Abstract：
:Recent studies have indicated a role for a MECOM allele in susceptibility to osteoporotic fractures in humans. We have generated a mutation in Mecom in mouse (termed ME(m1)) via lacZ knock-in into the upstream transcription start site for the gene, resulting in disruption of Mds1 and Mds1-Evi1 transcripts, but not of Evi1 transcripts. We demonstrate that ME(m1/m1) mice have severe kyphoscoliosis that is reminiscent of human congenital or primary kyphoscoliosis. ME(m1/m1) mice appear normal at birth, but by 2weeks, they exhibit a slight lumbar lordosis and narrowed intervertebral space. This progresses to severe lordosis with disc collapse and synostosis, together with kyphoscoliosis. Bone formation and strength testing show that ME(m1/m1) mice have normal bone formation and composition but are osteopenic. While endochondral bone development is normal, it is markedly dysplastic in its organization. Electron micrographs of the 1week postnatal intervertebral discs reveals marked disarray of collagen fibers, consistent with an inherent weakness in the non-osseous connective tissue associated with the spine. These findings indicate that lack of ME leads to a complex defect in both osseous and non-osseous musculoskeletal tissues, including a marked vertebral osteopenia, degeneration of the IVD, and disarray of connective tissues, which is likely due to an inherent inability to establish and/or maintain components of these tissues.
journal_name
Bonejournal_title
Boneauthors
Juneja SC,Vonica A,Zeiss C,Lezon-Geyda K,Yatsula B,Sell DR,Monnier VM,Lin S,Ardito T,Eyre D,Reynolds D,Yao Z,Awad HA,Yu H,Wilson M,Honnons S,Boyce BF,Xing L,Zhang Y,Perkins ASdoi
10.1016/j.bone.2013.11.020subject
Has Abstractpub_date
2014-03-01 00:00:00pages
148-61eissn
8756-3282issn
1873-2763pii
S8756-3282(13)00482-1journal_volume
60pub_type
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