Abstract:
:Several animal studies have showed that gelatin may be effective for minimizing bone loss in OVX rats with established osteopenia. To gain insight into how cod bone gelatin administration affects bone loss after ovariectomy, studies were carried out focusing on bone quality and the molecular mechanisms. Eighty-four female rats were ovariectomized, 12 sham-operated, divided into six groups of 12 each and treated one week after ovariectomy either with vehicle or cod bone gelatin (0.375, 0.75, 1.5, 3, 6 mg/kg body weight) for 90 days. Bone densitometry, microCT analysis, real-time PCR analysis and biochemical analysis were used at the end of the study. After 90 days, BMD of proximal tibia and femoral neck decreased in OVX rats, whereas the loss of BMD in those regions was prevented at 3 g/kg (P<0.05). However, the BMD of midshaft femurs showed no significant differences. BV/TV, Tb.N. and Tb.Th. in the 3 g/kg group were, respectively, 30.4% (P<0.05), 145.5% (P<0.05) and 81.5% (P<0.05) higher than in the OVX group. A significant decrease was detected in urine CTX, NTX and DPD, suggesting decreased bone resorption. Treatment with 3 g/kg and 6 g/kg cod bone gelatin attenuated the increase in serum IL-1beta, IL-6 and TNF-alpha observed in the OVX group. Real-time PCR showed significantly decreased levels of mRNA expression for RANKL at the dosage of 6 g/kg and the RANKL/OPG mRNA ratio in the 3 g/kg and 6 g/kg group significantly decreased compared to the OVX group (P<0.05). In conclusion, our data confirmed that the cod bone gelatin treatment at 3 g/kg is effective in the prevention of estrogen deficient bone loss by modulating the expression of RANKL and OPG and suppressing the release of proinflammatory cytokines.
journal_name
Bonejournal_title
Boneauthors
Han X,Xu Y,Wang J,Pei X,Yang R,Li N,Li Ydoi
10.1016/j.bone.2008.12.005subject
Has Abstractpub_date
2009-05-01 00:00:00pages
942-7issue
5eissn
8756-3282issn
1873-2763pii
S8756-3282(08)00954-Xjournal_volume
44pub_type
杂志文章相关文献
BONE文献大全abstract::The transcription factor nuclear factor E2 p45-related factor 2 (Nrf2) forms heterodimers with small musculoaponeurotic fibrosarcoma (Maf) proteins for the selective recognition of the antioxidant responsive element on target genes, followed by the regulation of gene expression of phase II detoxifying enzymes as well ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2006.08.016
更新日期:2007-02-01 00:00:00
abstract::Osteocalcin, the gamma-carboxyglutamic acid-containing protein, which in most species is the predominant noncollagenous protein of bone and dentin, has been postulated to play roles in bone formation and remodeling. Recently, genetic studies showed that osteocalcin acts as an inhibitor of osteoblast function. Based on...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(98)00092-1
更新日期:1998-09-01 00:00:00
abstract::Due to the increasing number of osteoporotic fractures of hip, spine, and wrist there is a growing need for methods to track down the subjects with inferior bone structure and to monitor the effects of therapeutic measures. This study aims at a noninvasive diagnostic tool, deriving architectural properties of trabecul...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(97)00233-0
更新日期:1998-02-01 00:00:00
abstract::The R51Q mutation in sorting nexin 10 (SNX10) was shown to cause a lethal genetic disease in humans, namely autosomal recessive osteopetrosis (ARO). We describe here the first R51Q SNX10 knock-in mouse model and show that mice homozygous for this mutation exhibit massive, early-onset, and widespread osteopetrosis. The...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2020.115360
更新日期:2020-07-01 00:00:00
abstract::Osteonecrosis of the jaws (ONJ) is a complication of antiresorptive medications, such as denosumab or bisphosphonates, prescribed to patients with bone malignancy or osteoporosis. The most common instigating local factor in ONJ pathogenesis is tooth extraction. However, in adults the great majority of teeth are extrac...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2016.06.011
更新日期:2016-09-01 00:00:00
abstract::The propensity of individual trabeculae to fracture (microfracture) may be important clinically since it could be indicative of bone fragility. Whether or not an overloaded trabecula fractures is determined in part by its structural ductility, a mechanical property that describes how much deformation a trabecula can s...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2005.07.019
更新日期:2005-12-01 00:00:00
abstract::Leptin has been suggested to mediate a variety of actions, including bone development, via its ubiquitously expressed receptor (Ob-Rb). In this study, we investigated the role of leptin in endochondral ossification at the growth plate. The growth plates of wild-type and ob/ob mice were analyzed. Effects of leptin on c...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2005.05.009
