Effect of zoledronate acid treatment on osseointegration and fixation of implants in autologous iliac bone grafts in ovariectomized rabbits.

abstract：:In patients with osteoporosis, alendronate treatment causes an increase in bone mineral density (BMD) and a decrease in fracture incidence. Alendronate acts by changing the bone remodeling process. Changes in bone remodeling resulting in decreased remodeling space, increased bone balance per remodeling cycle, and incr...

journal_title：Bone

authors： Hernandez CJ,Beaupré GS,Marcus R,Carter DR

更新日期：2001-12-01 00:00:00

abstract：:Osteocytes are the most abundant cell type in bone and are responsible for sensing mechanical strain and signaling bone (re)modeling, making them the primary mechanosensors within bone. Under aging and osteoporotic conditions, bone is known to be less responsive to loading (exercise), but it is unclear why. Perhaps, t...

journal_title：Bone

authors： Stern AR,Nicolella DP

更新日期：2013-06-01 00:00:00

abstract：:Levels of circulating cytokines are elevated in inflammatory diseases. Previously, it was shown that interleukin (IL-)17A, in synergism with 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] and tumor necrosis factor α (TNFα), induces the release of granulocyte-macrophage colony-stimulating factor (GM-CSF) by murine osteoblasts ...

journal_title：Bone

authors： Ruef N,Dolder S,Aeberli D,Seitz M,Balani D,Hofstetter W

更新日期：2017-04-01 00:00:00

abstract：:Previous reports have shown that bone mass and architecture will partially recover by remobilization (RM) in immobilization (IM)-induced osteopenia. The aim of this study was to test whether PTH can accelerate the recovery during RM from the IM-induced osteopenia. Six-month-old Sprague-Dawley female rats were divided ...

journal_title：Bone

authors： Yuan ZZ,Jee WS,Ma YF,Wei W,Ijiri K

更新日期：1995-10-01 00:00:00

abstract：:Large, cylindrical implants of a porous calcium phosphate ceramic ("hydroxyapatite" starting material, HAC) were used to replace far greater than critical-sized sections of the midshaft of sheep tibiae and retrieved at 2 and 9 months; external fixation was used in the first 5 months. Excellent clinical function of the...

journal_title：Bone

authors： Boyde A,Corsi A,Quarto R,Cancedda R,Bianco P

更新日期：1999-06-01 00:00:00

abstract：OBJECTIVES:Progression of an incomplete atypical femoral fracture (IF) to a complete fracture in patients on long term bisphosphonate (BP) therapy can be catastrophic. We aimed to determine the frequency and imaging features of IF in asymptomatic patients on long-term BP therapy and to identify distinguishing clinical ...

journal_title：Bone

authors： Allison MB,Markman L,Rosenberg Z,Vieira RL,Babb J,Tejwani N,Peck V

更新日期：2013-07-01 00:00:00

abstract：:Nanoindentation has been widely used to study bone tissue mechanical properties. The common method and equations for analyzing nanoindentation, developed by Oliver and Pharr, are based on the assumption that the material is linearly elastic. In the present study, we adjusted the constraint of linearly elastic behavior...

journal_title：Bone

authors： Wang X,Allen MR,Burr DB,Lavernia EJ,Jeremić B,Fyhrie DP

更新日期：2008-10-01 00:00:00

abstract：:This paper reviews the mechanisms of action of the bisphosphonates, a new class of recently developed drugs. The geminal bisphosphonates are characterized by a P-C-P bond and are thus analogs of pyrophosphate. They bind strongly to hydroxyapatite crystals and in vitro inhibit both crystal formation and dissolution. In...

journal_title：Bone

authors： Fleisch H

更新日期：1987-01-01 00:00:00

abstract：:Understanding the cellular basis of osteoblastic cell-biomaterial interaction is crucial to the analysis of the mechanism of osseointegration, a requirement of long-term orthopedic implant stability. Clinically, the amount of bone ingrowth is variable, and cellular parameters that influence ingrowth have yet to be cle...

journal_title：Bone

authors： Shah AK,Sinha RK,Hickok NJ,Tuan RS

更新日期：1999-05-01 00:00:00

abstract：:Compelling evidences suggest that increased production of osteoclastogenic cytokines by activated T cells plays a relevant role in the bone loss induced by estrogen deficiency in the mouse. However, little information is available on the role of T cells in post-menopausal bone loss in humans. To investigate this issue...

journal_title：Bone

authors： D'Amelio P,Grimaldi A,Di Bella S,Brianza SZM,Cristofaro MA,Tamone C,Giribaldi G,Ulliers D,Pescarmona GP,Isaia G

更新日期：2008-07-01 00:00:00

abstract：:This multicenter study assessed the safety and efficacy of teriparatide 20 microg/day in Japanese men and women with osteoporosis at high risk of fracture during a 12-month, randomized, double-blind, placebo-controlled treatment period followed by second and third treatment periods (to 18 and 24 months, respectively,)...

