Sclerostin deficiency in humans.

abstract：:One year of treatment with bisphosphonates at 5x the dose used for post-menopausal osteoporosis significantly increases failure load and microdamage, and decreases toughness at multiple skeletal sites in intact female beagles. The goal of this study was to determine if similar changes occur with doses equivalent to th...

journal_title：Bone

authors： Allen MR,Iwata K,Phipps R,Burr DB

更新日期：2006-10-01 00:00:00

abstract：:We believe that the assembled data are consistent with the presence of mRNA species and/or proteins in pagetic bone that are recognized by some paramyxovirus antibodies and nucleic acid probes. The evidence presented so far is insufficient to substantiate claims for the "unequivocal" presence of paramyxovirus sequence...

journal_title：Bone

authors： Ralston SH,Helfrich MH

更新日期：1999-05-01 00:00:00

abstract：:The lamellar bone's strength is mainly affected by the organization of its mineralized collagen fibers and material composition. In the present study, Raman microspectroscopic and imaging analyses were employed to study a normal human femoral midshaft bone cube-like specimen with a spatial resolution of approximately ...

journal_title：Bone

authors： Kazanci M,Wagner HD,Manjubala NI,Gupta HS,Paschalis E,Roschger P,Fratzl P

更新日期：2007-09-01 00:00:00

abstract：AIM:Factorial design was used to test our hypothesis whether a group of flavonoids (FE) derived from herbal Epimedium Brevicornum Maxim exerted its preventive effects on estrogen-deficiency-induced osteoporosis mainly through an enhancement in intestinal calcium absorption. MATERIALS AND METHODS:Forty-five 12-month-ol...

journal_title：Bone

authors： Zhang G,Qin L,Hung WY,Shi YY,Leung PC,Yeung HY,Leung KS

更新日期：2006-06-01 00:00:00

abstract：:With the increased burden of low back pain (LBP) in our globally aging population there is a need to develop preclinical models of LBP that capture clinically relevant features of physiological aging, degeneration, and disability. Here we assess the validity of using a mouse model system for age-related LBP by charact...

journal_title：Bone

authors： Vincent K,Mohanty S,Pinelli R,Bonavita R,Pricop P,Albert TJ,Dahia CL

更新日期：2019-06-01 00:00:00

abstract：:We have previously found BMD and fracture risk to be significantly associated with the MTHFR (C677T) polymorphism in healthy postmenopausal women in the first years after menopause. Since then, other cohort studies have suggested that sufficient intake of riboflavin and/or folate may have the potential to prevent deve...

journal_title：Bone

authors： Abrahamsen B,Madsen JS,Tofteng CL,Stilgren L,Bladbjerg EM,Kristensen SR,Brixen K,Mosekilde L

更新日期：2005-03-01 00:00:00

abstract：:Thanatophoric dysplasia (TD) is a lethal human bone dysplasia characterized by severe dwarfism. It pathogenesis is thought to involve an abnormal ossifying fibrous tissue that disrupts the skeletal growth plate. We employed a combined morphologic, immunohistochemical and biochemical approach to better define the natur...

journal_title：Bone

authors： Horton WA,Hood OJ,Machado MA,Ahmed S,Griffey ES

更新日期：1988-01-01 00:00:00

abstract：:Vitamin K may be important in bone metabolism. Notably, high-dose menaquinone-4 (menatetrenone, MK4) has been reported to reduce ovariectomy (ovx)-induced bone loss in rats and to decrease osteoporotic fracture in postmenopausal women. However, it is unclear whether these beneficial effects reflect a physiologic effec...

journal_title：Bone

authors： Binkley N,Krueger D,Engelke J,Crenshaw T,Suttie J

更新日期：2002-06-01 00:00:00

abstract：:We performed a comprehensive analysis of the relationships between histologic indices in the iliac crest (cancellous bone volume, trabecular structural indices, cortical width, and core width) and bone density in the spine, hip, and wrist in 81 patients with various metabolic bone diseases including osteoporosis, oste...

journal_title：Bone

authors： Cosman F,Schnitzer MB,McCann PD,Parisien MV,Dempster DW,Lindsay R

更新日期：1992-01-01 00:00:00

abstract：:The cathepsin K (CatK) inhibitor odanacatib (ODN) is currently being developed for the treatment of osteoporosis. In clinical trials, efficacy and resolution of effect of ODN treatment on bone turnover biomarkers and accrued bone mass have been demonstrated. Here, we examine the effects of continuing treatment and dis...

journal_title：Bone

authors： Zhuo Y,Gauthier JY,Black WC,Percival MD,Duong LT

更新日期：2014-10-01 00:00:00

abstract：:Hypophosphatasia (HPP) is the inborn-error-of-metabolism characterized enzymatically by insufficient activity of the tissue-nonspecific isoenzyme of alkaline phosphatase (TNSALP) and caused by either mono- or bi-allelic loss-of-function mutation(s) of the gene ALPL that encodes this cell surface phosphomonoester phosp...

