Does nutrition affect bone porosity and mineral tissue distribution in deer antlers? The relationship between histology, mechanical properties and mineral composition.

abstract：:Paget's disease of bone (PDB) is a chronic bone metabolic disorder. Currently, PDB is the second most frequent bone disorder. PDB is a focal disorder affecting the skeleton segmentally but the cause of which is unknown. It has been hypothesised that somatic mutations could be responsible for the mosaicism described in...

journal_title：Bone

authors： Usategui-Martín R,Gutiérrez-Cerrajero C,Jiménez-Vázquez S,Calero-Paniagua I,García-Aparicio J,Corral-Gudino L,Del Pino-Montes J,González-Sarmiento R

更新日期：2018-07-01 00:00:00

abstract：:In order to delineate the influence of mechanical unloading on the formation and resorption of trabecular and cortical bone, the effects of mechanical unloading on the volume, structure, and turnover of hindlimbs were examined using tail-suspended rapidly growing rats. In addition, to clarify the mechanism of how mech...

journal_title：Bone

authors： Matsumoto T,Nakayama K,Kodama Y,Fuse H,Nakamura T,Fukumoto S

更新日期：1998-05-01 00:00:00

abstract：:With the increased burden of low back pain (LBP) in our globally aging population there is a need to develop preclinical models of LBP that capture clinically relevant features of physiological aging, degeneration, and disability. Here we assess the validity of using a mouse model system for age-related LBP by charact...

journal_title：Bone

authors： Vincent K,Mohanty S,Pinelli R,Bonavita R,Pricop P,Albert TJ,Dahia CL

更新日期：2019-06-01 00:00:00

abstract：:The objective was to quantify the outcome of osteoporosis (OP) in terms of health-related quality of life (HR-QOL) and cost of ambulatory care and to look at the association between these two outcomes variables. A cross-sectional health survey of 4800 Belgian individuals over the age of 45 years was used. Individuals ...

journal_title：Bone

authors： Ethgen O,Tellier V,Sedrine WB,De Maeseneer J,Gosset C,Reginster JY

更新日期：2003-06-01 00:00:00

abstract：:Apert syndrome (AS) is one of the most severe craniosynostoses and is characterized by premature fusion of craniofacial sutures. Mutations of either Ser252Trp or Pro253Arg in fibroblast growth factor receptor 2 (FGFR2) are responsible for nearly all known cases of AS. Here we show that mutant mice carrying the activat...

journal_title：Bone

authors： Chen L,Li D,Li C,Engel A,Deng CX

更新日期：2003-08-01 00:00:00

abstract：:Impaired osteoblast and osteocyte maturation contribute to mineralization defects and excess FGF23 expression in CKD bone. Vitamin D sterols decrease osteoid accumulation and increase FGF23 expression; these agents also increase osteoblast maturation in vitro but a link between changes in bone cell maturation, bone mi...

journal_title：Bone

authors： Pereira RC,Salusky IB,Bowen RE,Freymiller EG,Wesseling-Perry K

更新日期：2019-10-01 00:00:00

abstract：:Bone remodeling is a process involving both dynamic and static bone strain. Although there exist numerous studies on the effect of dynamic strain on implant stability and bone remodeling, the effect of static strain has yet to be clarified. Hence, for this purpose, the effect of static bone strain on implant stability...

journal_title：Bone

authors： Halldin A,Jimbo R,Johansson CB,Wennerberg A,Jacobsson M,Albrektsson T,Hansson S

更新日期：2011-10-01 00:00:00

abstract：:Bone geometry plays a prominent role in bone strength. Cross-sectional studies have shown that advancing age is associated with increasing diameter of long bones, related to both periostal apposition and endosteal resorption. However, there are few data provided by prospective studies, especially concerning the change...

journal_title：Bone

authors： Briot K,Kolta S,Fechtenbaum J,Said-Nahal R,Benhamou CL,Roux C

更新日期：2010-08-01 00:00:00

abstract：:The skeleton is characterized by anatomic heterogeneity of metabolic turnover. Site-dependent differences in hormonal effects seem likely. Hyporesponsiveness of osteoclasts to parathyroid hormone (PTH) and probably calcitriol was recently demonstrated in the fifth lumbar vertebra of a rat model with moderate renal fai...

journal_title：Bone

authors： Freesmeyer MG,Abendroth K,Faldum A,Krauss C,Stein G

更新日期：2001-09-01 00:00:00

abstract：:To better understand the effects of prolonged bed-rest in women, 24 healthy women aged 25 to 40 years participated in 60-days of strict 6° head-down tilt bed-rest (WISE-2005). Subjects were assigned to either a control group (CON, n=8) which performed no countermeasure, an exercise group (EXE, n=8) undertaking a combi...

