当前位置： SCI文献检索 > BONE期刊下所有文献 > Increase in vertebral body size in postmenopausal women with osteoporosis.

Increase in vertebral body size in postmenopausal women with osteoporosis.

Abstract：

:Bone geometry plays a prominent role in bone strength. Cross-sectional studies have shown that advancing age is associated with increasing diameter of long bones, related to both periostal apposition and endosteal resorption. However, there are few data provided by prospective studies, especially concerning the changes in vertebral body dimensions. The objective of this prospective study was to measure the changes occurring in the vertebral body size of women with postmenopausal osteoporosis. Three-year data from placebo groups of the SOTI and TROPOS trials, performed in women with postmenopausal osteoporosis, were used for this study. In these trials, patients underwent lateral radiographs of the thoracic and lumbar spine at baseline and annually over 3 years, according to standardized procedures. Six-point digitization method was used: the four corner points of the vertebral body from T4 to L4 are marked, as well as an additional point in the middle of the upper and lower endplates. From these 6 points, the vertebral body perimeter, area and depth were measured at baseline and at 3 years. The analysis excluded all vertebrae with prevalent or incident fracture. A total of 2017 postmenopausal women (mean age 73.4+/-6.1 years) with a mean lumbar spine T score of -3.1+/-1.5, and a mean femoral neck T score of -3.0+/-0.7 are included in the analysis. Vertebral body dimensions increased over 3 years, by 2.1+/-5.5% (mean depth+/-SD), by 1.7+/-8.3% (mean area+/-SD) and by 1.5+/-4.9% (mean perimeter+/-SD) at the thoracic level (T4 to T12). At the lumbar level (L1 to L4), these dimensions increased as well: 1.4+/-3.6% (mean depth+/-SD), 1.4+/-5.7% (mean area+/-SD), 0.7+/-2.9% (mean perimeter+/-SD). A significant increase in vertebral body size was observed for each vertebral level from T5 to L4 for each of these parameters (p<0.01). These prospective results demonstrate that vertebral body dimensions increase over 3 years in women with postmenopausal osteoporosis.

journal_name

Bone

journal_title

Bone

authors

Briot K,Kolta S,Fechtenbaum J,Said-Nahal R,Benhamou CL,Roux C

doi

10.1016/j.bone.2010.03.020

subject

Has Abstract

pub_date

2010-08-01 00:00:00

pages

229-34

issue

2

eissn

8756-3282

issn

1873-2763

pii

S8756-3282(10)00534-X

journal_volume

47

pub_type

杂志文章

相关文献

BONE文献大全
  • Epidemiology of hip fractures in Oslo, Norway.

    abstract：:The incidence of hip fractures in Oslo has shown a secular increase during the past decades. The main aims of the present study were to report the current incidence of hip fractures in Oslo and to determine whether there is a seasonal variation in the occurrence of fractures. Using the electronic diagnosis registers a...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/s8756-3282(01)00603-2

    authors： Lofthus CM,Osnes EK,Falch JA,Kaastad TS,Kristiansen IS,Nordsletten L,Stensvold I,Meyer HE

    更新日期：2001-11-01 00:00:00

  • Qualitative alterations of cortical bone in female rats after long-term administration of growth hormone and glucocorticoid.

    abstract：:A serious side effect of glucocorticoid treatment is the development of osteoporosis. We have earlier shown that long-term glucocorticoid administration results in a decrease in longitudinal bone growth, cortical bone mass, and biomechanical strength, while growth hormone administration increases these parameters. The...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/8756-3282(96)00077-4

    authors： Ortoft G,Oxlund H

    更新日期：1996-06-01 00:00:00

  • The Sox2 high mobility group transcription factor inhibits mature osteoblast function in transgenic mice.

    abstract：:We have previously shown that in osteoblasts Sox2 expression can be induced by Fgfs, and can inhibit Wnt signaling and differentiation. Furthermore, in mice in which Sox2 is conditionally deleted in the osteoblastic lineage, bones are osteopenic, and Sox2 inactivation in cultured osteoblasts leads to a loss of prolife...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2011.06.008

    authors： Holmes G,Bromage TG,Basilico C

    更新日期：2011-10-01 00:00:00

  • Controversy of physiological vs. pharmacological effects of BMP signaling: Constitutive activation of BMP type IA receptor-dependent signaling in osteoblast lineage enhances bone formation and resorption, not affecting net bone mass.

