Localization of cathepsin K in human osteoclasts by in situ hybridization and immunohistochemistry.

abstract：:In 1994, the World Health Organization published diagnostic criteria for osteoporosis. Since then, many new technologies have been developed for the measurement of bone mineral at multiple skeletal sites. The information provided by each assessment will describe the clinical characteristics, fracture risk and epidemio...

journal_title：Bone

authors： Kanis JA,McCloskey EV,Johansson H,Oden A,Melton LJ 3rd,Khaltaev N

更新日期：2008-03-01 00:00:00

abstract：:Impact microindentation (IMI) is a Reference Point Indentation technique measuring tissue-level properties of cortical bone in humans in vivo. The nature, however, of the properties that can affect bone strength is incompletely understood. In the present study we examined bone material properties in transiliac bone bi...

journal_title：Bone

authors： Rokidi S,Bravenboer N,Gamsjaeger S,Misof B,Blouin S,Chavassieux P,Klaushofer K,Paschalis E,Papapoulos S,Appelman-Dijkstra N

更新日期：2020-02-01 00:00:00

abstract：:The prevalence of osteoarthritis (OA) is greater in women then men. Weight, a factor strongly associated with osteoarthritis, is significantly increased over the menopausal transition. Despite the high prevalence of osteoarthritis, a disabling disease with limited treatment options, there is a paucity of studies in wo...

journal_title：Bone

authors： Szoeke CEI,Cicuttini FM,Guthrie JR,Clark MS,Dennerstein L

更新日期：2006-11-01 00:00:00

abstract：:Bone structure is the key to the understanding of fracture risk. The hypothesis tested in this prospective study is that dense mandibular trabeculation predicts low fracture risk, whereas sparse trabeculation is predictive of high fracture risk. Out of 731 women from the Prospective Population Study of Women in Gothen...

journal_title：Bone

authors： Jonasson G,Sundh V,Ahlqwist M,Hakeberg M,Björkelund C,Lissner L

更新日期：2011-10-01 00:00:00

abstract：OBJECTIVES:Osteoarthritis (OA) is a disease of the whole joint characterized by cartilage loss and subchondral bone remodeling. The role of microcracks in cartilage integrity and subchondral bone homeostasis is not fully understood. The main goal of this work was to evaluate microcrack density in both calcified cartila...

journal_title：Bone

authors： Zarka M,Hay E,Ostertag A,Marty C,Chappard C,Oudet F,Engelke K,Laredo JD,Cohen-Solal M

更新日期：2019-06-01 00:00:00

abstract：:Osteoclast differentiation and activation is controlled, at least in part, by the counterbalancing influences of osteoprotegerin ligand (OPGL) and osteoprotegerin (OPG). Nonsteroidal anti-inflammatory drugs have been shown to inhibit bone loss in vivo and bone resorption in vitro, and this is associated with a loss of...

journal_title：Bone

authors： O'Brien EA,Williams JH,Marshall MJ

更新日期：2001-02-01 00:00:00

abstract：:Ectopic calcification of soft tissues can have severe clinical consequences especially when localized to vital organs such as heart, arteries and kidneys. Mammalian stanniocalcin (STC) 1 and 2 are glycoprotein hormones identified as calcium/phosphate-regulating hormones. The mRNA of STCs is upregulated in the kidney o...

journal_title：Bone

authors： Takei Y,Yamamoto H,Sato T,Otani A,Kozai M,Masuda M,Taketani Y,Muto-Sato K,Lanske B,Takeda E

更新日期：2012-04-01 00:00:00

abstract：:Osteoclasts form when hematopoietic cells are stimulated by macrophage colony-stimulating factor (M-CSF) and receptor activator of NF-kappaB ligand (RANKL) or tumor necrosis factor-alpha (TNFalpha). Osteoclast precursors derive from M-CSF-dependent proliferating hematopoietic cells but cannot yet be purified from mixe...

journal_title：Bone

authors： Quinn JM,Whitty GA,Byrne RJ,Gillespie MT,Hamilton JA

更新日期：2002-01-01 00:00:00

abstract：:GM1 gangliosidosis is a lysosomal storage disorder caused by mutations in GLB1 encoding a lysosomal β-galactosidase. This disease is a continuum from the severe infantile form with rapid neurological decline to the chronic adult form, which is not life-limiting. The intermediate or type 2 form can be further classifie...

journal_title：Bone

authors： Ferreira CR,Regier DS,Yoon R,Pan KS,Johnston JM,Yang S,Spranger JW,Tifft CJ

更新日期：2020-02-01 00:00:00

abstract：:A previously developed in vivo X-ray fluorescence (IVXRF) I-125 based system was used to measure bone strontium levels non-invasively in an osteoporotic female volunteer. The volunteer was recruited in December 2008, as part of the Ryerson and McMaster University Strontium in Bone Research Study and measured at twice ...

