Orthopedic complications in diabetes.

abstract：:Osteogenesis imperfecta (OI) is a heritable collagen-related bone dysplasia, characterized by brittle bones with increased fracture risk that presents most severely in children. Anti-resorptive bisphosphonates are frequently used to treat pediatric OI and controlled clinical trials have shown that bisphosphonate thera...

journal_title：Bone

authors： Sinder BP,Salemi JD,Ominsky MS,Caird MS,Marini JC,Kozloff KM

更新日期：2015-02-01 00:00:00

abstract：:Bisphosphonates are widely used to treat children with osteogenesis imperfecta (OI), a bone fragility disorder that is most often caused by mutations in COL1A1 or COL1A2. However, it is unclear whether this treatment decreases the risk of developing scoliosis. We retrospectively evaluated spine radiographs and charts ...

journal_title：Bone

authors： Sato A,Ouellet J,Muneta T,Glorieux FH,Rauch F

更新日期：2016-05-01 00:00:00

abstract：:Ronacaleret is an orally-active calcium-sensing receptor (CaSR) antagonist that has the potential for therapeutic utility in the stimulation of PTH release, notably as a bone anabolic agent comparable to recombinant human PTH(1-34) (rhPTH(1-34)). A recent study has shown that, despite the ability to increase circulati...

journal_title：Bone

authors： Caltabiano S,Dollery CT,Hossain M,Kurtinecz MT,Desjardins JP,Favus MJ,Kumar R,Fitzpatrick LA

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:High-resolution peripheral quantitative computed tomography (HR-pQCT) represents a three-dimensional tool for the screening of osteoporosis patients i.e., regarding fracture risk. The purpose of this study was to determine the baseline and follow-up bone microarchitecture in relation to incident fracture ris...

journal_title：Bone

authors： Butscheidt S,Rolvien T,Vettorazzi E,Frieling I

更新日期：2018-09-01 00:00:00

abstract：:In order to delineate the influence of mechanical unloading on the formation and resorption of trabecular and cortical bone, the effects of mechanical unloading on the volume, structure, and turnover of hindlimbs were examined using tail-suspended rapidly growing rats. In addition, to clarify the mechanism of how mech...

journal_title：Bone

authors： Matsumoto T,Nakayama K,Kodama Y,Fuse H,Nakamura T,Fukumoto S

更新日期：1998-05-01 00:00:00

abstract：:Metastatic bone disease has a major impact on the morbidity and mortality of breast cancer patients, and studies on bone metastasis biology have led to the development of the most widely used drugs for bone metastases treatment: zoledronate (Zol) and denosumab (Den). The aim of the present study was to assess the effe...

journal_title：Bone

authors： Liverani C,Mercatali L,Spadazzi C,La Manna F,De Vita A,Riva N,Calpona S,Ricci M,Bongiovanni A,Gunelli E,Zanoni M,Fabbri F,Zoli W,Amadori D,Ibrahim T

更新日期：2014-09-01 00:00:00

abstract：:Bone mineral density is under strong genetic control and polymorphisms of the vitamin D receptor (VDR) have been suggested to account for some of the genetic variation in bone mass. However, the relationship between VDR polymorphisms and bone density is controversial and has not been confirmed by all workers. Since th...

journal_title：Bone

authors： Houston LA,Grant SF,Reid DM,Ralston SH

更新日期：1996-03-01 00:00:00

abstract：:Anterior cruciate ligament (ACL) tears are a common sports-related knee injury that increases the risk of developing post-traumatic osteoarthritis (OA). During OA progression bone microarchitecture changes in the affected knee, however, little is known about bone microarchitecture in knees with early stage OA. The pur...

journal_title：Bone

authors： Kroker A,Bhatla JL,Emery CA,Manske SL,Boyd SK

更新日期：2018-06-01 00:00:00

abstract：:This study reports the effects of a recreational team handball exercise programme (randomised controlled trial, RCT) on bone health, postural balance and body composition in inactive postmenopausal women without previous experience of the sport. Sixty-seven postmenopausal women (68.3 ± 6.2 years, stature 156.9 ± 5.8 c...

journal_title：Bone

authors： Pereira R,Krustrup P,Castagna C,Coelho E,Santos R,Helge EW,Jørgensen NR,Magalhães J,Póvoas S

更新日期：2021-01-13 00:00:00

abstract：:Alterations in bone strength and structure were found in knockout (KO) mouse strains with deletion of several acetylcholine receptors. Interestingly, the expression of the nicotinic acetylcholine receptors (nAChR) subunit α10 was down-regulated in osteogenic differentiated mesenchymal stem cells of patients with osteo...

journal_title：Bone

authors： Baumann L,Kauschke V,Vikman A,Dürselen L,Krasteva-Christ G,Kampschulte M,Heiss C,Yee KT,Vetter DE,Lips KS

