Abstract:
:In 1994, the World Health Organization published diagnostic criteria for osteoporosis. Since then, many new technologies have been developed for the measurement of bone mineral at multiple skeletal sites. The information provided by each assessment will describe the clinical characteristics, fracture risk and epidemiology of osteoporosis differently. Against this background, there is a need for a reference standard for describing osteoporosis. In the absence of a true gold standard, this paper proposes that the reference standard should be based on bone mineral density (BMD) measurement made at the femoral neck with dual-energy X-ray absorptiometry (DXA). This site has been the most extensively validated, and provides a gradient of fracture risk as high as or higher than that of many other techniques. The recommended reference range is the NHANES III reference database for femoral neck measurements in women aged 20-29 years. A similar cut-off value for femoral neck BMD that is used to define osteoporosis in women can be used for the diagnosis of osteoporosis in men - namely, a value for BMD 2.5 SD or more below the average for young adult women. The adoption of DXA as a reference standard provides a platform on which the performance characteristics of less well established and new methodologies can be compared.
journal_name
Bonejournal_title
Boneauthors
Kanis JA,McCloskey EV,Johansson H,Oden A,Melton LJ 3rd,Khaltaev Ndoi
10.1016/j.bone.2007.11.001subject
Has Abstractpub_date
2008-03-01 00:00:00pages
467-75issue
3eissn
8756-3282issn
1873-2763pii
S8756-3282(07)00823-Xjournal_volume
42pub_type
杂志文章,评审相关文献
BONE文献大全abstract:INTRODUCTION:Trace elements are known to influence bone metabolism; however, their effects may be exacerbated in renal failure because dialysis patients are unable to excrete excess elements properly. Our study correlated bone quality in dialysis patients with levels of bone fluoride, magnesium, and aluminum. A number ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2003.08.006
更新日期:2004-01-01 00:00:00
abstract::Mandibuloacral dysplasia (MAD) is a rare recessively inherited premature aging disease characterized by skeletal and metabolic anomalies. It is part of the spectrum of diseases called laminopathies and results from mutations in genes regulating the synthesis of the nuclear laminar protein, lamin A. Homozygous or compo...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2010.06.004
更新日期:2010-09-01 00:00:00
abstract::Connective tissue growth factor (CTGF) has been identified as a secretory protein encoded by an immediate early gene and is a member of the CCN family. In vitro CTGF directly regulates the proliferation and differentiation of chondrocytes; however, a previous study showed that it was localized only in the hypertrophic...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2003.07.010
更新日期:2003-12-01 00:00:00
abstract::The rat model has previously been used to test the effect of ovariectomy and of PTH administration on vertebral bone mass, size, and biomechanical competence. In this study, we used the same "biomechanical rat model" to assess the effect of long-term exercise on vertebral bone mass and quality and also on femoral bone...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(94)90291-7
更新日期:1994-05-01 00:00:00
abstract::Both mechanical loading and nitric oxide (NO) have positive influences on bone mass. NO production is induced by mechanical strain via upregulation of eNOS mRNA and protein, the predominant NOS in adult bone. At the same time, strain causes decreased expression of RANKL, a factor critical for osteoclastogenesis. In th...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2008.03.006
更新日期:2008-07-01 00:00:00
abstract:INTRODUCTION:Spinal mobilization is commonly used in the treatment of patients with back pain, including individuals with osteoporosis. Previous data indicated that traditional predictors of skeletal failure-lateral or anteroposterior bone mineral density (BMD) by dual energy X-ray absorptiometry (DXA) or geometry of t...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2006.10.003
更新日期:2007-03-01 00:00:00
abstract::High fat diets can have detrimental effects on the skeleton as well as cause intestinal dysbiosis. Exercise prevents high fat (HF) diet-induced obesity and also improves bone density and prevents the intestinal dysbiosis that promotes energy storage. Previous studies indicate a link between intestinal microbial balanc...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2018.03.024
更新日期:2019-01-01 00:00:00
abstract::Suppression of bone remodeling by bisphosphonates leads to accumulation of microdamage in bone. If this microdamage develops due to suppressed repair of remodeling only, more potent bisphosphonates should cause more damage. In this study, we evaluated the effects of reduced bone turnover produced by a potent bisphosph...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2013.01.016
更新日期:2013-05-01 00:00:00
abstract::Osteoclasts are specialized secretory cells of the myeloid lineage important for normal skeletal homeostasis as well as pathologic conditions of bone including osteoporosis, inflammatory arthritis and cancer metastasis. Differentiation of these multinucleated giant cells from precursors is controlled by the cytokine R...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2012.08.113
