Effect of eplerenone on markers of bone turnover in patients with primary hyperparathyroidism - The randomized, placebo-controlled EPATH trial.

abstract：:Three siblings, aged 12, 4 and 2 years, presented at a Gambian clinic with bone deformities. Radiographs of knees and wrists confirmed the presence of florid rickets. The family (including 2 unaffected siblings and the mother) were investigated for hereditary rickets. The three affected siblings had biochemical featur...

journal_title：Bone

authors： Braithwaite V,Pettifor JM,Prentice A

更新日期：2013-03-01 00:00:00

abstract：INTRODUCTION:Because osteoporotic patients are prone to fractures, it must be considered whether or not patients undergoing drug therapies should discontinue treatment after sustaining a non-vertebral fracture. This study has tested the effect of novel active vitamin D3 analog, 1alpha,25-dihydroxy-2beta(3-hydroxypropox...

journal_title：Bone

authors： Cao Y,Mori S,Mashiba T,Kaji Y,Manabe T,Iwata K,Miyamoto K,Komatsubara S,Yamamoto T

更新日期：2007-01-01 00:00:00

abstract：:Metastatic cancer is lethal and patients who suffer bone metastases fare especially poorly. Bone-specific metastatic progression in prostate and breast cancers is a highly observed example of organ-specific metastasis, or organotropism. Though research has delineated the sequential steps of the metastatic cascade, the...

journal_title：Bone

authors： Mallin MM,Pienta KJ,Amend SR

更新日期：2020-12-03 00:00:00

abstract：:In this study, we observed mitotic preosteoblasts that have the structural features of osteoblasts in the primary spongiosa of the rat mandibular condyle. The rough endoplasmic reticulum and the Golgi apparatus showed remarkable disorganization during mitosis. The Golgi saccules were replaced by groups of large vacuol...

journal_title：Bone

authors： Shibata S,Baba O,Sakamoto Y,Ohsako M,Yamashita Y,Ichijo T

更新日期：1993-01-01 00:00:00

abstract：:The potency of magnetic resonance imaging (MRI) to measure the exact extent of osteonecrosis of the femoral head (ONFH) remains uncertain. The objective of this study was to determine if the volume of necrosis assessed with MRI accurately reflects the volume of architectural mineral alterations in osteonecrosis of the...

journal_title：Bone

authors： Pascart T,Paccou J,Colard T,Norberciak L,Girard J,Delattre J,Marchandise P,Legrand J,Penel G,Coursier R,Putman S,Cortet B,Kerckhofs G,Budzik JF

更新日期：2020-01-01 00:00:00

abstract：:The increasing application of approaches that allow tracing of individual cells over time, together with transcriptomic and epigenomic analyses is changing the way resident stromal stem cells (mesenchymal stem cells) are viewed. Rather than being a defined, homogeneous cell population as described following in vitro e...

journal_title：Bone

authors： Yianni V,Sharpe PT

更新日期：2020-05-01 00:00:00

abstract：:Progressive osseous heteroplasia (POH) is a rare autosomal dominant disorder of mesenchymal differentiation characterized by progressive heterotopic ossification (HO) of dermis, deep connective tissues and skeletal muscle. Usually, initial bone formation occurs during infancy as primary osteoma cutis (OC) then progres...

journal_title：Bone

authors： Elli FM,Barbieri AM,Bordogna P,Ferrari P,Bufo R,Ferrante E,Giardino E,Beck-Peccoz P,Spada A,Mantovani G

更新日期：2013-10-01 00:00:00

abstract：:To study the osteoinductive action of hyaluronic acid (HA), we examined the effects of applying an elastoviscous high-molecular HA preparation on bone wound healing after bone marrow ablation. The middiaphyses of cortical bones from rat femurs were perforated with a round bar, and excavated marrow cavities were filled...

journal_title：Bone

authors： Sasaki T,Watanabe C

更新日期：1995-01-01 00:00:00

abstract：:Principal strains and their orientation, determined from in vivo and in situ strains recorded from the lateral cortical surface of the calcaneus of potoroos (a small marsupial) during treadmill exercise and tension applied via the Achilles tendon, were compared with the underlying trabecular architecture and its align...

journal_title：Bone

authors： Biewener AA,Fazzalari NL,Konieczynski DD,Baudinette RV

更新日期：1996-07-01 00:00:00

abstract：:G protein-coupled receptors (GPCRs) require G proteins for intracellular signaling to regulate a variety of growth and maintenance processes, including osteogenesis and bone turnover. Bone maintenance events may be altered by changes in the activity or level of G proteins, which then modify signaling in bone cells suc...

