Abstract:
:A serious side effect of glucocorticoid treatment is the development of osteoporosis. We have earlier shown that long-term glucocorticoid administration results in a decrease in longitudinal bone growth, cortical bone mass, and biomechanical strength, while growth hormone administration increases these parameters. The result of biomechanical testing also indicates that glucocorticoid administration reduces the quality of bone. The glucocorticoid-induced osteopenia could not be inhibited by concomitant administration of large doses of growth hormone. The aim of the present study was to evaluate why glucocorticoid administration decreases the quality of cortical bone and why growth hormone administration had no beneficial effect on glucocorticoid-induced osteopenia. Five groups of female rats (3 1/2 months old) were treated for 80 days as follows: (1) glucocorticoid (prednisolone: Delcortol 5 mg/kg/day); (2) glucocorticoid and growth hormone; (3) saline; (4) growth hormone (recombinant human growth hormone 5 mg/kg/day); (5) Food restriction (consisting of restricted access to food to reduce their weight gain to match with that of the glucocorticoid injected rats). The animals were injected with tetracycline (15 mg/kg), 18 and 3 days before sacrifice, respectively. Furthermore, a baseline group (3 1/2-month-old female rats) was examined in order to enable us to differentiate between age-related changes and changes due to the hormone administration. Cortical mid-diaphysial cross sections of the femora were prepared and used for histological examination including determination of bone porosity, bone formation rate, and determination of the area of endosteal cavities as an indication of bone resorption. Furthermore, a cortical bone cylinder was cut from the mid-diaphysis and used for examinations of wet weight, dry weight, ash weight, volume, collagen content, and apparent density. Glucocorticoid administration resulted in an almost complete arrest of bone formation as shown by a decreased bone formation rate and a decreased periosteal mineralizing surface. Glucocorticoid administration also increased the porosity of bone indicating increased osteoclast activity. The increased porosity was due to a glucocorticoid-induced increase in the number of endosteal cavities in the mid-diaphysial cross section of the femora. The decreased bone formation and the increased bone resorption can explain the decrease in bone mass (volume and ash weight) found after glucocorticoid administration. Growth hormone administration, on the other hand, resulted in a marked increase in bone formation as shown by a marked increase in bone formation rate and periosteal mineralizing surface. In agreement with this, we found an increase in cortical bone mass (volume and ash weight). When the two hormones were given concomitantly, growth hormone administration did not increase bone formation. Our findings indicate the reason why growth hormone has no beneficial effect on cortical osteopenia induced by a high dose of glucocorticoid with protracted effect.
journal_name
Bonejournal_title
Boneauthors
Ortoft G,Oxlund Hdoi
10.1016/8756-3282(96)00077-4subject
Has Abstractpub_date
1996-06-01 00:00:00pages
581-90issue
6eissn
8756-3282issn
1873-2763pii
8756328296000774journal_volume
18pub_type
杂志文章相关文献
BONE文献大全abstract::Low body weight is associated with an increased risk for osteoporosis and fractures, but the contribution of other lifestyle related factors have not been previously studied within lean elderly women. The present study evaluated the association between lifelong lifestyle factors and bone density, falls and postmenopau...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2006.01.143
更新日期:2006-08-01 00:00:00
abstract::Biochemical bone turnover markers (BTMs) provide important information on the diagnosis, therapy and monitoring of metabolic bone diseases including osteoporosis. One goal of antiresorptive therapy in women is to decrease biochemical BTMs to the lower half of reference intervals for healthy pre-menopausal counterparts...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2010.07.017
更新日期:2010-10-01 00:00:00
abstract::Mutations in the SCN8A gene encoding the neuronal voltage-gated sodium channel Nav1.6 are known to be associated with epileptic encephalopathy type 13. We identified a novel de novo SCN8A mutation (p.Phe360Ala, c.1078_1079delTTinsGC, Exon 9) in a 6-year-old girl with epileptic encephalopathy accompanied by severe juve...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2017.06.025
更新日期:2017-10-01 00:00:00
abstract::Recent proton magnetic resonance (MR) spectroscopy studies have shown that cortical bone exists as different components which have distinct transverse relaxation times (T2s). However, cortical bone shows zero or near zero signal with all conventional MR sequences on clinical scanners and the different water components...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2011.11.029
更新日期:2012-03-01 00:00:00
abstract:PURPOSE:In the Fracture Prevention Trial, the risks of any nonvertebral fracture (relative risk [RR] 0.65, P=0.04) and any fragility nonvertebral fracture (RR 0.47, P=0.02) were significantly reduced in the teriparatide 20 μg/day (teriparatide) versus placebo group. The purpose of this analysis was to examine the effic...