journal_title：Bone

authors： Miyauchi A,Matsumoto T,Sugimoto T,Tsujimoto M,Warner MR,Nakamura T

更新日期：2010-09-01 00:00:00

abstract：:The eValuation of IBandronate Efficacy (VIBE) head-to-head database fracture study compared fracture rates between patients treated with monthly ibandronate and weekly oral bisphosphonates (BPs). This large study included women >/=45 years old, newly prescribed monthly oral ibandronate or weekly oral alendronate or ri...

journal_title：Bone

authors： Harris ST,Reginster JY,Harley C,Blumentals WA,Poston SA,Barr CE,Silverman SL

更新日期：2009-05-01 00:00:00

abstract：:Inhaled corticosteroids are the cornerstone of the modern therapy for asthma. In recent years, inhaled corticosteroids have been used in higher doses than previously. This has caused concern about possible osteoporotic side-effects. We studied bone mineral densities (BMDs) in 19 non-smoking women (mean age 53 years, r...

journal_title：Bone

authors： Herrala J,Puolijoki H,Impivaara O,Liippo K,Tala E,Nieminen MM

更新日期：1994-11-01 00:00:00

abstract：BACKGROUND:Studies in childhood suggest that both body composition and early postnatal growth are associated with bone mineral density (BMD). However, little is known of the relationships between longitudinal changes in fat (FM) and lean mass (LM) and bone development in pre-pubertal children. We therefore investigated...

journal_title：Bone

authors： Moon RJ,Cole ZA,Crozier SR,Curtis EM,Davies JH,Gregson CL,Robinson SM,Dennison EM,Godfrey KM,Inskip HM,Cooper C,Harvey NC,Southampton Women's Survey Study Group.

更新日期：2015-06-01 00:00:00

abstract：:Hypophosphatasia (HPP) is the inborn-error-of-metabolism caused by loss-of-function mutation(s) of the ALPL gene that encodes the tissue-nonspecific isoenzyme of alkaline phosphatase (TNSALP). TNSALP in healthy individuals is on cell surfaces richly in bone, liver, and kidney. Thus, TNSALP natural substrates accumulat...

journal_title：Bone

authors： Whyte MP,Zhang F,Wenkert D,Mumm S,Berndt TJ,Kumar R

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:This observational safety study used national registers to compare the real world cardiovascular and skeletal safety of zoledronic acid (ZA) against oral bisphosphonates (oBP) and untreated population controls. METHODS:Propensity score matched cohort study in Sweden and Denmark. RESULTS:Matched cohort 1 in...

journal_title：Bone

authors： Rubin KH,Möller S,Choudhury A,Zorina O,Kalsekar S,Eriksen EF,Andersen M,Abrahamsen B

更新日期：2020-05-01 00:00:00

abstract：:Ginsenoside Rh2 is one of the most active components of red ginseng, controlling cancer and other metabolic diseases including osteoclast differentiation. However, the molecular mechanism underlying the inhibition of osteoclast differentiation by ginsenoside Rh2 remains poorly understood. In the present study, it was ...

journal_title：Bone

authors： He L,Lee J,Jang JH,Lee SH,Nan MH,Oh BC,Lee SG,Kim HH,Soung NK,Ahn JS,Kim BY

更新日期：2012-06-01 00:00:00

abstract：:Peroxisome proliferator activated receptors (PPARs) are DNA-binding nuclear hormone receptors that are upregulated in response to high fat diets. PPARs are structurally related to the type II nuclear receptors, including the thyroid hormone receptors (TRs). To investigate if PPARs modulate TR-mediated terminal differe...

journal_title：Bone

authors： Wang L,Shao YY,Ballock RT

更新日期：2005-09-01 00:00:00

abstract：:In order to analyze the role of the estrogen receptor (ER) gene allelic polymorphisms on bone mineral density (BMD), 173 pre- and postmenopausal women were divided into four groups according to their menstrual status (group A: premenopausal women; group B: late premenopausal women; group C: postmenopausal women who ha...

journal_title：Bone

authors： Mizunuma H,Hosoi T,Okano H,Soda M,Tokizawa T,Kagami I,Miyamoto S,Ibuki Y,Inoue S,Shiraki M,Ouchi Y

更新日期：1997-11-01 00:00:00

abstract：:Paramagnetic manganese can be employed as a calcium surrogate to sensitize the magnetic resonance imaging (MRI) technique to the processing of calcium during the bone formation process. At low doses, after just 48h of exposure, osteoblasts take up sufficient quantities of manganese to cause marked reductions in the wa...

