Cartilage-derived retinoic acid-sensitive protein (CD-RAP): A stage-specific biomarker of heterotopic endochondral ossification (HEO) in fibrodysplasia ossificans progressiva (FOP).

abstract：:On the basis of studies with bone-seeking isotopes, it is generally believed that the metabolic activity of osteoblasts of the trabecular bone is greater than that of the osteoblasts of the cortex. This implies that the oxidative activity, which provides the energy for biosyntheses, will also be greater in the former ...

journal_title：Bone

authors： Dodds RA,Emery RJ,Klenerman L,Chayen J,Bitensky L

更新日期：1989-01-01 00:00:00

abstract：:The assessment of fracture risk often relies primarily on measuring bone mineral density, thereby accounting for only a single pathology: the loss of bone mass. However, bone's ability to resist fracture is a result of its biphasic composition and hierarchical structure that imbue it with high strength and toughness. ...

journal_title：Bone

authors： Abraham AC,Agarwalla A,Yadavalli A,Liu JY,Tang SY

更新日期：2016-06-01 00:00:00

abstract：:Liver X receptors (LXRs) are nuclear receptors that play a crucial role in the transcriptional control of lipid metabolism. Pharmacological LXR activation is an attractive concept for the treatment of atherosclerosis. Genetic LXR deficiency in mice has been shown to have an effect on bone turnover and structure and LX...

journal_title：Bone

authors： Prawitt J,Beil FT,Marshall RP,Bartelt A,Ruether W,Heeren J,Amling M,Staels B,Niemeier A

更新日期：2011-02-01 00:00:00

abstract：:Treatment with parathyroid hormone 1-84 (PTH) or teriparatide increases osteonal remodeling and decreases bone mineral density (BMD) at cortical (Ct) bone sites but may also increase bone size. Decreases in BMD and increases in size exert opposing effects on bone strength. In adult ovariectomized (OVX) rhesus monkeys,...

journal_title：Bone

authors： Fox J,Miller MA,Newman MK,Recker RR,Turner CH,Smith SY

更新日期：2007-09-01 00:00:00

abstract：:It is known that marrow fat content increases in a variety of osteoporoses. This study sought to clarify this phenomenon by combining bone and marrow histomorphometry, and to determine (1) whether the marrow fat increase follows or precedes diminishment of bone volume, and (2) whether the increase in fat volume is due...

journal_title：Bone

authors： Martin RB,Zissimos SL

更新日期：1991-01-01 00:00:00

abstract：:We have previously shown that in osteoblasts Sox2 expression can be induced by Fgfs, and can inhibit Wnt signaling and differentiation. Furthermore, in mice in which Sox2 is conditionally deleted in the osteoblastic lineage, bones are osteopenic, and Sox2 inactivation in cultured osteoblasts leads to a loss of prolife...

journal_title：Bone

authors： Holmes G,Bromage TG,Basilico C

更新日期：2011-10-01 00:00:00

abstract：:The purpose was to investigate whether the reduction in bone mechanical strength induced by immobilization could be prevented by a bisphosphonate compound, clodronate. The torsional breaking strength of the tibia was measured using a specially constructed torsion machine. Maximum torque capacity, maximum angle of defo...

journal_title：Bone

authors： Lepola V,Jalovaara P,Väänänen K

更新日期：1994-05-01 00:00:00

abstract：:Juvenile osteoporosis (JO) is characterized by bone fragility during development, low bone mass and absence of extraskeletal features. Heterozygous loss-of-function mutations in LRP5 have been found in a few patients, but bone tissue and bone material abnormalities associated with such mutations have not been determin...

journal_title：Bone

authors： Fahiminiya S,Majewski J,Roughley P,Roschger P,Klaushofer K,Rauch F

更新日期：2013-11-01 00:00:00

abstract：:Trabecular bone score (TBS) is a recently-developed analytical tool that performs novel grey-level texture measurements on lumbar spine dual X-ray absorptiometry (DXA) images, and thereby captures information relating to trabecular microarchitecture. In order for TBS to usefully add to bone mineral density (BMD) and c...

journal_title：Bone

authors： Harvey NC,Glüer CC,Binkley N,McCloskey EV,Brandi ML,Cooper C,Kendler D,Lamy O,Laslop A,Camargos BM,Reginster JY,Rizzoli R,Kanis JA

更新日期：2015-09-01 00:00:00

abstract：:Disuse osteopenia and bone loss have been extensively reported in long duration space mission and long term bed rest. The pathology of the bone loss is similar to osteoporosis but highly confined to weight bearing bones. The current anabolic and/or anti-resorptive drugs have systemic effects and are costly over extend...

journal_title：Bone

authors： Uddin SM,Qin YX

更新日期：2015-06-01 00:00:00

abstract：:Androgen receptor (AR) is expressed throughout the osteoblast lineage. Two different AR transgenic families (AR2.3-tg and AR3.6-tg mice) demonstrating overlapping and distinct expression profiles were employed to assess the effects of enhanced androgen sensitivity to ameliorate hypogonadal loss. Two different paradigm...

