Correlation of estradiol, parathyroid hormone, interleukin-6, and soluble interleukin-6 receptor during the normal menstrual cycle.

abstract：:Five strains of inbred mice were found to have variations in bone mass although they were similar in body weight. Two of these strains, C57BL/6J and A/J, were studied in greater detail and the former had more bone in both femur and tibia. The increased bone mass was associated with larger quadriceps muscles in the C57...

journal_title：Bone

authors： Kaye M,Kusy RP

更新日期：1995-08-01 00:00:00

abstract：:Bone morphogenetic protein 2 (BMP-2) is a member of the transforming growth factor-β superfamily, it is known to be a factor involved in skeletal development and capable of inducing in vitro osteogenic differentiation of mesenchymal stem cells (MSCs). Dental pulp stem cells (DPSCs) isolated from extracted third molar ...

journal_title：Bone

authors： Tóth F,Gáll JM,Tőzsér J,Hegedűs C

更新日期：2020-03-01 00:00:00

abstract：:Fibroblast growth factor 23 (FGF23) is a potent regulator of Pi and 1,25-(OH)(2)D homeostasis. Early postpartum infants show intriguing changes in serum levels of Ca, Pi, PTH and 1,25-(OH)(2)D. However, the role of FGF23 in the early neonatal mineral metabolism has not been clarified. In order to evaluate the signific...

journal_title：Bone

authors： Takaiwa M,Aya K,Miyai T,Hasegawa K,Yokoyama M,Kondo Y,Kodani N,Seino Y,Tanaka H,Morishima T

更新日期：2010-08-01 00:00:00

abstract：:The incidence of hip fractures in Oslo has shown a secular increase during the past decades. The main aims of the present study were to report the current incidence of hip fractures in Oslo and to determine whether there is a seasonal variation in the occurrence of fractures. Using the electronic diagnosis registers a...

journal_title：Bone

authors： Lofthus CM,Osnes EK,Falch JA,Kaastad TS,Kristiansen IS,Nordsletten L,Stensvold I,Meyer HE

更新日期：2001-11-01 00:00:00

abstract：:The ovariectomized (OVX) rat is a well established model for osteoporosis research. The recent development of in vivo micro-computed tomography (micro-CT) provides new possibilities to monitor individual bone changes over time. The purpose of this study was to establish the normal time course of bone loss in the OVX r...

journal_title：Bone

authors： Boyd SK,Davison P,Müller R,Gasser JA

更新日期：2006-10-01 00:00:00

abstract：:With the increased burden of low back pain (LBP) in our globally aging population there is a need to develop preclinical models of LBP that capture clinically relevant features of physiological aging, degeneration, and disability. Here we assess the validity of using a mouse model system for age-related LBP by charact...

journal_title：Bone

authors： Vincent K,Mohanty S,Pinelli R,Bonavita R,Pricop P,Albert TJ,Dahia CL

更新日期：2019-06-01 00:00:00

abstract：PURPOSE:Vertebral fractures are associated with persistent pain, disability and mortality. However, around two thirds of women with vertebral fractures are unaware of them. We aimed to analyze which factors could mostly be associated to the presence of vertebral fractures in post-menopausal women, and evaluate the effe...

journal_title：Bone

authors： Pizzato S,Trevisan C,Lucato P,Girotti G,Mazzochin M,Zanforlini BM,Bano G,Piovesan F,Bertocco A,Zoccarato F,Dianin M,Manzato E,Sergi G

更新日期：2018-08-01 00:00:00

abstract：:Osteoblasts are believed to differentiate into osteocytes, becoming embedded in bone, or to undergo apoptosis after the bone formation phase. The regulation of this terminal differentiation seems to be critical for bone homeostasis. However the mechanism remains unclear and there is no assay system currently available...

journal_title：Bone

authors： Uchihashi K,Aoki S,Matsunobu A,Toda S

更新日期：2013-01-01 00:00:00

abstract：:The enlargement of osteocyte lacunae via osteocytic osteolysis was previously detected in situations of increased calcium demand (e.g., lactation, vitamin D deficiency). However, it is unclear whether similar processes occur also in the growing infantile skeleton and how this is linked to the mineral distribution with...

journal_title：Bone

authors： Jandl NM,von Kroge S,Stürznickel J,Baranowsky A,Stockhausen KE,Mushumba H,Beil FT,Püschel K,Amling M,Rolvien T

更新日期：2020-06-01 00:00:00

abstract：:Regulation of calcium release from mouse calvariae by glycosaminoglycans and known modulators of bone resorption has been examined. Anticoagulant and nonanticoagulant fragments of heparin were combined with parathyroid hormone (PTH) and interleukin-1, beta (IL1), and calcium release from radiolabeled bone was determin...

