Abstract:
:Five strains of inbred mice were found to have variations in bone mass although they were similar in body weight. Two of these strains, C57BL/6J and A/J, were studied in greater detail and the former had more bone in both femur and tibia. The increased bone mass was associated with larger quadriceps muscles in the C57BL/6J animals when measured at 18 weeks of age. Activities of animals from these two strains were studied over 24 h periods using a cage with an ultrasonic movement detector and automatic counter. The C57BL/6J animals were more active than the A/J mice. The male C57BL/6J mice tended to have larger testicles and higher testosterone levels than the A/J animals, whereas the female A/J animals had larger ovaries and higher oestradiol levels. As both male and female C57BL/6J animals were more active, it was concluded that the sex hormone differences between the two strains was not responsible for either the changes in bone mass or physical activity. These findings indicate that in the mouse, activity is in part genetically determined. We have hypothesized that this, in turn, could affect muscle mass and secondarily, bone size and strength. If these results can be applied to humans, it would suggest that differences at birth between individuals are important for bone mass in later life and that muscle mass and activity are in part genetically influenced. If this was the case, then muscle mass and strength could be a factor in bone mass and one of the goals in prevention and treatment of osteoporosis should be directed toward preservation and/or augmentation of muscle strength.
journal_name
Bonejournal_title
Boneauthors
Kaye M,Kusy RPdoi
10.1016/s8756-3282(00)00164-2subject
Has Abstractpub_date
1995-08-01 00:00:00pages
131-5issue
2eissn
8756-3282issn
1873-2763pii
S8756328200001642journal_volume
17pub_type
杂志文章相关文献
BONE文献大全abstract::Osteocytes are cells buried in the bone matrix. They largely contribute to the regulation of bone remodeling in response to mechanical and microenvironmental changes. Much has been recognized in recent years regarding the role of osteocytes in bone homeostasis, nevertheless their ability to directly contribute to mine...
journal_title:Bone
pub_type: 杂志文章,评审
doi:10.1016/j.bone.2008.09.017
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVE:Rheumatoid arthritis (RA) is accompanied by potential risk of bone mineral loss. In this study, we developed a screening index for the osteoporosis related level of bone mineral density loss for RA patients as a substitute to the dual-energy X-ray absorptiometry (DXA) method. METHODS:X-ray pictures of both s...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2020.115405
更新日期:2020-08-01 00:00:00
abstract::Chondrocytes are derived from mesenchymal stem cells, and play an important role in cartilage formation. Sex determining region Y box (Sox) family transcription factors are essential for chondrogenic differentiation, whereas the intracellular signal pathways of Sox activation have not been clearly elucidated. AMP-acti...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2014.12.001
更新日期:2015-05-01 00:00:00
abstract::Collagen sponge disks (6 mm diameter, 1 mm thickness) were impregnated with recombinant human bone morphogenetic protein-2 (rhBMP-2) (5 microg/disk) and implanted onto the back muscles of mice. Ten or 20 mg/kg per day of Rolipram, a selective inhibitory agent to phosphodiesterase type 4 (PDE-4), or vehicle, was inject...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(02)00681-6
更新日期:2002-04-01 00:00:00
abstract::Fibroblast growth factor 23 (FGF23) is a potent regulator of Pi and 1,25-(OH)(2)D homeostasis. Early postpartum infants show intriguing changes in serum levels of Ca, Pi, PTH and 1,25-(OH)(2)D. However, the role of FGF23 in the early neonatal mineral metabolism has not been clarified. In order to evaluate the signific...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2010.05.024
更新日期:2010-08-01 00:00:00
abstract:PURPOSE:The accepted mechanism explaining the accelerated growth following periosteal resection is that the periosteum serves as a mechanical restraint to restrict physeal growth. To test the veracity of this mechanism we first utilized Second Harmonic Generation (SHG) imaging to measure differences of periosteal fiber...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2016.08.021
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND:Patients with primary hyperparathyroidism (PHPT) generally show reduced bone mineral density (BMD) at cortical sites with relatively preserved trabecular bone. However, the increased fracture risk at all skeletal sites suggests that areal BMD probably is not effective in capturing all the determinants of bon...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2012.11.041
更新日期:2013-03-01 00:00:00
abstract::High-resolution peripheral quantitative computed tomography (HR-pQCT) assesses both volumetric bone mineral density (vBMD) and trabecular and cortical microarchitecture. However, studies of the association of HR-pQCT parameters with fracture history have been small, predominantly limited to postmenopausal women, often...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2018.05.005