journal_title：Bone

authors： Whyte MP,McAlister WH,Mumm S,Bierhals AJ

更新日期：2019-05-01 00:00:00

abstract：:The effect of clodronate on healing of the fracture of osteopenic bone was studied in rats. A total of 165 female rats (14 +/- 1 weeks, 216 +/- 2 g) were divided into five fracture groups (n = 30), and a neurectomized group (n = 15). Osteopenia (op) was induced by right sciatic neurectomy 4 weeks before the fracture. ...

journal_title：Bone

authors： Tarvainen R,Olkkonen H,Nevalainen T,Hyvönen P,Arnala I,Alhava E

更新日期：1994-11-01 00:00:00

abstract：:Controversial results were reported on the association of vitamin D receptor (VDR) polymorphisms and bone mineral density (BMD). We studied allelic frequencies of the BsmI, ApaI, and TaqI restriction fragment length polymorphisms (RFLPs) in 144 normal healthy southern Chinese premenopausal women aged between 30 and 40...

journal_title：Bone

authors： Kung AW,Yeung SS,Lau KS

更新日期：1998-04-01 00:00:00

abstract：:Loss of bone and muscle mass are two major clinical complications among the growing list of chronic diseases that primarily affect elderly individuals. Persistent low-grade inflammation, one of the major drivers of aging, is also associated with both bone and muscle dysfunction in aging. Particularly, chronic activati...

journal_title：Bone

authors： Davis HM,Essex AL,Valdez S,Deosthale PJ,Aref MW,Allen MR,Bonetto A,Plotkin LI

更新日期：2019-07-01 00:00:00

abstract：:The eValuation of IBandronate Efficacy (VIBE) head-to-head database fracture study compared fracture rates between patients treated with monthly ibandronate and weekly oral bisphosphonates (BPs). This large study included women >/=45 years old, newly prescribed monthly oral ibandronate or weekly oral alendronate or ri...

journal_title：Bone

authors： Harris ST,Reginster JY,Harley C,Blumentals WA,Poston SA,Barr CE,Silverman SL

更新日期：2009-05-01 00:00:00

abstract：:The degradation of the main fibrillar collagens, collagens I and II, is a crucial process for skeletal development. The most abundant dipeptides generated from the catabolism of collagens contain proline and hydroxyproline. In humans, prolidase is the only enzyme able to hydrolyze dipeptides containing these amino aci...

journal_title：Bone

authors： Besio R,Maruelli S,Gioia R,Villa I,Grabowski P,Gallagher O,Bishop NJ,Foster S,De Lorenzi E,Colombo R,Diaz JL,Moore-Barton H,Deshpande C,Aydin HI,Tokatli A,Kwiek B,Kasapkara CS,Adisen EO,Gurer MA,Di Rocco M,Phang J

更新日期：2015-03-01 00:00:00

abstract：:Little has been understood about vitamin D status in relation to bone health in Asian women. The purpose of this study was to identify how the serum 25-hydroxyvitamin D (25[OH]D) concentration is associated with bone mass and bone metabolism. This cross-sectional, community-based epidemiologic study was conducted amon...

journal_title：Bone

authors： Nakamura K,Tsugawa N,Saito T,Ishikawa M,Tsuchiya Y,Hyodo K,Maruyama K,Oshiki R,Kobayashi R,Nashimoto M,Yoshihara A,Ozaki R,Okano T,Yamamoto M

更新日期：2008-02-01 00:00:00

abstract：:The cartilage- and bone-forming properties of the periosteum have long since been recognized. As one of the major sources of skeletal progenitor cells, the periosteum plays a crucial role not only in bone development and growth, but also during bone fracture healing. Aided by the continuous expansion of tools and tech...

journal_title：Bone

authors： Roberts SJ,van Gastel N,Carmeliet G,Luyten FP

更新日期：2015-01-01 00:00:00

abstract：:Peroxisome proliferator activated receptors (PPARs) are DNA-binding nuclear hormone receptors that are upregulated in response to high fat diets. PPARs are structurally related to the type II nuclear receptors, including the thyroid hormone receptors (TRs). To investigate if PPARs modulate TR-mediated terminal differe...

journal_title：Bone

authors： Wang L,Shao YY,Ballock RT

更新日期：2005-09-01 00:00:00

abstract：:In the present study, we investigate the implication of the mitogen-activated protein kinases (MAPKs) Erk, p38, and JNK in mediating the effect of fetal calf serum (FCS) on the differentiation of MC3T3-E1 osteoblast-like cells. Erk is stimulated by FCS in proliferating, early-differentiating, as well as in mature cell...

journal_title：Bone

authors： Suzuki A,Guicheux J,Palmer G,Miura Y,Oiso Y,Bonjour JP,Caverzasio J

更新日期：2002-01-01 00:00:00

abstract：:Profound bone loss at weight bearing sites is a primary effect of long-duration spaceflight. Moreover, a significant increase in estimated fracture risk remains even 1 year after returning to Earth; hence, it is important to define how quickly bone integrity can recover following prolonged disuse. This study character...