更新日期:2012-11-01 00:00:00
abstract::The combination of PTH with OPG has been proposed as a potential therapy in patients with severe osteoporosis. In the present study, we examined the bone material of aged ovariectomized (OVX) rats treated either with PTH (1-34) or OPG alone or in combination of both. The micro- and nanostructural characteristics of th...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2005.03.013
更新日期:2005-07-01 00:00:00
abstract::1,25-Dihydroxyvitamin D [1,25(OH)(2)D] insufficiency appears to be associated with several age-related diseases. Insufficient levels of serum 25-hydroxyvitamin D has been shown to lead to the progression of osteoarthritis (OA) while underlying biological mechanisms remain largely unknown. In this study, we sought to d...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2013.04.015
更新日期:2013-08-01 00:00:00
abstract::Recently, there have been remarkable advances in medical techniques for regenerating bone defects. To determine the degree of bone regeneration, it is essential to develop a new method that can analyze microstructure and related mechanical function. Here, quantitative analysis of the orientation distribution of biolog...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2012.07.003
更新日期:2012-10-01 00:00:00
abstract::The lamellar bone's strength is mainly affected by the organization of its mineralized collagen fibers and material composition. In the present study, Raman microspectroscopic and imaging analyses were employed to study a normal human femoral midshaft bone cube-like specimen with a spatial resolution of approximately ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2007.04.200
更新日期:2007-09-01 00:00:00
abstract::Mouse serum alkaline phosphatase (ALP) is frequently measured and interpreted in mammalian bone research. However, little is known about the circulating ALPs in mice and their relation to human ALP isozymes and isoforms. Mouse ALP was extracted from liver, kidney, intestine, and bone from vertebra, femur and calvaria ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2012.12.048
更新日期:2013-04-01 00:00:00
abstract::Ginsenoside Rh2 is one of the most active components of red ginseng, controlling cancer and other metabolic diseases including osteoclast differentiation. However, the molecular mechanism underlying the inhibition of osteoclast differentiation by ginsenoside Rh2 remains poorly understood. In the present study, it was ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2012.03.022
更新日期:2012-06-01 00:00:00
abstract::Parathyroid hormone (PTH) and tumor necrosis factoralpha (TNFalpha) are bone resorptive agents that upregulate interleukin-6 (IL-6) and RANKL production by osteoblasts. IL-6 mRNA expression induced by PTH is rapid and transient in osteoblasts both in vitro and in vivo. This study found that IL-6 secretion induced by P...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2005.10.007
更新日期:2006-04-01 00:00:00
abstract::Increases in local and systemic bone resorption are hallmarks of rheumatoid arthritis (RA). Osteoclasts are implicated in these processes and their enhanced differentiation may contribute to bone destruction. We observed that in vitro osteoclastogenesis varies among healthy individuals and hypothesized that increased ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2010.10.167
更新日期:2011-03-01 00:00:00
abstract::Both bone density and quality are important determinants of bone strength. Bone quality is prescribed by matrix characteristic including collagen cross-linking and bone structural characteristics and is important in reinforcement of bone strength. We investigated the effects of alfacalcidol (ALF), a prodrug of calcitr...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2009.12.008
更新日期:2010-04-01 00:00:00
abstract::Recent proton magnetic resonance (MR) spectroscopy studies have shown that cortical bone exists as different components which have distinct transverse relaxation times (T2s). However, cortical bone shows zero or near zero signal with all conventional MR sequences on clinical scanners and the different water components...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2011.11.029
更新日期:2012-03-01 00:00:00
abstract::The effects of prostaglandin E2 (PGE2) were histomorphometrically evaluated in cancellous bone of the axial skeleton of ovariectomized, osteopenic rats. Four months following bilateral ovariectomy (OVX) and sham-ovariectomy (SHAM) at 3 months of age, rats received daily subcutaneous injections of PGE2 at 0, 0.3, 1.0, ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(90)90057-6
更新日期:1990-01-01 00:00:00
abstract::Ordinary measurements of the wall thickness (the end result of the osteoblastic work) of trabecular bone packets (completed remodeling sites) describe the average thickness of walls formed during the previous two to three years. If the bone biopsy is obtained shortly after onset of disease or initiation of treatment, ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(92)90004-g
更新日期:1992-01-01 00:00:00
abstract::There are conflicting reports on the influence of lean and fat mass on bone accrual during childhood. No infant's studies have been reported that describe the influence of changes in body composition with changes in bone accrual during the first year of life. The objective of this research was to test the hypothesis t...