更新日期:2005-11-01 00:00:00
abstract::One year of treatment with bisphosphonates at 5x the dose used for post-menopausal osteoporosis significantly increases failure load and microdamage, and decreases toughness at multiple skeletal sites in intact female beagles. The goal of this study was to determine if similar changes occur with doses equivalent to th...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2006.04.028
更新日期:2006-10-01 00:00:00
abstract::Low-trauma fractures of older women are a major public health problem. Nevertheless, nationwide information on recent trends of proximal humeral fractures is sparse. We assessed the current trend in the number and rate (per 100,000 persons) of low-trauma fractures of the proximal humerus among 80-year-old or older wom...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2008.12.007
更新日期:2009-04-01 00:00:00
abstract::The enlargement of osteocyte lacunae via osteocytic osteolysis was previously detected in situations of increased calcium demand (e.g., lactation, vitamin D deficiency). However, it is unclear whether similar processes occur also in the growing infantile skeleton and how this is linked to the mineral distribution with...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2020.115324
更新日期:2020-06-01 00:00:00
abstract::Although basic fibroblast growth factor (bFGF) is a potent stimulator of bone formation when administered intravenously, less is known regarding the effects of this peptide on bone following subcutaneous (s.c.) administration. In addition, it is unknown whether coadministration of estrogen enhances the bone response t...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(03)00118-2
更新日期:2003-09-01 00:00:00
abstract:INTRODUCTION:Alström syndrome (ALMS) is an ultra-rare metabolic disorder caused by biallelic loss-of-function in the Alms1 gene which encodes a ubiquitously expressed centrosomal protein of the primary cilium. Although ALMS is characterised by several metabolic and hormonal dysfunctions that can lead to an increased ri...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2020.115756
更新日期:2021-02-01 00:00:00
abstract::Ectonucleotide phosphatase/phosphodiesterase 1 (ENPP1) deficiency results in either lethal arterial calcifications ('Generalized Arterial Calcification of Infancy' - GACI), phosphate wasting rickets ('Autosomal Recessive Hypophosphatemic Rickets type 2' - ARHR2), early onset osteoporosis, or progressive spinal rigidit...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2020.115656
更新日期:2021-01-01 00:00:00
abstract::Percutaneous vertebroplasty consists of injecting polymethylmethacrylate cement into the cancellous bone of vertebral bodies for the treatment of various lesions of the spine, including osteoporotic compression fractures. Clinicians practicing vertebroplasty commonly alter the mixture of monomer-to-powder recommended ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(99)00129-5
更新日期:1999-08-01 00:00:00
abstract::Approximately 7.9 million fractures occur annually in the United States with 5-10% of these resulting in delayed or impaired healing. Nearly half of the trauma cost of $56 billion per year is used for the treatment of fractures. More importantly, fracture results in a substantial reduction in the quality of life. New ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2011.06.037
更新日期:2011-11-01 00:00:00
abstract::We proposed a novel surface modification for an artificial hip joint stem from the viewpoint of maintenance and establishment of appropriate bone function and microstructure, represented by the preferred alignment of biological apatite (BAp) and collagen (Col). Oriented grooves were introduced into the proximal medial...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2012.11.005
更新日期:2013-02-01 00:00:00
abstract::FK506 is a commonly used immunosuppressant that mediates its action by exclusively interacting with the cytosolic immunophilin, FK506 binding protein 12 (FKBP12). Although FK506-induced acute osteoporosis is now well recognised, its precise mode of action in osteoblasts remains unclear. Therefore, in the present study...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2004.09.021
更新日期:2005-02-01 00:00:00
abstract:BACKGROUND:The association between beta-blockers (BB) and fracture risk is controversial, due largely to conflicting findings from previous studies. The present study sought to evaluate the effect of BB on fracture risk by using a Bayesian meta-analysis approach. METHODS AND RESULTS:We systematically retrieved 13 obse...
