Abstract：
:Fatigue behavior of compact bone at physiological strain ranges was examined in vitro. Standardized specimens of bovine compact bone were cyclically loaded in uniaxial tension of 0-1200 or 0-1500 microstrain for up to 13-37 million cycles to study the long-term fatigue properties. All specimens exhibited fatigue during the first several million cycles of loading, evidenced by a gradual decrease of specimen modulus during this initial loading period; mean modulus loss for all specimens was approximately 6%. After this initial stiffness loss, specimen modulus stabilized and did not change again for the duration of the loading. Osteonal bone specimens lost significantly more stiffness than primary bone specimens during the early loading history, but neither microstructural type progressed to fatigue failure. These data suggest that some fatigue of compact bone is a realistic expectation of the normal loading environment, but this fatigue does not progress to fatigue failure within a physiologically reasonable number of cycles when tested in vitro at strain magnitudes like those measured in living animals. Implications for fatigue/stress fractures in vivo are discussed.
journal_name
Bonejournal_title
Boneauthors
Schaffler MB,Radin EL,Burr DBdoi
10.1016/8756-3282(90)90087-fsubject
Has Abstractpub_date
1990-01-01 00:00:00pages
321-6issue
5eissn
8756-3282issn
1873-2763pii
8756-3282(90)90087-Fjournal_volume
11pub_type
杂志文章相关文献
BONE文献大全abstract：:This paper describes a new alternative for individualized mechanical analysis of bone trabecular structure. This new method closes the gap between the classic homogenization approach that is applied to macro-scale models and the modern micro-finite element method that is applied directly to micro-scale high-resolution...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2010.12.022
更新日期：2011-04-01 00:00:00
abstract：BACKGROUND:Specific physical loading leads to enhanced bone development during childhood. A general physical activity program mimicking a real-life situation was successful at increasing general physical health in children. Yet, it is not clear whether it can equally increase bone mineral mass. We performed a cluster-r...
journal_title：Bone
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.bone.2010.11.018
更新日期：2011-04-01 00:00:00
abstract：:Several animal studies have showed that gelatin may be effective for minimizing bone loss in OVX rats with established osteopenia. To gain insight into how cod bone gelatin administration affects bone loss after ovariectomy, studies were carried out focusing on bone quality and the molecular mechanisms. Eighty-four fe...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2008.12.005
更新日期：2009-05-01 00:00:00
abstract：:Increases in local and systemic bone resorption are hallmarks of rheumatoid arthritis (RA). Osteoclasts are implicated in these processes and their enhanced differentiation may contribute to bone destruction. We observed that in vitro osteoclastogenesis varies among healthy individuals and hypothesized that increased ...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2010.10.167
更新日期：2011-03-01 00:00:00
abstract：:Fibroblast growth factor 23 (FGF23) is a potent regulator of Pi and 1,25-(OH)(2)D homeostasis. Early postpartum infants show intriguing changes in serum levels of Ca, Pi, PTH and 1,25-(OH)(2)D. However, the role of FGF23 in the early neonatal mineral metabolism has not been clarified. In order to evaluate the signific...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2010.05.024
更新日期：2010-08-01 00:00:00
abstract：:The Wnt/β-catenin signaling pathway plays an essential role in osteoblast biology. Sclerostin is a soluble antagonist of Wnt/β-catenin signaling secreted primarily by osteocytes. Current evidence indicates that sclerostin likely functions as a local/paracrine regulator of bone metabolism rather than as an endocrine ho...
