growth of long bones are influenced by mechanical stimuli. Using the noninvasive rat ulna loading model, we tested the hypothesis that brief-duration (10 min/day) static loads have an inhibitory effect on appositional bone formation in the middiaphysis of growing rat ulnae. Several report...

journal_title：Bone

authors： Robling AG,Duijvelaar KM,Geevers JV,Ohashi N,Turner CH

更新日期：2001-08-01 00:00:00

abstract：:Within-bone variation in mineral density could be functional. A heterogeneous mineral-density distribution might serve to maintain habitual amplitudes of bone strain within a non-harmful, i.e., physiological range. Regions of a bone that would be strained the most on the basis of architecture alone might have a higher...

journal_title：Bone

authors： de Jong WC,van Ruijven LJ,Brugman P,Langenbach GE

更新日期：2013-08-01 00:00:00

abstract：:Recently, there have been remarkable advances in medical techniques for regenerating bone defects. To determine the degree of bone regeneration, it is essential to develop a new method that can analyze microstructure and related mechanical function. Here, quantitative analysis of the orientation distribution of biolog...

journal_title：Bone

authors： Nakano T,Kaibara K,Ishimoto T,Tabata Y,Umakoshi Y

更新日期：2012-10-01 00:00:00

abstract：:Bone sialoprotein (BSP) is highly expressed in early bone deposition and may play a part in primary bone mineralization. We previously showed that while BSP−/− mice have a mild secondary bone phenotype and are responsive to mechanical (unloading) and hormonal (ovariectomy, parathyroid hormone (PTH)) challenges, repair...

journal_title：Bone

authors： Wade-Gueye NM,Boudiffa M,Vanden-Bossche A,Laroche N,Aubin JE,Vico L,Lafage-Proust MH,Malaval L

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND:Lipotoxicity is defined as cellular toxicity observed in the presence of an abnormal accumulation of fat and adipocyte-derived factors in non-fat tissues. Palmitic acid (PA), an abundant fatty acid in the bone marrow and particularly in osteoporotic bones, affects osteoblastogenesis and osteoblast function, ...

journal_title：Bone

authors： Al Saedi A,Bermeo S,Plotkin L,Myers DE,Duque G

更新日期：2019-10-01 00:00:00

abstract：:X-linked hypophosphatemia (XLH) is characterized by rickets and osteomalacia and arises from mutations in the Phex and PHEX genes in mice (Hyp) and humans, respectively. The present study was undertaken to examine the effect of gene dose on the skeletal phenotype using a histomorphometric approach. Metrical traits (ve...

journal_title：Bone

authors： Qiu ZQ,Travers R,Rauch F,Glorieux FH,Scriver CR,Tenenhouse HS

更新日期：2004-01-01 00:00:00

abstract：:Juvenile osteoporosis (JO) is characterized by bone fragility during development, low bone mass and absence of extraskeletal features. Heterozygous loss-of-function mutations in LRP5 have been found in a few patients, but bone tissue and bone material abnormalities associated with such mutations have not been determin...

journal_title：Bone

authors： Fahiminiya S,Majewski J,Roughley P,Roschger P,Klaushofer K,Rauch F

更新日期：2013-11-01 00:00:00

abstract：:Given the adaptation of bone to prevalent loading, bone loss should follow, but lag behind, the decline in physical performance during aging. Furthermore, bone responsiveness to load-induced strains is believed to decrease with aging. However, the relationship between bone and lean body ( approximately muscle) mass ap...

journal_title：Bone

authors： Rantalainen T,Sievänen H,Linnamo V,Hoffrén M,Ishikawa M,Kyröläinen H,Avela J,Selänne H,Komi PV,Heinonen A

更新日期：2009-11-01 00:00:00

abstract：:Parathyroid hormone (PTH) and tumor necrosis factoralpha (TNFalpha) are bone resorptive agents that upregulate interleukin-6 (IL-6) and RANKL production by osteoblasts. IL-6 mRNA expression induced by PTH is rapid and transient in osteoblasts both in vitro and in vivo. This study found that IL-6 secretion induced by P...

journal_title：Bone

authors： Dai JC,He P,Chen X,Greenfield EM

更新日期：2006-04-01 00:00:00

abstract：:The clinical development of tiludronate (tiludronic acid, disodium salt) for the treatment of Paget's disease of bone is now being complemented by another clinical trials program to investigate its use in osteoporosis. It is expected that osteoporosis will become a major indication for tiludronate, and this paper desc...

