Association of High-resolution Peripheral Quantitative Computed Tomography (HR-pQCT) bone microarchitectural parameters with previous clinical fracture in older men: The Osteoporotic Fractures in Men (MrOS) study.

abstract：:The relative bioavailability of enteric-coated sodium fluoride (NaF) tablets (10 mg F-) has been assessed following administration with a standard calcium-rich breakfast or calcium-poor lunch, and 2 h before or simultaneously with antacid administration (2.4 g aluminum-magnesium hydroxide), versus intake on an empty s...

journal_title：Bone

authors： Arnold P,Wermeille M,Chapuy MC,Biollaz J,Grandjean EM,Schelling JL,Meunier PJ

更新日期：1989-01-01 00:00:00

abstract：:As the world's population ages, the occurrence of osteoporosis-related fractures is projected to increase. Low areal bone mineral density (aBMD), a well-known risk factor for fractures, may be influenced by physical activity (PA). In this cross-sectional study, we aimed to investigate potential associations between ob...

journal_title：Bone

authors： Johansson J,Nordström A,Nordström P

更新日期：2015-12-01 00:00:00

abstract：:The prevalence of vertebral deformity, estimated in lateral spine radiographs (Th4-L4) using quantitative morphometry, in 64 men and 132 women with hip fractures was compared with the prevalence of vertebral deformity in individuals in two population-based studies. A vertebral deformity of a specific vertebra was defi...

journal_title：Bone

authors： Hasserius R,Johnell O,Nilsson BE,Thorngren KG,Jonsson K,Mellström D,Redlund-Johnell I,Karlsson MK

更新日期：2003-02-01 00:00:00

abstract：:During normal aging and menopause, cancellous bone is lost at all skeletal sites due to remodeling-related factors: negative formation balance; temporarily increased remodeling space; and osteoclastic perforations. The relative importance of the various factors in inducing bone mass loss and perforations is still cont...

journal_title：Bone

authors： Thomsen JS,Mosekilde L,Mosekilde E

更新日期：1996-11-01 00:00:00

abstract：:We previously reported that a type II sodium phosphate (Na(+)-Pi) cotransporter (Npt2) protein is expressed in osteoclasts and that Pi limitation decreases osteoclast-mediated bone resorption in vitro. We also demonstrated that mice homozygous for the disrupted Npt2 gene (Npt2-/-) exhibit a unique age-dependent bone p...

journal_title：Bone

authors： Gupta A,Tenenhouse HS,Hoag HM,Wang D,Khadeer MA,Namba N,Feng X,Hruska KA

更新日期：2001-11-01 00:00:00

abstract：:The cartilage- and bone-forming properties of the periosteum have long since been recognized. As one of the major sources of skeletal progenitor cells, the periosteum plays a crucial role not only in bone development and growth, but also during bone fracture healing. Aided by the continuous expansion of tools and tech...

journal_title：Bone

authors： Roberts SJ,van Gastel N,Carmeliet G,Luyten FP

更新日期：2015-01-01 00:00:00

abstract：:Intermittent PTH increases trabecular bone mass in vivo by stimulating osteoblast differentiation to increase bone formation. The molecular events that mediate the anabolic effect of PTH on osteoblasts have not been characterized. We investigated if PTH regulated mRNA expression of proto-oncogenes, c-fos, c-jun, and c...

journal_title：Bone

authors： Onyia JE,Bidwell J,Herring J,Hulman J,Hock JM

更新日期：1995-11-01 00:00:00

abstract：:We examined the mode of action of bisphosphonates on osteoclastic cell recruitment using mouse marrow cultures with or without osteoblastic cells. Tartrate-resistant acid phosphatase-positive multinucleated cells [TRAP(+)MNC] formed in cultures were determined to be osteoclastic cells. In marrow cultures, TRAP(+) MNC ...

journal_title：Bone

authors： Nishikawa M,Akatsu T,Katayama Y,Yasutomo Y,Kado S,Kugal N,Yamamoto M,Nagata N

更新日期：1996-01-01 00:00:00

abstract：:Alagille syndrome (ALGS) is an autosomal dominant disorder attributed to mutations in the Notch signaling pathway. Children with ALGS are at increased risk for fragility fracture of unknown etiology. Our objective was to characterize bone mass, geometry, and microarchitecture in children with ALGS. This was a cross-se...

journal_title：Bone

authors： Kindler JM,Mitchell EL,Piccoli DA,Grimberg A,Leonard MB,Loomes KM,Zemel BS

更新日期：2020-12-01 00:00:00

abstract：:We have previously found BMD and fracture risk to be significantly associated with the MTHFR (C677T) polymorphism in healthy postmenopausal women in the first years after menopause. Since then, other cohort studies have suggested that sufficient intake of riboflavin and/or folate may have the potential to prevent deve...

journal_title：Bone

authors： Abrahamsen B,Madsen JS,Tofteng CL,Stilgren L,Bladbjerg EM,Kristensen SR,Brixen K,Mosekilde L

