Abstract:
:A set of key developmental genes is essential for skeletal growth from multipotent progenitor cells at weaning. Polycomb group proteins, which regulate such genes contributes to the cell lineage commitment and subsequent differentiation via epigenetic chromatin modification and remodeling. However, it is unclear which cell lineage and gene sets are targeted by polycomb proteins during skeletal growth. We now report that mice deficient in a polycomb group gene Cbx2cterm/cterm exhibited skeletal hypoplasia in the tibia, femur, and cranium. Long bone cavities in these mice contained fewer multipotent mesenchymal stromal cells. RNA-sequencing of bone marrow cells showed downregulation and upregulation of osteoblastic and adipogenic genes, respectively. Furthermore, the expression levels of genes specifically expressed in B-cell precursors were decreased. Forced expression of Cbx2 in Cbx2cterm/cterm bone marrow stromal cell recovered fibroblastic colony formation and suppressed adipogenic differentiation. Collectively, our results suggest that Cbx2 controls the maintenance and adipogenic differentiation of mesenchymal stromal cells in the bone marrow.
journal_name
Bonejournal_title
Boneauthors
Katoh-Fukui Y,Baba T,Sato T,Otake H,Nagakui-Noguchi Y,Shindo M,Suyama M,Ohkawa Y,Tsumura H,Morohashi KI,Fukami Mdoi
10.1016/j.bone.2018.10.021subject
Has Abstractpub_date
2019-03-01 00:00:00pages
219-231eissn
8756-3282issn
1873-2763pii
S8756-3282(18)30401-0journal_volume
120pub_type
杂志文章相关文献
BONE文献大全abstract::Genetic heterogeneity, high burden and the paucity of genetic testing for rare diseases challenge genomic healthcare for these disorders in India. Here we report our experience over the past decade, of establishing the genomic evaluation of skeletal dysplasia at a tertiary university hospital in India. Research or cli...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2018.10.026
更新日期:2019-03-01 00:00:00
abstract::The loss of trabecular bone in the ovariectomized (OVX) rat provides a useful experimental model of postmenopausal osteoporosis. In this study, two bone-modulating compounds, an NSAID (flurbiprofen: FBP) and a chemically modified nonantimicrobial tetracycline (CMT), were tested either individually or in combination in...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(96)00280-3
更新日期:1996-12-01 00:00:00
abstract::Calcification of end plate chondrocytes is a major cause of intervertebral disc (IVD) degeneration. However, the underlying molecular mechanism of end plate chondrocyte calcification is still unclear. The aim of this study was to clarify whether autophagy in end plate chondrocytes could protect the calcification of en...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2014.06.018
更新日期:2014-09-01 00:00:00
abstract::Disuse osteopenia and bone loss have been extensively reported in long duration space mission and long term bed rest. The pathology of the bone loss is similar to osteoporosis but highly confined to weight bearing bones. The current anabolic and/or anti-resorptive drugs have systemic effects and are costly over extend...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2015.01.020
更新日期:2015-06-01 00:00:00
abstract::During our survey of herbs looking for activity on bone metabolism, we found that the dried leaves of sage strongly inhibit bone resorption. Therefore, we investigated several common herbs rich in essential oils (sage, rosemary, and thyme) and essential oils extracted from these herbs and other plants (oils of sage, r...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(03)00027-9
更新日期:2003-04-01 00:00:00
abstract::The effects of imaging parameters and special configuration of objects within the reconstruction space on the micro computed tomography (μCT) based mineral density have been explored, and a series of density correction curves have been presented. A manufacturer-provided calibration phantom (0, 100, 200, 400, 800 mg HA...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2011.10.004
更新日期:2012-03-01 00:00:00
abstract::Control of systemic inorganic phosphate (Pi) levels is crucial for osteoid mineralization. Parathyroid hormone (PTH) mediates actions on phosphate homeostasis mostly by regulating the activity of the type 2 sodium-phosphate cotransporter (Npt2), and this action requires the PDZ protein NHERF1. Osteoblasts express Npt2...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2012.10.001
更新日期:2013-01-01 00:00:00
abstract::To determine osteocalcin (OC) and adipokines in type 1 diabetes (T1D) and healthy controls, and to explore possible associations between glucose and bone metabolism, body composition and adipokines. Serum levels of total OC, undercarboxylated (UC-OC), leptin, adiponectin, and other parameters of glucose and bone metab...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2015.04.017
更新日期:2016-01-01 00:00:00
abstract::We previously reported the effects of cyclic therapy with etidronate (CTE) on periprosthetic bone mineral density (BMD) after cementless total hip arthroplasty (THA). This study aimed to evaluate the effects of withdrawal and intervention of CTE after cementless THA. The control group consisted of 24 patients without ...