journal_title：Bone

authors： Chesnut CH 3rd

更新日期：1995-11-01 00:00:00

abstract：:Bisphosphonates (BP), especially alendronate and risedronate, are the drugs most commonly used for osteoporosis treatment, being incorporated into the skeleton where they inhibit bone resorption and are thereafter slowly released during bone turnover. However, there are few data on the release of BP in patients who ha...

journal_title：Bone

authors： Peris P,Torra M,Olivares V,Reyes R,Monegal A,Martínez-Ferrer A,Guañabens N

更新日期：2011-10-01 00:00:00

abstract：:G protein-coupled receptors (GPCRs) require G proteins for intracellular signaling to regulate a variety of growth and maintenance processes, including osteogenesis and bone turnover. Bone maintenance events may be altered by changes in the activity or level of G proteins, which then modify signaling in bone cells suc...

journal_title：Bone

authors： Dela Cruz A,Mattocks M,Sugamori KS,Grynpas MD,Mitchell J

更新日期：2014-02-01 00:00:00

abstract：INTRODUCTION:The GH-IGF axis has profound effects on bone metabolism and may be important in the etiology of idiopathic osteoporosis. Serum IGF-I is often low in men with osteoporosis, which may be attributable to GH hypo-secretion or hepatic GH insensitivity. We studied the GH-IGF axis in depth to look for evidence to...

journal_title：Bone

authors： Patel MB,Arden NK,Masterson LM,Phillips DI,Swaminathan R,Syddall HE,Byrne CD,Wood PJ,Cooper C,Holt RI,Hertfordshire Cohort Study Group.

更新日期：2005-12-01 00:00:00

abstract：:While increasing age, decreasing body mass index (BMI), and physical inactivity are known to increase hip fracture risk, whether these factors have similar effects on other common fractures is not well established. We used prospectively-collected data from a large cohort to examine the role of these factors on the ris...

journal_title：Bone

authors： Armstrong ME,Cairns BJ,Banks E,Green J,Reeves GK,Beral V,Million Women Study Collaborators.

更新日期：2012-06-01 00:00:00

abstract：:During normal aging and menopause, cancellous bone is lost at all skeletal sites due to remodeling-related factors: negative formation balance; temporarily increased remodeling space; and osteoclastic perforations. The relative importance of the various factors in inducing bone mass loss and perforations is still cont...

journal_title：Bone

authors： Thomsen JS,Mosekilde L,Mosekilde E

更新日期：1996-11-01 00:00:00

abstract：:High fat diets can have detrimental effects on the skeleton as well as cause intestinal dysbiosis. Exercise prevents high fat (HF) diet-induced obesity and also improves bone density and prevents the intestinal dysbiosis that promotes energy storage. Previous studies indicate a link between intestinal microbial balanc...

journal_title：Bone

authors： McCabe LR,Irwin R,Tekalur A,Evans C,Schepper JD,Parameswaran N,Ciancio M

更新日期：2019-01-01 00:00:00

abstract：INTRODUCTION:Trace elements are known to influence bone metabolism; however, their effects may be exacerbated in renal failure because dialysis patients are unable to excrete excess elements properly. Our study correlated bone quality in dialysis patients with levels of bone fluoride, magnesium, and aluminum. A number ...

journal_title：Bone

authors： Ng AH,Hercz G,Kandel R,Grynpas MD

更新日期：2004-01-01 00:00:00

abstract：:Osteocytes are cells buried in the bone matrix. They largely contribute to the regulation of bone remodeling in response to mechanical and microenvironmental changes. Much has been recognized in recent years regarding the role of osteocytes in bone homeostasis, nevertheless their ability to directly contribute to mine...

journal_title：Bone

authors： Teti A,Zallone A

更新日期：2009-01-01 00:00:00

abstract：:The effect of vitamin D supplementation on growth of fetal bones during pregnancy is unclear. The aim of this study was to assess the effect of low dose vitamin D supplementation during pregnancy on bony anthropometric aspects of the fetus. In this prospective randomized trial, 140 patients were divided into two equal...