journal_title:Bone
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.bone.2012.07.013
更新日期:2012-11-01 00:00:00
abstract::Peripheral quantitative computed tomography (pQCT) captures novel aspects of bone geometry that may contribute to fracture risk and offers the ability to measure both volumetric bone mineral density (vBMD) and a separation of trabecular and cortical compartments of bone, but longitudinal data relating measures obtaine...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2014.03.040
更新日期:2014-07-01 00:00:00
abstract::Myostatin (GDF8) is a negative regulator of skeletal muscle growth and mice lacking myostatin show a significant increase in muscle mass and bone density compared to normal mice. In order to further define the role of myostatin in regulating bone mass we sought to determine if loss of myostatin function significantly ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2007.02.012
更新日期:2007-06-01 00:00:00
abstract::The loss of trabecular bone in the ovariectomized (OVX) rat provides a useful experimental model of postmenopausal osteoporosis. In this study, two bone-modulating compounds, an NSAID (flurbiprofen: FBP) and a chemically modified nonantimicrobial tetracycline (CMT), were tested either individually or in combination in...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(96)00280-3
更新日期:1996-12-01 00:00:00
abstract::A computerised technique is described for the quantitative assessment of resorption cavities in iliac trabecular bone. Using an Ibas II image analyser, the original bone surface, eroded by bone resorbing cells, is reconstructed using a curve fitting technique that maintains a smooth continuity with the trabecular bone...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(90)90076-b
更新日期:1990-01-01 00:00:00
abstract::Type 1 diabetes mellitus (T1DM) has been associated with deterioration of bone microarchitecture and strength, resulting in increased fracture risk. Substantial studies have revealed the capacity of moderate-intensity static magnetic fields (SMF) on promoting osteoblastogenesis in vitro and stimulating bone growth and...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2017.10.024
更新日期:2018-02-01 00:00:00
abstract::Bone losses are common as a consequence of unloading and also in patients with chronic obstructive pulmonary disease (COPD). Although hypoxia has been implicated as an important factor to drive bone loss, its interaction with unloading remains unresolved. The objective therefore was to assess whether human bone loss c...
journal_title:Bone
pub_type: 临床试验,杂志文章
doi:10.1016/j.bone.2016.07.013
更新日期:2016-10-01 00:00:00
abstract::We previously reported the effects of cyclic therapy with etidronate (CTE) on periprosthetic bone mineral density (BMD) after cementless total hip arthroplasty (THA). This study aimed to evaluate the effects of withdrawal and intervention of CTE after cementless THA. The control group consisted of 24 patients without ...
journal_title:Bone
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.bone.2004.03.017
更新日期:2004-07-01 00:00:00
abstract::We examined the effect of nicotine on cellular proliferation, as measured by [3H]thymidine (TdR) incorporation and cell count, and on alkaline phosphatase activity in UMR 106-01 rat osteoblastic osteosarcoma cells. The cells were cultured with varying concentrations of nicotine in serum-free medium for 2 to 72 hours. ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(91)90077-v
更新日期:1991-01-01 00:00:00
abstract::Mandibuloacral dysplasia (MAD) is a rare recessively inherited premature aging disease characterized by skeletal and metabolic anomalies. It is part of the spectrum of diseases called laminopathies and results from mutations in genes regulating the synthesis of the nuclear laminar protein, lamin A. Homozygous or compo...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2010.06.004
更新日期:2010-09-01 00:00:00
abstract::Glucocorticoids act on the osteoblasts to up-regulate the expression of RANKL, which is very important in the etiology of glucocorticoid-induced osteoclast differentiation and bone resorption. The mechanisms of this process are still not completely understood. Recent studies have shown that glucocorticoids mediate ost...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2014.08.004
更新日期:2014-11-01 00:00:00
abstract::Leptin, a small polypeptide hormone secreted by the adipocytes, controls body weight and gonadal function by binding to a special receptor located in the hypothalamus. Observational studies have demonstrated a controversial association between leptin and bone mineral density (BMD), and functional studies of the relati...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2019.05.006
更新日期:2019-08-01 00:00:00
abstract:BACKGROUND:Dietary acid charge enhances bone loss. Bicarbonate or alkali diet decreases bone resorption in humans. We compared the effect of an alkaline mineral water, rich in bicarbonate, with that of an acid one, rich in calcium only, on bone markers, in young women with a normal calcium intake. METHODS:This study c...
journal_title:Bone
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.bone.2008.09.007
更新日期:2009-01-01 00:00:00