Alkaline mineral water lowers bone resorption even in calcium sufficiency: alkaline mineral water and bone metabolism.

abstract：BACKGROUND:Lipotoxicity is defined as cellular toxicity observed in the presence of an abnormal accumulation of fat and adipocyte-derived factors in non-fat tissues. Palmitic acid (PA), an abundant fatty acid in the bone marrow and particularly in osteoporotic bones, affects osteoblastogenesis and osteoblast function, ...

journal_title：Bone

authors： Al Saedi A,Bermeo S,Plotkin L,Myers DE,Duque G

更新日期：2019-10-01 00:00:00

abstract：:Prenatal dexamethasone exposure (PDE) induces developmental toxicities of multi-organs and susceptibility to multi-diseases in offspring. However, the effects of PDE on osteoarthritis susceptibility in adult offspring and its mechanism have not been reported. In the present study, we treated pregnant Wistar rats with ...

journal_title：Bone

authors： Xiao H,Xie X,Wen Y,Tan Y,Shangguan Y,Li B,Magdalou J,Wang H,Chen L

更新日期：2020-04-01 00:00:00

abstract：:Achondroplasia (ACH), the most common form of human dwarfism is caused by a mutation in the Fibroblast Growth Factor Receptor 3 (FGFR3) gene, resulting in constitutive activation of the receptor. Typical radiological features include shortening of the tubular bones and macrocephaly, due to disruption of endochondral o...

journal_title：Bone

authors： Pannier S,Mugniery E,Jonquoy A,Benoist-Lasselin C,Odent T,Jais JP,Munnich A,Legeai-Mallet L

更新日期：2010-11-01 00:00:00

abstract：:Strontium ranelate (S12911) has previously been shown to stimulate bone formation and inhibit bone resorption in rats. To determine whether strontium ranelate affects normal bone remodeling, we studied the effect of strontium ranelate on alveolar bone in monkeys. Strontium ranelate, at dosages of 100, 275, and 750 mg/...

journal_title：Bone

authors： Buehler J,Chappuis P,Saffar JL,Tsouderos Y,Vignery A

更新日期：2001-08-01 00:00:00

abstract：:Tumor necrosis factor (TNF) actions in target tissues are mediated by various signalling pathways. The effect of TNF to stimulate resorption in fetal rat limb bones is not inhibited by indomethacin. The current studies were designed to assess the role of cyclic AMP (cAMP) and calcium as second messengers in this prost...

journal_title：Bone

authors： Shankar G,Stern PH

更新日期：1993-11-01 00:00:00

abstract：PURPOSE:The accepted mechanism explaining the accelerated growth following periosteal resection is that the periosteum serves as a mechanical restraint to restrict physeal growth. To test the veracity of this mechanism we first utilized Second Harmonic Generation (SHG) imaging to measure differences of periosteal fiber...

journal_title：Bone

authors： Chaudhary R,Lee MS,Mubyana K,Duenwald-Kuehl S,Johnson L,Kaiser J,Vanderby R Jr,Eliceiri KW,Corr DT,Chin MS,Li WJ,Campagnola PJ,Halanski MA

更新日期：2016-11-01 00:00:00

abstract：:The reversible calcitonin (CT)-induced inhibition of osteoclastic activity has been studied to clarify the mechanisms responsible for the so-called "escape phenomenon." Osteoclasts disaggregated from neonatal rabbits were cultured on glass coverslips or thin bovine bone slices. Resorption activity was evaluated by usi...

journal_title：Bone

authors： Kanehisa J

更新日期：1989-01-01 00:00:00

abstract：:Osteoclasts are multinucleated cells of monocyte/macrophage origin that degrade bone matrix. The differentiation of osteoclasts is dependent on a tumor necrosis factor (TNF) family cytokine, receptor activator of nuclear factor (NF)-kappaB ligand (RANKL), as well as macrophage colony-stimulating factor (M-CSF). Congen...

journal_title：Bone

authors： Asagiri M,Takayanagi H

更新日期：2007-02-01 00:00:00

abstract：:Microcephalic osteodysplastic primordial dwarfism type 1 (MOPD1), or Taybi-Linder syndrome is characterized by distinctive skeletal dysplasia, severe intrauterine and postnatal growth retardation, microcephaly, dysmorphic features, and neurological malformations. It is an autosomal recessive disorder caused by homozyg...

journal_title：Bone

authors： Krøigård AB,Frost M,Larsen MJ,Ousager LB,Frederiksen AL

更新日期：2016-11-01 00:00:00

abstract：:The Rickets Severity Score (RSS) was used to evaluate X-linked hypophosphatemic rickets (XLH), a genetic disorder mediated by increased circulating FGF23. The reliability of the RSS was assessed using data from a randomized, phase 2 clinical trial that evaluated the effects of burosumab, a fully human anti-FGF23 monoc...

