Uncovering the periosteum for skeletal regeneration: the stem cell that lies beneath.

abstract：:Skeletal disorders in rapidly growing poultry are commonplace. This study was performed to investigate the effect of ornithine alpha-ketoglutarate (OKG) administration during the last 7 weeks of life on structural properties, mineralization, and mechanical endurance of skeleton in turkeys at slaughter. Healthy HB Medi...

journal_title：Bone

authors： Tatara MR,Sliwa E,Krupski W,Brodzki A,Pasternak K

更新日期：2006-07-01 00:00:00

abstract：BACKGROUND:Fibrodysplasia ossificans progressiva (FOP) is a catastrophic genetic disorder of progressive heterotopic ossification (HO). Assessment of functional mobility in FOP will be essential to support clinical trials of investigational agents. RESULTS:Of necessity, we developed a simple, rapidly-administered, cum...

journal_title：Bone

authors： Kaplan FS,Al Mukaddam M,Pignolo RJ

更新日期：2017-08-01 00:00:00

abstract：:It is well known that physical inactivity leads to loss of muscle mass, but it also causes bone loss. Mechanistically, osteoclastogenesis and bone resorption have recently been shown to be regulated by vibration. However, the underlying mechanism behind the inhibition of osteoclast formation is yet unknown. Therefore,...

journal_title：Bone

authors： Kulkarni RN,Voglewede PA,Liu D

更新日期：2013-12-01 00:00:00

abstract：:On the basis of previous investigations indicating that the distribution of osteonic and interstitial lamellae in a normal femur depends on its mechanical properties, a procedure has been devised to provide information on the distribution of lamellae in human femora diaphyses deformed by bending. To achieve this, exac...

journal_title：Bone

authors： Ascenzi A,Improta S,Portigliatti Barbos M,Carando S,Boyde A

更新日期：1987-01-01 00:00:00

abstract：:Prenatal dexamethasone exposure (PDE) induces developmental toxicities of multi-organs and susceptibility to multi-diseases in offspring. However, the effects of PDE on osteoarthritis susceptibility in adult offspring and its mechanism have not been reported. In the present study, we treated pregnant Wistar rats with ...

journal_title：Bone

authors： Xiao H,Xie X,Wen Y,Tan Y,Shangguan Y,Li B,Magdalou J,Wang H,Chen L

更新日期：2020-04-01 00:00:00

abstract：:High-resolution peripheral quantitative computed tomography (HR-pQCT) assesses both volumetric bone mineral density (vBMD) and trabecular and cortical microarchitecture. However, studies of the association of HR-pQCT parameters with fracture history have been small, predominantly limited to postmenopausal women, often...

journal_title：Bone

authors： Fink HA,Langsetmo L,Vo TN,Orwoll ES,Schousboe JT,Ensrud KE,Osteoporotic Fractures in Men (MrOS) Study Group.

更新日期：2018-08-01 00:00:00

abstract：:Ectopic calcification of soft tissues can have severe clinical consequences especially when localized to vital organs such as heart, arteries and kidneys. Mammalian stanniocalcin (STC) 1 and 2 are glycoprotein hormones identified as calcium/phosphate-regulating hormones. The mRNA of STCs is upregulated in the kidney o...

journal_title：Bone

authors： Takei Y,Yamamoto H,Sato T,Otani A,Kozai M,Masuda M,Taketani Y,Muto-Sato K,Lanske B,Takeda E

更新日期：2012-04-01 00:00:00

abstract：:Bone morphogenetic proteins (BMPs) are known to induce new bone formation in vivo but treating trabecular bone defects with a BMP based therapeutic remains controversial. Here, we evaluated the safety and efficacy of a novel Autologous Bone Graft Substitute (ABGS) comprised of recombinant human BMP6 (rhBMP6) dispersed...

journal_title：Bone

authors： Durdevic D,Vlahovic T,Pehar S,Miklic D,Oppermann H,Bordukalo-Niksic T,Gavrankapetanovic I,Jamakosmanovic M,Milosevic M,Martinovic S,Sampath TK,Peric M,Grgurevic L,Vukicevic S

更新日期：2020-11-01 00:00:00

abstract：:Osteoporosis is a common complex disorder with reduced bone mineral density (BMD) and increased susceptibility to fracture. Peak BMD is one of the primary determinants of osteoporotic fracture risk, and is under substantial genetic control. Extracellular matrix, a major component of the bone, influences BMD by regulat...

journal_title：Bone

authors： Alam I,Padgett LR,Ichikawa S,Alkhouli M,Koller DL,Lai D,Peacock M,Xuei X,Foroud T,Edenberg HJ,Econs MJ

更新日期：2014-07-01 00:00:00

abstract：:Osteocyte apoptosis precedes osteoclast resorption, and may act as a critical signal to trigger bone remodeling. While osteoclast precursors are known to travel via the circulation, the specific mechanisms by which they accumulate at remodeling sites are unclear. We hypothesized that osteocyte apoptosis mediates osteo...

