Evaluation of the role of second messenger systems in tumor necrosis factor-stimulated resorption of fetal rat limb bones.

abstract：INTRODUCTION AND HYPOTHESIS:Diagnosis of prevalent osteoporotic vertebral fracture is complicated by normal or developmental variation in vertebral shape or size and non-osteoporotic deformities that appear to have 'reduced' height. Using our visual approach, the algorithm-based qualitative method (ABQ) a vertebra with...

journal_title：Bone

authors： Ferrar L,Jiang G,Armbrecht G,Reid DM,Roux C,Glüer CC,Felsenberg D,Eastell R

更新日期：2007-07-01 00:00:00

abstract：:Epigenetic regulatory proteins support mammalian development, cancer, aging and tissue repair by controlling many cellular processes including stem cell self-renewal, lineage-commitment and senescence in both skeletal and non-skeletal tissues. We review here our knowledge of epigenetic regulatory protein complexes tha...

journal_title：Bone

authors： van Wijnen AJ,Bagheri L,Badreldin AA,Larson AN,Dudakovic A,Thaler R,Paradise CR,Wu Z

更新日期：2021-02-01 00:00:00

abstract：:Paget's disease is the most exaggerated example of bone remodeling in which abnormal osteoclastic bone resorption remains coupled to new bone formation. There are abnormalities in the stages of osteoclast development, and studies in Paget's disease have suggested a major role for IL-6 in human osteoclast activity. The...

journal_title：Bone

authors： Roodman GD

更新日期：1996-09-01 00:00:00

abstract：:Bone geometry plays a prominent role in bone strength. Cross-sectional studies have shown that advancing age is associated with increasing diameter of long bones, related to both periostal apposition and endosteal resorption. However, there are few data provided by prospective studies, especially concerning the change...

journal_title：Bone

authors： Briot K,Kolta S,Fechtenbaum J,Said-Nahal R,Benhamou CL,Roux C

更新日期：2010-08-01 00:00:00

abstract：:Bone losses are common as a consequence of unloading and also in patients with chronic obstructive pulmonary disease (COPD). Although hypoxia has been implicated as an important factor to drive bone loss, its interaction with unloading remains unresolved. The objective therefore was to assess whether human bone loss c...

journal_title：Bone

authors： Rittweger J,Debevec T,Frings-Meuthen P,Lau P,Mittag U,Ganse B,Ferstl PG,Simpson EJ,Macdonald IA,Eiken O,Mekjavic IB

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:Bone scintigraphy used as a diagnostic technique frequently yields non-specific intense uptake by vertebrae. Bone biopsy may therefore be required to establish a diagnosis in cases of Paget's disease of bone. The aim of the study was to ascertain the sensitivity and specificity of two new images-heart sign a...

journal_title：Bone

authors： Rotés-Sala D,Monfort J,Solano A,Miralles E,Vila J,Carbonell J

更新日期：2004-04-01 00:00:00

abstract：:Osteoporosis is a major cause of disability in the United States. Numerous factors contribute to the decline in bone mineral density (BMD) that characterizes this disease, and the importance of heredity is now widely appreciated. We evaluated the joint contributions of genes and environmental factors on variation in B...

journal_title：Bone

authors： Mitchell BD,Kammerer CM,Schneider JL,Perez R,Bauer RL

更新日期：2003-11-01 00:00:00

abstract：:Percutaneous vertebroplasty consists of injecting polymethylmethacrylate cement into the cancellous bone of vertebral bodies for the treatment of various lesions of the spine, including osteoporotic compression fractures. Clinicians practicing vertebroplasty commonly alter the mixture of monomer-to-powder recommended ...

journal_title：Bone

authors： Jasper LE,Deramond H,Mathis JM,Belkoff SM

更新日期：1999-08-01 00:00:00

abstract：:Osteocytes form over 90% of the bone cells and are postulated to be mechanosensors responsible for regulating the function of osteoclasts and osteoblasts in bone modeling and remodeling. Physical activity results in mechanical loading on the bones. Osteocytes are thought to be the main mechanosensory cells in bone. Up...

journal_title：Bone

authors： Ganesh T,Laughrey LE,Niroobakhsh M,Lara-Castillo N

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:Vertebral fractures (VF) upon Denosumab (DMAB) discontinuation were first described as a distinct phenomenon in 2015, yet the magnitude of this event remains undetermined. OBJECTIVES:To estimate fracture risk after DMAB discontinuation, in a real-world setting. METHODS:The computerized database of a 2.3-mi...

