The influence of bone morphology on fracture toughness of the human femur and tibia.

Abstract:

:The influence of porosity, osteon density, osteonal area, osteonal lamellar area, osteon size, and haversian canal size on the tension and shear fracture toughness, that is, the mode I and mode II strain energy release rate (GIc and GIIc), respectively, were investigated for the human femur and the tibia. The results suggest that porosity and osteon density were the best explanatory morphological parameters for GIc and GIIc. Both GIc and GIIc significantly decrease with increasing porosity. They also increase with increasing osteon density, the increase being significant for the femur only. Morphological parameters, altogether, can explain 49%-68% of the variation in fracture toughness. We concluded that, although there must be other factors such as biochemical components and microdamage, osteon morphology has an important influence on fracture resistance of the cortical bone.

journal_name

Bone

journal_title

Bone

authors

Yeni YN,Brown CU,Wang Z,Norman TL

doi

10.1016/s8756-3282(97)00173-7

subject

Has Abstract

pub_date

1997-11-01 00:00:00

pages

453-9

issue

5

eissn

8756-3282

issn

1873-2763

pii

S8756328297001737

journal_volume

21

pub_type

杂志文章

相关文献

BONE文献大全
  • Estrogen deficiency increases osteoclastogenesis up-regulating T cells activity: a key mechanism in osteoporosis.

    abstract::Compelling evidences suggest that increased production of osteoclastogenic cytokines by activated T cells plays a relevant role in the bone loss induced by estrogen deficiency in the mouse. However, little information is available on the role of T cells in post-menopausal bone loss in humans. To investigate this issue...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/j.bone.2008.02.017

    authors: D'Amelio P,Grimaldi A,Di Bella S,Brianza SZM,Cristofaro MA,Tamone C,Giribaldi G,Ulliers D,Pescarmona GP,Isaia G

    更新日期:2008-07-01 00:00:00

  • The generation of highly enriched osteoclast-lineage cell populations.

    abstract::Osteoclasts form when hematopoietic cells are stimulated by macrophage colony-stimulating factor (M-CSF) and receptor activator of NF-kappaB ligand (RANKL) or tumor necrosis factor-alpha (TNFalpha). Osteoclast precursors derive from M-CSF-dependent proliferating hematopoietic cells but cannot yet be purified from mixe...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/s8756-3282(01)00654-8

    authors: Quinn JM,Whitty GA,Byrne RJ,Gillespie MT,Hamilton JA

    更新日期:2002-01-01 00:00:00

  • Scoliosis in osteogenesis imperfecta caused by COL1A1/COL1A2 mutations - genotype-phenotype correlations and effect of bisphosphonate treatment.

    abstract::Bisphosphonates are widely used to treat children with osteogenesis imperfecta (OI), a bone fragility disorder that is most often caused by mutations in COL1A1 or COL1A2. However, it is unclear whether this treatment decreases the risk of developing scoliosis. We retrospectively evaluated spine radiographs and charts ...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/j.bone.2016.02.018

    authors: Sato A,Ouellet J,Muneta T,Glorieux FH,Rauch F

    更新日期:2016-05-01 00:00:00

  • Postnatal β-catenin deletion from Dmp1-expressing osteocytes/osteoblasts reduces structural adaptation to loading, but not periosteal load-induced bone formation.

    abstract::Mechanical signal transduction in bone tissue begins with load-induced activation of several cellular pathways in the osteocyte population. A key pathway that participates in mechanotransduction is Wnt/Lrp5 signaling. A putative downstream mediator of activated Lrp5 is the nucleocytoplasmic shuttling protein β-catenin...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/j.bone.2016.04.028

    authors: Kang KS,Hong JM,Robling AG

    更新日期:2016-07-01 00:00:00

  • Effects of vitamin D3, 17beta-estradiol, vasoactive intestinal peptide, and glutamate on electric coupling between rat osteoblast-like cells in vitro.

    abstract::Osteoblast-like cells express receptors for various hormones and neurotransmitters that induce widespread actions in the bone to which intercellular communication and its modulation may contribute. Therefore, we examined the effects of the osteotropic hormones vitamin D3 (vitD3) and 17beta-estradiol (17beta-E2) as wel...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/s8756-3282(98)00142-2

    authors: Schirrmacher K,Bingmann D

    更新日期:1998-12-01 00:00:00

  • Bidirectional signaling between stromal and hemopoietic cells regulates interleukin-1 expression during human osteoclast formation.

    abstract::Interleukin-1 (IL-1) has been shown to promote osteoclast (OC) differentiation, in addition to acting as a survival factor for mature osteoclasts. In this study, we investigate the expression of IL-1 during human osteoclast formation, taking advantage of a recently reported in vitro culture system that generates human...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/s8756-3282(99)00176-3

    authors: Haynes DR,Atkins GJ,Loric M,Crotti TN,Geary SM,Findlay DM

    更新日期:1999-09-01 00:00:00

  • Aging of mouse intervertebral disc and association with back pain.

