Abstract:
BACKGROUND:Evidence of the effect of vitamin K on bone health is conflicting. The aim was to investigate the association between intake of vitamins K1 and K2 and subsequent risk of hip fracture in a general population sample, as well as potential effect modification by apolipoprotein E gene (APOE) status by presence of the E4 allele. METHODS:1238 men and 1569 women 71-75 years of age were included in the community-based Hordaland Health Study 1997-1999 in Western Norway. Information on hip fracture was obtained from hospitalizations in the region from enrolment until 31 December 2009. Information on intake of vitamins K1 and K2 collected at baseline was used as potential predictors of hip fracture in Cox proportional hazards regression analyses. RESULTS:Participants in the lowest compared to the highest quartile of vitamin K1 intake had increased risk of suffering a hip fracture (hazard ratio (HR)=1.57 [95% CI 1.09, 2.26]). Vitamin K2 intake was not associated with hip fracture. Presence of APOE4-allele did not increase the risk of hip fracture, nor was there any effect modification with vitamin K1 in relation to risk of hip fracture. CONCLUSIONS:A low intake of vitamin K1, but not K2, was associated with an increased risk of hip fractures.
journal_name
Bonejournal_title
Boneauthors
Apalset EM,Gjesdal CG,Eide GE,Tell GSdoi
10.1016/j.bone.2011.07.035subject
Has Abstractpub_date
2011-11-01 00:00:00pages
990-5issue
5eissn
8756-3282issn
1873-2763pii
S8756-3282(11)01137-9journal_volume
49pub_type
杂志文章相关文献
BONE文献大全abstract::In order to investigate the effect of fluoride on bone mineral crystals, we gave groups of female rats 8 mM NaF/L water and distilled water to control groups. The rats were sacrificed at six weeks, three months, and six months. The fluor content of the bone was determined by neutron activation. X-ray diffraction showe...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(92)90085-b
更新日期:1992-01-01 00:00:00
abstract::Bone loss represents a major unsolved problem in rheumatoid arthritis (RA). The skeletal complications of RA consist of focal bone erosions and periarticular osteoporosis at sites of active inflammation, and generalized bone loss with reduced bone mass. New evidence indicates that osteoclasts are key mediators of all ...
journal_title:Bone
pub_type: 杂志文章,评审
doi:10.1016/s8756-3282(01)00682-2
更新日期:2002-02-01 00:00:00
abstract::Ovariectomized cynomolgus monkeys have previously been investigated as a nonhuman primate model of postmenopausal osteoporosis (Jerome et al., Bone Miner 9:527-540; 1994). In the present study, Fourier transform infrared microspectroscopy (FTIRM) was used to verify that differences in bone mineral quality and quantity...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(00)00362-8
更新日期:2000-10-01 00:00:00
abstract::The lamellar bone's strength is mainly affected by the organization of its mineralized collagen fibers and material composition. In the present study, Raman microspectroscopic and imaging analyses were employed to study a normal human femoral midshaft bone cube-like specimen with a spatial resolution of approximately ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2007.04.200
更新日期:2007-09-01 00:00:00
abstract::The formation of cartilage prior to bone in an endochondral bone formation process suggests that some osteogenic factors exist in the cartilage. This osteogenic activity of cartilage or cartilage cells was examined by implanting ribs and costal cartilage zone into a subcutaneous pocket of abdominal wall, or the growth...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(92)90455-6
更新日期:1992-01-01 00:00:00
abstract::Osteoarthritis (OA) occurs naturally in cynomolgus macaques. The purposes of the present study were to: 1) develop histological measurement schemes to measure the cross-sectional area of axial and abaxial osteophytes in the proximal tibia; 2) determine the effects of long-term estrogen replacement therapy (ERT) on ost...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2007.04.175
更新日期:2007-08-01 00:00:00
abstract::Progressive osseous heteroplasia (POH) is a rare autosomal dominant disorder of mesenchymal differentiation characterized by progressive heterotopic ossification (HO) of dermis, deep connective tissues and skeletal muscle. Usually, initial bone formation occurs during infancy as primary osteoma cutis (OC) then progres...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2013.06.015
更新日期:2013-10-01 00:00:00
abstract:AIMS:Hip fracture patients have severe deterioration of their quality of life and function after their injury. Markers of malnutrition such as low albumin and low body mass index (BMI) have been shown to increase mortality and complication rates but their effect on recovery of quality of life and function after hip fra...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2020.115567
