Methodology of MEDOS multicentre study of hip fracture incidence: validity and relevance considerations.

abstract：:Feral adult female cynomolgus monkeys were divided into three groups and treated for two years: (1) normal controls; (2) weak androgenic treatment (androstenedione+estrone); and (3) strong androgenic treatment (testosterone). The tibiae and the trabecular bone of femoral head from each group were tested mechanically. ...

journal_title：Bone

authors： Kasra M,Grynpas MD

更新日期：1995-09-01 00:00:00

abstract：:Six women, aged 24-67 years, had osteopenia and insufficiency fractures, which suggested a diagnosis of osteomalacia. The insufficiency fractures occurred at traditional sites for Looser zones, were multiple in number, were symmetrically distributed in three patients, and did not heal promptly. Bone mass was low, as a...

journal_title：Bone

authors： McKenna MJ,Kleerekoper M,Ellis BI,Rao DS,Parfitt AM,Frame B

更新日期：1987-01-01 00:00:00

abstract：:There is no adequate animal model to mimic the difficult clinical situation of infected non-union of the tibia after intramedullary stabilization. The purpose was to establish an animal model of implant-related infected non-unions of the tibia in rats. Furthermore, it was evaluated if detection of bacteria by fluoresc...

journal_title：Bone

authors： Alt V,Lips KS,Henkenbehrens C,Muhrer D,Oliveira Cavalcanti MC,Sommer U,Thormann U,Szalay G,Heiss C,Pavlidis T,Domann E,Schnettler R

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND:U.S. Army Basic Combat Training (BCT) is a physically-demanding program at the start of military service. Whereas animal studies have shown that increased mechanical loading rapidly alters bone structure, there is limited evidence of changes in bone density and structure in humans exposed to a brief period o...

journal_title：Bone

authors： Hughes JM,Gaffney-Stomberg E,Guerriere KI,Taylor KM,Popp KL,Xu C,Unnikrishnan G,Staab JS,Matheny RW Jr,McClung JP,Reifman J,Bouxsein ML

更新日期：2018-08-01 00:00:00

abstract：:Alagille syndrome (ALGS) is an autosomal dominant disorder attributed to mutations in the Notch signaling pathway. Children with ALGS are at increased risk for fragility fracture of unknown etiology. Our objective was to characterize bone mass, geometry, and microarchitecture in children with ALGS. This was a cross-se...

journal_title：Bone

authors： Kindler JM,Mitchell EL,Piccoli DA,Grimberg A,Leonard MB,Loomes KM,Zemel BS

更新日期：2020-12-01 00:00:00

abstract：INTRODUCTION:Heterotopic ossification (HO), or the abnormal formation of bone in soft tissue, occurs in over 60% of major burn injuries and blast traumas. A significant need exists to improve the current diagnostic modalities for HO which are inadequate to diagnose and intervene on HO at early time-points. Raman spectr...

journal_title：Bone

authors： Peterson JR,Okagbare PI,De La Rosa S,Cilwa KE,Perosky JE,Eboda ON,Donneys A,Su GL,Buchman SR,Cederna PS,Wang SC,Kozloff KM,Morris MD,Levi B

更新日期：2013-05-01 00:00:00

abstract：:In order to investigate the effect of fluoride on bone mineral crystals, we gave groups of female rats 8 mM NaF/L water and distilled water to control groups. The rats were sacrificed at six weeks, three months, and six months. The fluor content of the bone was determined by neutron activation. X-ray diffraction showe...

journal_title：Bone

authors： Grynpas MD,Rey C

更新日期：1992-01-01 00:00:00

abstract：INTRODUCTION:Changes in hip structure and geometry during aging contribute to decreased bone strength. Little is known, however, about these characteristics at advanced age, when fragility fractures are common. We examined hip structural geometry in men and women of old age (72-84 years) and old-old age (85-96 years) t...

journal_title：Bone

authors： Yates LB,Karasik D,Beck TJ,Cupples LA,Kiel DP

更新日期：2007-10-01 00:00:00

abstract：:The underlying causes of maxillary bone loss during lactation remain poorly understood. We evaluated the impact of lactation on physiological and mechanically-induced alveolar bone remodeling. Nulliparous non-lactating (N-LAC) and 21-day lactating (LAC) mice underwent mechanically-induced bone remodeling by orthodonti...

journal_title：Bone

authors： Macari S,Sharma LA,Wyatt A,da Silva JM,Dias GJ,Silva TA,Szawka RE,Grattan DR

更新日期：2018-05-01 00:00:00

abstract：OBJECTIVE:To compare the effects of TNF-α and IL-17A on osteogenic differentiation of isolated fibroblast-like synoviocytes (FLS) from healthy donors, osteoarthritis (OA) and rheumatoid arthritis (RA) patients. METHODS:FLS were cultured in osteogenic medium, with and without TNF-α and/or IL-17A. Extracellular matrix m...