journal_title:Bone
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.bone.2004.03.017
更新日期:2004-07-01 00:00:00
abstract:INTRODUCTION:Alström syndrome (ALMS) is an ultra-rare metabolic disorder caused by biallelic loss-of-function in the Alms1 gene which encodes a ubiquitously expressed centrosomal protein of the primary cilium. Although ALMS is characterised by several metabolic and hormonal dysfunctions that can lead to an increased ri...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2020.115756
更新日期:2021-02-01 00:00:00
abstract::Chondrocytes are derived from mesenchymal stem cells, and play an important role in cartilage formation. Sex determining region Y box (Sox) family transcription factors are essential for chondrogenic differentiation, whereas the intracellular signal pathways of Sox activation have not been clearly elucidated. AMP-acti...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2014.12.001
更新日期:2015-05-01 00:00:00
abstract::Osteoblasts are believed to differentiate into osteocytes, becoming embedded in bone, or to undergo apoptosis after the bone formation phase. The regulation of this terminal differentiation seems to be critical for bone homeostasis. However the mechanism remains unclear and there is no assay system currently available...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2012.09.001
更新日期:2013-01-01 00:00:00
abstract::To investigate whether exercise training can produce increases in bone mass in spinal cord-injured (SCI) individuals with established disuse osteopenia, nine subjects (age 28.2 years, time since injury 6.0 years, level of injury C5-T7) were recruited for a 9-month training program using functional electrical stimulati...
journal_title:Bone
pub_type: 临床试验,杂志文章
doi:10.1016/8756-3282(96)00109-3
更新日期:1996-07-01 00:00:00
abstract::Insulin-dependent type 1 diabetes mellitus (IDDM) has been shown to alter the properties of bone and impair bone repair in both humans and animals. The objective of this study was the detailed histomorphometric evaluation of the influence of the diabetic metabolic state on bone formation and remodeling during bone def...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2004.03.011
更新日期:2004-07-01 00:00:00
abstract::To elucidate the histological events that follow administration of eldecalcitol, a second-generation of vitamin D analog currently awaiting approval as a drug for treatment of osteoporosis, we employed the ovariectomy (OVX) rat model. OVX rats received vehicle or 30ng/kg of eldecalcitol, and sham-operated animals rece...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2011.05.022
更新日期:2011-09-01 00:00:00
abstract::Sclerosteosis and van Buchem disease are two rare bone sclerosing dysplasias caused by genetic defects in the synthesis of sclerostin. In this article we review the demographic, clinical, biochemical, radiological, and histological characteristics of patients with sclerosteosis and van Buchem disease that led to a bet...