    abstract::With the increased burden of low back pain (LBP) in our globally aging population there is a need to develop preclinical models of LBP that capture clinically relevant features of physiological aging, degeneration, and disability. Here we assess the validity of using a mouse model system for age-related LBP by charact...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/j.bone.2019.03.037

    authors: Vincent K,Mohanty S,Pinelli R,Bonavita R,Pricop P,Albert TJ,Dahia CL

    更新日期:2019-06-01 00:00:00

  • The relationship between porosity and specific surface in human cortical bone is subject specific.

    abstract::A characteristic relationship for bone between bone volume fraction (BV/TV) and specific surface (BS/TV) has previously been proposed based on 2D histological measurements. This relationship has been suggested to be bone intrinsic, i.e., to not depend on bone type, bone site and health state. In these studies, only li...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/j.bone.2014.11.016

    authors: Lerebours C,Thomas CD,Clement JG,Buenzli PR,Pivonka P

    更新日期:2015-03-01 00:00:00

  • Plasma cyclic AMP response to calcitonin: a potential clinical marker of bone turnover.

    abstract::A noninvasive marker of bone turnover would be useful in predicting which patients are at risk of rapid bone loss and in monitoring response to therapy. Calcitonin (CT)-induced hypocalcemia correlates with bone turnover but has not been a clinically useful test because changes in serum calcium are small, and test dura...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/8756-3282(85)90316-3

    authors: Minkoff JR,Grant BF,Marcus R

    更新日期:1985-01-01 00:00:00

  • Quantitative evaluation on osteocyte canalicular density in human secondary osteons.

    abstract::Osteocyte canalicular density (OCD) was evaluated at different levels of the wall of human secondary osteons, in subjects of different ages, to find out whether any correlation exists between the extension of the canalicular network and the exponential decrement of the appositional growth rate (AGR), which has been sh...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/s8756-3282(94)00019-0

    authors: Marotti G,Ferretti M,Remaggi F,Palumbo C

    更新日期:1995-01-01 00:00:00

  • Has reimbursement of bone mineral density testing and anti-osteoporotic treatments improved management of osteoporosis in France?

    abstract:BACKGROUND:Since July 1, 2006 bone mineral density (BMD) testing has been reimbursed for osteoporosis screening under specific clinical conditions in France. Concurrently, drug coverage has been extended to all anti-osteoporotic treatments in women with low BMD. It was thus expected that the utilisation of BMD testing ...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/j.bone.2010.06.026

    authors: Canoui-Poitrine F,Jaglal S,Chapurlat R,Tainturier V,Colin C,Schott AM

    更新日期:2010-10-01 00:00:00

  • Differential effects of homocysteine and beta aminopropionitrile on preosteoblastic MC3T3-E1 cells.

    abstract::Compounds, like beta-aminopropionitrile (bAPN) and homocysteine (hcys), are known to inhibit a stable matrix formation. Osteoblast-synthesized collagen matrix regulates the differentiation of precursor cells into mature osteoblasts. They express lysyl oxidase, an enzyme involved in the collagen cross-linking process. ...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/j.bone.2009.10.038

    authors: Thaler R,Spitzer S,Rumpler M,Fratzl-Zelman N,Klaushofer K,Paschalis EP,Varga F

    更新日期:2010-03-01 00:00:00

  • Three-dimensional confocal images of microdamage in cancellous bone.

    abstract::The accumulation of microdamage in bone may contribute to loss of bone quality in osteoporosis, and the role of microdamage in the etiology of fatigue fractures is unknown. Microdamage created during testing, ex vivo, can increase the fragility of bone by decreasing the load necessary to cause fracture. Microdamage ca...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/s8756-3282(98)00111-2

    authors: Fazzalari NL,Forwood MR,Manthey BA,Smith K,Kolesik P

    更新日期:1998-10-01 00:00:00

  • Drinking water fluoridation: bone mineral density and hip fracture incidence.

    abstract::The role of drinking water fluoride content for prevention of osteoporosis remains controversial. Therefore, we analyzed the influence of drinking water fluoridation on the incidence of osteoporotic hip fractures and bone mineral density (BMD) in two different communities in eastern Germany: in Chemnitz, drinking wate...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/s8756-3282(97)00273-1

    authors: Lehmann R,Wapniarz M,Hofmann B,Pieper B,Haubitz I,Allolio B

    更新日期:1998-03-01 00:00:00

  • Distal forearm fractures in immigrant groups: A national Swedish study.