journal_title：Bone
pub_type： 杂志文章,评审
doi：10.1016/j.bone.2016.12.004
更新日期：2017-03-01 00:00:00
abstract：:Depending on populations, 15 to 40% of patients have a familial form of Paget's disease of bone (PDB), which is transmitted in an autosomal-dominant mode of inheritance with incomplete penetrance. To date, only SQSTM1 gene mutations have been linked to the disease. Several single nucleotide polymorphisms (SNPs) have b...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2016.01.007
更新日期：2016-03-01 00:00:00
abstract：:Peak bone mass (PBM) is an important determinant of osteoporosis. Circulating monocytes serve as early progenitors of osteoclasts and produce important molecules for bone metabolism. To search for genes functionally important for PBM variation, we performed a whole genome gene differential expression study of circulat...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2008.05.016
更新日期：2009-05-01 00:00:00
abstract：:We have recently cloned cathepsin K from a human bone cDNA library. Since cathepsins are proposed to be involved in the degradation of mineralized bone matrix, we have investigated, by in situ hybridization and immunocytochemistry, the expression of the cathepsin K mRNA transcripts and protein in sections of bone and ...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/s8756-3282(96)00351-1
更新日期：1997-02-01 00:00:00
abstract：:We have tested the ability of the XCT960A to detect bone loss in OVX-rats, as well as bone gain in the proximal tibial metaphysis of healthy rats treated with hPTH(1-34). The results demonstrated that high precision can be achieved, with CV's for most measurement parameters in the range of 1.6 to 5.9% being obtained i...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/8756-3282(95)00287-n
更新日期：1995-10-01 00:00:00
abstract：:Conventional methods used to image and quantify microdamage accumulation in bone are limited to histological sections, which are inherently invasive, destructive, two-dimensional, and tedious. These limitations inhibit investigation of microdamage accumulation with respect to volumetric spatial variation in mechanical...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2010.10.160
更新日期：2011-03-01 00:00:00
abstract：:The long-term protective effect of stronger back muscles on the spine was determined in 50 healthy white postmenopausal women, aged 58-75 years, 8 years after they had completed a 2 year randomized, controlled trial. Twenty-seven subjects had performed progressive, resistive back-strengthening exercises for 2 years an...
journal_title：Bone
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s8756-3282(02)00739-1
更新日期：2002-06-01 00:00:00
abstract：:Osteocyte apoptosis precedes osteoclast resorption, and may act as a critical signal to trigger bone remodeling. While osteoclast precursors are known to travel via the circulation, the specific mechanisms by which they accumulate at remodeling sites are unclear. We hypothesized that osteocyte apoptosis mediates osteo...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2011.09.052
更新日期：2012-01-01 00:00:00
abstract：:Glucocorticoids (GC) are used for the treatment of a wide spectrum of diseases because of their potent anti-inflammatory and immunosuppressive effects, and they are serious and common causes of secondary osteoporosis. Administration of intermittent parathyroid hormone (PTH) may induce formation of new bone and may cou...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2006.01.142
更新日期：2006-08-01 00:00:00
abstract：:The role of vitamin D receptor (VDR) gene polymorphisms in the determination of bone mass and bone turnover is controversial in women. The aim of the study was to determine whether VDR polymorphisms are associated with indices of bone mineral density (BMD) (by dual-energy X-ray absorptiometry and by ultrasound) and/or...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/s8756-3282(02)00867-0
更新日期：2002-11-01 00:00:00
abstract：OBJECTIVES:This study aimed to evaluate the involvement of Angiotensin II (Ang II) in joint lesions associated with osteoarthritis (OA) in vitro and in vivo. METHODS:Chondrocyte cultures were obtained from knee joints of neonatal rats and stimulated with Ang II/MIA/ACE inhibitors. In vivo, rats treated or not with the...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2021.115842
更新日期：2021-01-07 00:00:00
abstract：BACKGROUND AND AIM:The safety of bisphosphonates in human pregnancy has not been well established. To characterize pregnancy outcome in women receiving bisphosphonates, we conducted a multi-centre, prospective cohort study with a comparison group. METHODS:Patients were recruited through 3 teratogen information centres...
