Effect of inducible bone morphogenetic protein 2 expression on the osteogenic differentiation of dental pulp stem cells in vitro.

abstract：:In this study we investigate bone metabolism in patients with rheumatoid arthritis (RA), with or without joint destruction, using serum biochemical markers of bone turnover. Three hundred eighteen patients (disease duration >2 years; mean 9 years) were divided into those with joint destruction, that is, with Larsen wr...

journal_title：Bone

authors： Garnero P,Jouvenne P,Buchs N,Delmas PD,Miossec P

更新日期：1999-04-01 00:00:00

abstract：PURPOSE:Low trauma rib fracture (hereinafter, rib fracture) is common in the elderly, but its risk factors and mortality consequence are rarely studied. We sought to define the epidemiology of rib fracture and the association between rib fracture and postfracture mortality. METHODS:The study was part of the Dubbo Oste...

journal_title：Bone

authors： Mai HT,Tran TS,Ho-Le TP,Pham TT,Center JR,Eisman JA,Nguyen TV

更新日期：2018-11-01 00:00:00

abstract：:Liver X receptors (LXRs) are nuclear receptors that play a crucial role in the transcriptional control of lipid metabolism. Pharmacological LXR activation is an attractive concept for the treatment of atherosclerosis. Genetic LXR deficiency in mice has been shown to have an effect on bone turnover and structure and LX...

journal_title：Bone

authors： Prawitt J,Beil FT,Marshall RP,Bartelt A,Ruether W,Heeren J,Amling M,Staels B,Niemeier A

更新日期：2011-02-01 00:00:00

abstract：:In order to delineate the influence of mechanical unloading on the formation and resorption of trabecular and cortical bone, the effects of mechanical unloading on the volume, structure, and turnover of hindlimbs were examined using tail-suspended rapidly growing rats. In addition, to clarify the mechanism of how mech...

journal_title：Bone

authors： Matsumoto T,Nakayama K,Kodama Y,Fuse H,Nakamura T,Fukumoto S

更新日期：1998-05-01 00:00:00

abstract：:Amelogenin is the major enamel protein produced by ameloblasts. Its expression has been shown to be down-regulated in ameloblasts of vitamin-D-deficient (-D) rats. The potential expression and localization of amelogenin in odontoblasts and its regulation by vitamin D were investigated in this study. RT-PCR and semi-qu...

journal_title：Bone

authors： Papagerakis P,MacDougall M,Hotton D,Bailleul-Forestier I,Oboeuf M,Berdal A

更新日期：2003-03-01 00:00:00

abstract：:Peripheral quantitative computed tomography (pQCT) captures novel aspects of bone geometry that may contribute to fracture risk and offers the ability to measure both volumetric bone mineral density (vBMD) and a separation of trabecular and cortical compartments of bone, but longitudinal data relating measures obtaine...

journal_title：Bone

authors： Dennison EM,Jameson KA,Edwards MH,Denison HJ,Aihie Sayer A,Cooper C

更新日期：2014-07-01 00:00:00

abstract：:Recent studies have shown that treatment with bisphosphonates could be effective against the myelomatous skeletal deterioration. However, the mechanisms of action of these drugs in multiple myeloma (MM) have been poorly studied. In the present study, 11 patients with MM and bone lesions were treated orally with 30 mg/...

journal_title：Bone

authors： Roux C,Ravaud P,Cohen-Solal M,de Vernejoul MC,Guillemant S,Cherruau B,Delmas P,Dougados M,Amor B

更新日期：1994-01-01 00:00:00

abstract：:Glucocorticoids have marked effects on bone metabolism, and continued exposure of skeletal tissue to excessive amounts of these steroids results in osteoporosis. Therefore, in the present proteomic study, we characterized the potential effects of glucocorticoids on protein expression in human osteoblastic cells. Using...

journal_title：Bone

authors： Olkku A,Bodine PV,Linnala-Kankkunen A,Mahonen A

更新日期：2004-02-01 00:00:00

abstract：:Fatigue behavior of compact bone at physiological strain ranges was examined in vitro. Standardized specimens of bovine compact bone were cyclically loaded in uniaxial tension of 0-1200 or 0-1500 microstrain for up to 13-37 million cycles to study the long-term fatigue properties. All specimens exhibited fatigue durin...

journal_title：Bone

authors： Schaffler MB,Radin EL,Burr DB

更新日期：1990-01-01 00:00:00

abstract：:Bisphosphonates are a unique class of drugs. As a family, they are characterized pharmacologically by their ability to inhibit bone resorption, whereas, pharmacokinetically, they are classified by their similarity in absorption, distribution, and elimination. Although all bisphosphonates have similar physicochemical p...