    abstract:OBJECTIVE:The aim was to analyse risk of forearm fractures in first- and second-generation immigrants to Sweden. METHODS:A nationwide study of individuals 20 years of age and older was conducted. Forearm fractures were defined as at least one registered diagnosis in the National Patient Register between January 1, 199...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/j.bone.2020.115508

    authors: Wändell P,Li X,Carlsson AC,Sundquist J,Sundquist K

    更新日期:2020-09-01 00:00:00

  • Mouse genetic model for bone strength and size phenotypes: NZB/B1NJ and RF/J inbred strains.

    abstract::The relationships of bone size, bone strength, and bone formation were investigated in two strains of mice, NZB/B1NJ and RF/J. Measurement of the femur midshaft size by peripheral quantitative computed tomography (pQCT) showed that the RF/J mice had a 32% greater cross-sectional area than NZB/B1NJ mice at 10 weeks of ...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/s8756-3282(02)00908-0

    authors: Wergedal JE,Sheng MH,Ackert-Bicknell CL,Beamer WG,Baylink DJ

    更新日期:2002-12-01 00:00:00

  • A physical, chemical, and mechanical study of lumbar vertebrae from normal, ovariectomized, and nandrolone decanoate-treated cynomolgus monkeys (Macaca fascicularis).

    abstract::Ovariectomized cynomolgus monkeys have previously been investigated as a nonhuman primate model of postmenopausal osteoporosis (Jerome et al., Bone Miner 9:527-540; 1994). In the present study, Fourier transform infrared microspectroscopy (FTIRM) was used to verify that differences in bone mineral quality and quantity...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/s8756-3282(00)00362-8

    authors: Gadeleta SJ,Boskey AL,Paschalis E,Carlson C,Menschik F,Baldini T,Peterson M,Rimnac CM

    更新日期:2000-10-01 00:00:00

  • Treatment with risedronate or alendronate prevents hind-limb immobilization-induced loss of bone density and strength in adult female rats.

    abstract::Immobilization leads to rapid loss of bone mass and mechanical competence, and long-term immobilization or repeated periods of short-term immobilization can have serious skeletal consequences and may lead to increased fracture liability. The aim of the present preclinical study was, therefore, to assess whether two an...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/s8756-3282(00)00375-6

    authors: Mosekilde L,Thomsen JS,Mackey MS,Phipps RJ

    更新日期:2000-11-01 00:00:00

  • Age at first oral contraceptive use as a major determinant of vertebral bone mass in female endurance athletes.

    abstract::It was the aim of this retrospective analysis to examine the influence of low-dose monophasic oral contraceptives (OCs) on bone mineral density (BMD) of the femoral neck and of the spine in young female endurance athletes. Data on training intensity, dietary intake, menarche, menstrual cycle disorders, years of OC use...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/j.bone.2004.05.017

    authors: Hartard M,Kleinmond C,Kirchbichler A,Jeschke D,Wiseman M,Weissenbacher ER,Felsenberg D,Erben RG

    更新日期:2004-10-01 00:00:00

  • TNFalpha and PTH utilize distinct mechanisms to induce IL-6 and RANKL expression with markedly different kinetics.

    abstract::Parathyroid hormone (PTH) and tumor necrosis factoralpha (TNFalpha) are bone resorptive agents that upregulate interleukin-6 (IL-6) and RANKL production by osteoblasts. IL-6 mRNA expression induced by PTH is rapid and transient in osteoblasts both in vitro and in vivo. This study found that IL-6 secretion induced by P...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/j.bone.2005.10.007

    authors: Dai JC,He P,Chen X,Greenfield EM

    更新日期:2006-04-01 00:00:00

  • Influence of vitamin D status on hyaluronan localization in bone.

    abstract::The distribution of hyaluronan was investigated in the proximal tibiotarsal bones of normal (vitamin D-treated) chicks, and chicks with rachitic lesions induced by vitamin D deficiency. Localization studies using a biotinylated hyaluronan-binding probe revealed that in vitamin D-treated chicks, a high level of hyaluro...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/8756-3282(96)00046-4

    authors: Genever PG,Dickson IR

    更新日期:1996-05-01 00:00:00

  • Extracellular nucleotides activate Runx2 in the osteoblast-like HOBIT cell line: a possible molecular link between mechanical stress and osteoblasts' response.

    abstract::Dynamic mechanical loading increases bone density and strength and promotes osteoblast proliferation, differentiation and matrix production, by acting at the gene expression level. Molecular mechanisms through which mechanical forces are conversed into biochemical signalling in bone are still poorly understood. A grow...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/j.bone.2004.10.016

    authors: Costessi A,Pines A,D'Andrea P,Romanello M,Damante G,Cesaratto L,Quadrifoglio F,Moro L,Tell G

    更新日期:2005-03-01 00:00:00

  • Objectively measured physical activity is associated with parameters of bone in 70-year-old men and women.

