Abstract:
:The total remodeling sequences in 19 primary hyperparathyroid patients and 16 approximately age-matched and sex-matched controls were reconstructed from histomorphometric analyses of bone specimens obtained after intravital tetracycline double labeling. In the primary hyperparathyroid group the total amount of work performed by resorptive cells was reduced, as indicated by the significantly lower three-dimensional mononuclear and preosteoblast-like cell resorption depths (35.8 microns vs 44.5 microns in normals, P less than 0.01 and 45.3 microns vs 56.6 microns in normals, P less than 0.01, respectively). The active resorption period (i.e., the function period for osteoclasts and mononuclear cells) was reduced to 19 days compared to 29 days in normals (P less than 0.05), but no difference with respect to bone resorption rates could be demonstrated between the two groups. The median bone formation period (Sigmaf) in primary hyperparathyroid patients was not different from the value obtained in normals (172 days vs 134 days, respectively), and the matrix appositional rate (Ama), as well as the mineralization lag time (tm), were also unchanged. The initial mineralization rate (Ami(i)) was not significantly different from the value obtained in normals, but averaged over the total bone formation period, a reduced mineralization rate could be demonstrated (0.32 micron3/micron2 per day vs 0.46 micron3/micron2 per day in normals, P less than 0.01). The measured final three-dimensional thickness of bone formed during Sigmaf (mcwTm) was reduced in the primary hyperparathyroid group (51.1 microns vs 55.9 microns in normals, P less than 0.02).(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Bonejournal_title
Boneauthors
Eriksen EF,Mosekilde L,Melsen Fdoi
10.1016/8756-3282(86)90020-7subject
Has Abstractpub_date
1986-01-01 00:00:00pages
213-21issue
3eissn
8756-3282issn
1873-2763pii
8756-3282(86)90020-7journal_volume
7pub_type
杂志文章相关文献
BONE文献大全abstract::Nanoindentation has been widely used to study bone tissue mechanical properties. The common method and equations for analyzing nanoindentation, developed by Oliver and Pharr, are based on the assumption that the material is linearly elastic. In the present study, we adjusted the constraint of linearly elastic behavior...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2008.05.023
更新日期:2008-10-01 00:00:00
abstract::One main problem associated with alveolar bone augmentation in implant dentistry is resorption of grafted bone, which may be further compromised by systemic skeletal disorders such as osteoporosis. Zoledronate acid (ZOL) is the most potent bisphosphonate to treat osteoporosis and therefore it is hypothesized to be abl...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2011.10.011
更新日期:2012-01-01 00:00:00
abstract::Percutaneous vertebroplasty consists of injecting polymethylmethacrylate cement into the cancellous bone of vertebral bodies for the treatment of various lesions of the spine, including osteoporotic compression fractures. Clinicians practicing vertebroplasty commonly alter the mixture of monomer-to-powder recommended ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(99)00129-5
更新日期:1999-08-01 00:00:00
abstract:BACKGROUND:Patients with chronic kidney disease (CKD) are at high risk for fracture. The ability of bone mineral density (BMD) to predict fractures in CKD patients has been inconsistent. Other measures such as trabecular bone score (TBS) and impact microindentation (IMI) may be more useful in this group. This study aim...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2020.115241
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Chronic kidney disease (CKD) is commonly associated with mineral and bone metabolism disorders, but these are less frequently studied in non-dialysis CKD patients than in dialysis patients. We examined and described international variation in mineral and bone disease (MBD) markers and their tr...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2019.115058
更新日期:2019-12-01 00:00:00
abstract::The magnetic resonance-guided focused ultrasound (MRgFUS) system uses MR imaging for real-time aiming of thermal ablation of bone and soft tissue tumors. Past clinical studies showed no increase in fracture rate after MRgFUS treatment. The purpose of this study was to determine the effect of MRgFUS treatment on mechan...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2013.06.032
更新日期:2013-11-01 00:00:00
abstract::Osteonecrosis of the jaw (ONJ) is now defined by the presence of exposed bone in the mouth, which fails to heal after appropriate intervention over a period of six or eight weeks. It is commonly precipitated by a tooth extraction in patients treated with zoledronate, pamidronate or a combination of these agents, for t...