journal_title：Bone

authors： Cochran DL,Abernathy CK

更新日期：1988-01-01 00:00:00

abstract：:In this study we describe the generation and influences on in vitro and in vivo osteogenesis of photo-cured hyaluronic acid (HA) hydrogels loaded with growth and differentiation factor 5 (GDF-5). Prior to loading GDF-5, we characterized the release profiles from these hydrogels and tested their respective cell viabili...

journal_title：Bone

authors： Bae MS,Ohe JY,Lee JB,Heo DN,Byun W,Bae H,Kwon YD,Kwon IK

更新日期：2014-02-01 00:00:00

abstract：:This study is designed to test how intermittent application of prostaglandin E2 (PGE2) and risedronate (Ris) alone or in combination acts on the cancellous bone mass in estrogen-deficient rats. Sprague-Dawley rats were ovariectomized (ovx) or sham-ovx'd at 6 months of age. PGE2 (6mg/kg/d), Ris (5 micrograms/kg/twice a...

journal_title：Bone

authors： Chen HK,Jee WS,Ma YF,Pan Z,McOsker JE,Li XJ

更新日期：1995-10-01 00:00:00

abstract：:Many osteoporotic fracture patients are candidates for concurrent treatment with bisphosphonates and bioceramic bone graft substitutes. Osteopromotive silica-based bioactive glasses are known to induce accelerated local bone turnover and adjunct antiresorptive agents, such as zoledronic acid, may affect the process. T...

journal_title：Bone

authors： Välimäki VV,Moritz N,Yrjans JJ,Vuorio E,Aro HT

更新日期：2006-03-01 00:00:00

abstract：:The purpose of this study is twofold: (a) to investigate the application of transosseous low-intensity pulsed ultrasound (LiUS) on the enhancement of fracture healing and (b) to demonstrate the ability of transosseous ultrasound propagation to monitor the healing process. A midshaft tibial osteotomy model was used on ...

journal_title：Bone

authors： Malizos KN,Papachristos AA,Protopappas VC,Fotiadis DI

更新日期：2006-04-01 00:00:00

abstract：:Trabecular bone fracture represents a major health problem, therefore the improvement of its assessment is mandatory for the reduction of the economic and social burden. The micro-structure of the trabecular bone was found to have an important effect on trabecular mechanical behavior. Nonetheless, the high variability...

journal_title：Bone

authors： Tassani S,Matsopoulos GK

更新日期：2014-03-01 00:00:00

abstract：:The rat model has previously been used to test the effect of ovariectomy and of PTH administration on vertebral bone mass, size, and biomechanical competence. In this study, we used the same "biomechanical rat model" to assess the effect of long-term exercise on vertebral bone mass and quality and also on femoral bone...

journal_title：Bone

authors： Mosekilde L,Danielsen CC,Søgaard CH,Thorling E

更新日期：1994-05-01 00:00:00

abstract：:The use of combined antiretroviral agents during pregnancy is important to prevent mother-to-child transmission of human immunodeficiency virus (HIV). Antiretroviral treatment (ARV) is associated with reduced bone mass and altered bone metabolism in HIV-infected patients. There are no data regarding the effect of ARV ...

journal_title：Bone

authors： Mora S,Giacomet V,Viganò A,Cafarelli L,Stucchi S,Pivetti V,Manfredini V,Puzzovio M,Zuccotti G

更新日期：2012-01-01 00:00:00

abstract：:Hypophosphatasia (HPP) is caused by loss-of-function mutation(s) within the gene TNSALP that encodes the "tissue-nonspecific" isoenzyme of alkaline phosphatase (TNSALP). In HPP, inorganic pyrophosphate, an inhibitor of mineralization and substrate for TNSALP, accumulates extracellularly often leading to rickets or ost...

journal_title：Bone

authors： Whyte MP,Zhang F,Wenkert D,McAlister WH,Mack KE,Benigno MC,Coburn SP,Wagy S,Griffin DM,Ericson KL,Mumm S

更新日期：2015-06-01 00:00:00

abstract：:Bone sialoprotein (BSP) is highly expressed in early bone deposition and may play a part in primary bone mineralization. We previously showed that while BSP−/− mice have a mild secondary bone phenotype and are responsive to mechanical (unloading) and hormonal (ovariectomy, parathyroid hormone (PTH)) challenges, repair...

journal_title：Bone

authors： Wade-Gueye NM,Boudiffa M,Vanden-Bossche A,Laroche N,Aubin JE,Vico L,Lafage-Proust MH,Malaval L

更新日期：2012-05-01 00:00:00

abstract：:Immobilization leads to rapid loss of bone mass and mechanical competence, and long-term immobilization or repeated periods of short-term immobilization can have serious skeletal consequences and may lead to increased fracture liability. The aim of the present preclinical study was, therefore, to assess whether two an...

journal_title：Bone

authors： Mosekilde L,Thomsen JS,Mackey MS,Phipps RJ

更新日期：2000-11-01 00:00:00

abstract：OBJECTIVE:To test the hypothesis that low birth weight twins have a higher risk of osteoportotic fracture in later life, we investigated the association between fetal IGF axis and type-1 collagen markers of bone turnover in monochorionic (MC) twins with or without discordant birth weight of >or=20%. METHODS:Maternal a...