journal_title：Bone

authors： Shirazi-Fard Y,Kupke JS,Bloomfield SA,Hogan HA

更新日期：2013-01-01 00:00:00

abstract：:Due to the increasing number of osteoporotic fractures of hip, spine, and wrist there is a growing need for methods to track down the subjects with inferior bone structure and to monitor the effects of therapeutic measures. This study aims at a noninvasive diagnostic tool, deriving architectural properties of trabecul...

journal_title：Bone

authors： Geraets WG,Van der Stelt PF,Lips P,Van Ginkel FC

更新日期：1998-02-01 00:00:00

abstract：:High bone mass (HBM), detected in 0.2% of DXA scans, is characterised by a mild skeletal dysplasia largely unexplained by known genetic mutations. We conducted the first systematic assessment of the skeletal phenotype in unexplained HBM using pQCT in our unique HBM population identified from screening routine UK NHS D...

journal_title：Bone

authors： Gregson CL,Sayers A,Lazar V,Steel S,Dennison EM,Cooper C,Smith GD,Rittweger J,Tobias JH

更新日期：2013-01-01 00:00:00

abstract：CONTEXT:Low energy availability causes disruption of hypothalamic gonadotropin-releasing hormone secretion leading to functional hypothalamic amenorrhea (FHA) and hypoestrogenism, which in turn contributes to decreased bone mineral density (BMD) and increased bone marrow adipose tissue (MAT). Transdermal estradiol admi...

journal_title：Bone

authors： Singhal V,Karzar NH,Bose A,Buckless C,Ackerman KE,Bredella MA,Klibanski A,Misra M

更新日期：2021-01-06 00:00:00

abstract：:Deficiency of Sirtuin 6 (SIRT6), a chromatin-related deacetylase, in mice reveals severe premature aging phenotypes including osteopenia. However, the underlying molecular mechanisms of SIRT6 in bone metabolism are unknown. Here we show that SIRT6 deficiency in mice produces low-turnover osteopenia caused by impaired ...

journal_title：Bone

authors： Sugatani T,Agapova O,Malluche HH,Hruska KA

更新日期：2015-12-01 00:00:00

abstract：:The clinical development of tiludronate (tiludronic acid, disodium salt) for the treatment of Paget's disease of bone is now being complemented by another clinical trials program to investigate its use in osteoporosis. It is expected that osteoporosis will become a major indication for tiludronate, and this paper desc...

journal_title：Bone

authors： Chesnut CH 3rd

更新日期：1995-11-01 00:00:00

abstract：:Mineralocorticoid receptor (MR) antagonism may affect bone turnover via direct and indirect pathways involving parathyroid hormone, but randomized controlled trials are lacking. In a pre-specified analysis of the "Eplerenone in primary hyperparathyroidism" placebo-controlled, randomized trial (ISRCTN 33941607), effect...

journal_title：Bone

authors： Verheyen N,Grübler MR,Meinitzer A,Trummer C,Schwetz V,Amrein K,Dimai HP,März W,Catena C,von Lewinski D,Voelkl J,Alesutan I,Fahrleitner-Pammer A,Brussee H,Pilz S,Tomaschitz A

更新日期：2017-12-01 00:00:00

abstract：:Female Wistar rats aged 3 months were ovariectomized (OX, n = 27). Three months later they were given i.v. doses of 150 (6), 300 (7), or 600 (6) ug/kg 2/wk of olpadronate during 12 weeks or left as OX controls (OXc). Bending fracture load of femur diaphyses, reduced in OXc, was recovered by olpadronate. This effect wa...

journal_title：Bone

authors： Cointry GR,Mondelo N,Zanchetta JR,Montuori E,Ferretti JL

更新日期：1995-10-01 00:00:00

abstract：:Rough-surfaced substrates made by a variety of methods have been shown to influence osteoblast proliferation and differentiation. The purpose of this study is to confirm the role of surface roughness in promoting osteoblastic differentiation using tissue culture polystyrene as substrate, by excluding factors other tha...

journal_title：Bone

authors： Hatano K,Inoue H,Kojo T,Matsunaga T,Tsujisawa T,Uchiyama C,Uchida Y

更新日期：1999-10-01 00:00:00

abstract：:To assess the affect of mild diabetes on calcium metabolism in an animal model, we evaluated calcium homeostasis before pregnancy and during gestation and lactation in non-insulindependent (NIDD) diabetic rat mothers and their neonates (NeoDM). Plasma glucose, calcium (Ca), magnesium (Mg), phosphate (Pi), and immunore...

journal_title：Bone

authors： Levy J,Gavin JR 3rd,Scott MJ,Avioli LV

更新日期：1987-01-01 00:00:00