journal_title:Bone
pub_type: 杂志文章,评审
doi:10.1016/j.bone.2008.09.012
更新日期:2009-01-01 00:00:00
abstract::Odontoblasts and osteoblasts are two among the myriads of cell types present in the craniofacial complex. Both have a common ectomesenchymal origin and secrete macromolecules that are necessary for the formation of dentin and alveolar bone via matrix-mediated mechanisms. The mineralized matrices of bone and dentin dif...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2005.05.013
更新日期:2005-10-01 00:00:00
abstract::Skeleton is the most common organ targeted by breast cancer cells, especially from estrogen receptor alpha (ER)-positive neoplasms. Metastatic cells can stimulate directly or indirectly osteoclast-mediated bone resorption. Tumor-induced osteolysis is often extensive and leads to the release of large quantities of calc...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2004.03.021
更新日期:2004-08-01 00:00:00
abstract::Bisphosphonates play an important role in the treatment of metabolic bone diseases such as osteoporosis. In addition to their anti-resorptive activity by triggering osteoclast apoptosis, nitrogen-containing bisphosphonates (N-BP) may also influence osteogenic differentiation, which might rely on their capacity to inhi...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2018.03.020
更新日期:2018-06-01 00:00:00
abstract::Alendronate has been shown to reduce bone turnover and increase bone mass. However, little is known about the duration of the effect on bone after treatment withdrawal. The aim of this study was to investigate the long-term effects on bone mineral density (BMD) and bone turnover of various alendronate regimens after t...
journal_title:Bone
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s8756-3282(03)00112-1
更新日期:2003-09-01 00:00:00
abstract::Bisphosphonates (BPs), bone targeted drugs that disrupt osteoclast function, are routinely used to treat complications of bone metastasis. Studies in preclinical models of cancer have shown that BPs reduce skeletal tumor burden and increase survival. Similarly, we observed in the present study that administration of t...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2009.01.010
更新日期:2009-05-01 00:00:00
abstract:BACKGROUND:This observational safety study used national registers to compare the real world cardiovascular and skeletal safety of zoledronic acid (ZA) against oral bisphosphonates (oBP) and untreated population controls. METHODS:Propensity score matched cohort study in Sweden and Denmark. RESULTS:Matched cohort 1 in...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2020.115296
更新日期:2020-05-01 00:00:00
abstract::The aims of this study were to clarify the role of cell maturation stage on chondrocyte response to parathyroid hormone (PTH) by examining the effect of PTH(1-34) on alkaline-phosphatase-specific activity (ALPase) of chondrocyte cultures at two distinct stages of maturation, and to determine the signaling pathways use...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(97)00123-3
更新日期:1997-09-01 00:00:00
abstract::This paper reviews the mechanisms of action of the bisphosphonates, a new class of recently developed drugs. The geminal bisphosphonates are characterized by a P-C-P bond and are thus analogs of pyrophosphate. They bind strongly to hydroxyapatite crystals and in vitro inhibit both crystal formation and dissolution. In...
journal_title:Bone
pub_type: 历史文章,杂志文章,评审
doi:
更新日期:1987-01-01 00:00:00
abstract::This study is designed to test how intermittent application of prostaglandin E2 (PGE2) and risedronate (Ris) alone or in combination acts on the cancellous bone mass in estrogen-deficient rats. Sprague-Dawley rats were ovariectomized (ovx) or sham-ovx'd at 6 months of age. PGE2 (6mg/kg/d), Ris (5 micrograms/kg/twice a...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(95)00305-w
更新日期:1995-10-01 00:00:00
abstract::Vertebral fracture risk is a heritable complex trait. The aim of this study was to identify genetic susceptibility factors for osteoporotic vertebral fractures applying a genome-wide association study (GWAS) approach. The GWAS discovery was based on the Rotterdam Study, a population-based study of elderly Dutch indivi...