更新日期：2019-03-01 00:00:00

abstract：:Six women, aged 24-67 years, had osteopenia and insufficiency fractures, which suggested a diagnosis of osteomalacia. The insufficiency fractures occurred at traditional sites for Looser zones, were multiple in number, were symmetrically distributed in three patients, and did not heal promptly. Bone mass was low, as a...

journal_title：Bone

authors： McKenna MJ,Kleerekoper M,Ellis BI,Rao DS,Parfitt AM,Frame B

更新日期：1987-01-01 00:00:00

abstract：:Recently the third generation aromatase inhibitors have proved their efficacy and tolerability compared with tamoxifen in the adjuvant treatment of women with hormone responsive early breast cancer. However, there is some concern about the possible negative impact of these drugs on bone. The aim of the study was to ev...

journal_title：Bone

authors： Gonnelli S,Cadirni A,Caffarelli C,Petrioli R,Montagnani A,Franci MB,Lucani B,Francini G,Nuti R

更新日期：2007-01-01 00:00:00

abstract：:In order to evaluate the effects of uremia and low levels of dietary phosphorus on bone, male Sprague-Dawley rats weighing 320 +/- 20 g (12 weeks old) were subjected to either a two-step, subtotal nephrectomy or sham-operation (SO), and then fed a custom diet with either normal calcium (0.5%) and normal phosphorus (0....

journal_title：Bone

authors： Lieuallen WG,Weisbrode SE,Horst RL,Nagode LA

更新日期：1990-01-01 00:00:00

abstract：INTRODUCTION:Parathyroid hormone (PTH) is a key regulator of calcium metabolism. Parathyroid hormone-like hormone (PTHrP) contributes to skeletal development through regulation of chondrocyte proliferation and differentiation during early bone growth. Both PTH and PTHrP act through the same receptor (PTHR1). A second r...

journal_title：Bone

authors： Tenne M,McGuigan F,Jansson L,Gerdhem P,Obrant KJ,Luthman H,Akesson K

更新日期：2008-04-01 00:00:00

abstract：:The Microphthalmia-associated transcription factor (Mitf) is required for the proper development of several cell lineages including osteoclasts, melanocytes, retinal pigment epithelial cells, mast cells and natural killer cells. Mutations in Mitf in multiple organisms result in osteopetrosis due to defective osteoclas...

journal_title：Bone

authors： Hershey CL,Fisher DE

更新日期：2004-04-01 00:00:00

abstract：:The enlargement of osteocyte lacunae via osteocytic osteolysis was previously detected in situations of increased calcium demand (e.g., lactation, vitamin D deficiency). However, it is unclear whether similar processes occur also in the growing infantile skeleton and how this is linked to the mineral distribution with...

journal_title：Bone

authors： Jandl NM,von Kroge S,Stürznickel J,Baranowsky A,Stockhausen KE,Mushumba H,Beil FT,Püschel K,Amling M,Rolvien T

更新日期：2020-06-01 00:00:00

abstract：:Depending on populations, 15 to 40% of patients have a familial form of Paget's disease of bone (PDB), which is transmitted in an autosomal-dominant mode of inheritance with incomplete penetrance. To date, only SQSTM1 gene mutations have been linked to the disease. Several single nucleotide polymorphisms (SNPs) have b...

journal_title：Bone

authors： Guay-Bélanger S,Simonyan D,Bureau A,Gagnon E,Albert C,Morissette J,Siris ES,Orcel P,Brown JP,Michou L

更新日期：2016-03-01 00:00:00

abstract：:Inhaled corticosteroids are the cornerstone of the modern therapy for asthma. In recent years, inhaled corticosteroids have been used in higher doses than previously. This has caused concern about possible osteoporotic side-effects. We studied bone mineral densities (BMDs) in 19 non-smoking women (mean age 53 years, r...

journal_title：Bone

authors： Herrala J,Puolijoki H,Impivaara O,Liippo K,Tala E,Nieminen MM

更新日期：1994-11-01 00:00:00

abstract：:Acceleration of remodeling activity after menopause leads to bone loss and fragility, however, whether this is associated with modifications of bone matrix quality has been less studied. The impact of variation in bone remodeling rate on bone matrix has been studied mainly in pathologies or anti-osteoporotic treatment...

journal_title：Bone

authors： Farlay D,Bala Y,Rizzo S,Bare S,Lappe JM,Recker R,Boivin G

更新日期：2019-11-01 00:00:00

abstract：:This paper reviews the mechanisms of action of the bisphosphonates, a new class of recently developed drugs. The geminal bisphosphonates are characterized by a P-C-P bond and are thus analogs of pyrophosphate. They bind strongly to hydroxyapatite crystals and in vitro inhibit both crystal formation and dissolution. In...