journal_title：Bone

authors： Tripto-Shkolnik L,Fund N,Rouach V,Chodick G,Shalev V,Goldshtein I

更新日期：2020-01-01 00:00:00

abstract：:Ronacaleret is an orally-active calcium-sensing receptor (CaSR) antagonist that has the potential for therapeutic utility in the stimulation of PTH release, notably as a bone anabolic agent comparable to recombinant human PTH(1-34) (rhPTH(1-34)). A recent study has shown that, despite the ability to increase circulati...

journal_title：Bone

authors： Caltabiano S,Dollery CT,Hossain M,Kurtinecz MT,Desjardins JP,Favus MJ,Kumar R,Fitzpatrick LA

更新日期：2013-09-01 00:00:00

abstract：:The long-term protective effect of stronger back muscles on the spine was determined in 50 healthy white postmenopausal women, aged 58-75 years, 8 years after they had completed a 2 year randomized, controlled trial. Twenty-seven subjects had performed progressive, resistive back-strengthening exercises for 2 years an...

journal_title：Bone

authors： Sinaki M,Itoi E,Wahner HW,Wollan P,Gelzcer R,Mullan BP,Collins DA,Hodgson SF

更新日期：2002-06-01 00:00:00

abstract：:Bone morphogenetic protein 2 (BMP-2) is a member of the transforming growth factor-β superfamily, it is known to be a factor involved in skeletal development and capable of inducing in vitro osteogenic differentiation of mesenchymal stem cells (MSCs). Dental pulp stem cells (DPSCs) isolated from extracted third molar ...

journal_title：Bone

authors： Tóth F,Gáll JM,Tőzsér J,Hegedűs C

更新日期：2020-03-01 00:00:00

abstract：:Paramagnetic manganese can be employed as a calcium surrogate to sensitize the magnetic resonance imaging (MRI) technique to the processing of calcium during the bone formation process. At low doses, after just 48h of exposure, osteoblasts take up sufficient quantities of manganese to cause marked reductions in the wa...

journal_title：Bone

authors： Chesnick IE,Centeno JA,Todorov TI,Koenig AE,Potter K

更新日期：2011-05-01 00:00:00

abstract：:Bisphosphonates are widely used in the treatment of osteoporosis and contribute to the reduction of bone fractures. Ibandronate (IBN) is a highly potent, nitrogen-containing bisphosphonate, which is administered orally or intravenously at extended dosing intervals. Vitamin D or active vitamin D3 derivatives are also u...

journal_title：Bone

authors： Sakai S,Takeda S,Sugimoto M,Shimizu M,Shimonaka Y,Yogo K,Hashimoto J,Bauss F,Endo K

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:X-linked hypophosphatemia (XLH) causes rickets, osteomalacia, skeletal deformities and growth impairment, due to elevated fibroblast growth factor 23 and hypophosphatemia. Conventional therapy requires high doses of phosphate salts combined with active vitamin D analogues. Risks of this regimen include nephr...

journal_title：Bone

authors： DeLacey S,Liu Z,Broyles A,El-Azab SA,Guandique CF,James BC,Imel EA

更新日期：2019-10-01 00:00:00

abstract：:Conventional methods used to image and quantify microdamage accumulation in bone are limited to histological sections, which are inherently invasive, destructive, two-dimensional, and tedious. These limitations inhibit investigation of microdamage accumulation with respect to volumetric spatial variation in mechanical...

journal_title：Bone

authors： Landrigan MD,Li J,Turnbull TL,Burr DB,Niebur GL,Roeder RK

更新日期：2011-03-01 00:00:00

abstract：INTRODUCTION:Mechanical stresses on the bone are an important aspect of physical activity that promotes bone preservation and increases in bone mass. Exercise intensities leading to bone preservation and accrual have not been adequately defined for humans in general, and postmenopausal women in particular. MATERIALS A...

journal_title：Bone

authors： Borer KT,Fogleman K,Gross M,La New JM,Dengel D

更新日期：2007-10-01 00:00:00

abstract：:The Mediterranean osteoporosis (MEDOS) study was carried out in 14 centres from six countries in Southern Europe to determine the incidence rates and risk factors associated with hip fracture over the age of 50 years. This paper discusses both the validity and relevance of the data, that is, whether the number of coll...

journal_title：Bone

authors： Elffors L,Gullberg B,Allander E,Johnell O,Kanis JA

更新日期：1993-01-01 00:00:00

abstract：:While increasing age, decreasing body mass index (BMI), and physical inactivity are known to increase hip fracture risk, whether these factors have similar effects on other common fractures is not well established. We used prospectively-collected data from a large cohort to examine the role of these factors on the ris...

journal_title：Bone

authors： Armstrong ME,Cairns BJ,Banks E,Green J,Reeves GK,Beral V,Million Women Study Collaborators.

