Abstract:
:During normal aging and menopause, cancellous bone is lost at all skeletal sites due to remodeling-related factors: negative formation balance; temporarily increased remodeling space; and osteoclastic perforations. The relative importance of the various factors in inducing bone mass loss and perforations is still controversial. We have previously used a computer simulation model to describe the effect of several bone remodeling parameters on vertebral cancellous bone loss. The model focused on two different scenarios for the menopause and three different treatment regimens. The aim of the present study was to extend the previous study by quantifying remodeling parameter sensitivity for changes in the bone mass with the use of the computer model we had previously formulated. The menopause scenario, with increased activation frequency and increased resorption depth, was chosen as the base case scenario, and the following parameters were investigated in the sensitivity analysis: activation frequency; formation balance; resorption depth; and critical trabecular thickness. Simulations were performed for a period of 20 years starting at the age of 48 years. The analysis showed that the number of perforations and the perforation-related mass loss both exhibited a large sensitivity toward variations in the final resorption depth. However, the formation balance was the factor that was responsible for the greater part of the bone mass loss. The computer model allowed us to quantify the sensitivity of different output variables with respect to changes in some of the model parameters. This can give information about the biological mechanisms responsible for bone mass loss around the surgically induced or natural menopause and also provide an indication of the type of treatment that would be most useful in preventing the deterioration of the cancellous network.
journal_name
Bonejournal_title
Boneauthors
Thomsen JS,Mosekilde L,Mosekilde Edoi
10.1016/s8756-3282(96)00231-1subject
Has Abstractpub_date
1996-11-01 00:00:00pages
505-11issue
5eissn
8756-3282issn
1873-2763pii
S8756328296002311journal_volume
19pub_type
杂志文章相关文献
BONE文献大全abstract::Twenty patients with mild Paget's disease of bone were given either 20 (10 patients) or 40 mg alendronate daily for 6 months. The 20-mg dose was well tolerated, but in 3 patients on 40 mg/d alendronate, the treatment was withdrawn after 3-5 months because of gastric and oesophageal disturbances. Urinary hydroxyproline...
journal_title:Bone
pub_type: 临床试验,杂志文章
doi:10.1016/8756-3282(94)90818-4
更新日期:1994-07-01 00:00:00
abstract:BACKGROUND:Lipotoxicity is defined as cellular toxicity observed in the presence of an abnormal accumulation of fat and adipocyte-derived factors in non-fat tissues. Palmitic acid (PA), an abundant fatty acid in the bone marrow and particularly in osteoporotic bones, affects osteoblastogenesis and osteoblast function, ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2019.06.016
更新日期:2019-10-01 00:00:00
abstract::Compounds, like beta-aminopropionitrile (bAPN) and homocysteine (hcys), are known to inhibit a stable matrix formation. Osteoblast-synthesized collagen matrix regulates the differentiation of precursor cells into mature osteoblasts. They express lysyl oxidase, an enzyme involved in the collagen cross-linking process. ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2009.10.038
更新日期:2010-03-01 00:00:00
abstract::Bisphosphonates are one of the most well studied groups of medications and they are bone specific. This tissue specificity is a rare property for a drug introduced into clinical practice as long as 40 years ago. Over the years, the therapeutic boundaries of bisphosphonates were explored and their safety profile has wi...
journal_title:Bone
pub_type: 杂志文章,评审
doi:10.1016/j.bone.2011.01.003
更新日期:2011-07-01 00:00:00
abstract::The gamma-carboxy glutamic acid (Gla)-containing protein of mammalian bone (BGP, also called osteocalcin) is a 49 amino acid polypeptide containing two to three residues of gamma-carboxyglutamic acid. BGP is synthesized by osteoblastlike cells, and plasma BGP in laboratory animals is derived principally from recently ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(85)90400-4
更新日期:1985-01-01 00:00:00
abstract::Vitamin D deficiency may depress bone formation but its effect on bone resorption is not well defined. As an index of bone resorption, the activity of acid phosphatase, a lysosomal enzyme found in osteoclasts, was quantitated in situ from a bone tissue smear preparation. Activity of the enzyme, measured by integrative...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(87)90171-2
更新日期:1987-01-01 00:00:00
abstract::Chondrocyte proliferation and differentiation are crucial for endochondral ossification and strictly regulated by numerous signaling molecules and transcription factors, but the hierarchical regulatory network remains to be deciphered. The present study emphasized the interplay of Activin A, Foxa, Notch and Shh signal...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2019.03.036
更新日期:2019-06-01 00:00:00
abstract::Physician recommendation for prophylactic surgical fixation of a femur with metastatic bone disease (MBD) is usually based on Mirels' criteria and clinical experience, both of which suffer from poor specificity. This may result in a significant number of these health compromised patients undergoing unnecessary surgery...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2018.02.011
更新日期:2018-05-01 00:00:00
abstract::Ronacaleret is an orally-active calcium-sensing receptor (CaSR) antagonist that has the potential for therapeutic utility in the stimulation of PTH release, notably as a bone anabolic agent comparable to recombinant human PTH(1-34) (rhPTH(1-34)). A recent study has shown that, despite the ability to increase circulati...