journal_title：Bone

authors： Thacher TD,Pettifor JM,Tebben PJ,Creo AL,Skrinar A,Mao M,Chen CY,Chang T,San Martin J,Carpenter TO

更新日期：2019-05-01 00:00:00

abstract：:Cancellous microanatomy, bone remodelling, and hematopoietic tissue were studied in iliac crest and femoral neck biopsies taken intraoperatively in 102 consecutive patients with displaced intracapsular fractures. About half of the femoral biopsies had osteopenia, and most showed replacement of hematopoietic tissue by ...

journal_title：Bone

authors： Eventov I,Frisch B,Cohen Z,Hammel I

更新日期：1991-01-01 00:00:00

abstract：:Sclerosteosis and van Buchem disease are two rare bone sclerosing dysplasias caused by genetic defects in the synthesis of sclerostin. In this article we review the demographic, clinical, biochemical, radiological, and histological characteristics of patients with sclerosteosis and van Buchem disease that led to a bet...

journal_title：Bone

authors： van Lierop AH,Appelman-Dijkstra NM,Papapoulos SE

更新日期：2017-03-01 00:00:00

abstract：:One hundred Sprague-Dawley rats were ovariectomized (OVX) or sham-operated (Sham) at the age of 12 weeks. Eight or six animals from each group were sacrificed at the following time points: 0, 2, 4, 8, 16, 28, and 40 weeks. Mechanical testing of the bones showed that the maximal load of the femoral neck remained at the...

journal_title：Bone

authors： Peng ZQ,Väänänen HK,Zhang HX,Tuukkanen J

更新日期：1997-03-01 00:00:00

abstract：:A noninvasive marker of bone turnover would be useful in predicting which patients are at risk of rapid bone loss and in monitoring response to therapy. Calcitonin (CT)-induced hypocalcemia correlates with bone turnover but has not been a clinically useful test because changes in serum calcium are small, and test dura...

journal_title：Bone

authors： Minkoff JR,Grant BF,Marcus R

更新日期：1985-01-01 00:00:00

abstract：:Trabecular bone score (TBS) is a texture index derived from standard lumbar spine dual energy X-ray absorptiometry (DXA) images and provides information about the underlying bone independent of the bone mineral density (BMD). Several salient observations have emerged. Numerous studies have examined the relationship be...

journal_title：Bone

authors： Martineau P,Leslie WD

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:Cancer progression and metastasis occur such that cells with acquired mutations enhancing growth and survival (or inhibiting cell death) increase in number, a concept that has been recognized as analogous to Darwinian evolution of species since Peter C. Nowell's description in 1976. Selective forces include ...

journal_title：Bone

authors： Arnold RS,Fedewa SA,Goodman M,Osunkoya AO,Kissick HT,Morrissey C,True LD,Petros JA

更新日期：2015-09-01 00:00:00

abstract：:Giant osteoclasts and other cells were isolated from Pagetic bone tissue using 0.5 mM ethylene diamine tetraacetic acid on bone samples from 8 patients with Paget's disease. The cell suspension contained osteoclasts and osteoblasts as well as some mononuclear cells such as monocytes. The number of nuclei in isolated o...

journal_title：Bone

authors： Basle MF,Mazaud P,Malkani K,Chretien MF,Moreau MF,Rebel A

更新日期：1988-01-01 00:00:00

abstract：:1,25-Dihydroxyvitamin D [1,25(OH)(2)D] insufficiency appears to be associated with several age-related diseases. Insufficient levels of serum 25-hydroxyvitamin D has been shown to lead to the progression of osteoarthritis (OA) while underlying biological mechanisms remain largely unknown. In this study, we sought to d...

journal_title：Bone

authors： Shen M,Luo Y,Niu Y,Chen L,Yuan X,Goltzman D,Chen N,Miao D

更新日期：2013-08-01 00:00:00

abstract：:Hypophosphatasia (HPP) is a multi-systemic inborn disease with an extraordinary spectrum of severity, ranging from the absence of mineralization to high lethality and it involves different organs including bone, muscle, kidney, lung, gastrointestinal tract and the nervous system. The disease is characterized by low le...

journal_title：Bone

authors： Mentrup B,Girschick H,Jakob F,Hofmann C

更新日期：2017-01-01 00:00:00

abstract：:The last step of the osteoclast differentiation process is cell fusion. Most efforts to understand the fusion mechanism have focused on the identification of molecules involved in the fusion process. Surprisingly, the basic fusion modalities, which are well known for fusion of other cell types, are not known for the o...

