Abstract:
:Compelling evidences suggest that increased production of osteoclastogenic cytokines by activated T cells plays a relevant role in the bone loss induced by estrogen deficiency in the mouse. However, little information is available on the role of T cells in post-menopausal bone loss in humans. To investigate this issue we have assessed the production of cytokines involved in osteoclastogenesis (RANKL, TNFalpha and OPG), in vitro osteoclast (OC) formation in pre and post-menopausal women, the latter with or without osteoporosis. We evaluated also OC precursors in peripheral blood and the ability of peripheral blood mononuclear cells to produce TNFalpha in both basal and stimulated condition by flow cytometry in these subjects. Our data demonstrate that estrogen deficiency enhances the production of the pro-osteoclastogenetic cytokines TNFalpha and RANKL and increases the number of circulating OC precursors. Furthermore, we show that T cells and monocytes from women with osteoporosis exhibit a higher production of TNFalpha than those from the other two groups. Our findings suggest that estrogen deficiency stimulates OC formation both by increasing the production of TNFalpha and RANKL and increasing the number of OC precursors. Women with post-menopausal osteoporosis have a higher T cell activity than healthy post-menopausal subjects; T cells thus contribute to the bone loss induced by estrogen deficiency in humans as they do in the mouse.
journal_name
Bonejournal_title
Boneauthors
D'Amelio P,Grimaldi A,Di Bella S,Brianza SZM,Cristofaro MA,Tamone C,Giribaldi G,Ulliers D,Pescarmona GP,Isaia Gdoi
10.1016/j.bone.2008.02.017subject
Has Abstractpub_date
2008-07-01 00:00:00pages
92-100issue
1eissn
8756-3282issn
1873-2763pii
S8756-3282(08)00102-6journal_volume
43pub_type
杂志文章相关文献
BONE文献大全abstract:OBJECTIVE:Selenium deficiency is a risk factor for Kashin-Beck Disease (KBD), an endemic osteoarthropathy. Although promoter hypermethylation of glutathione peroxidase 3 (GPX3) (a selenoprotein) has been identified in several cancers, little is known about promoter methylation and expression of GPX3 and their relation ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2018.08.017
更新日期:2018-12-01 00:00:00
abstract::Cementum, a mineralized tissue lining the surface of the tooth root, is required for formation of a functional periodontal ligament attachment during development. Additionally, during regeneration of tissues after disease, cementum is thought to play a critical role in the reparative process. Research efforts aimed to...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(99)00096-4
更新日期:1999-07-01 00:00:00
abstract::Bone geometry plays a prominent role in bone strength. Cross-sectional studies have shown that advancing age is associated with increasing diameter of long bones, related to both periostal apposition and endosteal resorption. However, there are few data provided by prospective studies, especially concerning the change...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2010.03.020
更新日期:2010-08-01 00:00:00
abstract::Eldecalcitol (ELD), an active form of vitamin D analog approved for the treatment of osteoporosis in Japan, increases lumbar spine bone mineral density (BMD), suppresses bone turnover markers, and reduces fracture risk in patients with osteoporosis. We have previously reported that treatment with ELD for 6 months impr...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2014.11.025
更新日期:2015-04-01 00:00:00
abstract::Osteoporotic bone fragility is due not only to decreased bone mass but to inadequate repair of fatigue damage and to trabecular disconnection. The precise roles and relative contributions of these three factors are not known for osteoporosis in general, and certainly not in any individual case. However, it is known th...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(92)90192-y
更新日期:1992-01-01 00:00:00
abstract:PURPOSE:To assess the ability of the Spanish version of the WHO fracture risk assessment tool (FRAX®) to predict the observed incident fractures in the ECOSAP Study cohort. METHODS:5201 women, aged 65 or older, were enrolled in a three-year, prospective study by a non-randomized sampling of consecutive cases in 58 pri...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2011.11.006
更新日期:2012-01-01 00:00:00
abstract::Although a critical role of COX-2 in bone repair has been established, the mechanism involved remains unclear. During early inflammatory phase of bone healing, COX-2 is produced by the surrounding inflammatory cells as well as bone/cartilage progenitors. Based on the temporal and spatial expression of COX-2 during the...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2008.08.109
更新日期:2008-12-01 00:00:00
abstract::The hypocalcemic and hypophosphatemic effect of salmon calcitonin (sCT) given by intranasal (i.n.) spray to 12 patients with histological confirmed primary hyperparathyroidism (1 degree HPT) was studied. The concentration of ionized calcium in whole blood (B-Ca++), serum phosphate (S-P), magnesium (S-Mg), plasma sCT (...