    abstract：:Bone morphogenetic proteins (BMPs) were first described over 50 years ago as potent inducers of ectopic bone formation when administrated subcutaneously. Preclinical studies have extensively examined the osteoinductive properties of BMPs in vitro and new bone formation in vivo. BMPs (BMP-2, BMP-7) have been used in or...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2020.115513

    authors： Kamiya N,Atsawasuwan P,Joiner DM,Waldorff EI,Goldstein S,Yamauchi M,Mishina Y

    更新日期：2020-09-01 00:00:00

  • Management of hypercalcemia in relation to pathophysiology.

    abstract：:Hypercalcemia results from an imbalance between the fluxes of calcium (Ca) entering and leaving the extracellular space. The two most important influxes are the net intestinal Ca absorption and the net skeletal Ca resorption, whereas the renal excretion represents the main route of elimination. When produced in excess...

    journal_title：Bone

    pub_type： 杂志文章,评审

    doi：

    authors： Bonjour JP,Rizzoli R,Hirschel-Scholz S,Caverzasio J

    更新日期：1987-01-01 00:00:00

  • Zinc deficiency suppresses matrix mineralization and retards osteogenesis transiently with catch-up possibly through Runx 2 modulation.

    abstract：:A characteristic sign of zinc deficiency is retarded skeletal growth, but the role of zinc in osteoblasts is not well understood. Two major events for bone formation include osteoblast differentiation by bone marker gene expression, which is mainly regulated by bone-specific transcription factor Runx2 and extracellula...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2009.11.003

    authors： Kwun IS,Cho YE,Lomeda RA,Shin HI,Choi JY,Kang YH,Beattie JH

    更新日期：2010-03-01 00:00:00

  • Stimulation of osteoinduction in bone wound healing by high-molecular hyaluronic acid.

    abstract：:To study the osteoinductive action of hyaluronic acid (HA), we examined the effects of applying an elastoviscous high-molecular HA preparation on bone wound healing after bone marrow ablation. The middiaphyses of cortical bones from rat femurs were perforated with a round bar, and excavated marrow cavities were filled...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/s8756-3282(94)00001-8

    authors： Sasaki T,Watanabe C

    更新日期：1995-01-01 00:00:00

  • Potential predictive factors of osteoporosis in HIV-positive subjects.

    abstract：:Recent reports showed a high frequency of osteopenia/osteoporosis in HIV-infected subjects. Mechanism on the basis of this alteration is still unclear, as the direct effect of virus or of antiretroviral drugs. One hundred sixty-one consecutive HIV-infected outpatients aged 30-50 years, both naive and HAART-treated for...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2005.11.001

    authors： Fausto A,Bongiovanni M,Cicconi P,Menicagli L,Ligabò EV,Melzi S,Bini T,Sardanelli F,Cornalba G,Monforte Ad

    更新日期：2006-06-01 00:00:00

  • Spatial mapping of mineralization with manganese-enhanced magnetic resonance imaging.

    abstract：:Paramagnetic manganese can be employed as a calcium surrogate to sensitize the magnetic resonance imaging (MRI) technique to the processing of calcium during the bone formation process. At low doses, after just 48h of exposure, osteoblasts take up sufficient quantities of manganese to cause marked reductions in the wa...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2011.02.014

    authors： Chesnick IE,Centeno JA,Todorov TI,Koenig AE,Potter K

    更新日期：2011-05-01 00:00:00

  • Serum periostin is associated with cancer mortality but not cancer risk in older home-dwelling men: A 8-year prospective analysis of the STRAMBO study.

    abstract：BACKGROUND:Periostin (POSTN) regulates multiple biological behaviors of tumor cells. We studied the association of serum POSTN with mortality in home-dwelling men. METHODS:POSTN was measured at baseline using immunoassay (USCN life science, China) in 815 home-dwelling men aged 60-87 followed-up for 8 years. RESULTS:I...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2019.115184

    authors： Rousseau JC,Bertholon C,Chapurlat R,Szulc P

    更新日期：2020-03-01 00:00:00

  • MSTN is a key mediator for low-intensity pulsed ultrasound preventing bone loss in hindlimb-suspended rats.