更新日期：2005-03-01 00:00:00

abstract：:Microcephalic osteodysplastic primordial dwarfism type 1 (MOPD1), or Taybi-Linder syndrome is characterized by distinctive skeletal dysplasia, severe intrauterine and postnatal growth retardation, microcephaly, dysmorphic features, and neurological malformations. It is an autosomal recessive disorder caused by homozyg...

journal_title：Bone

authors： Krøigård AB,Frost M,Larsen MJ,Ousager LB,Frederiksen AL

更新日期：2016-11-01 00:00:00

abstract：:Bone morphogenetic proteins (BMPs) are known to induce new bone formation in vivo but treating trabecular bone defects with a BMP based therapeutic remains controversial. Here, we evaluated the safety and efficacy of a novel Autologous Bone Graft Substitute (ABGS) comprised of recombinant human BMP6 (rhBMP6) dispersed...

journal_title：Bone

authors： Durdevic D,Vlahovic T,Pehar S,Miklic D,Oppermann H,Bordukalo-Niksic T,Gavrankapetanovic I,Jamakosmanovic M,Milosevic M,Martinovic S,Sampath TK,Peric M,Grgurevic L,Vukicevic S

更新日期：2020-11-01 00:00:00

abstract：:Osteoclastic bone degradation depends on the activity of several proteolytic enzymes, in particular to those belonging to the classes of cysteine proteinases and matrix metalloproteinases (MMPs). Yet, several findings suggest that the two types of plasminogen activators (PA), the tissue- and urokinase-type PA (tPA and...

journal_title：Bone

authors： Everts V,Daci E,Tigchelaar-Gutter W,Hoeben KA,Torrekens S,Carmeliet G,Beertsen W

更新日期：2008-11-01 00:00:00

abstract：:Bone remodeling is a process involving both dynamic and static bone strain. Although there exist numerous studies on the effect of dynamic strain on implant stability and bone remodeling, the effect of static strain has yet to be clarified. Hence, for this purpose, the effect of static bone strain on implant stability...

journal_title：Bone

authors： Halldin A,Jimbo R,Johansson CB,Wennerberg A,Jacobsson M,Albrektsson T,Hansson S

更新日期：2011-10-01 00:00:00

abstract：:We proposed a novel surface modification for an artificial hip joint stem from the viewpoint of maintenance and establishment of appropriate bone function and microstructure, represented by the preferred alignment of biological apatite (BAp) and collagen (Col). Oriented grooves were introduced into the proximal medial...

journal_title：Bone

authors： Noyama Y,Nakano T,Ishimoto T,Sakai T,Yoshikawa H

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:Vertebral fracture (VF) is the most common osteoporotic fracture in postmenopausal women, although most VFs are subclinical. Prevalent VFs are a significant predictor of subsequent fracture and therefore, identification of VF improves the identification of those with high fracture risk. The aim of present st...

journal_title：Bone

authors： Yang J,Mao Y,Nieves JW

更新日期：2020-07-01 00:00:00

abstract：:Rodent models suggest that estradiol deficiency promotes bone loss through increasing interleukin-6 (IL-6) activity. However, it is controversial as to whether these findings are applicable to humans. To evaluate estradiol-mediated modulation of IL-6 activity in relation to bone metabolism in humans, we measured serum...

journal_title：Bone

authors： Chiu KM,Arnaud CD,Ju J,Mayes D,Bacchetti P,Weitz S,Keller ET

更新日期：2000-01-01 00:00:00

abstract：:This review begins with an introduction to the malignant bone tumor, osteosarcoma [OS] and then moves to a discussion of the commonly used vectors for gene transfer. We first briefly highlight non-viral vectors including polymeric and liposomal delivery systems but concentrate predominantly on the 5 leading viral vect...

journal_title：Bone

authors： Witlox MA,Lamfers ML,Wuisman PI,Curiel DT,Siegal GP

更新日期：2007-04-01 00:00:00

abstract：:Bisphosphonates play an important role in the treatment of metabolic bone diseases such as osteoporosis. In addition to their anti-resorptive activity by triggering osteoclast apoptosis, nitrogen-containing bisphosphonates (N-BP) may also influence osteogenic differentiation, which might rely on their capacity to inhi...

journal_title：Bone

authors： Adam C,Glück L,Ebert R,Goebeler M,Jakob F,Schmidt M

更新日期：2018-06-01 00:00:00

abstract：:Ecto-nucleotide pyrophosphatase/phosphodiesterases (NPPs) hydrolyse nucleotide triphosphates to the corresponding nucleotide monophosphates and the mineralisation inhibitor, pyrophosphate (PPi). This study examined the role of NPP1 in osteocytes, osteoclasts and cortical bone, using a mouse model lacking NPP1 (Enpp1(-...

journal_title：Bone

authors： Hajjawi MO,MacRae VE,Huesa C,Boyde A,Millán JL,Arnett TR,Orriss IR

更新日期：2014-12-01 00:00:00

abstract：:Matrix extracellular phosphoglycoprotein (MEPE) is an extracellular matrix protein that was first detected in tumor-induced osteomalacia (TIO). Investigations in mice revealed that MEPE is expressed in bone and teeth in a maturation-dependent manner, reaching its maximum during mineralization. However, from knockout e...