journal_title：Bone
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1016/j.bone.2008.11.001
更新日期：2009-03-01 00:00:00
abstract：:The formation of cartilage prior to bone in an endochondral bone formation process suggests that some osteogenic factors exist in the cartilage. This osteogenic activity of cartilage or cartilage cells was examined by implanting ribs and costal cartilage zone into a subcutaneous pocket of abdominal wall, or the growth...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/8756-3282(92)90455-6
更新日期：1992-01-01 00:00:00
abstract：:SAM-P/6 is a recently developed strain of osteoporotic mice. In this study we tried to determine whether calcium, vitamin D3, parathyroid hormone (PTH), and estrogen modified the peak bone mass of young SAM-P/6 mice, and whether the effect of these medications persisted after treatment had been discontinued. Calcium s...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/8756-3282(94)90710-2
更新日期：1994-03-01 00:00:00
abstract：:Regulation of calcium release from mouse calvariae by glycosaminoglycans and known modulators of bone resorption has been examined. Anticoagulant and nonanticoagulant fragments of heparin were combined with parathyroid hormone (PTH) and interleukin-1, beta (IL1), and calcium release from radiolabeled bone was determin...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/8756-3282(88)90018-x
更新日期：1988-01-01 00:00:00
abstract：:Matrix extracellular phosphoglycoprotein (MEPE) is an extracellular matrix protein that was first detected in tumor-induced osteomalacia (TIO). Investigations in mice revealed that MEPE is expressed in bone and teeth in a maturation-dependent manner, reaching its maximum during mineralization. However, from knockout e...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2004.03.033
更新日期：2004-08-01 00:00:00
abstract：PURPOSE:Bone acquisition in childhood impacts adult bone mass, and can be influenced by childhood socioeconomic conditions. Socioeconomic status is also associated with body weight which affects the load that bone is exposed to in a fall. We hypothesized that socioeconomic advantage in childhood is associated with grea...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2013.06.021
更新日期：2013-10-01 00:00:00
abstract：:Profound bone loss at weight bearing sites is a primary effect of long-duration spaceflight. Moreover, a significant increase in estimated fracture risk remains even 1 year after returning to Earth; hence, it is important to define how quickly bone integrity can recover following prolonged disuse. This study character...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2012.09.021
更新日期：2013-01-01 00:00:00
abstract：:High-resolution peripheral quantitative computed tomography (HR-pQCT) is clinically available today and provides a non-invasive measure of 3D bone geometry and micro-architecture with unprecedented detail. In combination with microarchitectural finite element (μFE) models it can be used to determine bone strength usin...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2011.02.022
更新日期：2011-06-01 00:00:00
abstract：:High fat diets can have detrimental effects on the skeleton as well as cause intestinal dysbiosis. Exercise prevents high fat (HF) diet-induced obesity and also improves bone density and prevents the intestinal dysbiosis that promotes energy storage. Previous studies indicate a link between intestinal microbial balanc...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2018.03.024
更新日期：2019-01-01 00:00:00
abstract：:Mandibuloacral dysplasia (MAD) is a rare recessively inherited premature aging disease characterized by skeletal and metabolic anomalies. It is part of the spectrum of diseases called laminopathies and results from mutations in genes regulating the synthesis of the nuclear laminar protein, lamin A. Homozygous or compo...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2010.06.004
更新日期：2010-09-01 00:00:00
abstract：:We have previously found BMD and fracture risk to be significantly associated with the MTHFR (C677T) polymorphism in healthy postmenopausal women in the first years after menopause. Since then, other cohort studies have suggested that sufficient intake of riboflavin and/or folate may have the potential to prevent deve...
journal_title：Bone
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1016/j.bone.2004.12.014
更新日期：2005-03-01 00:00:00
abstract：:Rough-surfaced substrates made by a variety of methods have been shown to influence osteoblast proliferation and differentiation. The purpose of this study is to confirm the role of surface roughness in promoting osteoblastic differentiation using tissue culture polystyrene as substrate, by excluding factors other tha...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/s8756-3282(99)00192-1
更新日期：1999-10-01 00:00:00
abstract：:This study investigated the possible role in vitro of insulin-like growth factor I (IGF-I) as a mediator of the effects of growth hormone (GH) on osteoclastic resorption in an unfractioned rabbit bone cell model. After 4 days of rabbit bone cell culture, human GH (hGH) (50 ng/mL) and human IGF-I (hIGF-I) (50 ng/mL) si...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/s8756-3282(97)00224-x
更新日期：1998-01-01 00:00:00
abstract：:The prediction of bone strength can be improved when determining bone mineral density (BMD) in combination with measures of trabecular microarchitecture. The goal of this study was to assess parameters of trabecular bone structure and texture of the calcaneus by clinical multi-detector row computed tomography (MDCT) i...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2009.01.372
更新日期：2009-05-01 00:00:00