journal_title:Bone
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.bone.2013.05.021
更新日期:2013-09-01 00:00:00
abstract::Insulin-dependent type 1 diabetes mellitus (IDDM) has been shown to alter the properties of bone and impair bone repair in both humans and animals. The objective of this study was the detailed histomorphometric evaluation of the influence of the diabetic metabolic state on bone formation and remodeling during bone def...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2004.03.011
更新日期:2004-07-01 00:00:00
abstract::Autologous marrow stromal cells have been proposed as an adjuvant in the treatment of bone defects and diseases. This will require the development of culture conditions that permit their rapid expansion ex vivo while retaining their potential for further differentiation. Fibroblast growth factor (FGF)-2 has been propo...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(00)00319-7
更新日期:2000-08-01 00:00:00
abstract:BACKGROUND:Skeletal loading and proper nutrition are necessary for optimal bone health. The appropriate amount of dietary protein to maximize skeletal health, however, is under constant debate. OBJECTIVE:To determine if 6 months of protein supplementation in conjunction with a strength and conditioning training progra...
journal_title:Bone
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.bone.2005.10.020
更新日期:2006-06-01 00:00:00
abstract::Cementum, a mineralized tissue lining the surface of the tooth root, is required for formation of a functional periodontal ligament attachment during development. Additionally, during regeneration of tissues after disease, cementum is thought to play a critical role in the reparative process. Research efforts aimed to...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(99)00096-4
更新日期:1999-07-01 00:00:00
abstract::We previously reported that calcium intake enhanced the leg bone response to physical activity of preschool children in a 12-month randomized trial of calcium supplementation and physical activity. To determine whether the intervention-induced changes in leg bone mineral content and size were maintained through the su...
journal_title:Bone
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.bone.2004.08.012
更新日期:2004-12-01 00:00:00
abstract::In this study we describe the generation and influences on in vitro and in vivo osteogenesis of photo-cured hyaluronic acid (HA) hydrogels loaded with growth and differentiation factor 5 (GDF-5). Prior to loading GDF-5, we characterized the release profiles from these hydrogels and tested their respective cell viabili...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2013.11.019
更新日期:2014-02-01 00:00:00
abstract::Trabecular thickness and the trabecular star volume were estimated in 49 normal individuals (20 males and 29 females) using an unbiased sampling procedure consisting of anisotropic, vertical sections, and a corresponding anisotropic test system. Eight-microns-thick undecalcified stained vertical sections were obtained...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(89)90129-4
更新日期:1989-01-01 00:00:00
abstract::Recently, the involvement of immune responses in metabolic bone disease and/or local bone destruction has received much attention. Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4), a member of the immunoglobulin (Ig) superfamily, negatively regulates T cell activation. The deficiency of CTLA-4 induces profound ost...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2004.06.018
更新日期:2004-11-01 00:00:00
abstract::Although much is known about hip fracture epidemiology, there are relatively little data regarding fractures at other peripheral sites. Epidemiological differences between fractures are important, since they imply that an understanding of the consequences and clinical expression of osteoporosis requires the study of m...