    abstract：:Low-intensity pulsed ultrasound (LIPUS) has been used to accelerate bone fracture healing. However, the issue whether LIPUS is effective in preventing osteoporosis has not been clarified, and if so, what possible mechanisms might be responsible. Myostatin (MSTN) is a negative regulator of muscle growth, and its absenc...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2020.115610

    authors： Tang L,An S,Zhang Z,Fan X,Guo J,Sun L,Ta D

    更新日期：2021-02-01 00:00:00

  • Animal model for medication-related osteonecrosis of the jaw with precedent metabolic bone disease.

    abstract：:Despite the fact that the medications used to treat abnormal bone conditions often induce osteonecrosis of the jaw (ONJ), previous attempts to establish an animal model for ONJ have shown insufficient consideration for this important prerequisite for the development of the disease. The purpose of this study was to est...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2015.08.012

    authors： Kim JW,Tatad JCI,Landayan MEA,Kim SJ,Kim MR

    更新日期：2015-12-01 00:00:00

  • Risk of fracture in women treated with monthly oral ibandronate or weekly bisphosphonates: the eValuation of IBandronate Efficacy (VIBE) database fracture study.

    abstract：:The eValuation of IBandronate Efficacy (VIBE) head-to-head database fracture study compared fracture rates between patients treated with monthly ibandronate and weekly oral bisphosphonates (BPs). This large study included women >/=45 years old, newly prescribed monthly oral ibandronate or weekly oral alendronate or ri...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2009.01.002

    authors： Harris ST,Reginster JY,Harley C,Blumentals WA,Poston SA,Barr CE,Silverman SL

    更新日期：2009-05-01 00:00:00

  • Expression of bone microsomal casein kinase II, bone sialoprotein, and osteopontin during the repair of calvarial defects.

    abstract：:The temporal expression of bone microsomal casein kinase II, osteopontin, bone sialoprotein, alkaline phosphatase, and the accumulation of a solid calcium-inorganic orthophosphate mineral phase, have been charted from day 2 to day 21 during the repair of calvarial defects in rats induced by the implantation of decalci...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/s8756-3282(98)00057-x

    authors： Wang J,Glimcher MJ,Mah J,Zhou HY,Salih E

    更新日期：1998-06-01 00:00:00

  • Bone and muscle: Interactions beyond mechanical.

    abstract：:The musculoskeletal system is significantly more complex than portrayed by traditional reductionist approaches that have focused on and studied the components of this system separately. While bone and skeletal muscle are the two largest tissues within this system, this system also includes tendons, ligaments, cartilag...

    journal_title：Bone

    pub_type： 杂志文章,评审

    doi：10.1016/j.bone.2015.02.010

    authors： Brotto M,Bonewald L

    更新日期：2015-11-01 00:00:00

  • Microstructural and compositional contributions towards the mechanical behavior of aging human bone measured by cyclic and impact reference point indentation.

    abstract：:The assessment of fracture risk often relies primarily on measuring bone mineral density, thereby accounting for only a single pathology: the loss of bone mass. However, bone's ability to resist fracture is a result of its biphasic composition and hierarchical structure that imbue it with high strength and toughness. ...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2016.03.013

    authors： Abraham AC,Agarwalla A,Yadavalli A,Liu JY,Tang SY

    更新日期：2016-06-01 00:00:00

  • Stanniocalcin 2 is associated with ectopic calcification in α-klotho mutant mice and inhibits hyperphosphatemia-induced calcification in aortic vascular smooth muscle cells.

    abstract：:Ectopic calcification of soft tissues can have severe clinical consequences especially when localized to vital organs such as heart, arteries and kidneys. Mammalian stanniocalcin (STC) 1 and 2 are glycoprotein hormones identified as calcium/phosphate-regulating hormones. The mRNA of STCs is upregulated in the kidney o...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2012.01.006

    authors： Takei Y,Yamamoto H,Sato T,Otani A,Kozai M,Masuda M,Taketani Y,Muto-Sato K,Lanske B,Takeda E