journal_title:Bone
pub_type: 杂志文章,评审
doi:10.1016/j.bone.2016.10.010
更新日期:2017-03-01 00:00:00
abstract::The effects of glucocorticoid (GC) excess, thyrotoxicosis, and hypothyroidism on linear growth indicate that growth plate chondrocytes are exquisitely sensitive to GC and thyroid hormone (T(3)). Murine ATDC5 cells undergo chondrogenesis in vitro and were used to evaluate the effects of dexamethasone (Dex) and T(3) on ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(02)00855-4
更新日期:2002-10-01 00:00:00
abstract::While the role of T cells in the regulation of bone homeostasis is well defined, little is known about the role of innate lymphoid cells (ILCs) on bone. ILCs are innate immune cells that share cytokine expression patterns with T cells but lack the T cell receptor. In this study we show that type 2 ILCs (ILC2) potently...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2020.115335
更新日期:2020-07-01 00:00:00
abstract::One hundred Sprague-Dawley rats were ovariectomized (OVX) or sham-operated (Sham) at the age of 12 weeks. Eight or six animals from each group were sacrificed at the following time points: 0, 2, 4, 8, 16, 28, and 40 weeks. Mechanical testing of the bones showed that the maximal load of the femoral neck remained at the...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(96)00369-9
更新日期:1997-03-01 00:00:00
abstract::The risk of fragility fractures in elderly men is only partly explained by areal bone mineral density (aBMD) measured by dual X-ray absorptiometry (DXA). Several studies suggest the importance of bone morphology for the risk of fracture. The aim of this study was to assess the value of bone size and estimated structur...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2005.09.004
更新日期:2006-04-01 00:00:00
abstract::Large segmental defects of the weight bearing long bones are very difficult to reconstruct. Current treatment options are afflicted with several limitations and disadvantages. We describe a novel approach to regenerate a segmental long bone defect in a patient using a multiple disc graft. Decellularized bovine trabecu...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2010.02.011
更新日期:2010-05-01 00:00:00
abstract::Recent in vitro and animal studies suggest that cholesterol and its metabolites inhibit the functional activity of osteoblasts and thereby induce reduced bone mineralization. However, scant information is available on the clinical implication of these findings with special regard to postmenopausal bone loss. Therefore...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(02)00918-3
更新日期:2003-01-01 00:00:00
abstract::The Euler number and the connectivity of an arbitrary object is defined, and it is illustrated why the connectivity of an n-dimensional object cannot be estimated in an (n-1)-dimensional section. The disector--principle for 3-D counting of the Euler--events is illustrated in cancellous bone. The correct handling for u...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(93)90144-y
更新日期:1993-05-01 00:00:00
abstract::Measurement of bone mineral density (BMD) is the clinical gold standard in cases of compromised skeletal integrity, such as with osteoporosis. While BMD is a useful measurement to index skeletal health, it is also limited since it cannot directly assess any mechanical properties. The ability to directly assess mechani...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2015.01.019
更新日期:2015-06-01 00:00:00
abstract::The conventional stereologic procedure for estimating bone surface densities in iliac crest biopsies gives biased estimates because bone substructure is anisotropic and the sectioning of the biopsies is intended to be parallel to the cylindrical axis of the iliac crest biopsy. It has recently been shown that random an...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(87)90126-8
更新日期:1987-01-01 00:00:00
abstract::Metastatic cancer is lethal and patients who suffer bone metastases fare especially poorly. Bone-specific metastatic progression in prostate and breast cancers is a highly observed example of organ-specific metastasis, or organotropism. Though research has delineated the sequential steps of the metastatic cascade, the...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2020.115788
更新日期:2020-12-03 00:00:00
abstract::Despite the remarkable healing potential of long bone fractures, traumatic injuries that result in critical defects require challenging reconstructive limb sparing surgery. While devitalized allografts are the gold standard for these procedures, they are prone to failure due to their limited osseointegration with the ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2010.10.003
更新日期:2011-03-01 00:00:00
abstract:INTRODUCTION:Changes in hip structure and geometry during aging contribute to decreased bone strength. Little is known, however, about these characteristics at advanced age, when fragility fractures are common. We examined hip structural geometry in men and women of old age (72-84 years) and old-old age (85-96 years) t...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2007.06.001
更新日期:2007-10-01 00:00:00
abstract::General dental practitioners use a vast amount of panoramic radiography in their routine clinical work, but valuable information about patients' osteoporotic status is not collected. There are many reasons for this, but one of the prime reasons must be the disruption involved in clinical routine with lengthy manual ra...
journal_title:Bone
pub_type: 杂志文章,多中心研究
doi:10.1016/j.bone.2006.10.024
更新日期:2007-04-01 00:00:00
abstract::Sclerostin monoclonal antibody (Scl-Ab) has been shown to increase bone mass and bone strength by stimulating bone formation in an ovariectomy-induced bone loss rat model. The purpose of this study was to determine the effects of Scl-Ab in a rat immobilization/disuse model in which there was both a decrease in bone fo...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2010.09.009
更新日期:2011-02-01 00:00:00