journal_title：Bone

authors： Dela Cruz A,Mattocks M,Sugamori KS,Grynpas MD,Mitchell J

更新日期：2014-02-01 00:00:00

abstract：:The degradation of the main fibrillar collagens, collagens I and II, is a crucial process for skeletal development. The most abundant dipeptides generated from the catabolism of collagens contain proline and hydroxyproline. In humans, prolidase is the only enzyme able to hydrolyze dipeptides containing these amino aci...

journal_title：Bone

authors： Besio R,Maruelli S,Gioia R,Villa I,Grabowski P,Gallagher O,Bishop NJ,Foster S,De Lorenzi E,Colombo R,Diaz JL,Moore-Barton H,Deshpande C,Aydin HI,Tokatli A,Kwiek B,Kasapkara CS,Adisen EO,Gurer MA,Di Rocco M,Phang J

更新日期：2015-03-01 00:00:00

abstract：:Despite the remarkable healing potential of long bone fractures, traumatic injuries that result in critical defects require challenging reconstructive limb sparing surgery. While devitalized allografts are the gold standard for these procedures, they are prone to failure due to their limited osseointegration with the ...

journal_title：Bone

authors： Reynolds DG,Takahata M,Lerner AL,O'Keefe RJ,Schwarz EM,Awad HA

更新日期：2011-03-01 00:00:00

abstract：:The purpose of this in vitro biomechanical study is to determine the force attenuation capacity of four different hip protectors (KPH1, KPH2, Safehip, and Safetypants) in falling simulations in elderly subjects (falls to the side). The simulated falling conditions were created by a biomechanical testing system, which ...

journal_title：Bone

authors： Kannus P,Parkkari J,Poutala J

更新日期：1999-08-01 00:00:00

abstract：:Prenatal dexamethasone exposure (PDE) induces developmental toxicities of multi-organs and susceptibility to multi-diseases in offspring. However, the effects of PDE on osteoarthritis susceptibility in adult offspring and its mechanism have not been reported. In the present study, we treated pregnant Wistar rats with ...

journal_title：Bone

authors： Xiao H,Xie X,Wen Y,Tan Y,Shangguan Y,Li B,Magdalou J,Wang H,Chen L

更新日期：2020-04-01 00:00:00

abstract：:The Sost gene encodes Sclerostin, an inhibitor of Wnt-signaling, generally considered a main response gene to mechanical loading in bone. Several papers describe that unloading leads to upregulation of Sost, which in turn may lead to loss of bone. These studies were based on whole bone homogenates or cortical bone. By...

journal_title：Bone

authors： Macias BR,Aspenberg P,Agholme F

更新日期：2013-04-01 00:00:00

abstract：INTRODUCTION:Mechanical stresses on the bone are an important aspect of physical activity that promotes bone preservation and increases in bone mass. Exercise intensities leading to bone preservation and accrual have not been adequately defined for humans in general, and postmenopausal women in particular. MATERIALS A...

journal_title：Bone

authors： Borer KT,Fogleman K,Gross M,La New JM,Dengel D

更新日期：2007-10-01 00:00:00

abstract：:In order to delineate the influence of mechanical unloading on the formation and resorption of trabecular and cortical bone, the effects of mechanical unloading on the volume, structure, and turnover of hindlimbs were examined using tail-suspended rapidly growing rats. In addition, to clarify the mechanism of how mech...

journal_title：Bone

authors： Matsumoto T,Nakayama K,Kodama Y,Fuse H,Nakamura T,Fukumoto S

更新日期：1998-05-01 00:00:00

abstract：:Preliminary studies have shown that dual-energy X-ray absorptiometry (DXA) produces images of sufficient quality for a precise and accurate measurement at density of the subchondral bone. The objective of this study was to investigate the relationship between baseline subchondral tibial bone mineral density (BMD) and ...

journal_title：Bone

authors： Bruyere O,Dardenne C,Lejeune E,Zegels B,Pahaut A,Richy F,Seidel L,Ethgen O,Henrotin Y,Reginster JY

更新日期：2003-05-01 00:00:00

abstract：:Trabecular bone score (TBS) is a texture index derived from standard lumbar spine dual energy X-ray absorptiometry (DXA) images and provides information about the underlying bone independent of the bone mineral density (BMD). Several salient observations have emerged. Numerous studies have examined the relationship be...

journal_title：Bone

authors： Martineau P,Leslie WD

更新日期：2017-11-01 00:00:00

abstract：:Bone is a hierarchical, multiphasic and anisotropic structure which in addition possess piezoelectric properties. The generation of piezoelectricity in bone is a complex process which has been shown to play a key role both in bone adaptation and regeneration. In order to understand the complex biological, mechanical a...