journal_title：Bone

authors： Moise H,Adachi JD,Chettle DR,Pejović-Milić A

更新日期：2012-07-01 00:00:00

abstract：:Levels of HtrA1 protein in cartilage have been reported to elevate in joints of human osteoarthritis patients. To understand roles of HtrA1 in normal osteogenesis as well as in pathogenesis of arthritis, we examine HtrA1 expression pattern during bone and cartilage development and in articular cartilage affected by ex...

journal_title：Bone

authors： Tsuchiya A,Yano M,Tocharus J,Kojima H,Fukumoto M,Kawaichi M,Oka C

更新日期：2005-09-01 00:00:00

abstract：:Bone structure is an important determinant of osteoporotic fracture. In women, bone structure is highly heritable, and several quantitative trait loci (QTL) have been reported. There are few comparable data in men. This study in men aimed at establishing the heritability of bone structure at the proximal femur, identi...

journal_title：Bone

authors： Peacock M,Koller DL,Lai D,Hui S,Foroud T,Econs MJ

更新日期：2005-10-01 00:00:00

abstract：:Skeletal unloading in an animal hindlimb suspension model and microgravity experienced by astronauts or as a result of prolonged bed rest causes site-specific losses in bone mineral density of 1%-2% per month. This is accompanied by reductions in circulating levels of 1,25-(OH)(2)D(3), the active metabolite of vitamin...

journal_title：Bone

authors： Narayanan R,Smith CL,Weigel NL

更新日期：2002-09-01 00:00:00

abstract：:The gap junction protein, connexin43 (Cx43) controls both bone formation and osteoclastogenesis via osteoblasts and/or osteocytes. Cx43 has also been proposed to mediate an anti-apoptotic effect of bisphosphonates, potent inhibitors of bone resorption. We studied whether bisphosphonates are effective in protecting mic...

journal_title：Bone

authors： Watkins MP,Norris JY,Grimston SK,Zhang X,Phipps RJ,Ebetino FH,Civitelli R

更新日期：2012-10-01 00:00:00

abstract：:Sulfate conjugation is an important pathway in the metabolism of many drugs, xenobiotic compounds, and hormones. Sulfotransferases (SULTs) catalyze these reactions and have been detected and characterized in various human tissues including the liver and small intestine. Substrates for SULTs that include estrogen and t...

journal_title：Bone

authors： Dubin RL,Hall CM,Pileri CL,Kudlacek PE,Li XY,Yee JA,Johnson ML,Anderson RJ

更新日期：2001-06-01 00:00:00

abstract：:Whether glucocorticoids directly enhance or interrupt osteoclastogenesis is still a controversial subject. In this study, we ascertained the dose-dependent positive effects of glucocorticoids on osteoclastogenesis in vivo and in vitro as well as investigated the mechanism in vitro. As the dose of glucocorticoids incre...

journal_title：Bone

authors： Shi J,Wang L,Zhang H,Jie Q,Li X,Shi Q,Huang Q,Gao B,Han Y,Guo K,Liu J,Yang L,Luo Z

更新日期：2015-10-01 00:00:00

abstract：:The accumulation of microdamage in bone may contribute to loss of bone quality in osteoporosis, and the role of microdamage in the etiology of fatigue fractures is unknown. Microdamage created during testing, ex vivo, can increase the fragility of bone by decreasing the load necessary to cause fracture. Microdamage ca...

journal_title：Bone

authors： Fazzalari NL,Forwood MR,Manthey BA,Smith K,Kolesik P

更新日期：1998-10-01 00:00:00

abstract：:Alendronate has been shown to reduce bone turnover and increase bone mass. However, little is known about the duration of the effect on bone after treatment withdrawal. The aim of this study was to investigate the long-term effects on bone mineral density (BMD) and bone turnover of various alendronate regimens after t...

journal_title：Bone

authors： Bagger YZ,Tankó LB,Alexandersen P,Ravn P,Christiansen C

更新日期：2003-09-01 00:00:00

abstract：:Changes in skeletal remodeling (biochemical bone markers) and regional bone mineral density (spine, hip, and forearm bone mineral density [BMD]) were observed for 3 years in 20 patients (15 women and 5 men; age 54 +/- 11 years, range 29-69 years) after successful surgery for primary hyperparathyroidism (PHPT). Fifteen...

journal_title：Bone

authors： Christiansen P,Steiniche T,Brixen K,Hessov I,Melsen F,Heickendorff L,Mosekilde L

更新日期：1999-11-01 00:00:00

abstract：:Type 1 diabetes mellitus (T1DM) has been associated with deterioration of bone microarchitecture and strength, resulting in increased fracture risk. Substantial studies have revealed the capacity of moderate-intensity static magnetic fields (SMF) on promoting osteoblastogenesis in vitro and stimulating bone growth and...