journal_title：Bone

authors： Wiren KM,Zhang XW,Olson DA,Turner RT,Iwaniec UT

更新日期：2012-11-01 00:00:00

abstract：:Diabetes increases the risk of fracture, impairs fracture healing and causes rapid loss of the fracture callus cartilage, which was linked to increased FOXO1 expression in chondrocytes. We recently demonstrated that deletion of FOXO1 in chondrocytes blocked the premature removal of cartilage associated with endochondr...

journal_title：Bone

authors： Lu Y,Alharbi M,Zhang C,O'Connor JP,Graves DT

更新日期：2019-06-01 00:00:00

abstract：:Aging is associated with gradual bone loss in men and premenopausal women, with an accelerated rate of loss after menopause in women. Although many studies have investigated bone loss due to surgically induced estrogen depletion, little is known regarding normal age-related changes in bone mass in animal models. We us...

journal_title：Bone

authors： Black A,Tilmont EM,Handy AM,Scott WW,Shapses SA,Ingram DK,Roth GS,Lane MA

更新日期：2001-03-01 00:00:00

abstract：:Three distinct osteoblastic cell lines (KS418, KS460, and KS483) were subcloned from the mouse osteoblastic KS-4 cells, which possessed the abilities not only to differentiate into mature osteoblasts, but also to support osteoclast differentiation in coculture with spleen cells. The order of the magnitude of the basal...

journal_title：Bone

authors： Yamashita T,Ishii H,Shimoda K,Sampath TK,Katagiri T,Wada M,Osawa T,Suda T

更新日期：1996-11-01 00:00:00

abstract：:The parathyroid hormone (PTH) signaling pathways that effect changes in osteoblast gene expression also alter the organization of the cytoskeletal proteins. PTH regulates the expression of nucleoskeletal proteins, such as nuclear mitotic apparatus protein (NuMA) and topoisomerase II-alpha. NuMA is a structural compone...

journal_title：Bone

authors： Torrungruang K,Feister H,Swartz D,Hancock EB,Hock J,Bidwell JP

更新日期：1998-04-01 00:00:00

abstract：INTRODUCTION:Trace elements are known to influence bone metabolism; however, their effects may be exacerbated in renal failure because dialysis patients are unable to excrete excess elements properly. Our study correlated bone quality in dialysis patients with levels of bone fluoride, magnesium, and aluminum. A number ...

journal_title：Bone

authors： Ng AH,Hercz G,Kandel R,Grynpas MD

更新日期：2004-01-01 00:00:00

abstract：:The effect of homologous recombinant porcine growth hormone (r-pGH) on secondary fracture healing was investigated in a diaphyseal defect of the tibia in Yucatan micropigs. A 1 cm defect of the tibia was created surgically and stabilized with an AO 3.5 mm DCP plate. The treatment group (12 animals) received 100 microg...

journal_title：Bone

authors： Raschke M,Kolbeck S,Bail H,Schmidmaier G,Flyvbjerg A,Lindner T,Dahne M,Roenne IA,Haas N

更新日期：2001-10-01 00:00:00

abstract：:G protein-coupled receptor kinase 2 interacting protein-1 (GIT1) is a scaffold protein that plays a vital role in bone modeling and remodeling during osteogenesis coupled with angiogenesis. Recent studies have shown that a specialized subset of vascular endothelium strongly positive for CD31 and Endomucin (CD31hiEmcnh...

journal_title：Bone

authors： Xu T,Luo Y,Kong F,Lv B,Zhao S,Chen J,Liu W,Cheng L,Zhou Z,Zhou Z,Huang Y,Li L,Zhao X,Qian D,Fan J,Yin G

更新日期：2019-05-01 00:00:00

abstract：:Hypercalcemia is a relatively common terminal complication of malignancy. In the majority of the patients it is due to excessive bone resorption, secondary either to local destruction by metastases or by the activity of several paracrine and/or endocrine factors. Increased renal tubular reabsorption of calcium plays a...

journal_title：Bone

authors： Adami S,Rossini M

更新日期：1992-01-01 00:00:00

abstract：:Disuse osteoporosis, which occurs commonly in prolonged bed rest and immobilization, is becoming a major problem in modern societies; however, the molecular mechanisms underlying unloading-driven bone loss have not been fully elucidated. The osteocyte network is considered to be an ideal mechanosensor and mechanotrans...

journal_title：Bone

authors： Wang Y,Liu W,Masuyama R,Fukuyama R,Ito M,Zhang Q,Komori H,Murakami T,Moriishi T,Miyazaki T,Kitazawa R,Yoshida CA,Kawai Y,Izumi S,Komori T