journal_title:Bone
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.bone.2011.10.018
更新日期:2012-01-01 00:00:00
abstract:PURPOSE:Traditional epidemiological studies suggest that there is an association between age at menarche (years) (AAM) and bone mineral density (BMD) at the sites of the femoral neck and lumbar spine (FNK and LS BMD), indicating a potentially important relationship between AAM and the development of osteoporosis (OP). ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2018.09.015
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND:Neuropathic foot impairments treated with immobilization and off-loading result in osteolysis. In order to prescribe and optimize rehabilitation programs after immobilization we need to understand the magnitude of pedal osteolysis after immobilization and the time course for recovery. OBJECTIVE:To determine...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2017.09.009
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:Vertebral fracture (VF) is the most common osteoporotic fracture in postmenopausal women, although most VFs are subclinical. Prevalent VFs are a significant predictor of subsequent fracture and therefore, identification of VF improves the identification of those with high fracture risk. The aim of present st...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2020.115358
更新日期:2020-07-01 00:00:00
abstract::A characteristic relationship for bone between bone volume fraction (BV/TV) and specific surface (BS/TV) has previously been proposed based on 2D histological measurements. This relationship has been suggested to be bone intrinsic, i.e., to not depend on bone type, bone site and health state. In these studies, only li...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2014.11.016
更新日期:2015-03-01 00:00:00
abstract::The incidence of hip fractures in Oslo has shown a secular increase during the past decades. The main aims of the present study were to report the current incidence of hip fractures in Oslo and to determine whether there is a seasonal variation in the occurrence of fractures. Using the electronic diagnosis registers a...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/s8756-3282(01)00603-2
更新日期:2001-11-01 00:00:00
abstract::The effects of tumor-conditioned media (TCM) derived from cultured cells from an oncogenic hypophosphatemic osteomalacia (OHO) tumor on transformed human kidney cells were investigated. Dose-dependent cell detachment and aggregation occurred in kidney cells cultured in serum-free medium supplemented with TCM, but not ...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(95)00458-0
更新日期:1996-02-01 00:00:00
abstract::To elucidate the histological events that follow administration of eldecalcitol, a second-generation of vitamin D analog currently awaiting approval as a drug for treatment of osteoporosis, we employed the ovariectomy (OVX) rat model. OVX rats received vehicle or 30ng/kg of eldecalcitol, and sham-operated animals rece...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2011.05.022
更新日期:2011-09-01 00:00:00
abstract::Vitamin D deficiency may depress bone formation but its effect on bone resorption is not well defined. As an index of bone resorption, the activity of acid phosphatase, a lysosomal enzyme found in osteoclasts, was quantitated in situ from a bone tissue smear preparation. Activity of the enzyme, measured by integrative...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(87)90171-2
更新日期:1987-01-01 00:00:00
abstract:INTRODUCTION:While the anti-resorptive effects of the bisphosphonates (BPs) are well documented, many questions remain about their mechanisms of action, particularly following long-term use. This study evaluated the effects of alendronate (Ale) treatment on TGF-β1 signaling in mesenchymal stem cells (MSCs) and osteocyt...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2012.10.017
更新日期:2013-01-01 00:00:00
abstract::Tumor necrosis factor (TNF) actions in target tissues are mediated by various signalling pathways. The effect of TNF to stimulate resorption in fetal rat limb bones is not inhibited by indomethacin. The current studies were designed to assess the role of cyclic AMP (cAMP) and calcium as second messengers in this prost...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/8756-3282(93)90317-4
更新日期:1993-11-01 00:00:00
abstract:BACKGROUND:Avoidant Restrictive Food Intake Disorder (ARFID) and Anorexia Nervosa (AN) cause significant underweight in children and young people (CYP). The association of low bone mineral density (BMD) and underweight CYP in AN is well established, but less is known about BMD in ARFID. METHODS:Retrospective case-note...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2020.115307
更新日期:2020-05-01 00:00:00
abstract::Achondroplasia (ACH), the most common form of human dwarfism is caused by a mutation in the Fibroblast Growth Factor Receptor 3 (FGFR3) gene, resulting in constitutive activation of the receptor. Typical radiological features include shortening of the tubular bones and macrocephaly, due to disruption of endochondral o...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2010.07.020
更新日期:2010-11-01 00:00:00
abstract::Evidence indicates that astronauts experience significant bone loss during space mission. Recently, we used the NASA developed rotary cell culture system (RCCS) to simulate microgravity (μXg) conditions and demonstrated increased osteoclastogenesis in mouse bone marrow cultures. Autophagy is a cellular recycling proce...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2014.01.004
更新日期:2014-04-01 00:00:00
abstract::Several Biophosphonates have been used as therapeutic agents for Paget's bone disease. (Chloro-4 phenyl)thiomethylene-bisphosphonate (CIPsMBP) has recently been shown to have significant antiosteoclastic activity while an affect of CIPsMBP on mineralization was only observed at high doses. We tested this drug for 6 mo...