journal_title：Bone

authors： Chesnick IE,Centeno JA,Todorov TI,Koenig AE,Potter K

更新日期：2011-05-01 00:00:00

abstract：:Several Biophosphonates have been used as therapeutic agents for Paget's bone disease. (Chloro-4 phenyl)thiomethylene-bisphosphonate (CIPsMBP) has recently been shown to have significant antiosteoclastic activity while an affect of CIPsMBP on mineralization was only observed at high doses. We tested this drug for 6 mo...

journal_title：Bone

authors： Reginster JY,Jeugmans-Huynen AM,Albert A,Denis D,Deroisy R,Lecart MP,Fontaine MA,Collette J,Franchimont P

更新日期：1988-01-01 00:00:00

abstract：:Rare bone diseases account for 5% of all birth defects and can cause significant morbidity throughout patients' lives. Significant progress is being made to elucidate the pathophysiological mechanisms underlying these diseases. This paper summarizes presentation highlights of a workshop on Rare Skeletal Diseases conve...

journal_title：Bone

authors： Tosi LL,Warman ML

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:Avoidant Restrictive Food Intake Disorder (ARFID) and Anorexia Nervosa (AN) cause significant underweight in children and young people (CYP). The association of low bone mineral density (BMD) and underweight CYP in AN is well established, but less is known about BMD in ARFID. METHODS:Retrospective case-note...

journal_title：Bone

authors： Alberts Z,Fewtrell M,Nicholls DE,Biassoni L,Easty M,Hudson LD

更新日期：2020-05-01 00:00:00

abstract：:Several animal studies have showed that gelatin may be effective for minimizing bone loss in OVX rats with established osteopenia. To gain insight into how cod bone gelatin administration affects bone loss after ovariectomy, studies were carried out focusing on bone quality and the molecular mechanisms. Eighty-four fe...

journal_title：Bone

authors： Han X,Xu Y,Wang J,Pei X,Yang R,Li N,Li Y

更新日期：2009-05-01 00:00:00

abstract：:Sclerostin, product of the SOST gene, is an important determinant of bone formation and resorption. Adolescents with anorexia nervosa (AN) have low bone density and decreased levels of bone turnover markers. However, sclerostin has not been examined in AN as a potential mediator of impaired bone metabolism. Our study ...

journal_title：Bone

authors： Faje AT,Fazeli PK,Katzman DK,Miller KK,Breggia A,Rosen CJ,Mendes N,Klibanski A,Misra M

更新日期：2012-09-01 00:00:00

abstract：:The temporal expression of bone microsomal casein kinase II, osteopontin, bone sialoprotein, alkaline phosphatase, and the accumulation of a solid calcium-inorganic orthophosphate mineral phase, have been charted from day 2 to day 21 during the repair of calvarial defects in rats induced by the implantation of decalci...

journal_title：Bone

authors： Wang J,Glimcher MJ,Mah J,Zhou HY,Salih E

更新日期：1998-06-01 00:00:00

abstract：:A set of key developmental genes is essential for skeletal growth from multipotent progenitor cells at weaning. Polycomb group proteins, which regulate such genes contributes to the cell lineage commitment and subsequent differentiation via epigenetic chromatin modification and remodeling. However, it is unclear which...

journal_title：Bone

authors： Katoh-Fukui Y,Baba T,Sato T,Otake H,Nagakui-Noguchi Y,Shindo M,Suyama M,Ohkawa Y,Tsumura H,Morohashi KI,Fukami M

更新日期：2019-03-01 00:00:00

abstract：:The hypocalcemic and hypophosphatemic effect of salmon calcitonin (sCT) given by intranasal (i.n.) spray to 12 patients with histological confirmed primary hyperparathyroidism (1 degree HPT) was studied. The concentration of ionized calcium in whole blood (B-Ca++), serum phosphate (S-P), magnesium (S-Mg), plasma sCT (...

journal_title：Bone

authors： Tørring O,Bucht E,Sjöstedt U,Sjöberg HE

更新日期：1991-01-01 00:00:00

abstract：:Osteoporosis is a major public health problem in Western countries and is projected to have a similar impact in the Middle East. It has been suggested that peak bone mineral density (BMD), a major determinant of osteoporotic fractures later in life, may be lower in this part of the world compared with the Western worl...

journal_title：Bone

authors： El-Hajj Fuleihan G,Baddoura R,Awada H,Salam N,Salamoun M,Rizk P

更新日期：2002-10-01 00:00:00

abstract：:Recent increasing evidence supports a role for neuronal type signaling in bone. Specifically glutamate receptors have been found in cells responsible for bone remodeling, namely the osteoblasts and the osteoclasts. While most studies have focused on ionotropic glutamate receptors, the relevance of the metabotropic glu...

journal_title：Bone

authors： Musante I,Mattinzoli D,Otescu LA,Bossi S,Ikehata M,Gentili C,Cangemi G,Gatti C,Emionite L,Messa P,Ravazzolo R,Rastaldi MP,Riccardi D,Puliti A

更新日期：2017-01-01 00:00:00