journal_title:Bone
pub_type: 杂志文章,评审
doi:10.1016/8756-3282(95)00504-8
更新日期:1996-03-01 00:00:00
abstract::Mandibuloacral dysplasia (MAD) is a rare recessively inherited premature aging disease characterized by skeletal and metabolic anomalies. It is part of the spectrum of diseases called laminopathies and results from mutations in genes regulating the synthesis of the nuclear laminar protein, lamin A. Homozygous or compo...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2010.06.004
更新日期:2010-09-01 00:00:00
abstract::The gap junction protein, connexin43 (Cx43) controls both bone formation and osteoclastogenesis via osteoblasts and/or osteocytes. Cx43 has also been proposed to mediate an anti-apoptotic effect of bisphosphonates, potent inhibitors of bone resorption. We studied whether bisphosphonates are effective in protecting mic...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2012.06.018
更新日期:2012-10-01 00:00:00
abstract::Interleukin-1 (IL-1) has been shown to promote osteoclast (OC) differentiation, in addition to acting as a survival factor for mature osteoclasts. In this study, we investigate the expression of IL-1 during human osteoclast formation, taking advantage of a recently reported in vitro culture system that generates human...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(99)00176-3
更新日期:1999-09-01 00:00:00
abstract:BACKGROUND:Good bone and joint health is essential for the physical tasks of daily living and poorer indicators of physical capability in older adults have been associated with increased mortality rates. Genetic variants of indicators of bone and joint health may be associated with measures of physical capability. MET...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2012.10.004
更新日期:2013-01-01 00:00:00
abstract::The prevalence of osteoarthritis (OA) is greater in women then men. Weight, a factor strongly associated with osteoarthritis, is significantly increased over the menopausal transition. Despite the high prevalence of osteoarthritis, a disabling disease with limited treatment options, there is a paucity of studies in wo...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2006.05.016
更新日期:2006-11-01 00:00:00
abstract::Radiation of the hip is an established method to prevent heterotopic ossification (HO) following total hip arthroplasty (THA) but the precise mechanism is unclear. As inflammatory processes are suggested to be involved in the pathogenesis of HO, we hypothesized that the preoperative irradiation impacts local immune co...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2013.03.020
更新日期:2013-07-01 00:00:00
abstract::Significant decreases in ovine compact bone viscoelastic properties (specifically, stress-rate sensitivity, and damping efficiency) are associated with three years of ovariectomy and are particularly evident at higher frequencies [Proc. Orthop. Res. Soc. 27 (2002) 89]. It is unclear what materials or architectural fea...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2004.04.006
更新日期:2004-09-01 00:00:00
abstract::Inhaled corticosteroids are the cornerstone of the modern therapy for asthma. In recent years, inhaled corticosteroids have been used in higher doses than previously. This has caused concern about possible osteoporotic side-effects. We studied bone mineral densities (BMDs) in 19 non-smoking women (mean age 53 years, r...
journal_title:Bone
pub_type: 临床试验,杂志文章
doi:10.1016/8756-3282(94)90309-3
更新日期:1994-11-01 00:00:00
abstract::Rodent models suggest that estradiol deficiency promotes bone loss through increasing interleukin-6 (IL-6) activity. However, it is controversial as to whether these findings are applicable to humans. To evaluate estradiol-mediated modulation of IL-6 activity in relation to bone metabolism in humans, we measured serum...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(99)00243-4
更新日期:2000-01-01 00:00:00
abstract::MicroRNAs (miRNAs) are a class of short RNA molecules that mediate the regulation of gene activity through interactions with target mRNAs and subsequent silencing of gene expression. It has become increasingly clear the miRNAs regulate many diverse aspects of bone biology, including bone formation and bone resorption ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2020.115757
更新日期:2021-02-01 00:00:00
abstract:INTRODUCTION:Heterotopic ossification (HO), or the abnormal formation of bone in soft tissue, occurs in over 60% of major burn injuries and blast traumas. A significant need exists to improve the current diagnostic modalities for HO which are inadequate to diagnose and intervene on HO at early time-points. Raman spectr...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2013.01.002
更新日期:2013-05-01 00:00:00
abstract::We have previously shown that after bone fracture, galanin (GAL) and GAL receptor expression is increased in osteoblast-like cells of callus; however, the role of elevated GAL/GAL receptors in this instance of bone injury is not known. We hypothesize that in injury, GAL may facilitate bone formation by suppressing the...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2006.10.018
更新日期:2007-04-01 00:00:00