journal_title：Bone

authors： Beller G,Belavý DL,Sun L,Armbrecht G,Alexandre C,Felsenberg D

更新日期：2011-10-01 00:00:00

abstract：:Compelling evidences suggest that increased production of osteoclastogenic cytokines by activated T cells plays a relevant role in the bone loss induced by estrogen deficiency in the mouse. However, little information is available on the role of T cells in post-menopausal bone loss in humans. To investigate this issue...

journal_title：Bone

authors： D'Amelio P,Grimaldi A,Di Bella S,Brianza SZM,Cristofaro MA,Tamone C,Giribaldi G,Ulliers D,Pescarmona GP,Isaia G

更新日期：2008-07-01 00:00:00

abstract：OBJECTIVE:Type IIB procollagen is characteristic of cartilage, comprising 50% of the extracellular matrix. The NH(2)-propeptide of type IIB collagen, PIIBNP, can kill tumor cells via binding to integrins α(V)β(3) and α(V)β(5). As osteoclasts rely on α(V)β(3) integrins for function in bone erosion, we sought to determin...

journal_title：Bone

authors： Hayashi S,Wang Z,Bryan J,Kobayashi C,Faccio R,Sandell LJ

更新日期：2011-10-01 00:00:00

abstract：:The process of bone turnover displays variations over 24 h, with C-terminal cross-linked telopeptide of type 1 collagen (CTX) and osteocalcin exhibiting a nadir in the afternoon and a peak in the night. In contrast, N-terminal propeptide of type 1 procollagen (P1NP) did not display an apparent 24-hour rhythm. Other em...

journal_title：Bone

authors： van der Spoel E,Oei N,Cachucho R,Roelfsema F,Berbée JFP,Blauw GJ,Pijl H,Appelman-Dijkstra NM,van Heemst D

更新日期：2019-03-01 00:00:00

abstract：:Bisphosphonates (BP), especially alendronate and risedronate, are the drugs most commonly used for osteoporosis treatment, being incorporated into the skeleton where they inhibit bone resorption and are thereafter slowly released during bone turnover. However, there are few data on the release of BP in patients who ha...

journal_title：Bone

authors： Peris P,Torra M,Olivares V,Reyes R,Monegal A,Martínez-Ferrer A,Guañabens N

更新日期：2011-10-01 00:00:00

abstract：:Osteoclastic bone degradation depends on the activity of several proteolytic enzymes, in particular to those belonging to the classes of cysteine proteinases and matrix metalloproteinases (MMPs). Yet, several findings suggest that the two types of plasminogen activators (PA), the tissue- and urokinase-type PA (tPA and...

journal_title：Bone

authors： Everts V,Daci E,Tigchelaar-Gutter W,Hoeben KA,Torrekens S,Carmeliet G,Beertsen W

更新日期：2008-11-01 00:00:00

abstract：:The assay for the cross-linked carboxyterminal telopeptide of type I collagen (ICTP) has been shown to reflect increased type I collagen degradation in such pathological conditions as bone metastases and rheumatoid arthritis, but to be rather insensitive to the changes in physiological bone collagen turnover (e.g., in...

journal_title：Bone

authors： Sassi ML,Eriksen H,Risteli L,Niemi S,Mansell J,Gowen M,Risteli J

更新日期：2000-04-01 00:00:00

abstract：:Although a critical role of COX-2 in bone repair has been established, the mechanism involved remains unclear. During early inflammatory phase of bone healing, COX-2 is produced by the surrounding inflammatory cells as well as bone/cartilage progenitors. Based on the temporal and spatial expression of COX-2 during the...

journal_title：Bone

authors： Xie C,Ming X,Wang Q,Schwarz EM,Guldberg RE,O'Keefe RJ,Zhang X

更新日期：2008-12-01 00:00:00

abstract：:Osteoclasts are multinucleated cells of monocyte/macrophage origin that degrade bone matrix. The differentiation of osteoclasts is dependent on a tumor necrosis factor (TNF) family cytokine, receptor activator of nuclear factor (NF)-kappaB ligand (RANKL), as well as macrophage colony-stimulating factor (M-CSF). Congen...

journal_title：Bone

authors： Asagiri M,Takayanagi H

更新日期：2007-02-01 00:00:00

abstract：BACKGROUND:Evidence of the effect of vitamin K on bone health is conflicting. The aim was to investigate the association between intake of vitamins K1 and K2 and subsequent risk of hip fracture in a general population sample, as well as potential effect modification by apolipoprotein E gene (APOE) status by presence of...

journal_title：Bone

authors： Apalset EM,Gjesdal CG,Eide GE,Tell GS

更新日期：2011-11-01 00:00:00

abstract：:Biochemical bone turnover markers (BTMs) provide important information on the diagnosis, therapy and monitoring of metabolic bone diseases including osteoporosis. One goal of antiresorptive therapy in women is to decrease biochemical BTMs to the lower half of reference intervals for healthy pre-menopausal counterparts...