journal_title：Bone

authors： Fleisch H

更新日期：1987-01-01 00:00:00

abstract：:New methods to increase vertical bone growth are needed to permit dental implant placement in patients with low alveolar ridge height after extended periods of tooth loss. While ectopic rodent models are typically used to evaluate new osteogenic implant surface coatings, a more relevant intramembraneous rodent model w...

journal_title：Bone

authors： Freilich M,M Patel C,Wei M,Shafer D,Schleier P,Hortschansky P,Kompali R,Kuhn L

更新日期：2008-10-01 00:00:00

abstract：:The neuropeptide Y system has emerged as one of the major neural signalling pathways regulating bone homeostasis. Absence of Y1 receptor signalling from bone forming osteoblasts is responsible for an enhancement on bone mass in mice, suggesting that pharmacological blockade of Y1 receptors may offer a novel anabolic t...

journal_title：Bone

authors： Sousa DM,Baldock PA,Enriquez RF,Zhang L,Sainsbury A,Lamghari M,Herzog H

更新日期：2012-07-01 00:00:00

abstract：:Hypophosphatasia (HPP) is the inborn-error-of-metabolism caused by loss-of-function mutation(s) of the ALPL gene that encodes the tissue-nonspecific isoenzyme of alkaline phosphatase (TNSALP). TNSALP in healthy individuals is on cell surfaces richly in bone, liver, and kidney. Thus, TNSALP natural substrates accumulat...

journal_title：Bone

authors： Whyte MP,Zhang F,Wenkert D,Mumm S,Berndt TJ,Kumar R

更新日期：2020-05-01 00:00:00

abstract：:Bone structure is the key to the understanding of fracture risk. The hypothesis tested in this prospective study is that dense mandibular trabeculation predicts low fracture risk, whereas sparse trabeculation is predictive of high fracture risk. Out of 731 women from the Prospective Population Study of Women in Gothen...

journal_title：Bone

authors： Jonasson G,Sundh V,Ahlqwist M,Hakeberg M,Björkelund C,Lissner L

更新日期：2011-10-01 00:00:00

abstract：:Osteoblast-like cells express receptors for various hormones and neurotransmitters that induce widespread actions in the bone to which intercellular communication and its modulation may contribute. Therefore, we examined the effects of the osteotropic hormones vitamin D3 (vitD3) and 17beta-estradiol (17beta-E2) as wel...

journal_title：Bone

authors： Schirrmacher K,Bingmann D

更新日期：1998-12-01 00:00:00

abstract：:In this study, we observed mitotic preosteoblasts that have the structural features of osteoblasts in the primary spongiosa of the rat mandibular condyle. The rough endoplasmic reticulum and the Golgi apparatus showed remarkable disorganization during mitosis. The Golgi saccules were replaced by groups of large vacuol...

journal_title：Bone

authors： Shibata S,Baba O,Sakamoto Y,Ohsako M,Yamashita Y,Ichijo T

更新日期：1993-01-01 00:00:00

abstract：:Five strains of inbred mice were found to have variations in bone mass although they were similar in body weight. Two of these strains, C57BL/6J and A/J, were studied in greater detail and the former had more bone in both femur and tibia. The increased bone mass was associated with larger quadriceps muscles in the C57...

journal_title：Bone

authors： Kaye M,Kusy RP

更新日期：1995-08-01 00:00:00

abstract：:The human calvarium is a sandwich structure with two dense layers of cortical bone separated by porous cancellous bone. The variation of the three dimensional geometry, including the layer thicknesses and the volume fraction of the cancellous layer across the population, is unavailable in the current literature. This ...

journal_title：Bone

authors： Boruah S,Paskoff GR,Shender BS,Subit DL,Salzar RS,Crandall JR

更新日期：2015-08-01 00:00:00

abstract：:With age, alterations occurring in bone quality, quantity, and microarchitecture affect the resistance of trabecular bone to local failure. The clinical implications of these changes are evident by the observed exponential increase in fracture incidence with age. Although age-related development of skeletal fragility ...

journal_title：Bone

authors： Nagaraja S,Lin AS,Guldberg RE

更新日期：2007-04-01 00:00:00

abstract：:Although extensive studies have done much to clarify the molecular mechanisms of osteoclastogenesis during the last ten years, there may still be unknown molecules associated with osteoclast differentiation. Thus, we used fluorescent differential display to screen for genes whose expression is induced by receptor acti...

journal_title：Bone

authors： Hada N,Okayasu M,Ito J,Nakayachi M,Hayashida C,Kaneda T,Uchida N,Muramatsu T,Koike C,Masuhara M,Sato T,Hakeda Y

更新日期：2012-01-01 00:00:00