journal_title:Bone
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/8756-3282(91)90016-c
更新日期:1991-01-01 00:00:00
abstract::Saracatinib (AZD0530) is an orally active once-daily Src kinase inhibitor which modulates key signaling pathways in cancer cells. In a Phase I study in patients with advanced solid malignancies resistant to standard treatment we assessed the effect of saracatinib on bone turnover. Fifty-one patients were randomized in...
journal_title:Bone
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.bone.2011.12.017
更新日期:2012-04-01 00:00:00
abstract::Juvenile Paget's disease (JPD) is a rare condition with an autosomal recessive mode of inheritance. Typically presenting in infancy or early childhood, the disorder is characterized by a generalized widening of the long bones and thickening of the skull combined with sustained elevation of serum alkaline phosphatase l...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2004.12.004
更新日期:2005-03-01 00:00:00
abstract::Osteopontin (OPN) gene expression and alkaline phosphatase activity were evaluated in the epiphyseal growth plates of normal chickens and in diet-induced tibial dyschdroplasia (TD)-afflicted chickens. In the normal growth plate, OPN gene was expressed by a) cells of the subperichondrial zone surrounding the articular ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(94)00048-5
更新日期:1995-04-01 00:00:00
abstract::Nitric oxide (NO), produced by endothelial cells, is a signaling molecule synthesized from l-arginine by nitric oxide synthases (NOS). NO is known to reduce the ratio of receptor activator of nuclear factor KappaB (RANKL)/osteoprotegerin (OPG), leading to decreased osteoclastogenesis and a reduction in bone resorption...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2007.09.051
更新日期:2008-01-01 00:00:00
abstract::In 1994, the World Health Organization published diagnostic criteria for osteoporosis. Since then, many new technologies have been developed for the measurement of bone mineral at multiple skeletal sites. The information provided by each assessment will describe the clinical characteristics, fracture risk and epidemio...
journal_title:Bone
pub_type: 杂志文章,评审
doi:10.1016/j.bone.2007.11.001
更新日期:2008-03-01 00:00:00
abstract:PURPOSE:Bone acquisition in childhood impacts adult bone mass, and can be influenced by childhood socioeconomic conditions. Socioeconomic status is also associated with body weight which affects the load that bone is exposed to in a fall. We hypothesized that socioeconomic advantage in childhood is associated with grea...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2013.06.021
更新日期:2013-10-01 00:00:00
abstract:CONTEXT:Selective serotonin reuptake inhibitors (SSRIs) are commonly prescribed medications to treat depression and anxiety. SSRIs exert their effects by inhibiting the serotonin transporter and modulating extracellular serotonin levels, a neurotransmitter that has been shown to affect bone metabolism in animals. Studi...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2015.04.042
更新日期:2015-09-01 00:00:00
abstract::Bone metastases and skeletal complications are major causes of morbidity in prostate cancer patients. Despite the osteoblastic appearance of bone metastases on imaging studies, patients have elevated serum and urinary markers of bone resorption, indicative of high osteoclast activity. Increased osteoclast activity is ...