journal_title：Bone

authors： Ardawi MS,Maimani AA,Bahksh TA,Rouzi AA,Qari MH,Raddadi RM

更新日期：2010-10-01 00:00:00

abstract：:Tropomyosins are coiled-coil dimers that bind to the major groove of F-actin and regulate its accessibility to actin-modifying proteins. Although approximately 40 tropomyosin isoforms have been identified in mammals, they can broadly be classified into two groups based on protein size, that is, high molecular weight a...

journal_title：Bone

authors： Kotadiya P,McMichael BK,Lee BS

更新日期：2008-11-01 00:00:00

abstract：BACKGROUND:Studies in childhood suggest that both body composition and early postnatal growth are associated with bone mineral density (BMD). However, little is known of the relationships between longitudinal changes in fat (FM) and lean mass (LM) and bone development in pre-pubertal children. We therefore investigated...

journal_title：Bone

authors： Moon RJ,Cole ZA,Crozier SR,Curtis EM,Davies JH,Gregson CL,Robinson SM,Dennison EM,Godfrey KM,Inskip HM,Cooper C,Harvey NC,Southampton Women's Survey Study Group.

更新日期：2015-06-01 00:00:00

abstract：:We have previously shown that in osteoblasts Sox2 expression can be induced by Fgfs, and can inhibit Wnt signaling and differentiation. Furthermore, in mice in which Sox2 is conditionally deleted in the osteoblastic lineage, bones are osteopenic, and Sox2 inactivation in cultured osteoblasts leads to a loss of prolife...

journal_title：Bone

authors： Holmes G,Bromage TG,Basilico C

更新日期：2011-10-01 00:00:00

abstract：:The lung interfaces with atmospheric oxygen via a large surface area and is perfused by the entire venous return bearing waste products collected from the whole body. It is logical that the lung is endowed with generous anti-oxidative capacity derived both locally and from the circulation. The single-pass pleiotropic ...

journal_title：Bone

authors： Hsia CCW,Ravikumar P,Ye J

更新日期：2017-07-01 00:00:00

abstract：:Fibroblast growth factor 23 (FGF23) circulates as active protein and inactive fragments. Low iron status increases FGF23 gene expression, and iron deficiency is common. We hypothesized that in healthy premenopausal women, serum iron influences C-terminal and intact FGF23 concentrations, and that iron and FGF23 associa...

journal_title：Bone

authors： Imel EA,Liu Z,McQueen AK,Acton D,Acton A,Padgett LR,Peacock M,Econs MJ

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:Although 25-hydroxyvitamin D (25[OH]D) is commonly used to define vitamin D status, there is no consensus on the cutoff levels for vitamin D deficiency and insufficiency. In this study, we aimed to identify the 25(OH)D threshold that maximally suppressed parathyroid hormone (PTH) in Hong Kong Chinese populat...

journal_title：Bone

authors： Leung RY,Cheung BM,Nguyen US,Kung AW,Tan KC,Cheung CL

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:Skeletal loading and proper nutrition are necessary for optimal bone health. The appropriate amount of dietary protein to maximize skeletal health, however, is under constant debate. OBJECTIVE:To determine if 6 months of protein supplementation in conjunction with a strength and conditioning training progra...

journal_title：Bone

authors： Ballard TL,Specker BL,Binkley TL,Vukovich MD

更新日期：2006-06-01 00:00:00

abstract：:The R51Q mutation in sorting nexin 10 (SNX10) was shown to cause a lethal genetic disease in humans, namely autosomal recessive osteopetrosis (ARO). We describe here the first R51Q SNX10 knock-in mouse model and show that mice homozygous for this mutation exhibit massive, early-onset, and widespread osteopetrosis. The...

journal_title：Bone

authors： Stein M,Barnea-Zohar M,Shalev M,Arman E,Brenner O,Winograd-Katz S,Gerstung J,Thalji F,Kanaan M,Elinav H,Stepensky P,Geiger B,Tuckermann J,Elson A

更新日期：2020-07-01 00:00:00

abstract：:Nitric oxide (NO), produced by endothelial cells, is a signaling molecule synthesized from l-arginine by nitric oxide synthases (NOS). NO is known to reduce the ratio of receptor activator of nuclear factor KappaB (RANKL)/osteoprotegerin (OPG), leading to decreased osteoclastogenesis and a reduction in bone resorption...

journal_title：Bone

authors： Cho K,Demissie S,Dupuis J,Cupples LA,Kathiresan S,Beck TJ,Karasik D,Kiel DP

更新日期：2008-01-01 00:00:00

abstract：:Connective tissue growth factor (CTGF) has been identified as a secretory protein encoded by an immediate early gene and is a member of the CCN family. In vitro CTGF directly regulates the proliferation and differentiation of chondrocytes; however, a previous study showed that it was localized only in the hypertrophic...

journal_title：Bone

authors： Fukunaga T,Yamashiro T,Oya S,Takeshita N,Takigawa M,Takano-Yamamoto T

更新日期：2003-12-01 00:00:00