journal_title：Bone

authors： Lin JH

更新日期：1996-02-01 00:00:00

abstract：:Bone morphogenetic protein 2 (BMP-2) is a secreted signaling molecule that acts as an inducer of bone formation and a regulator of embryonic development. The objectives of this work were as follows: (1) to clone the full-length cDNA of BMP-2 in a marine fish model, (2) analyze its gene expression during development, i...

journal_title：Bone

authors： Rafael MS,Laizé V,Cancela ML

更新日期：2006-12-01 00:00:00

abstract：:Osteocytes are suggested to play a central role in bone remodeling. Evaluation of iliac crest biopsies is a standard procedure for evaluating bone conditions in the clinical setting. Despite the widespread use of such biopsies, little is known about the population of osteocytes in the iliac crest from normal individua...

journal_title：Bone

authors： Bach-Gansmo FL,Brüel A,Jensen MV,Ebbesen EN,Birkedal H,Thomsen JS

更新日期：2016-10-01 00:00:00

abstract：:Tight interactions among different cell types contributing to bone formation are of key importance in the maintenance of bone homeostasis. Based on the high similarity in responses to (anti)osteogenic signals between zebrafish scales and mammalian bone, we developed and validated a model to screen large numbers of com...

journal_title：Bone

authors： de Vrieze E,Zethof J,Schulte-Merker S,Flik G,Metz JR

更新日期：2015-05-01 00:00:00

abstract：:Fracture healing is a regenerative process in which bone is restored without scar tissue formation. The healing cascade initiates with a cycle of inflammation, cell migration, proliferation and differentiation. Immune cells invade the fracture site immediately upon bone damage and contribute to the initial phase of th...

journal_title：Bone

authors： Könnecke I,Serra A,El Khassawna T,Schlundt C,Schell H,Hauser A,Ellinghaus A,Volk HD,Radbruch A,Duda GN,Schmidt-Bleek K

更新日期：2014-07-01 00:00:00

abstract：:Low-intensity pulsed ultrasound (LIPUS) has been used to accelerate bone fracture healing. However, the issue whether LIPUS is effective in preventing osteoporosis has not been clarified, and if so, what possible mechanisms might be responsible. Myostatin (MSTN) is a negative regulator of muscle growth, and its absenc...

journal_title：Bone

authors： Tang L,An S,Zhang Z,Fan X,Guo J,Sun L,Ta D

更新日期：2021-02-01 00:00:00

abstract：:Endoplasmic reticulum (ER) stress is associated with increased reactive oxygen species (ROS), results from accumulation of misfolded/unfolded proteins, and can trigger apoptosis. ER stress is alleviated by phosphorylation of eukaryotic translation initiation factor 2α (eIF2α), which inhibits protein translation allowi...

journal_title：Bone

authors： Sato AY,Tu X,McAndrews KA,Plotkin LI,Bellido T

更新日期：2015-04-01 00:00:00

abstract：:Within-bone variation in mineral density could be functional. A heterogeneous mineral-density distribution might serve to maintain habitual amplitudes of bone strain within a non-harmful, i.e., physiological range. Regions of a bone that would be strained the most on the basis of architecture alone might have a higher...

journal_title：Bone

authors： de Jong WC,van Ruijven LJ,Brugman P,Langenbach GE

更新日期：2013-08-01 00:00:00

abstract：:CCN2/connective tissue growth factor (CCN2/CTGF) is known to promote both the proliferation and differentiation of chondrocytes, which actions are mediated by ERK and p38 MAPK, respectively. In this study, we first re-evaluated the involvement of multiple MAPKs therein and found that JNK also mediated such CCN2 signal...

journal_title：Bone

authors： Yosimichi G,Kubota S,Nishida T,Kondo S,Yanagita T,Nakao K,Takano-Yamamoto T,Takigawa M

更新日期：2006-06-01 00:00:00

abstract：:Cancellous microanatomy, bone remodelling, and hematopoietic tissue were studied in iliac crest and femoral neck biopsies taken intraoperatively in 102 consecutive patients with displaced intracapsular fractures. About half of the femoral biopsies had osteopenia, and most showed replacement of hematopoietic tissue by ...

journal_title：Bone

authors： Eventov I,Frisch B,Cohen Z,Hammel I

更新日期：1991-01-01 00:00:00

abstract：:It is well-known that pathways normally functioning during embryonic development are dysregulated in cancer. Experimental and clinical studies have established strong connections between aberrant developmental pathways and transformation, as well as other early stage events of cancer progression. There is now emerging...