journal_title：Bone

authors： Zhang H,Gan L,Zhu X,Wang J,Han L,Cheng P,Jing D,Zhang X,Shan Q

更新日期：2018-02-01 00:00:00

abstract：:Recent studies have indicated a critical role for vascular endothelial growth factor (VEGF) during the process of endochondral ossification, in particular in coupling cartilage resorption with bone formation. Therefore, we studied the chemoattractive and proliferative properties of human VEGF-A on primary human osteob...

journal_title：Bone

authors： Mayr-Wohlfart U,Waltenberger J,Hausser H,Kessler S,Günther KP,Dehio C,Puhl W,Brenner RE

更新日期：2002-03-01 00:00:00

abstract：:We previously reported that a type II sodium phosphate (Na(+)-Pi) cotransporter (Npt2) protein is expressed in osteoclasts and that Pi limitation decreases osteoclast-mediated bone resorption in vitro. We also demonstrated that mice homozygous for the disrupted Npt2 gene (Npt2-/-) exhibit a unique age-dependent bone p...

journal_title：Bone

authors： Gupta A,Tenenhouse HS,Hoag HM,Wang D,Khadeer MA,Namba N,Feng X,Hruska KA

更新日期：2001-11-01 00:00:00

abstract：:Although osteoporosis is usually associated with women, 1 in 12 men in the UK have the disease, and a third of these cases are idiopathic. Estrogen is now known to be associated with bone loss in older men, but we found, previously, that levels of this hormone were normal in younger cases of male idiopathic osteoporos...

journal_title：Bone

authors： Braidman I,Baris C,Wood L,Selby P,Adams J,Freemont A,Hoyland J

更新日期：2000-05-01 00:00:00

abstract：:Although extensive studies have done much to clarify the molecular mechanisms of osteoclastogenesis during the last ten years, there may still be unknown molecules associated with osteoclast differentiation. Thus, we used fluorescent differential display to screen for genes whose expression is induced by receptor acti...

journal_title：Bone

authors： Hada N,Okayasu M,Ito J,Nakayachi M,Hayashida C,Kaneda T,Uchida N,Muramatsu T,Koike C,Masuhara M,Sato T,Hakeda Y

更新日期：2012-01-01 00:00:00

abstract：:In recent years, great interest in combined treatment of parathyroid hormone (PTH) with anti-resorptive therapy has emerged. PTH has been suggested to aid bridging of atrophic fractures and improve strength in closed fracture models. Bisphosphonate treatments typically result in a larger woven bone callus that is slow...

journal_title：Bone

authors： Casanova M,Herelle J,Thomas M,Softley R,Schindeler A,Little D,Schneider P,Müller R

更新日期：2016-11-01 00:00:00

abstract：:The magnetic resonance-guided focused ultrasound (MRgFUS) system uses MR imaging for real-time aiming of thermal ablation of bone and soft tissue tumors. Past clinical studies showed no increase in fracture rate after MRgFUS treatment. The purpose of this study was to determine the effect of MRgFUS treatment on mechan...

journal_title：Bone

authors： Herman A,Avivi E,Brosh T,Schwartz I,Liberman B

更新日期：2013-11-01 00:00:00

abstract：:Ultrashort echo time magnetic resonance imaging (UTE-MRI) techniques have been increasingly used to assess cortical bone microstructure. High resolution micro computed tomography (μCT) is routinely employed for validating the MRI-based assessments. However, water protons in cortical bone may reside in micropores small...

journal_title：Bone

authors： Jerban S,Ma Y,Wong JH,Nazaran A,Searleman A,Wan L,Williams J,Du J,Chang EY

更新日期：2019-06-01 00:00:00

abstract：:It is well known that physical inactivity leads to loss of muscle mass, but it also causes bone loss. Mechanistically, osteoclastogenesis and bone resorption have recently been shown to be regulated by vibration. However, the underlying mechanism behind the inhibition of osteoclast formation is yet unknown. Therefore,...

journal_title：Bone

authors： Kulkarni RN,Voglewede PA,Liu D

更新日期：2013-12-01 00:00:00

abstract：:The total remodeling sequences in 19 primary hyperparathyroid patients and 16 approximately age-matched and sex-matched controls were reconstructed from histomorphometric analyses of bone specimens obtained after intravital tetracycline double labeling. In the primary hyperparathyroid group the total amount of work pe...

journal_title：Bone

authors： Eriksen EF,Mosekilde L,Melsen F

更新日期：1986-01-01 00:00:00

abstract：OBJECTIVE:Rheumatoid arthritis (RA) is accompanied by potential risk of bone mineral loss. In this study, we developed a screening index for the osteoporosis related level of bone mineral density loss for RA patients as a substitute to the dual-energy X-ray absorptiometry (DXA) method. METHODS:X-ray pictures of both s...

journal_title：Bone

authors： Yoshii I,Akita K

更新日期：2020-08-01 00:00:00