journal_title:Bone
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.bone.2011.11.011
更新日期:2012-03-01 00:00:00
abstract::Interleukin-1 (IL-1) has been shown to promote osteoclast (OC) differentiation, in addition to acting as a survival factor for mature osteoclasts. In this study, we investigate the expression of IL-1 during human osteoclast formation, taking advantage of a recently reported in vitro culture system that generates human...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(99)00176-3
更新日期:1999-09-01 00:00:00
abstract::The role of drinking water fluoride content for prevention of osteoporosis remains controversial. Therefore, we analyzed the influence of drinking water fluoridation on the incidence of osteoporotic hip fractures and bone mineral density (BMD) in two different communities in eastern Germany: in Chemnitz, drinking wate...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(97)00273-1
更新日期:1998-03-01 00:00:00
abstract::Proteins of the extracellular matrix often have multiple functions to facilitate complex tasks ranging from signaling to structural support. Here we have focused on the function of one of the matrix proteins expressed in bones and teeth, the matrix adhesion protein ameloblastin (AMBN). Transgenic mice with 5-fold elev...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2013.01.041
更新日期:2013-05-01 00:00:00
abstract:INTRODUCTION:Teriparatide is a bone formation agent that increases bone turnover and mass, resulting in an increase in bone strength and a decrease in fracture risk. METHODS:The primary purpose of this analysis was to evaluate the association between pretreatment bone turnover marker (BTM) concentrations and the absol...
journal_title:Bone
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.bone.2006.02.003
更新日期:2006-08-01 00:00:00
abstract::This study describes the early interface reaction of cancellous bone to a nanocrystalline hydroxyapatite cement containing type I collagen (HA/Coll) and its modifications with sodium citrate (CI), calcium carbonate (CA), phosphoserine (P) and phosphoserine plus RGD-peptide (RGD). Cylindrical implants of HA/Coll and it...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2006.11.019
更新日期:2007-04-01 00:00:00
abstract::Immobilization leads to rapid loss of bone mass and mechanical competence, and long-term immobilization or repeated periods of short-term immobilization can have serious skeletal consequences and may lead to increased fracture liability. The aim of the present preclinical study was, therefore, to assess whether two an...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(00)00375-6
更新日期:2000-11-01 00:00:00
abstract:OBJECTIVES:The present study was motivated by the fact that bone regeneration in the compromised vascular microenvironment of T2DM is challenging and the factors that determine the adverse bone regeneration outcomes are poorly understood. For this purpose the effect of T2DM on osteogenic and angiogenic healing potentia...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2018.04.009
更新日期:2018-07-01 00:00:00
abstract::Fracture healing is influenced by numerous hormones, growth factors, and cytokines. The systemic administration of growth hormone (GH) has shown to accelerate bone regeneration. Local application of growth factors, such as insulin-like growth factor-1 (IGF-1) and transforming growth factor-beta-1 (TGF-beta1), are know...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(02)00798-6
更新日期:2002-07-01 00:00:00