journal_title：Bone

authors： Sethi N,Kang Y

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND AND AIM:Bone mineral density (BMD) is under strong genetic regulation, but it is not clear which genes are involved in the regulation, particularly in Asian populations. This study sought to determine the association between 29 genes discovered by Caucasian-based genome-wide association studies and BMD in a ...

journal_title：Bone

authors： Ho-Pham LT,Nguyen SC,Tran B,Nguyen TV

更新日期：2015-07-01 00:00:00

abstract：:A set of key developmental genes is essential for skeletal growth from multipotent progenitor cells at weaning. Polycomb group proteins, which regulate such genes contributes to the cell lineage commitment and subsequent differentiation via epigenetic chromatin modification and remodeling. However, it is unclear which...

journal_title：Bone

authors： Katoh-Fukui Y,Baba T,Sato T,Otake H,Nagakui-Noguchi Y,Shindo M,Suyama M,Ohkawa Y,Tsumura H,Morohashi KI,Fukami M

更新日期：2019-03-01 00:00:00

abstract：:Although ovariectomized cynomolgus monkeys are used extensively for studies examining perimenopausal changes in the skeleton, very little is known about the changes that occur naturally during growth and aging in these animals. To evaluate the changes in bone during growth and aging in female cynomolgus monkeys, 29 mo...

journal_title：Bone

authors： Lees CJ,Ramsay H

更新日期：1999-01-01 00:00:00

abstract：:Weekly administration of teriparatide has been shown to reduce the risk of vertebral and non-vertebral fractures in patients with osteoporosis at higher fracture risk in Japan. However, its efficacy for hip fracture has not been established. To gain insight into the effect of weekly teriparatide on the hip, hip struct...

journal_title：Bone

authors： Sone T,Ito M,Fukunaga M,Tomomitsu T,Sugimoto T,Shiraki M,Yoshimura T,Nakamura T

更新日期：2014-07-01 00:00:00

abstract：:The relationships of bone size, bone strength, and bone formation were investigated in two strains of mice, NZB/B1NJ and RF/J. Measurement of the femur midshaft size by peripheral quantitative computed tomography (pQCT) showed that the RF/J mice had a 32% greater cross-sectional area than NZB/B1NJ mice at 10 weeks of ...

journal_title：Bone

authors： Wergedal JE,Sheng MH,Ackert-Bicknell CL,Beamer WG,Baylink DJ

更新日期：2002-12-01 00:00:00

abstract：:The responses of bone cells to skeletal loading are clearly an important factor in bone biology, but much remains to be learned about the role of these responses in skeletal development, maintenance, and tissue repair. Bone morphogenetic proteins (BMPs) are key regulators of bone formation. We examined the effect of B...

journal_title：Bone

authors： Cheline AJ,Reddi AH,Martin RB

更新日期：2002-11-01 00:00:00

abstract：:Juvenile Paget's disease (JPD) is a rare condition with an autosomal recessive mode of inheritance. Typically presenting in infancy or early childhood, the disorder is characterized by a generalized widening of the long bones and thickening of the skull combined with sustained elevation of serum alkaline phosphatase l...

journal_title：Bone

authors： Janssens K,de Vernejoul MC,de Freitas F,Vanhoenacker F,Van Hul W

更新日期：2005-03-01 00:00:00

abstract：:Pseudoachondroplasia (PSACH), a severe short-limbed dwarfing condition, is associated with life-long joint pain and early onset osteoarthritis. PSACH is caused by mutations in cartilage oligomeric matrix protein (COMP), a pentameric matricellular protein expressed primarily in cartilage and other musculoskeletal tissu...

journal_title：Bone

authors： Posey KL,Hecht JT

更新日期：2017-09-01 00:00:00

abstract：:New methods to increase vertical bone growth are needed to permit dental implant placement in patients with low alveolar ridge height after extended periods of tooth loss. While ectopic rodent models are typically used to evaluate new osteogenic implant surface coatings, a more relevant intramembraneous rodent model w...

journal_title：Bone

authors： Freilich M,M Patel C,Wei M,Shafer D,Schleier P,Hortschansky P,Kompali R,Kuhn L

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND:Vertebral fracture (VF) is the most common osteoporotic fracture in postmenopausal women, although most VFs are subclinical. Prevalent VFs are a significant predictor of subsequent fracture and therefore, identification of VF improves the identification of those with high fracture risk. The aim of present st...

journal_title：Bone

authors： Yang J,Mao Y,Nieves JW

更新日期：2020-07-01 00:00:00