更新日期:2018-08-01 00:00:00
abstract::G protein-coupled receptors (GPCRs) require G proteins for intracellular signaling to regulate a variety of growth and maintenance processes, including osteogenesis and bone turnover. Bone maintenance events may be altered by changes in the activity or level of G proteins, which then modify signaling in bone cells suc...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2013.11.021
更新日期:2014-02-01 00:00:00
abstract::Vitamin D is well known for its role in promoting skeletal health. Vitamin D status is determined conventionally by circulating 25-dihydroxyvitamin D (25OHD) concentration. There is evidence indicating that circulating 25OHD concentration is affected by variation in Gc, the gene encoding the vitamin D binding protein ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2014.12.068
更新日期:2015-05-01 00:00:00
abstract::The effect of vitamin D supplementation on growth of fetal bones during pregnancy is unclear. The aim of this study was to assess the effect of low dose vitamin D supplementation during pregnancy on bony anthropometric aspects of the fetus. In this prospective randomized trial, 140 patients were divided into two equal...
journal_title:Bone
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.bone.2019.02.022
更新日期:2019-05-01 00:00:00
abstract::Embryonic/neonatal bones in culture are commonly used for the study of osteoclastic resorption in vitro. For this purpose, the release of 45calcium (45Ca) from prelabeled bones is measured as an index of resorption. We studied 45Ca release from two types of long bone explants after different preparation methods: 17-da...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(95)00135-z
更新日期:1995-07-01 00:00:00
abstract::In order to investigate the ultrastructure of bone resorptive cells in the two types of adult benign human osteopetrosis, iliac crest biopsies were obtained from 11 patients and 10 normal males, who served as a control group. Six patients had the radiological type I (4 women, 2 men, aged 23-58 years, mean = 36.5 years...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(93)90316-3
更新日期:1993-11-01 00:00:00
abstract::The effect of low-dose 1 alpha-hydroxyvitamin D3 [1 alpha(OH)D3] on experimental osteoporosis in rats induced by a combination of hemicordotomy and ovariectomy was evaluated. 1 alpha(OH)D3 (0.1 microgram/kg 1 alpha(OH)D3 three times a week) increased the femur score and photo-density. The administration of 1 alpha(OH)...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(87)90066-4
更新日期:1987-01-01 00:00:00
abstract::With age, alterations occurring in bone quality, quantity, and microarchitecture affect the resistance of trabecular bone to local failure. The clinical implications of these changes are evident by the observed exponential increase in fracture incidence with age. Although age-related development of skeletal fragility ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2006.10.028
更新日期:2007-04-01 00:00:00
abstract::Bone is a composite biomaterial of mineral crystals, organic matrix, and water. Each contributes to bone quality and strength and may change independently, or together, with disease progression and treatment. Even so, there is a near ubiquitous reliance on ionizing x-ray-based approaches to measure bone mineral densit...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2020.115615
更新日期:2021-02-01 00:00:00
abstract:INTRODUCTION:The clinically known importance of patient sex as a major risk factor for compromised bone healing is poorly reflected in animal models. Consequently, the underlying cellular mechanisms remain elusive. Because mesenchymal stem cells (MSCs) are postulated to regulate tissue regeneration and give rise to ess...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2009.08.005
更新日期:2009-12-01 00:00:00
abstract::There is increasing evidence that osteogenic cells are present not only in bone marrow (BM) but also in peripheral blood (PB). Since staining for alkaline phosphatase (AP) identifies osteoprogenitor cells in BM, we sought to further characterize BM versus PB hematopoietic lineage negative (lin-)/AP+ cells and to compa...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2010.03.018
更新日期:2010-07-01 00:00:00
abstract::This study reports the elastic material properties of cortical bone in the mandible of juvenile Alligator mississippiensis obtained by using an ultrasonic wave technique. The elastic modulus, the shear modulus, and Poisson's ratio were measured on 42 cylindrical Alligator bone specimens obtained from the lingual and f...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2009.11.010
更新日期:2010-03-01 00:00:00
abstract::The adult human skeleton is a multifunctional organ undergoing constant remodeling through the opposing activities of the bone-resorbing osteoclast and the bone-forming osteoblast. The exquisite balance between bone resorption and bone formation is responsible for bone homeostasis in healthy adults. However, evidence ...