journal_title：Bone

authors： Cheung WY,Simmons CA,You L

更新日期：2012-01-01 00:00:00

abstract：:Various substitution mutations in ALK2, a transmembrane serine/threonine kinase receptor for bone morphogenetic proteins (BMPs), have been identified in patients with genetic disorders such as fibrodysplasia ossificans progressiva (FOP), diffuse intrinsic pontine glioma (DIPG) and heart defects. In this study, we char...

journal_title：Bone

authors： Machiya A,Tsukamoto S,Ohte S,Kuratani M,Fujimoto M,Kumagai K,Osawa K,Suda N,Bullock AN,Katagiri T

更新日期：2018-06-01 00:00:00

abstract：:To better understand the effects of prolonged bed-rest in women, 24 healthy women aged 25 to 40 years participated in 60-days of strict 6° head-down tilt bed-rest (WISE-2005). Subjects were assigned to either a control group (CON, n=8) which performed no countermeasure, an exercise group (EXE, n=8) undertaking a combi...

journal_title：Bone

authors： Beller G,Belavý DL,Sun L,Armbrecht G,Alexandre C,Felsenberg D

更新日期：2011-10-01 00:00:00

abstract：:The last step of the osteoclast differentiation process is cell fusion. Most efforts to understand the fusion mechanism have focused on the identification of molecules involved in the fusion process. Surprisingly, the basic fusion modalities, which are well known for fusion of other cell types, are not known for the o...

journal_title：Bone

authors： Søe K,Hobolt-Pedersen AS,Delaisse JM

更新日期：2015-04-01 00:00:00

abstract：OBJECTIVES:Osteoarthritis (OA) is a disease of the whole joint characterized by cartilage loss and subchondral bone remodeling. The role of microcracks in cartilage integrity and subchondral bone homeostasis is not fully understood. The main goal of this work was to evaluate microcrack density in both calcified cartila...

journal_title：Bone

authors： Zarka M,Hay E,Ostertag A,Marty C,Chappard C,Oudet F,Engelke K,Laredo JD,Cohen-Solal M

更新日期：2019-06-01 00:00:00

abstract：:Localized proton spectra of the human lumbar vertebral body were recorded in vivo at 1.5 T, using the STEAM (stimulated echo acquisition mode) pulse sequence. Thirty-seven patients (18 men, 19 women) were examined, ranging in age from 21 to 68 years (mean = 40, SD = 13). The fat fraction of the bone marrow was calcula...

journal_title：Bone

authors： De Bisschop E,Luypaert R,Louis O,Osteaux M

更新日期：1993-03-01 00:00:00

abstract：:We described a chick periosteal osteogenesis model at the light microscopic level and biochemically. To confirm that morphologically identifiable bone is being formed, we performed an ultrastructural study of this model. Samples of freshly dissected periostea, as well as whole calvariae, were fixed in glutaraldehyde. ...

journal_title：Bone

authors： Tenenbaum HC,Palangio KG,Holmyard DP,Pritzker KP

更新日期：1986-01-01 00:00:00

abstract：INTRODUCTION:Because osteoporotic patients are prone to fractures, it must be considered whether or not patients undergoing drug therapies should discontinue treatment after sustaining a non-vertebral fracture. This study has tested the effect of novel active vitamin D3 analog, 1alpha,25-dihydroxy-2beta(3-hydroxypropox...

journal_title：Bone

authors： Cao Y,Mori S,Mashiba T,Kaji Y,Manabe T,Iwata K,Miyamoto K,Komatsubara S,Yamamoto T

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND AND AIM:The safety of bisphosphonates in human pregnancy has not been well established. To characterize pregnancy outcome in women receiving bisphosphonates, we conducted a multi-centre, prospective cohort study with a comparison group. METHODS:Patients were recruited through 3 teratogen information centres...

journal_title：Bone

authors： Levy S,Fayez I,Taguchi N,Han JY,Aiello J,Matsui D,Moretti M,Koren G,Ito S

更新日期：2009-03-01 00:00:00

abstract：:Fibroblast growth factor 23 (FGF23) circulates as active protein and inactive fragments. Low iron status increases FGF23 gene expression, and iron deficiency is common. We hypothesized that in healthy premenopausal women, serum iron influences C-terminal and intact FGF23 concentrations, and that iron and FGF23 associa...

journal_title：Bone

authors： Imel EA,Liu Z,McQueen AK,Acton D,Acton A,Padgett LR,Peacock M,Econs MJ

更新日期：2016-05-01 00:00:00

abstract：:Recent increasing evidence supports a role for neuronal type signaling in bone. Specifically glutamate receptors have been found in cells responsible for bone remodeling, namely the osteoblasts and the osteoclasts. While most studies have focused on ionotropic glutamate receptors, the relevance of the metabotropic glu...