journal_title：Bone

authors： Lavocat F,Osta B,Miossec P

更新日期：2016-06-01 00:00:00

abstract：:The lung interfaces with atmospheric oxygen via a large surface area and is perfused by the entire venous return bearing waste products collected from the whole body. It is logical that the lung is endowed with generous anti-oxidative capacity derived both locally and from the circulation. The single-pass pleiotropic ...

journal_title：Bone

authors： Hsia CCW,Ravikumar P,Ye J

更新日期：2017-07-01 00:00:00

abstract：:The Euler number and the connectivity of an arbitrary object is defined, and it is illustrated why the connectivity of an n-dimensional object cannot be estimated in an (n-1)-dimensional section. The disector--principle for 3-D counting of the Euler--events is illustrated in cancellous bone. The correct handling for u...

journal_title：Bone

authors： Gundersen HJ,Boyce RW,Nyengaard JR,Odgaard A

更新日期：1993-05-01 00:00:00

abstract：:Both bone density and quality are important determinants of bone strength. Bone quality is prescribed by matrix characteristic including collagen cross-linking and bone structural characteristics and is important in reinforcement of bone strength. We investigated the effects of alfacalcidol (ALF), a prodrug of calcitr...

journal_title：Bone

authors： Saito M,Shiraishi A,Ito M,Sakai S,Hayakawa N,Mihara M,Marumo K

更新日期：2010-04-01 00:00:00

abstract：:Several studies have shown that treatment with bisphosphonates can reduce the pain associated with different painful diseases. In a previous study we demonstrated that in mice two bisphosponates, clodronate and pamidronate, had an antinociceptive effect under acute conditions not related to bone processes, after in ve...

journal_title：Bone

authors： Bonabello A,Galmozzi MR,Canaparo R,Serpe L,Zara GP

更新日期：2003-10-01 00:00:00

abstract：INTRODUCTION:We still lack understanding of why some implants fail while most remain stable after decades of use. Proinflammatory cytokines, matrix proteins and bone regulating cytokines of the RANKL/OPG (receptor activator of nuclear factor kappa B ligand/osteoprotegerin) and Wnt/β-catenin pathways are mandatory for n...

journal_title：Bone

authors： Cassuto J,Folestad A,Göthlin J,Malchau H,Kärrholm J

更新日期：2018-02-01 00:00:00

abstract：:Although basic fibroblast growth factor (bFGF) is a potent stimulator of bone formation when administered intravenously, less is known regarding the effects of this peptide on bone following subcutaneous (s.c.) administration. In addition, it is unknown whether coadministration of estrogen enhances the bone response t...

journal_title：Bone

authors： Iwaniec UT,Magee KA,Mitova-Caneva NG,Wronski TJ

更新日期：2003-09-01 00:00:00

abstract：:In order to analyze the role of the estrogen receptor (ER) gene allelic polymorphisms on bone mineral density (BMD), 173 pre- and postmenopausal women were divided into four groups according to their menstrual status (group A: premenopausal women; group B: late premenopausal women; group C: postmenopausal women who ha...

journal_title：Bone

authors： Mizunuma H,Hosoi T,Okano H,Soda M,Tokizawa T,Kagami I,Miyamoto S,Ibuki Y,Inoue S,Shiraki M,Ouchi Y

更新日期：1997-11-01 00:00:00

abstract：:The influence of porosity, osteon density, osteonal area, osteonal lamellar area, osteon size, and haversian canal size on the tension and shear fracture toughness, that is, the mode I and mode II strain energy release rate (GIc and GIIc), respectively, were investigated for the human femur and the tibia. The results ...

journal_title：Bone

authors： Yeni YN,Brown CU,Wang Z,Norman TL

更新日期：1997-11-01 00:00:00

abstract：:Due to the increasing number of osteoporotic fractures of hip, spine, and wrist there is a growing need for methods to track down the subjects with inferior bone structure and to monitor the effects of therapeutic measures. This study aims at a noninvasive diagnostic tool, deriving architectural properties of trabecul...

journal_title：Bone

authors： Geraets WG,Van der Stelt PF,Lips P,Van Ginkel FC

更新日期：1998-02-01 00:00:00

abstract：BACKGROUND:Studies in childhood suggest that both body composition and early postnatal growth are associated with bone mineral density (BMD). However, little is known of the relationships between longitudinal changes in fat (FM) and lean mass (LM) and bone development in pre-pubertal children. We therefore investigated...

journal_title：Bone

authors： Moon RJ,Cole ZA,Crozier SR,Curtis EM,Davies JH,Gregson CL,Robinson SM,Dennison EM,Godfrey KM,Inskip HM,Cooper C,Harvey NC,Southampton Women's Survey Study Group.