    abstract::As the world's population ages, the occurrence of osteoporosis-related fractures is projected to increase. Low areal bone mineral density (aBMD), a well-known risk factor for fractures, may be influenced by physical activity (PA). In this cross-sectional study, we aimed to investigate potential associations between ob...

    journal_title:Bone

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.bone.2015.07.001

    authors: Johansson J,Nordström A,Nordström P

    更新日期:2015-12-01 00:00:00

  • Estrogen and calcium supplement use among Japanese-American women: effects upon bone loss when used singly and in combination.

    abstract::We examined the effects of estrogen and calcium supplementation upon bone loss among a cohort of Japanese-American women. The women averaged 64 years of age (age range 45-81) and 14 years postmenopause at their initial examination in 1981. They returned at 1-3-year intervals for subsequent examinations, most recently ...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/s8756-3282(95)00249-9

    authors: Davis JW,Ross PD,Johnson NE,Wasnich RD

    更新日期:1995-10-01 00:00:00

  • Differential turnover of cortical and trabecular bone in transgenic mice overexpressing cathepsin K.

    abstract::Cathepsin K is a major osteoclastic protease. We have recently shown that overexpression of mouse cathepsin K gene in transgenic UTU17 mouse model results in high turnover osteopenia of metaphyseal trabecular bone at the age of 7 months. The present report extends these studies to a systematic analysis of cortical bon...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/j.bone.2005.02.006

    authors: Morko J,Kiviranta R,Hurme S,Rantakokko J,Vuorio E

    更新日期:2005-05-01 00:00:00

  • Expression of fibrillins and other microfibril-associated proteins in human bone and osteoblast-like cells.

    abstract::Fibrillin-containing microfibrils are structural components of extracellular matrices of a diverse range of tissues, including bone. Their importance in bone biology is illustrated by the skeletal abnormalities manifest in the congenital disorder, Marfan syndrome, which results from mutations in the fibrillin-1 gene. ...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/s8756-3282(00)00292-1

    authors: Kitahama S,Gibson MA,Hatzinikolas G,Hay S,Kuliwaba JL,Evdokiou A,Atkins GJ,Findlay DM

    更新日期:2000-07-01 00:00:00

  • Evidence for secular change in Paget's disease.

    abstract::Death certification data has shown that death rates due to Paget's disease of bone and osteosarcoma in older people (assumed to be attributable to Paget's) declined in the latter part of the 19th and in the early 20th century, suggesting that there may be a secular trend toward less severe disease. We have reviewed a ...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/s8756-3282(96)00310-9

    authors: Cundy T,McAnulty K,Wattie D,Gamble G,Rutland M,Ibbertson HK

    更新日期:1997-01-01 00:00:00

  • MSTN is a key mediator for low-intensity pulsed ultrasound preventing bone loss in hindlimb-suspended rats.

    abstract::Low-intensity pulsed ultrasound (LIPUS) has been used to accelerate bone fracture healing. However, the issue whether LIPUS is effective in preventing osteoporosis has not been clarified, and if so, what possible mechanisms might be responsible. Myostatin (MSTN) is a negative regulator of muscle growth, and its absenc...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/j.bone.2020.115610

    authors: Tang L,An S,Zhang Z,Fan X,Guo J,Sun L,Ta D

    更新日期:2021-02-01 00:00:00

  • Leptin regulates chondrocyte differentiation and matrix maturation during endochondral ossification.

    abstract::Leptin has been suggested to mediate a variety of actions, including bone development, via its ubiquitously expressed receptor (Ob-Rb). In this study, we investigated the role of leptin in endochondral ossification at the growth plate. The growth plates of wild-type and ob/ob mice were analyzed. Effects of leptin on c...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/j.bone.2005.05.009

    authors: Kishida Y,Hirao M,Tamai N,Nampei A,Fujimoto T,Nakase T,Shimizu N,Yoshikawa H,Myoui A

    更新日期:2005-11-01 00:00:00

  • Prostaglandin E2 receptor (EP4) selective agonist (ONO-4819.CD) accelerates bone repair of femoral cortex after drill-hole injury associated with local upregulation of bone turnover in mature rats.

    abstract::Prostaglandin E(2) (PGE(2)) is essential for fracture healing. Systemic administration of EP4 ligands such as PGE(2) and other synthetic EP4 agonists appears to transduce anabolic signals by binding to receptor EP4. Therefore, the present study was designed to test whether administration of EP4 agonist accelerates the...

    journal_title:Bone

    pub_type: 杂志文章

    doi:10.1016/j.bone.2004.01.002

    authors: Tanaka M,Sakai A,Uchida S,Tanaka S,Nagashima M,Katayama T,Yamaguchi K,Nakamura T

    更新日期:2004-06-01 00:00:00