journal_title：Bone

authors： Musante I,Mattinzoli D,Otescu LA,Bossi S,Ikehata M,Gentili C,Cangemi G,Gatti C,Emionite L,Messa P,Ravazzolo R,Rastaldi MP,Riccardi D,Puliti A

更新日期：2017-01-01 00:00:00

abstract：:The purpose of this in vitro biomechanical study is to determine the force attenuation capacity of four different hip protectors (KPH1, KPH2, Safehip, and Safetypants) in falling simulations in elderly subjects (falls to the side). The simulated falling conditions were created by a biomechanical testing system, which ...

journal_title：Bone

authors： Kannus P,Parkkari J,Poutala J

更新日期：1999-08-01 00:00:00

abstract：:The influence of TGF beta 1 on bone was studied in a titanium device implanted into the tibia of rabbits. TGF beta 1 was infused via an Alzet osmotic pump calibrated to deliver at a rated of 200ng daily for 2 weeks before replacement. A hollow channel is incorporated into the device into which tissue can grow, and the...

journal_title：Bone

authors： Zhou H,Choong PC,Chou ST,Kartsogiannis V,Martin TJ,Ng KW

更新日期：1995-10-01 00:00:00

abstract：:The effects of imaging parameters and special configuration of objects within the reconstruction space on the micro computed tomography (μCT) based mineral density have been explored, and a series of density correction curves have been presented. A manufacturer-provided calibration phantom (0, 100, 200, 400, 800 mg HA...

journal_title：Bone

authors： Entezari V,Vartanians V,Zurakowski D,Patel N,Fajardo RJ,Müller R,Snyder BD,Nazarian A

更新日期：2012-03-01 00:00:00

abstract：:The present review summarizes the pathogenic mechanisms leading to hip fracture based on epidemiological, experimental, and controlled clinical studies. The estimated lifetime risk of hip fracture is about 14% in postmenopausal women and 6% in men. The incidence of hip fractures increases exponentially with aging, but...

journal_title：Bone

authors： Lauritzen JB

更新日期：1996-01-01 00:00:00

abstract：:Regulation of calcium release from mouse calvariae by glycosaminoglycans and known modulators of bone resorption has been examined. Anticoagulant and nonanticoagulant fragments of heparin were combined with parathyroid hormone (PTH) and interleukin-1, beta (IL1), and calcium release from radiolabeled bone was determin...

journal_title：Bone

authors： Cochran DL,Abernathy CK

更新日期：1988-01-01 00:00:00

abstract：:Several animal studies have showed that gelatin may be effective for minimizing bone loss in OVX rats with established osteopenia. To gain insight into how cod bone gelatin administration affects bone loss after ovariectomy, studies were carried out focusing on bone quality and the molecular mechanisms. Eighty-four fe...

journal_title：Bone

authors： Han X,Xu Y,Wang J,Pei X,Yang R,Li N,Li Y

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND:Genesis of a cartilaginous scaffold is an obligate precursor to bone formation in heterotopic endochondral ossification (HEO). We tested the hypothesis that cartilage-derived retinoic acid-sensitive protein (CD-RAP) can serve as a plasma biomarker for the pre-osseous cartilaginous stage of HEO. Palovarotene,...

journal_title：Bone

authors： Lindborg CM,Brennan TA,Wang H,Kaplan FS,Pignolo RJ

更新日期：2018-04-01 00:00:00

abstract：:Nitric oxide (NO), produced by endothelial cells, is a signaling molecule synthesized from l-arginine by nitric oxide synthases (NOS). NO is known to reduce the ratio of receptor activator of nuclear factor KappaB (RANKL)/osteoprotegerin (OPG), leading to decreased osteoclastogenesis and a reduction in bone resorption...

journal_title：Bone

authors： Cho K,Demissie S,Dupuis J,Cupples LA,Kathiresan S,Beck TJ,Karasik D,Kiel DP

更新日期：2008-01-01 00:00:00

abstract：:We compared the distribution of a cysteine proteinase inhibitor, cystatin C, with that of cathepsin K in osteoclasts of the mouse tibia by immunolight and immunoelectron microscopy. Light microscopically, strong immunoreactivity for cystatin C was found extracellularly along the resorption lacuna and intracellularly i...

journal_title：Bone

authors： Yamaza T,Tsuji Y,Goto T,Kido MA,Nishijima K,Moroi R,Akamine A,Tanaka T

更新日期：2001-07-01 00:00:00

abstract：:Tooth eruption involves the movement of a tooth from its site of development within the alveolar bone to its functional position in the oral cavity. Because this process is dependent upon monocytes and formation of osteoclasts, it represents an excellent model for examination of these processes under developmental reg...

journal_title：Bone

authors： Graves DT,Alsulaimani F,Ding Y,Marks SC Jr

更新日期：2002-08-01 00:00:00