更新日期:2021-02-01 00:00:00
abstract::The relationships of bone size, bone strength, and bone formation were investigated in two strains of mice, NZB/B1NJ and RF/J. Measurement of the femur midshaft size by peripheral quantitative computed tomography (pQCT) showed that the RF/J mice had a 32% greater cross-sectional area than NZB/B1NJ mice at 10 weeks of ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(02)00908-0
更新日期:2002-12-01 00:00:00
abstract::Autologous marrow stromal cells have been proposed as an adjuvant in the treatment of bone defects and diseases. This will require the development of culture conditions that permit their rapid expansion ex vivo while retaining their potential for further differentiation. Fibroblast growth factor (FGF)-2 has been propo...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(00)00319-7
更新日期:2000-08-01 00:00:00
abstract::Within each sex, there is an association between hip fracture risk and the size of the proximal femur, with larger femurs apparently more susceptible to fracture. Here, we investigate whether the thickness and density of the femoral cortex play a role in this association: might larger femurs harbour focal, cortical de...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2015.06.024
更新日期:2015-12-01 00:00:00
abstract::Previous reports have shown that bone mass and architecture will partially recover by remobilization (RM) in immobilization (IM)-induced osteopenia. The aim of this study was to test whether PTH can accelerate the recovery during RM from the IM-induced osteopenia. Six-month-old Sprague-Dawley female rats were divided ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(95)00295-o
更新日期:1995-10-01 00:00:00
abstract::Many clinical and experimental investigations address the influence of statins on bone formation and fracture healing. Simvastatin was shown to increase the expression of Bone morphogenetic protein (BMP-2), which is one of the most potent growth factors targeting bone formation. In this study, the effect of simvastati...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2009.05.010
更新日期:2009-09-01 00:00:00
abstract::Increases in local and systemic bone resorption are hallmarks of rheumatoid arthritis (RA). Osteoclasts are implicated in these processes and their enhanced differentiation may contribute to bone destruction. We observed that in vitro osteoclastogenesis varies among healthy individuals and hypothesized that increased ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2010.10.167
更新日期:2011-03-01 00:00:00
abstract::The accumulation of microdamage in bone may contribute to loss of bone quality in osteoporosis, and the role of microdamage in the etiology of fatigue fractures is unknown. Microdamage created during testing, ex vivo, can increase the fragility of bone by decreasing the load necessary to cause fracture. Microdamage ca...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(98)00111-2
更新日期:1998-10-01 00:00:00
abstract::Conventional methods used to image and quantify microdamage accumulation in bone are limited to histological sections, which are inherently invasive, destructive, two-dimensional, and tedious. These limitations inhibit investigation of microdamage accumulation with respect to volumetric spatial variation in mechanical...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2010.10.160
更新日期:2011-03-01 00:00:00
abstract::Bone morphogenetic protein (BMP) signaling in osteoblasts plays critical roles in skeletal development and bone homeostasis. Our previous studies showed loss of function of BMPR1A, one of the type 1 receptors for BMPs, in osteoblasts results in increased trabecular bone mass in long bones due to an imbalance between b...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2020.115402
更新日期:2020-08-01 00:00:00
abstract::Formoterol, a beta2-adrenergic agonist has been shown in ovariectomized rat models to have anabolic effects on bone. However, those studies did not determine whether the effect of formoterol was by a direct action on bone cells themselves or indirectly via anabolic action on muscle. To address the question of whether ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(98)00026-x
更新日期:1998-05-01 00:00:00
abstract::The long-term protective effect of stronger back muscles on the spine was determined in 50 healthy white postmenopausal women, aged 58-75 years, 8 years after they had completed a 2 year randomized, controlled trial. Twenty-seven subjects had performed progressive, resistive back-strengthening exercises for 2 years an...