journal_title：Bone

authors： Siggelkow H,Schmidt E,Hennies B,Hüfner M

更新日期：2004-08-01 00:00:00

abstract：OBJECTIVES:This study sought to identify the clinical and biochemical characteristics that would help distinguish hypophosphatasia (HPP) from other metabolic bone diseases in adult patients attending a metabolic bone clinic by comparing patients who have genetically confirmed HPP with a group of patients with low bone ...

journal_title：Bone

authors： Desborough R,Nicklin P,Gossiel F,Balasubramanian M,Walsh JS,Petryk A,Teynor M,Eastell R

更新日期：2021-03-01 00:00:00

abstract：:Prostaglandin E(2) (PGE(2)) is essential for fracture healing. Systemic administration of EP4 ligands such as PGE(2) and other synthetic EP4 agonists appears to transduce anabolic signals by binding to receptor EP4. Therefore, the present study was designed to test whether administration of EP4 agonist accelerates the...

journal_title：Bone

authors： Tanaka M,Sakai A,Uchida S,Tanaka S,Nagashima M,Katayama T,Yamaguchi K,Nakamura T

更新日期：2004-06-01 00:00:00

abstract：:Eldecalcitol (ELD), an active form of vitamin D analog approved for the treatment of osteoporosis in Japan, increases lumbar spine bone mineral density (BMD), suppresses bone turnover markers, and reduces fracture risk in patients with osteoporosis. We have previously reported that treatment with ELD for 6 months impr...

journal_title：Bone

authors： Saito M,Grynpas MD,Burr DB,Allen MR,Smith SY,Doyle N,Amizuka N,Hasegawa T,Kida Y,Marumo K,Saito H

更新日期：2015-04-01 00:00:00

abstract：:Giant osteoclasts and other cells were isolated from Pagetic bone tissue using 0.5 mM ethylene diamine tetraacetic acid on bone samples from 8 patients with Paget's disease. The cell suspension contained osteoclasts and osteoblasts as well as some mononuclear cells such as monocytes. The number of nuclei in isolated o...

journal_title：Bone

authors： Basle MF,Mazaud P,Malkani K,Chretien MF,Moreau MF,Rebel A

更新日期：1988-01-01 00:00:00

abstract：:Recent studies have indicated a role for a MECOM allele in susceptibility to osteoporotic fractures in humans. We have generated a mutation in Mecom in mouse (termed ME(m1)) via lacZ knock-in into the upstream transcription start site for the gene, resulting in disruption of Mds1 and Mds1-Evi1 transcripts, but not of ...

journal_title：Bone

authors： Juneja SC,Vonica A,Zeiss C,Lezon-Geyda K,Yatsula B,Sell DR,Monnier VM,Lin S,Ardito T,Eyre D,Reynolds D,Yao Z,Awad HA,Yu H,Wilson M,Honnons S,Boyce BF,Xing L,Zhang Y,Perkins AS

更新日期：2014-03-01 00:00:00

abstract：:Skeletal problems and osteoporosis occur in up to 50% affected neurofibromatosis type 1 (NF1) humans. Inactivation of neurofibromin results in deregulation of Ras signal transduction. Little is known of bone biology in humans with NF1. The goal of our work was to determine if loss-of-function of Nf1 gene was associate...

journal_title：Bone

authors： Yu X,Chen S,Potter OL,Murthy SM,Li J,Pulcini JM,Ohashi N,Winata T,Everett ET,Ingram D,Clapp WD,Hock JM

更新日期：2005-05-01 00:00:00

abstract：:Bisphosphonate (BP)-related osteonecrosis of the jaw, previously known as BRONJ, now referred to more broadly as medication-related osteonecrosis of the jaw (MRONJ), is a morbid condition that represents a significant risk for oncology patients who have received high dose intravenous (IV) infusion of a potent nitrogen...

journal_title：Bone

authors： Hokugo A,Kanayama K,Sun S,Morinaga K,Sun Y,Wu Q,Sasaki H,Okawa H,Evans C,Ebetino FH,Lundy MW,Sadrerafi K,McKenna CE,Nishimura I

更新日期：2019-06-01 00:00:00

abstract：:Osteocytes are suggested to play a central role in bone remodeling. Evaluation of iliac crest biopsies is a standard procedure for evaluating bone conditions in the clinical setting. Despite the widespread use of such biopsies, little is known about the population of osteocytes in the iliac crest from normal individua...

journal_title：Bone

authors： Bach-Gansmo FL,Brüel A,Jensen MV,Ebbesen EN,Birkedal H,Thomsen JS

更新日期：2016-10-01 00:00:00

abstract：:A previously developed in vivo X-ray fluorescence (IVXRF) I-125 based system was used to measure bone strontium levels non-invasively in an osteoporotic female volunteer. The volunteer was recruited in December 2008, as part of the Ryerson and McMaster University Strontium in Bone Research Study and measured at twice ...

journal_title：Bone

authors： Moise H,Adachi JD,Chettle DR,Pejović-Milić A

更新日期：2012-07-01 00:00:00