journal_title：Bone

authors： Vafaei H,Asadi N,Kasraeian M,Shahraki HR,Bazrafshan K,Namazi N

更新日期：2019-05-01 00:00:00

abstract：:We investigated the effect of 2-beta-(3-hydroxypropoxy)-1alpha,25-dihydroxyvitamin D3 (ED-71) on the modeling of bone in distraction osteogenesis. The tibiae of 30 rabbits were lengthened by 10 mm in 10 days. Following osteotomy, ED-71 (0.05 microg/kg) was administered subcutaneously twice a week to the ED-71 group un...

journal_title：Bone

authors： Yamane K,Okano T,Kishimoto H,Hagino H

更新日期：1999-03-01 00:00:00

abstract：:Spinal cord injury (SCI) results in a dramatic loss of bone mineral and a marked increase in fracture incidence in the femur; however, its effect on the femur's geometric structure and strength is poorly studied. The primary purpose of the present study was to assess the geometric structure, composition, and strength ...

journal_title：Bone

authors： Modlesky CM,Slade JM,Bickel CS,Meyer RA,Dudley GA

更新日期：2005-02-01 00:00:00

abstract：:Human vertebral cancellous bone from white males (N = 19), black males (N = 16), white females (N = 12), and black females (N = 17) was examined histologically for the presence, numerical density, and morphology of in vivo microscopic cracking (microdamage). Two patterns of microcracks, linear and cross-hatched, were ...

journal_title：Bone

authors： Wenzel TE,Schaffler MB,Fyhrie DP

更新日期：1996-08-01 00:00:00

abstract：:It is well known that physical inactivity leads to loss of muscle mass, but it also causes bone loss. Mechanistically, osteoclastogenesis and bone resorption have recently been shown to be regulated by vibration. However, the underlying mechanism behind the inhibition of osteoclast formation is yet unknown. Therefore,...

journal_title：Bone

authors： Kulkarni RN,Voglewede PA,Liu D

更新日期：2013-12-01 00:00:00

abstract：:It is known that marrow fat content increases in a variety of osteoporoses. This study sought to clarify this phenomenon by combining bone and marrow histomorphometry, and to determine (1) whether the marrow fat increase follows or precedes diminishment of bone volume, and (2) whether the increase in fat volume is due...

journal_title：Bone

authors： Martin RB,Zissimos SL

更新日期：1991-01-01 00:00:00

abstract：:Bisphosphonates are one of the most well studied groups of medications and they are bone specific. This tissue specificity is a rare property for a drug introduced into clinical practice as long as 40 years ago. Over the years, the therapeutic boundaries of bisphosphonates were explored and their safety profile has wi...

journal_title：Bone

authors： Pazianas M,Abrahamsen B

更新日期：2011-07-01 00:00:00

abstract：:The aim of the study was to compare the effects on bone mass and turnover of continuous vs. intermittent clodronate administration on 120 postmenopausal women (average age 61 years) with low bone mass (femoral neck bone mineral density [BMD] of at least -1 SD or more, T-score), with another 30 women as a control group...

journal_title：Bone

authors： Filipponi P,Cristallini S,Policani G,Schifini MF,Casciari C,Garinei P

更新日期：2000-03-01 00:00:00

abstract：:Osteocytes are the most abundant cell type in bone and are responsible for sensing mechanical strain and signaling bone (re)modeling, making them the primary mechanosensors within bone. Under aging and osteoporotic conditions, bone is known to be less responsive to loading (exercise), but it is unclear why. Perhaps, t...

journal_title：Bone

authors： Stern AR,Nicolella DP

更新日期：2013-06-01 00:00:00

abstract：:We studied the differences in the patterns of trabecular bone loss induced by various kinds of experimental osteopenia in the rat, including ovariectomy, sciatic neurotomy (partial paralysis of hind-limb), hemicordotomy (complete paralysis of hind-limb), and their combinations. The cut surface of the metaphysis of pro...

journal_title：Bone

authors： Yoshida S,Yamamuro T,Okumura H,Takahashi H

更新日期：1991-01-01 00:00:00

abstract：:In order to investigate the effect of fluoride on bone mineral crystals, we gave groups of female rats 8 mM NaF/L water and distilled water to control groups. The rats were sacrificed at six weeks, three months, and six months. The fluor content of the bone was determined by neutron activation. X-ray diffraction showe...

journal_title：Bone

authors： Grynpas MD,Rey C

更新日期：1992-01-01 00:00:00