更新日期：2012-06-01 00:00:00

abstract：PURPOSE:To investigate the effectiveness of the T-score values provided by Radiofrequency Echographic Multi Spectrometry (REMS) in the identification of patients at risk for incident osteoporotic fractures. METHODS:A population of Caucasian women (30-90 years), enrolled from 2013 to 2016, underwent dual X-ray absorpti...

journal_title：Bone

authors： Adami G,Arioli G,Bianchi G,Brandi ML,Caffarelli C,Cianferotti L,Gatti D,Girasole G,Gonnelli S,Manfredini M,Muratore M,Quarta E,Quarta L

更新日期：2020-05-01 00:00:00

abstract：:In order to assess the ability of six potential bone graft substitutes to support the growth of human osteoblasts, these cells were grown in culture and then plated onto fragments of the six materials and cultured for a further period of 15 days. Tests to confirm the osteoblastic phenotype of the cells included spectr...

journal_title：Bone

authors： Begley CT,Doherty MJ,Hankey DP,Wilson DJ

更新日期：1993-07-01 00:00:00

abstract：:Osteonecrosis of the jaw (ONJ) is now defined by the presence of exposed bone in the mouth, which fails to heal after appropriate intervention over a period of six or eight weeks. It is commonly precipitated by a tooth extraction in patients treated with zoledronate, pamidronate or a combination of these agents, for t...

journal_title：Bone

authors： Reid IR

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:Trace elements are known to influence bone metabolism; however, their effects may be exacerbated in renal failure because dialysis patients are unable to excrete excess elements properly. Our study correlated bone quality in dialysis patients with levels of bone fluoride, magnesium, and aluminum. A number ...

journal_title：Bone

authors： Ng AH,Hercz G,Kandel R,Grynpas MD

更新日期：2004-01-01 00:00:00

abstract：:Bone mineral density (BMD) is influenced by both environmental and genetic factors. We previously reported the association of the RUNX2 A allele with increased bone mineral density (BMD) and protection against a common form of osteoporotic fracture within a Geelong population. We genotyped 991 women from a Scottish co...

journal_title：Bone

authors： Vaughan T,Reid DM,Morrison NA,Ralston SH

更新日期：2004-06-01 00:00:00

abstract：:Compelling evidences suggest that increased production of osteoclastogenic cytokines by activated T cells plays a relevant role in the bone loss induced by estrogen deficiency in the mouse. However, little information is available on the role of T cells in post-menopausal bone loss in humans. To investigate this issue...

journal_title：Bone

authors： D'Amelio P,Grimaldi A,Di Bella S,Brianza SZM,Cristofaro MA,Tamone C,Giribaldi G,Ulliers D,Pescarmona GP,Isaia G

更新日期：2008-07-01 00:00:00

abstract：:The tooth root is essential for normal tooth physiological function. Studies on mice with mutations or targeted gene deletions revealed that osteoclasts (OCs) play an important role in tooth root development. However, knowledge on the cellular and molecular mechanism underlying how OCs mediate root formation is limite...

journal_title：Bone

authors： Huang H,Wang J,Zhang Y,Zhu G,Li YP,Ping J,Chen W

更新日期：2018-09-01 00:00:00

abstract：:Recent increasing evidence supports a role for neuronal type signaling in bone. Specifically glutamate receptors have been found in cells responsible for bone remodeling, namely the osteoblasts and the osteoclasts. While most studies have focused on ionotropic glutamate receptors, the relevance of the metabotropic glu...

journal_title：Bone

authors： Musante I,Mattinzoli D,Otescu LA,Bossi S,Ikehata M,Gentili C,Cangemi G,Gatti C,Emionite L,Messa P,Ravazzolo R,Rastaldi MP,Riccardi D,Puliti A

更新日期：2017-01-01 00:00:00

abstract：:Osteocytes are the most abundant cell type in bone and are responsible for sensing mechanical strain and signaling bone (re)modeling, making them the primary mechanosensors within bone. Under aging and osteoporotic conditions, bone is known to be less responsive to loading (exercise), but it is unclear why. Perhaps, t...

journal_title：Bone

authors： Stern AR,Nicolella DP

更新日期：2013-06-01 00:00:00

abstract：:Osteopetrotic bone shows dissociation between bone mineral density (BMD) and bone strength. In this study, volumetric BMD; preferential orientation of the extracellular matrix (ECM), which is composed of collagen fibers and apatite crystals as bone material quality; and mechanical properties of the src-/- osteopetroti...

journal_title：Bone

authors： Ishimoto T,Sato B,Lee JW,Nakano T

更新日期：2017-10-01 00:00:00