journal_title:Bone
pub_type: 杂志文章,评审
doi:10.1016/j.bone.2010.05.038
更新日期:2011-01-01 00:00:00
abstract::About 1 in 10 postmenopausal UK women are currently prescribed oral bisphosphonates, but there are concerns about their adverse effects. Osteonecrosis of the jaw is a recognised uncommon but important side effect of intravenous bisphosphonates, but epidemiological evidence on risk of osteonecrosis of the jaw associate...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2019.04.003
更新日期:2019-07-01 00:00:00
abstract:UNLABELLED:We evaluated the effect of glucocorticoids (GC) and growth hormone (GH) on cortical and cancellous bone turnover in adult rats using random vertical sections giving valid measurements of bone surfaces and bone formation parameters. GH administration could reverse GC-induced osteopenia and low bone turnover o...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2004.07.015
更新日期:2005-01-01 00:00:00
abstract::Androgen receptor (AR) is expressed throughout the osteoblast lineage. Two different AR transgenic families (AR2.3-tg and AR3.6-tg mice) demonstrating overlapping and distinct expression profiles were employed to assess the effects of enhanced androgen sensitivity to ameliorate hypogonadal loss. Two different paradigm...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2012.08.111
更新日期:2012-11-01 00:00:00
abstract::Levels of HtrA1 protein in cartilage have been reported to elevate in joints of human osteoarthritis patients. To understand roles of HtrA1 in normal osteogenesis as well as in pathogenesis of arthritis, we examine HtrA1 expression pattern during bone and cartilage development and in articular cartilage affected by ex...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2005.03.015
更新日期:2005-09-01 00:00:00
abstract::Investigators and clinicians use bone histomorphometry data from iliac bone biopsies to study bone abnormalities in diseased patients, and to understand the safety and effectiveness of pharmaceutical interventions. This requires access to a high quality normal data-set to be used for comparisons, a resource that has n...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2018.03.019
更新日期:2018-06-01 00:00:00
abstract::Alagille syndrome (ALGS) is an autosomal dominant disorder attributed to mutations in the Notch signaling pathway. Children with ALGS are at increased risk for fragility fracture of unknown etiology. Our objective was to characterize bone mass, geometry, and microarchitecture in children with ALGS. This was a cross-se...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2020.115576
更新日期:2020-12-01 00:00:00
abstract::Localized proton spectra of the human lumbar vertebral body were recorded in vivo at 1.5 T, using the STEAM (stimulated echo acquisition mode) pulse sequence. Thirty-seven patients (18 men, 19 women) were examined, ranging in age from 21 to 68 years (mean = 40, SD = 13). The fat fraction of the bone marrow was calcula...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(93)90239-7
更新日期:1993-03-01 00:00:00
abstract::In recent years, great interest in combined treatment of parathyroid hormone (PTH) with anti-resorptive therapy has emerged. PTH has been suggested to aid bridging of atrophic fractures and improve strength in closed fracture models. Bisphosphonate treatments typically result in a larger woven bone callus that is slow...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2016.08.012
更新日期:2016-11-01 00:00:00
abstract::Cortical bone, the dominant component of the human skeleton by volume, plays a key role in protecting bones from fracture. We analyzed the cortical bone effects of teriparatide treatment in postmenopausal women with osteoporosis who had previously received long-term alendronate (ALN) therapy or were treatment naïve (T...
journal_title:Bone
pub_type: 临床试验,杂志文章
doi:10.1016/j.bone.2013.11.011
更新日期:2014-02-01 00:00:00
abstract::Calcification of end plate chondrocytes is a major cause of intervertebral disc (IVD) degeneration. However, the underlying molecular mechanism of end plate chondrocyte calcification is still unclear. The aim of this study was to clarify whether autophagy in end plate chondrocytes could protect the calcification of en...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2014.06.018
更新日期:2014-09-01 00:00:00
abstract::Hypertension and osteoporosis are two major chronic diseases affecting the elderly. A cross-sectional study of 3887 Chinese men (n = 1958) and women (n = 1929) was used to explore the association between angiotensin converting enzyme inhibitor (ACEI) use and bone mineral density (BMD). The participants were aged 65 ye...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2005.09.011
更新日期:2006-04-01 00:00:00
abstract::Skeletal disorders in rapidly growing poultry are commonplace. This study was performed to investigate the effect of ornithine alpha-ketoglutarate (OKG) administration during the last 7 weeks of life on structural properties, mineralization, and mechanical endurance of skeleton in turkeys at slaughter. Healthy HB Medi...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2005.12.016
更新日期:2006-07-01 00:00:00
abstract::In order to investigate the ultrastructure of bone resorptive cells in the two types of adult benign human osteopetrosis, iliac crest biopsies were obtained from 11 patients and 10 normal males, who served as a control group. Six patients had the radiological type I (4 women, 2 men, aged 23-58 years, mean = 36.5 years...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(93)90316-3
更新日期:1993-11-01 00:00:00
abstract::We have recently cloned cathepsin K from a human bone cDNA library. Since cathepsins are proposed to be involved in the degradation of mineralized bone matrix, we have investigated, by in situ hybridization and immunocytochemistry, the expression of the cathepsin K mRNA transcripts and protein in sections of bone and ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(96)00351-1
更新日期:1997-02-01 00:00:00