    更新日期：2012-04-01 00:00:00

  • Glucocorticoids: Dose-related effects on osteoclast formation and function via reactive oxygen species and autophagy.

    abstract：:Whether glucocorticoids directly enhance or interrupt osteoclastogenesis is still a controversial subject. In this study, we ascertained the dose-dependent positive effects of glucocorticoids on osteoclastogenesis in vivo and in vitro as well as investigated the mechanism in vitro. As the dose of glucocorticoids incre...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2015.06.014

    authors： Shi J,Wang L,Zhang H,Jie Q,Li X,Shi Q,Huang Q,Gao B,Han Y,Guo K,Liu J,Yang L,Luo Z

    更新日期：2015-10-01 00:00:00

  • Systemic versus local application of gentamicin in prophylaxis of implant-related osteomyelitis in a rat model.

    abstract：:Administration of perioperative antibiotic prophylaxis is a routine procedure in orthopedic surgery. Besides systemic prophylaxis, only few techniques are established for local application of antibiotics to reduce infection related to orthopedic implants. The aim of this study was to evaluate the efficacy of locally v...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2005.01.008

    authors： Lucke M,Wildemann B,Sadoni S,Surke C,Schiller R,Stemberger A,Raschke M,Haas NP,Schmidmaier G

    更新日期：2005-05-01 00:00:00

  • A theoretical analysis of long-term bisphosphonate effects on trabecular bone volume and microdamage.

    abstract：:Bisphosphonates increase bone mass and reduce fracture risk, but their anti-resorptive action may lead to increases in fatigue microdamage. To investigate how bisphosphonate effects influence changes in bone volume and microdamage in the long term, a strain-adaptive model of bone remodeling and microdamage balance was...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2004.03.007

    authors： Nyman JS,Yeh OC,Hazelwood SJ,Martin RB

    更新日期：2004-07-01 00:00:00

  • Effect of eplerenone on markers of bone turnover in patients with primary hyperparathyroidism - The randomized, placebo-controlled EPATH trial.

    abstract：:Mineralocorticoid receptor (MR) antagonism may affect bone turnover via direct and indirect pathways involving parathyroid hormone, but randomized controlled trials are lacking. In a pre-specified analysis of the "Eplerenone in primary hyperparathyroidism" placebo-controlled, randomized trial (ISRCTN 33941607), effect...

    journal_title：Bone

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.bone.2017.08.030

    authors： Verheyen N,Grübler MR,Meinitzer A,Trummer C,Schwetz V,Amrein K,Dimai HP,März W,Catena C,von Lewinski D,Voelkl J,Alesutan I,Fahrleitner-Pammer A,Brussee H,Pilz S,Tomaschitz A

    更新日期：2017-12-01 00:00:00

  • Intermittent treatment of prostaglandin E2 with risedronate is more anabolic than prostaglandin E2 alone in the proximal tibial metaphysis of ovariectomized rats.

    abstract：:This study is designed to test how intermittent application of prostaglandin E2 (PGE2) and risedronate (Ris) alone or in combination acts on the cancellous bone mass in estrogen-deficient rats. Sprague-Dawley rats were ovariectomized (ovx) or sham-ovx'd at 6 months of age. PGE2 (6mg/kg/d), Ris (5 micrograms/kg/twice a...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/8756-3282(95)00305-w

    authors： Chen HK,Jee WS,Ma YF,Pan Z,McOsker JE,Li XJ

    更新日期：1995-10-01 00:00:00

  • Age-related changes in vertebral trabecular bone architecture--assessed by a new method.

    abstract：:Cylindrical trabecular bone specimens (d = 7 mm) were drilled in a vertical direction from the central part of the third vertebral body (L3) from 23 normal individuals aged 15-87 years (10 males and 13 females). The bone samples were embedded in methylmetacrylate and sawn in 400 microns thick sections with an arbitrar...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/8756-3282(88)90038-5

    authors： Mosekilde L

    更新日期：1988-01-01 00:00:00

  • International variation in the management of mineral bone disorder in patients with chronic kidney disease: Results from CKDopps.