journal_title：Bone

authors： Søe K,Hobolt-Pedersen AS,Delaisse JM

更新日期：2015-04-01 00:00:00

abstract：INTRODUCTION:The clinically known importance of patient sex as a major risk factor for compromised bone healing is poorly reflected in animal models. Consequently, the underlying cellular mechanisms remain elusive. Because mesenchymal stem cells (MSCs) are postulated to regulate tissue regeneration and give rise to ess...

journal_title：Bone

authors： Strube P,Mehta M,Baerenwaldt A,Trippens J,Wilson CJ,Ode A,Perka C,Duda GN,Kasper G

更新日期：2009-12-01 00:00:00

abstract：:Although vitamin D supplementation is a fundamental part of osteoporosis treatment, many patients do not regularly take adequate amounts. A once-weekly (OW) alendronate (ALN) preparation that includes 2800 IU of vitamin D3 in a single combination tablet (ALN+D2800) is available for treating patients and ensuring intak...

journal_title：Bone

authors： Binkley N,Ringe JD,Reed JI,Ljunggren O,Holick MF,Minne HW,Liu M,Lamotta A,West JA,Santora AC

更新日期：2009-04-01 00:00:00

abstract：:It is well known that porosity has an inverse relationship with the mechanical properties of bones. We examined cortical and trabecular porosity of antlers, and mineral composition, thickness and mechanical properties in the cortical wall. Samples belonged to two deer populations: a captive population of an experiment...

journal_title：Bone

authors： Landete-Castillejos T,Currey JD,Ceacero F,García AJ,Gallego L,Gomez S

更新日期：2012-01-01 00:00:00

abstract：:Although much is known about hip fracture epidemiology, there are relatively little data regarding fractures at other peripheral sites. Epidemiological differences between fractures are important, since they imply that an understanding of the consequences and clinical expression of osteoporosis requires the study of m...

journal_title：Bone

authors： Baron JA,Barrett JA,Karagas MR

更新日期：1996-03-01 00:00:00

abstract：:In 1994, the World Health Organization published diagnostic criteria for osteoporosis. Since then, many new technologies have been developed for the measurement of bone mineral at multiple skeletal sites. The information provided by each assessment will describe the clinical characteristics, fracture risk and epidemio...

journal_title：Bone

authors： Kanis JA,McCloskey EV,Johansson H,Oden A,Melton LJ 3rd,Khaltaev N

更新日期：2008-03-01 00:00:00

abstract：:A previously developed in vivo X-ray fluorescence (IVXRF) I-125 based system was used to measure bone strontium levels non-invasively in an osteoporotic female volunteer. The volunteer was recruited in December 2008, as part of the Ryerson and McMaster University Strontium in Bone Research Study and measured at twice ...

journal_title：Bone

authors： Moise H,Adachi JD,Chettle DR,Pejović-Milić A

更新日期：2012-07-01 00:00:00

abstract：:Global gene expression profiling has been used to study the molecular mechanisms of increased bone remodeling caused by PHPT. This disease is a model for chronic over-stimulation of target organs by PTH due to an inappropriate overproduction of the hormone. Hyperactivity of osteoblasts and osteoclasts lead to increase...

journal_title：Bone

authors： Reppe S,Stilgren L,Olstad OK,Brixen K,Nissen-Meyer LS,Gautvik KM,Abrahamsen B

更新日期：2006-07-01 00:00:00

abstract：:Bone morphogenetic protein 2 (BMP-2) is a secreted signaling molecule that acts as an inducer of bone formation and a regulator of embryonic development. The objectives of this work were as follows: (1) to clone the full-length cDNA of BMP-2 in a marine fish model, (2) analyze its gene expression during development, i...

journal_title：Bone

authors： Rafael MS,Laizé V,Cancela ML

更新日期：2006-12-01 00:00:00

abstract：:The hips are frequently involved in inheritable diseases which affect the bones. The clinical and radiological presentation of these diseases may be very similar to common hip disorders as developmental dysplasia of the hip, osteoarthritis and avascular necrosis, so the diagnosis may be easily overlooked and treatment...

journal_title：Bone

authors： Oussoren E,Wagenmakers MAEM,Link B,van der Meijden JC,Pijnappel WWMP,Ruijter GJG,Langeveld M,van der Ploeg AT

更新日期：2021-02-01 00:00:00

abstract：:The Wnt/β-catenin signaling pathway plays an essential role in osteoblast biology. Sclerostin is a soluble antagonist of Wnt/β-catenin signaling secreted primarily by osteocytes. Current evidence indicates that sclerostin likely functions as a local/paracrine regulator of bone metabolism rather than as an endocrine ho...

journal_title：Bone

authors： Drake MT,Khosla S

更新日期：2017-03-01 00:00:00