journal_title：Bone

authors： Mohammadkhah M,Marinkovic D,Zehn M,Checa S

更新日期：2019-10-01 00:00:00

abstract：:Epigenetic regulatory proteins support mammalian development, cancer, aging and tissue repair by controlling many cellular processes including stem cell self-renewal, lineage-commitment and senescence in both skeletal and non-skeletal tissues. We review here our knowledge of epigenetic regulatory protein complexes tha...

journal_title：Bone

authors： van Wijnen AJ,Bagheri L,Badreldin AA,Larson AN,Dudakovic A,Thaler R,Paradise CR,Wu Z

更新日期：2021-02-01 00:00:00

abstract：:SAM-P/6 is a recently developed strain of osteoporotic mice. In this study we tried to determine whether calcium, vitamin D3, parathyroid hormone (PTH), and estrogen modified the peak bone mass of young SAM-P/6 mice, and whether the effect of these medications persisted after treatment had been discontinued. Calcium s...

journal_title：Bone

authors： Takahashi K,Tsuboyama T,Matsushita M,Kasai R,Okumura H,Yamamuro T,Okamoto Y,Kitagawa K,Takeda T

更新日期：1994-03-01 00:00:00

abstract：:Low-intensity pulsed ultrasound (LIPUS) has been used to accelerate bone fracture healing. However, the issue whether LIPUS is effective in preventing osteoporosis has not been clarified, and if so, what possible mechanisms might be responsible. Myostatin (MSTN) is a negative regulator of muscle growth, and its absenc...

journal_title：Bone

authors： Tang L,An S,Zhang Z,Fan X,Guo J,Sun L,Ta D

更新日期：2021-02-01 00:00:00

abstract：:Loss of bone and muscle mass are two major clinical complications among the growing list of chronic diseases that primarily affect elderly individuals. Persistent low-grade inflammation, one of the major drivers of aging, is also associated with both bone and muscle dysfunction in aging. Particularly, chronic activati...

journal_title：Bone

authors： Davis HM,Essex AL,Valdez S,Deosthale PJ,Aref MW,Allen MR,Bonetto A,Plotkin LI

更新日期：2019-07-01 00:00:00

abstract：:We compared the distribution of a cysteine proteinase inhibitor, cystatin C, with that of cathepsin K in osteoclasts of the mouse tibia by immunolight and immunoelectron microscopy. Light microscopically, strong immunoreactivity for cystatin C was found extracellularly along the resorption lacuna and intracellularly i...

journal_title：Bone

authors： Yamaza T,Tsuji Y,Goto T,Kido MA,Nishijima K,Moroi R,Akamine A,Tanaka T

更新日期：2001-07-01 00:00:00

abstract：:It is well known that porosity has an inverse relationship with the mechanical properties of bones. We examined cortical and trabecular porosity of antlers, and mineral composition, thickness and mechanical properties in the cortical wall. Samples belonged to two deer populations: a captive population of an experiment...

journal_title：Bone

authors： Landete-Castillejos T,Currey JD,Ceacero F,García AJ,Gallego L,Gomez S

更新日期：2012-01-01 00:00:00

abstract：:Measurement of bone mineral density (BMD) is the clinical gold standard in cases of compromised skeletal integrity, such as with osteoporosis. While BMD is a useful measurement to index skeletal health, it is also limited since it cannot directly assess any mechanical properties. The ability to directly assess mechani...

journal_title：Bone

authors： Beutel BG,Kennedy OD

更新日期：2015-06-01 00:00:00

abstract：:Recent studies have established that generalized loss of trabecular bone occurs in the growing rat following day-to-day inflammatory irritation for a period of 3 wk. We can now demonstrate that there are similar effects on bone in milder but more prolonged chronic inflammation (14 wk). Thus, there were significant dec...

journal_title：Bone

authors： Pfeilschifter J,Minne HW,Enzmann E,Krempien B,Ziegler R

更新日期：1985-01-01 00:00:00

abstract：:We have previously shown that after bone fracture, galanin (GAL) and GAL receptor expression is increased in osteoblast-like cells of callus; however, the role of elevated GAL/GAL receptors in this instance of bone injury is not known. We hypothesize that in injury, GAL may facilitate bone formation by suppressing the...

journal_title：Bone

authors： McDonald AC,Schuijers JA,Gundlach AL,Grills BL

更新日期：2007-04-01 00:00:00

abstract：:Human vertebral cancellous bone from white males (N = 19), black males (N = 16), white females (N = 12), and black females (N = 17) was examined histologically for the presence, numerical density, and morphology of in vivo microscopic cracking (microdamage). Two patterns of microcracks, linear and cross-hatched, were ...

journal_title：Bone

authors： Wenzel TE,Schaffler MB,Fyhrie DP

更新日期：1996-08-01 00:00:00