    abstract：BACKGROUND AND OBJECTIVES:Chronic kidney disease (CKD) is commonly associated with mineral and bone metabolism disorders, but these are less frequently studied in non-dialysis CKD patients than in dialysis patients. We examined and described international variation in mineral and bone disease (MBD) markers and their tr...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2019.115058

    authors： Liabeuf S,McCullough K,Young EW,Pisoni R,Zee J,Reichel H,Pecoits-Filho R,Port FK,Stengel B,Csomor PA,Metzger M,Robinson B,Massy ZA

    更新日期：2019-12-01 00:00:00

  • Factors affecting the prevalence of osteoarthritis in healthy middle-aged women: data from the longitudinal Melbourne Women's Midlife Health Project.

    abstract：:The prevalence of osteoarthritis (OA) is greater in women then men. Weight, a factor strongly associated with osteoarthritis, is significantly increased over the menopausal transition. Despite the high prevalence of osteoarthritis, a disabling disease with limited treatment options, there is a paucity of studies in wo...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2006.05.016

    authors： Szoeke CEI,Cicuttini FM,Guthrie JR,Clark MS,Dennerstein L

    更新日期：2006-11-01 00:00:00

  • Impact microindentation assesses subperiosteal bone material properties in humans.

    abstract：:Impact microindentation (IMI) is a Reference Point Indentation technique measuring tissue-level properties of cortical bone in humans in vivo. The nature, however, of the properties that can affect bone strength is incompletely understood. In the present study we examined bone material properties in transiliac bone bi...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2019.115110

    authors： Rokidi S,Bravenboer N,Gamsjaeger S,Misof B,Blouin S,Chavassieux P,Klaushofer K,Paschalis E,Papapoulos S,Appelman-Dijkstra N

    更新日期：2020-02-01 00:00:00

  • Abnormal ossification in thanatophoric dysplasia.

    abstract：:Thanatophoric dysplasia (TD) is a lethal human bone dysplasia characterized by severe dwarfism. It pathogenesis is thought to involve an abnormal ossifying fibrous tissue that disrupts the skeletal growth plate. We employed a combined morphologic, immunohistochemical and biochemical approach to better define the natur...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/8756-3282(88)90027-0

    authors： Horton WA,Hood OJ,Machado MA,Ahmed S,Griffey ES

    更新日期：1988-01-01 00:00:00

  • Relationships between marrow fat and bone turnover in ovariectomized and intact rats.

    abstract：:It is known that marrow fat content increases in a variety of osteoporoses. This study sought to clarify this phenomenon by combining bone and marrow histomorphometry, and to determine (1) whether the marrow fat increase follows or precedes diminishment of bone volume, and (2) whether the increase in fat volume is due...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/8756-3282(91)90011-7

    authors： Martin RB,Zissimos SL

    更新日期：1991-01-01 00:00:00

  • Body mass influences cortical bone mass independent of leptin signaling.

    abstract：:Obesity in humans is associated with increased bone mass. Leptin, a hormone produced by fat cells, functions as a sentinel of energy balance, and may mediate the putative positive effects of body mass on bone. We performed studies in male C57Bl/6 wild type (WT) and leptin-deficient ob/ob mice to determine whether body...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/j.bone.2008.10.058

    authors： Iwaniec UT,Dube MG,Boghossian S,Song H,Helferich WG,Turner RT,Kalra SP

    更新日期：2009-03-01 00:00:00

  • Preliminary evidence for impaired estrogen receptor-alpha protein expression in osteoblasts and osteocytes from men with idiopathic osteoporosis.

    abstract：:Although osteoporosis is usually associated with women, 1 in 12 men in the UK have the disease, and a third of these cases are idiopathic. Estrogen is now known to be associated with bone loss in older men, but we found, previously, that levels of this hormone were normal in younger cases of male idiopathic osteoporos...

    journal_title：Bone

    pub_type： 杂志文章

    doi：10.1016/S8756-3282(00)00246-5

    authors： Braidman I,Baris C,Wood L,Selby P,Adams J,Freemont A,Hoyland J

    更新日期：2000-05-01 00:00:00