journal_title：Bone

authors： Bajoria R,Sooranna SR,Ward S,Chatterjee R

更新日期：2006-06-01 00:00:00

abstract：:We examined the mode of action of bisphosphonates on osteoclastic cell recruitment using mouse marrow cultures with or without osteoblastic cells. Tartrate-resistant acid phosphatase-positive multinucleated cells [TRAP(+)MNC] formed in cultures were determined to be osteoclastic cells. In marrow cultures, TRAP(+) MNC ...

journal_title：Bone

authors： Nishikawa M,Akatsu T,Katayama Y,Yasutomo Y,Kado S,Kugal N,Yamamoto M,Nagata N

更新日期：1996-01-01 00:00:00

abstract：:A sandwich enzyme-linked immunosorbent assay (ELISA) for quantification of the N-terminal propeptide of human procollagen type I (PINP) utilizing purified alpha 1-chain specific rabbit antibodies is described. The ELISA measured the content of the alpha 1-chain of PINP independent of the molecular form of the molecule...

journal_title：Bone

authors： Orum O,Hansen M,Jensen CH,Sørensen HA,Jensen LB,Hørslev-Petersen K,Teisner B

更新日期：1996-08-01 00:00:00

abstract：:We previously reported that a type II sodium phosphate (Na(+)-Pi) cotransporter (Npt2) protein is expressed in osteoclasts and that Pi limitation decreases osteoclast-mediated bone resorption in vitro. We also demonstrated that mice homozygous for the disrupted Npt2 gene (Npt2-/-) exhibit a unique age-dependent bone p...

journal_title：Bone

authors： Gupta A,Tenenhouse HS,Hoag HM,Wang D,Khadeer MA,Namba N,Feng X,Hruska KA

更新日期：2001-11-01 00:00:00

abstract：:Bisphosphonates are widely used to treat children with osteogenesis imperfecta (OI), a bone fragility disorder that is most often caused by mutations in COL1A1 or COL1A2. However, it is unclear whether this treatment decreases the risk of developing scoliosis. We retrospectively evaluated spine radiographs and charts ...

journal_title：Bone

authors： Sato A,Ouellet J,Muneta T,Glorieux FH,Rauch F

更新日期：2016-05-01 00:00:00

abstract：:Bisphosphonates are a unique class of drugs. As a family, they are characterized pharmacologically by their ability to inhibit bone resorption, whereas, pharmacokinetically, they are classified by their similarity in absorption, distribution, and elimination. Although all bisphosphonates have similar physicochemical p...

journal_title：Bone

authors： Lin JH

更新日期：1996-02-01 00:00:00

abstract：BACKGROUND:Genesis of a cartilaginous scaffold is an obligate precursor to bone formation in heterotopic endochondral ossification (HEO). We tested the hypothesis that cartilage-derived retinoic acid-sensitive protein (CD-RAP) can serve as a plasma biomarker for the pre-osseous cartilaginous stage of HEO. Palovarotene,...

journal_title：Bone

authors： Lindborg CM,Brennan TA,Wang H,Kaplan FS,Pignolo RJ

更新日期：2018-04-01 00:00:00

abstract：:The tooth root is essential for normal tooth physiological function. Studies on mice with mutations or targeted gene deletions revealed that osteoclasts (OCs) play an important role in tooth root development. However, knowledge on the cellular and molecular mechanism underlying how OCs mediate root formation is limite...

journal_title：Bone

authors： Huang H,Wang J,Zhang Y,Zhu G,Li YP,Ping J,Chen W

更新日期：2018-09-01 00:00:00

abstract：:Bisphosphonates (BPs), bone targeted drugs that disrupt osteoclast function, are routinely used to treat complications of bone metastasis. Studies in preclinical models of cancer have shown that BPs reduce skeletal tumor burden and increase survival. Similarly, we observed in the present study that administration of t...

journal_title：Bone

authors： Hirbe AC,Roelofs AJ,Floyd DH,Deng H,Becker SN,Lanigan LG,Apicelli AJ,Xu Z,Prior JL,Eagleton MC,Piwnica-Worms D,Rogers MJ,Weilbaecher K

更新日期：2009-05-01 00:00:00

abstract：:Bone morphogenetic proteins (BMPs) were first described over 50 years ago as potent inducers of ectopic bone formation when administrated subcutaneously. Preclinical studies have extensively examined the osteoinductive properties of BMPs in vitro and new bone formation in vivo. BMPs (BMP-2, BMP-7) have been used in or...

journal_title：Bone

authors： Kamiya N,Atsawasuwan P,Joiner DM,Waldorff EI,Goldstein S,Yamauchi M,Mishina Y

更新日期：2020-09-01 00:00:00