journal_title:Bone
pub_type: 临床试验,杂志文章
doi:10.1016/8756-3282(88)90115-9
更新日期:1988-01-01 00:00:00
abstract::Oral bisphosphonates are established therapeutics for postmenopausal osteoporosis. Alternative, simplified dosing regimens that improve tolerability and promote convenience may be advantageous. Ibandronate is a highly potent, nitrogen-containing bisphosphonate that can be administered as a convenient intravenous (i.v....
journal_title:Bone
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.bone.2004.01.007
更新日期:2004-05-01 00:00:00
abstract::Cathepsin K is a major osteoclastic protease. We have recently shown that overexpression of mouse cathepsin K gene in transgenic UTU17 mouse model results in high turnover osteopenia of metaphyseal trabecular bone at the age of 7 months. The present report extends these studies to a systematic analysis of cortical bon...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2005.02.006
更新日期:2005-05-01 00:00:00
abstract::Bone age is used widely by pediatricians to assess the skeletal maturity of a child and predict growth potential. This entails measuring the size of secondary ossification centers (SOCs), which develop with age in the ends of long bones, which are initially cartilaginous. However, little is presently known about the d...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2020.115701
更新日期:2021-01-01 00:00:00
abstract::General dental practitioners use a vast amount of panoramic radiography in their routine clinical work, but valuable information about patients' osteoporotic status is not collected. There are many reasons for this, but one of the prime reasons must be the disruption involved in clinical routine with lengthy manual ra...
journal_title:Bone
pub_type: 杂志文章,多中心研究
doi:10.1016/j.bone.2006.10.024
更新日期:2007-04-01 00:00:00
abstract:CONTEXT:Selective serotonin reuptake inhibitors (SSRIs) are commonly prescribed medications to treat depression and anxiety. SSRIs exert their effects by inhibiting the serotonin transporter and modulating extracellular serotonin levels, a neurotransmitter that has been shown to affect bone metabolism in animals. Studi...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2015.04.042
更新日期:2015-09-01 00:00:00
abstract::Chondrocyte proliferation and differentiation are crucial for endochondral ossification and strictly regulated by numerous signaling molecules and transcription factors, but the hierarchical regulatory network remains to be deciphered. The present study emphasized the interplay of Activin A, Foxa, Notch and Shh signal...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2019.03.036
更新日期:2019-06-01 00:00:00
abstract::Osteocytes are cells buried in the bone matrix. They largely contribute to the regulation of bone remodeling in response to mechanical and microenvironmental changes. Much has been recognized in recent years regarding the role of osteocytes in bone homeostasis, nevertheless their ability to directly contribute to mine...
journal_title:Bone
pub_type: 杂志文章,评审
doi:10.1016/j.bone.2008.09.017
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Like osteonecrosis of the femoral head (ONFH), subchondral insufficiency fracture of the femoral head (SIF) causes femoral head collapse. However, little is known about the differences between the two diseases regarding the morphological features of the collapsed lesion. We tested the hypothesis that the mor...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2020.115585
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:High-resolution peripheral quantitative computed tomography (HR-pQCT) represents a three-dimensional tool for the screening of osteoporosis patients i.e., regarding fracture risk. The purpose of this study was to determine the baseline and follow-up bone microarchitecture in relation to incident fracture ris...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2018.06.022
更新日期:2018-09-01 00:00:00
abstract::Osteonecrosis of the jaw (ONJ) is now defined by the presence of exposed bone in the mouth, which fails to heal after appropriate intervention over a period of six or eight weeks. It is commonly precipitated by a tooth extraction in patients treated with zoledronate, pamidronate or a combination of these agents, for t...
journal_title:Bone
pub_type: 杂志文章,评审
doi:10.1016/j.bone.2008.09.012
更新日期:2009-01-01 00:00:00
abstract::Although a critical role of COX-2 in bone repair has been established, the mechanism involved remains unclear. During early inflammatory phase of bone healing, COX-2 is produced by the surrounding inflammatory cells as well as bone/cartilage progenitors. Based on the temporal and spatial expression of COX-2 during the...
journal_title:Bone
pub_type: 杂志文章
doi:10.1016/j.bone.2008.08.109
更新日期:2008-12-01 00:00:00