journal_title:Bone
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s8756-3282(02)00739-1
更新日期:2002-06-01 00:00:00
abstract::Bisphosphonates increase bone mass and reduce fracture risk, but their anti-resorptive action may lead to increases in fatigue microdamage. To investigate how bisphosphonate effects influence changes in bone volume and microdamage in the long term, a strain-adaptive model of bone remodeling and microdamage balance was...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2004.03.007
更新日期:2004-07-01 00:00:00
abstract::Recent studies suggest that whole-body vibration (WBV) can improve measures of bone health for certain clinical conditions and ages. In the elderly, there also is particular interest in assessing the ability of physical interventions such as WBV to improve coordination, strength, and movement speed, which help prevent...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2010.07.014
更新日期:2010-10-01 00:00:00
abstract::Osteogenesis imperfecta (OI) is a rare and severe skeletal dysplasia marked by low bone mass and poor bone quality which is especially burdensome during childhood. Since clinical trials for pediatric OI are difficult, there is a widespread reliance on genetically modified murine models to understand the skeletal effec...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2019.115118
更新日期:2020-01-01 00:00:00
abstract::Heterotopic ossification (HO) involves formation of endochondral bone at non-skeletal sites, is prevalent in severely wounded service members, and causes significant complications and delayed rehabilitation. As common prophylactic treatments such as anti-inflammatory drugs and irradiation cannot be used after multi-sy...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2016.06.014
更新日期:2016-09-01 00:00:00
abstract:INTRODUCTION:Spinal cord injury (SCI) is characterized by rapid bone loss and an increased risk of fragility fracture around regions of the knee. Our purpose was to quantify changes in torsional stiffness K and strength Tult at the proximal tibia due to actual bone loss and simulated bone recovery in acute SCI. METHOD...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2013.12.012
更新日期:2014-03-01 00:00:00
abstract::Bone is a complex endocrine organ that facilitates structural support, protection to vital organs, sites for hematopoiesis, and calcium homeostasis. The bone marrow microenvironment is a heterogeneous niche consisting of multipotent musculoskeletal and hematopoietic progenitors and their derivative terminal cell types...
journal_title:Bone
pub_type: 杂志文章,评审
doi:10.1016/j.bone.2018.05.019
更新日期:2019-01-01 00:00:00
abstract::Eldecalcitol (ED-71), a 2β-hydroxypropyloxy derivative of 1α,25(OH)(2)D(3), inhibits bone resorption more potently than does alfacalcidol while maintaining osteoblastic function in an estrogen-deficient, high-turnover osteoporosis rat model. Alendronate (ALN) has been reported to increase bone mass by suppressing bone...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2012.02.005
更新日期:2012-05-01 00:00:00
abstract::High doses of caffeine will induce calcium loss and influence the normal development of bone, whereas the proper exercise has positive effects on bone metabolism. This study investigated the possible effects of exercise to antagonize the caffeine-induced impairment of bone development in young male Wistar rats. A tota...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(01)00659-7
更新日期:2002-01-01 00:00:00
abstract::The degree of mineralization of bone matrix is an important factor in determining the mechanical competence of bone. The remodeling and modeling activities of bone cells together with the time course of mineralization of newly formed bone matrix generate a characteristic bone mineralization density distribution (BMDD)...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(02)00973-0
更新日期:2003-03-01 00:00:00
abstract::Trabecular bone score (TBS) is a recently-developed analytical tool that performs novel grey-level texture measurements on lumbar spine dual X-ray absorptiometry (DXA) images, and thereby captures information relating to trabecular microarchitecture. In order for TBS to usefully add to bone mineral density (BMD) and c...
journal_title:Bone
pub_type: 杂志文章,评审
doi:10.1016/j.bone.2015.05.016
更新日期:2015-09-01 00:00:00
abstract::Giant osteoclasts and other cells were isolated from Pagetic bone tissue using 0.5 mM ethylene diamine tetraacetic acid on bone samples from 8 patients with Paget's disease. The cell suspension contained osteoclasts and osteoblasts as well as some mononuclear cells such as monocytes. The number of nuclei in isolated o...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(88)90020-8
更新日期:1988-01-01 00:00:00