journal_title:Bone
pub_type: 杂志文章
doi:
更新日期:2014-02-01 00:00:00
abstract::Combat-related heterotopic ossification (HO) has emerged as a common and problematic complication of modern wartime extremity injuries, contributing to substantial patient morbidity and loss of function. We have previously reported that HO-forming patients exhibit a more pronounced systemic and local inflammatory resp...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2013.05.016
更新日期:2013-09-01 00:00:00
abstract:INTRODUCTION:While the anti-resorptive effects of the bisphosphonates (BPs) are well documented, many questions remain about their mechanisms of action, particularly following long-term use. This study evaluated the effects of alendronate (Ale) treatment on TGF-β1 signaling in mesenchymal stem cells (MSCs) and osteocyt...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2012.10.017
更新日期:2013-01-01 00:00:00
abstract::Diabetes is associated with a number of lower extremity orthopedic conditions and complications including fractures, Charcot neuroarthropathy, plantar ulcers, and infection. These complications are of significant clinical concern in terms of morbidity, mortality, and socioeconomic costs. A review of each condition is ...
journal_title:Bone
pub_type: 杂志文章,评审
doi:10.1016/j.bone.2015.07.029
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:While the importance of cortical structure quantification is increasingly underscored by recent literature, conventional analysis techniques obscure potentially important regional variations in cortical structure. The objective of this study was to characterize the spatial variability in cortical geometry and...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2012.10.031
更新日期:2013-02-01 00:00:00
abstract::Eldecalcitol (ELD), an active form of vitamin D analog approved for the treatment of osteoporosis in Japan, increases lumbar spine bone mineral density (BMD), suppresses bone turnover markers, and reduces fracture risk in patients with osteoporosis. We have previously reported that treatment with ELD for 6 months impr...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2014.11.025
更新日期:2015-04-01 00:00:00
abstract::The effects of glucocorticoid (GC) excess, thyrotoxicosis, and hypothyroidism on linear growth indicate that growth plate chondrocytes are exquisitely sensitive to GC and thyroid hormone (T(3)). Murine ATDC5 cells undergo chondrogenesis in vitro and were used to evaluate the effects of dexamethasone (Dex) and T(3) on ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(02)00855-4
更新日期:2002-10-01 00:00:00
abstract::GNAS exons 1-13 encode the biallelically expressed alpha-subunit of the stimulatory G protein (Gαs). Additional transcripts derived from this locus use alternative first exons that undergo parent-specific methylation, thus allowing transcription only from the non-modified allele. Pseudohypoparathyroidism type Ia (PHP1...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2017.07.013
更新日期:2017-10-01 00:00:00
abstract:OBJECTIVE:To compare the effects of TNF-α and IL-17A on osteogenic differentiation of isolated fibroblast-like synoviocytes (FLS) from healthy donors, osteoarthritis (OA) and rheumatoid arthritis (RA) patients. METHODS:FLS were cultured in osteogenic medium, with and without TNF-α and/or IL-17A. Extracellular matrix m...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2016.04.008
更新日期:2016-06-01 00:00:00
abstract::On the basis of previous investigations indicating that the distribution of osteonic and interstitial lamellae in a normal femur depends on its mechanical properties, a procedure has been devised to provide information on the distribution of lamellae in human femora diaphyses deformed by bending. To achieve this, exac...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(87)90009-3
更新日期:1987-01-01 00:00:00
abstract::Due to the rising life expectancy, bone diseases (e.g. osteoporosis, osteoarthritis) and trauma (e.g. fracture) have become an important socio-economic burden. Accurate visualization and quantification of the bone microstructure in vivo is seen as an important step to enhance diagnosis and treatment. Micro-computed to...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2018.06.006
更新日期:2018-09-01 00:00:00
abstract::The Rickets Severity Score (RSS) was used to evaluate X-linked hypophosphatemic rickets (XLH), a genetic disorder mediated by increased circulating FGF23. The reliability of the RSS was assessed using data from a randomized, phase 2 clinical trial that evaluated the effects of burosumab, a fully human anti-FGF23 monoc...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2019.02.010
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND:X-linked hypophosphatemia (XLH) causes rickets, osteomalacia, skeletal deformities and growth impairment, due to elevated fibroblast growth factor 23 and hypophosphatemia. Conventional therapy requires high doses of phosphate salts combined with active vitamin D analogues. Risks of this regimen include nephr...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2019.06.025
更新日期:2019-10-01 00:00:00
abstract::Cyclic mechanical loading augments trabecular bone mass, mainly by increasing trabecular thickness. For this reason, we hypothesized that an in silico thickening algorithm using open-loop control would be sufficient to reliably predict the response of trabecular bone to cyclic mechanical loading. This would also mean ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2011.08.018
更新日期:2011-12-01 00:00:00