更新日期：2012-01-01 00:00:00

abstract：:This is a cross-sectional study of spine and hip bone density (BMD) in 124 female athletes, aged 16-68 years, who trained for at least 3 hs/week. The aim was to document the effects of competitive running on BMD in women over a broad age range. Thirty-three subjects, aged <35 years, were currently oligo- or amenorrhei...

journal_title：Bone

authors： Gibson JH,Harries M,Mitchell A,Godfrey R,Lunt M,Reeve J

更新日期：2000-06-01 00:00:00

abstract：:Selective sodium-dependent glucose co-transporter 2 inhibitors (SGLT2Is) are oral hypoglycemic medications utilized increasingly in the medical management of hyperglycemia among persons with type 2 diabetes (T2D). Despite favorable effects on cardiovascular events, specific SGLT2Is have been associated with an increas...

journal_title：Bone

authors： Thrailkill KM,Bunn RC,Uppuganti S,Ray P,Garrett K,Popescu I,Pennings JS,Fowlkes JL,Nyman JS

更新日期：2020-04-01 00:00:00

abstract：:Immunosuppressant drugs are currently required by transplant recipients for the remainder of their lives, despite the many adverse effects associated with these therapies. Acute osteoporosis is one such effect, and a reproducible osteoporosis model has been established through the administration of the immunosuppressa...

journal_title：Bone

authors： Fukunaga J,Yamaai T,Yamachika E,Ishiwari Y,Tsujigiwa H,Sawaki K,Lee YJ,Ueno T,Kirino S,Mizukawa N,Takagi S,Nagai N,Sugahara T

更新日期：2004-03-01 00:00:00

abstract：:The distribution of hyaluronan was investigated in the proximal tibiotarsal bones of normal (vitamin D-treated) chicks, and chicks with rachitic lesions induced by vitamin D deficiency. Localization studies using a biotinylated hyaluronan-binding probe revealed that in vitamin D-treated chicks, a high level of hyaluro...

journal_title：Bone

authors： Genever PG,Dickson IR

更新日期：1996-05-01 00:00:00

abstract：:Diabetes is associated with a number of lower extremity orthopedic conditions and complications including fractures, Charcot neuroarthropathy, plantar ulcers, and infection. These complications are of significant clinical concern in terms of morbidity, mortality, and socioeconomic costs. A review of each condition is ...

journal_title：Bone

authors： Gehling DJ,Lecka-Czernik B,Ebraheim NA

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND AND AIM:The safety of bisphosphonates in human pregnancy has not been well established. To characterize pregnancy outcome in women receiving bisphosphonates, we conducted a multi-centre, prospective cohort study with a comparison group. METHODS:Patients were recruited through 3 teratogen information centres...

journal_title：Bone

authors： Levy S,Fayez I,Taguchi N,Han JY,Aiello J,Matsui D,Moretti M,Koren G,Ito S

更新日期：2009-03-01 00:00:00

abstract：:Inhaled corticosteroids are the cornerstone of the modern therapy for asthma. In recent years, inhaled corticosteroids have been used in higher doses than previously. This has caused concern about possible osteoporotic side-effects. We studied bone mineral densities (BMDs) in 19 non-smoking women (mean age 53 years, r...

journal_title：Bone

authors： Herrala J,Puolijoki H,Impivaara O,Liippo K,Tala E,Nieminen MM

更新日期：1994-11-01 00:00:00

abstract：:Deficiency of Sirtuin 6 (SIRT6), a chromatin-related deacetylase, in mice reveals severe premature aging phenotypes including osteopenia. However, the underlying molecular mechanisms of SIRT6 in bone metabolism are unknown. Here we show that SIRT6 deficiency in mice produces low-turnover osteopenia caused by impaired ...

journal_title：Bone

authors： Sugatani T,Agapova O,Malluche HH,Hruska KA

更新日期：2015-12-01 00:00:00

abstract：:Interleukin (IL)-17 is crucial to osteoclast differentiation and activation. Osteocytes support osteoclast formation and are thought to orchestrate bone remodeling in response to fluid flow. The contribution of IL-17 to osteocyte-related bone resorption remains unclear. Here, we used the osteocyte-like MLO-Y4 cell lin...

journal_title：Bone

authors： Liao C,Cheng T,Wang S,Zhang C,Jin L,Yang Y

更新日期：2017-08-01 00:00:00

abstract：:ED-71, a novel analog of 1alpha,25-(OH)2 D3, increases bone mass to a greater extent than alfacalcidol, an 1alpha,25-(OH)2 D3 prodrug. In this study, we used a murine bone marrow ablation model to compare the effect of ED-71 on bone formation and resorption in vivo with that of 1alpha,25-(OH)2 D3. We discovered that b...

journal_title：Bone

authors： Okuda N,Takeda S,Shinomiya K,Muneta T,Itoh S,Noda M,Asou Y

更新日期：2007-02-01 00:00:00