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:Vertebral fractures (VF) upon Denosumab (DMAB) discontinuation were first described as a distinct phenomenon in 2015, yet the magnitude of this event remains undetermined. OBJECTIVES:To estimate fracture risk after DMAB discontinuation, in a real-world setting. METHODS:The computerized database of a 2.3-mi...

journal_title：Bone

authors： Tripto-Shkolnik L,Fund N,Rouach V,Chodick G,Shalev V,Goldshtein I

更新日期：2020-01-01 00:00:00

abstract：:Although much is known about hip fracture epidemiology, there are relatively little data regarding fractures at other peripheral sites. Epidemiological differences between fractures are important, since they imply that an understanding of the consequences and clinical expression of osteoporosis requires the study of m...

journal_title：Bone

authors： Baron JA,Barrett JA,Karagas MR

更新日期：1996-03-01 00:00:00

abstract：:The aim of this study was to provide insight into the bone mineral status and biochemical markers of bone metabolism in a Chinese population from Shenyang, in the north of China, where hip fracture incidence is low. A total of 194 healthy men and women, aged 25-35 years and 65-75 years, were studied. Bone mineral dens...

journal_title：Bone

authors： Yan L,Prentice A,Zhou B,Zhang H,Wang X,Stirling DM,Laidlaw A,Han Y,Laskey A

更新日期：2002-02-01 00:00:00

abstract：:Peak bone mass (PBM) is an important determinant of osteoporosis. Circulating monocytes serve as early progenitors of osteoclasts and produce important molecules for bone metabolism. To search for genes functionally important for PBM variation, we performed a whole genome gene differential expression study of circulat...

journal_title：Bone

authors： Lei SF,Wu S,Li LM,Deng FY,Xiao SM,Jiang C,Chen Y,Jiang H,Yang F,Tan LJ,Sun X,Zhu XZ,Liu MY,Liu YZ,Chen XD,Deng HW

更新日期：2009-05-01 00:00:00

abstract：:The association between sports participation during adolescence and peri- and postmenopausal bone mineral density (BMD) was examined among 2025 women aged 48-58 years. Adolescent recreational and competitive sporting activities were registered with a self-administered questionnaire. Altogether, 881 (43.5%) women state...

journal_title：Bone

authors： Puntila E,Kröger H,Lakka T,Honkanen R,Tuppurainen M

更新日期：1997-10-01 00:00:00

abstract：:It has been established during the past few years that interleukin(s)-1, -6, -11 (IL-1, IL-6, IL-11), and tumor necrosis factor (TNF) can stimulate osteoclast development and thereby the process of bone resorption. Moreover, upregulation of the production and/or action of IL-6 has been implicated in the pathogenesis o...

journal_title：Bone

authors： Manolagas SC

更新日期：1995-08-01 00:00:00

abstract：:Rough-surfaced substrates made by a variety of methods have been shown to influence osteoblast proliferation and differentiation. The purpose of this study is to confirm the role of surface roughness in promoting osteoblastic differentiation using tissue culture polystyrene as substrate, by excluding factors other tha...

journal_title：Bone

authors： Hatano K,Inoue H,Kojo T,Matsunaga T,Tsujisawa T,Uchiyama C,Uchida Y

更新日期：1999-10-01 00:00:00

abstract：:During our survey of herbs looking for activity on bone metabolism, we found that the dried leaves of sage strongly inhibit bone resorption. Therefore, we investigated several common herbs rich in essential oils (sage, rosemary, and thyme) and essential oils extracted from these herbs and other plants (oils of sage, r...

journal_title：Bone

authors： Mühlbauer RC,Lozano A,Palacio S,Reinli A,Felix R

更新日期：2003-04-01 00:00:00

abstract：:Parathyroid hormone (PTH) and tumor necrosis factoralpha (TNFalpha) are bone resorptive agents that upregulate interleukin-6 (IL-6) and RANKL production by osteoblasts. IL-6 mRNA expression induced by PTH is rapid and transient in osteoblasts both in vitro and in vivo. This study found that IL-6 secretion induced by P...

journal_title：Bone

authors： Dai JC,He P,Chen X,Greenfield EM

更新日期：2006-04-01 00:00:00

abstract：:Over 60% of our severely combat-injured patient population develops radiographically apparent heterotopic ossification. Nearly a third of these require surgical excision of symptomatic lesions, a procedure that is fraught with complications, and delays or regresses functional rehabilitation in many cases. Unfortunatel...

journal_title：Bone

authors： Crane NJ,Polfer E,Elster EA,Potter BK,Forsberg JA

更新日期：2013-12-01 00:00:00