journal_title:Bone
pub_type: 杂志文章,评审
doi:10.1016/j.bone.2017.08.008
更新日期:2018-10-01 00:00:00
abstract::There are increasing evidences suggesting bone marrow adiposity tissue (MAT) plays a critical role in affecting both bone quantity and quality. However, very limited studies that have investigated the association between the composition of MAT and bone mineral density (BMD). The goal of this study was to quantify MAT ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2017.08.014
更新日期:2017-12-01 00:00:00
abstract::The incidence of hip fractures in Oslo has shown a secular increase during the past decades. The main aims of the present study were to report the current incidence of hip fractures in Oslo and to determine whether there is a seasonal variation in the occurrence of fractures. Using the electronic diagnosis registers a...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(01)00603-2
更新日期:2001-11-01 00:00:00
abstract::Ultrashort echo time magnetic resonance imaging (UTE-MRI) techniques have been increasingly used to assess cortical bone microstructure. High resolution micro computed tomography (μCT) is routinely employed for validating the MRI-based assessments. However, water protons in cortical bone may reside in micropores small...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2019.03.013
更新日期:2019-06-01 00:00:00
abstract:INTRODUCTION:While the anti-resorptive effects of the bisphosphonates (BPs) are well documented, many questions remain about their mechanisms of action, particularly following long-term use. This study evaluated the effects of alendronate (Ale) treatment on TGF-β1 signaling in mesenchymal stem cells (MSCs) and osteocyt...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2012.10.017
更新日期:2013-01-01 00:00:00
abstract::Osteonecrosis of the femoral head is a serious orthopedic problem. Moderate loads with knee loading promote bone formation, but their effects on osteonecrosis have not been investigated. Using a rat model, we examined a hypothesis that knee loading enhances vessel remodeling and bone healing through the modulation of ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2015.09.012
更新日期:2015-12-01 00:00:00
abstract::In the present study, we investigate the implication of the mitogen-activated protein kinases (MAPKs) Erk, p38, and JNK in mediating the effect of fetal calf serum (FCS) on the differentiation of MC3T3-E1 osteoblast-like cells. Erk is stimulated by FCS in proliferating, early-differentiating, as well as in mature cell...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(01)00660-3
更新日期:2002-01-01 00:00:00
abstract::Two major mechanisms that could potentially be responsible for toughening in mineralized tissues, such as bone and dentin, have been identified-microcracking and crack bridging. While evidence has been reported for both mechanisms, there has been no consensus thus far on which mechanism plays the dominant role in toug...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2004.02.001
更新日期:2004-05-01 00:00:00
abstract::Women with prevalent fractures have an increased risk of developing additional, incident fractures. This article examines the relation between the location of prevalent fractures within the spine and the risk of subsequent vertebral fractures. The subjects were 721 Japanese-American women of mean age 69.5 +/- 5.3 (SD)...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(98)00176-8
更新日期:1999-03-01 00:00:00
abstract:BACKGROUND:Skeletal loading and proper nutrition are necessary for optimal bone health. The appropriate amount of dietary protein to maximize skeletal health, however, is under constant debate. OBJECTIVE:To determine if 6 months of protein supplementation in conjunction with a strength and conditioning training progra...
journal_title:Bone
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.bone.2005.10.020
更新日期:2006-06-01 00:00:00
abstract::The propensity of individual trabeculae to fracture (microfracture) may be important clinically since it could be indicative of bone fragility. Whether or not an overloaded trabecula fractures is determined in part by its structural ductility, a mechanical property that describes how much deformation a trabecula can s...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2005.07.019
更新日期:2005-12-01 00:00:00