Effect of eplerenone on markers of bone turnover in patients with primary hyperparathyroidism - The randomized, placebo-controlled EPATH trial.


:Mineralocorticoid receptor (MR) antagonism may affect bone turnover via direct and indirect pathways involving parathyroid hormone, but randomized controlled trials are lacking. In a pre-specified analysis of the "Eplerenone in primary hyperparathyroidism" placebo-controlled, randomized trial (ISRCTN 33941607), effects of eight weeks MR-blockade with eplerenone on bone turnover markers in 97 patients with primary hyperparathyroidism were tested. Mean age was 67.5±9.5years, and 76 (78.4%) were females. In analysis of covariance with adjustment for baseline values, eplerenone had no significant effect on isoform 5b of the tartrate-resistant acid phosphatase (TRAP), beta-crosslaps, N-terminal propeptide of procollagen type 1 (P1NP), osteocalcin and bone-specific alkaline phosphatase. There was no significant cross-sectional correlation between plasma aldosterone concentration or the aldosterone-to-renin ratio and markers of bone turnover in multivariate linear regression models at baseline. These data provide first evidence from a randomized and placebo-controlled trial that short-term MR antagonism may not affect bone turnover, at least in patients with primary hyperparathyroidism.






Verheyen N,Grübler MR,Meinitzer A,Trummer C,Schwetz V,Amrein K,Dimai HP,März W,Catena C,von Lewinski D,Voelkl J,Alesutan I,Fahrleitner-Pammer A,Brussee H,Pilz S,Tomaschitz A




Has Abstract


2017-12-01 00:00:00














  • Bone mineral density of the total body and forearm in premenopausal black and white women.

    abstract::This study was conducted to report and compare bone mineral density (BMD) of the total body and distal forearm, as measured by X-ray absorptiometry, in 65 black and 73 white premenopausal women between the ages of 20 and 40. The black women had higher current and recalled body weights, a higher percent body fat, and m...


    pub_type: 杂志文章


    authors: Harris SS,Wood MJ,Dawson-Hughes B

    更新日期:1995-04-01 00:00:00

  • Histomorphometric changes in the trabecular structure of a selected stress region in the femur in patients with osteoarthritis and fracture of the femoral neck.

    abstract::Histomorphometric changes in the trabecular structure of the principal compressive stress region in the femur in patients with osteoarthritis and fracture of the femoral neck are described. Femoral heads were obtained from patients who had surgery for the treatment of femoral neck fracture or total hip replacement for...


    pub_type: 杂志文章


    authors: Fazzalari NL,Darracott J,Vernon-Roberts B

    更新日期:1985-01-01 00:00:00

  • Bone matrix hypermineralization associated with low bone turnover in a case of Nasu-Hakola disease.

    abstract::Analysis of tissue from a 34-years-old male patient from Austrian origin with a history of multiple fractures associated with painful episodes over the carpal, tarsal and at the end of the long bones respectively is presented. Radiographic images and axial 3DCT scans showed widespread defects in trabecular bone archit...


    pub_type: 杂志文章


    authors: Shboul M,Roschger P,Ganger R,Paschalis L,Rokidi S,Zandieh S,Behunova J,Muschitz C,Fahrleitner-Pammer A,Ng AYJ,Tohari S,Venkatesh B,Bonnard C,Reversade B,Klaushofer K,Al Kaissi A

    更新日期:2019-06-01 00:00:00

  • Age at first oral contraceptive use as a major determinant of vertebral bone mass in female endurance athletes.

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    pub_type: 杂志文章


    authors: Hartard M,Kleinmond C,Kirchbichler A,Jeschke D,Wiseman M,Weissenbacher ER,Felsenberg D,Erben RG

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  • Acute lung injury complicating acute kidney injury: A model of endogenous αKlotho deficiency and distant organ dysfunction.

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    pub_type: 杂志文章,评审


    authors: Hsia CCW,Ravikumar P,Ye J

    更新日期:2017-07-01 00:00:00

  • Shear deformation and fracture of human cortical bone.

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    pub_type: 杂志文章


    authors: Tang T,Ebacher V,Cripton P,Guy P,McKay H,Wang R

    更新日期:2015-02-01 00:00:00

  • AMP-activated protein kinase (AMPK) activity negatively regulates chondrogenic differentiation.

    abstract::Chondrocytes are derived from mesenchymal stem cells, and play an important role in cartilage formation. Sex determining region Y box (Sox) family transcription factors are essential for chondrogenic differentiation, whereas the intracellular signal pathways of Sox activation have not been clearly elucidated. AMP-acti...


    pub_type: 杂志文章


    authors: Bandow K,Kusuyama J,Kakimoto K,Ohnishi T,Matsuguchi T

    更新日期:2015-05-01 00:00:00

  • Biochemical markers for prediction of 4-year response in bone mass during bisphosphonate treatment for prevention of postmenopausal osteoporosis.

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    pub_type: 杂志文章


    authors: Ravn P,Thompson DE,Ross PD,Christiansen C

    更新日期:2003-07-01 00:00:00

  • Effects of long-term vitamin K(1) (phylloquinone) or vitamin K(2) (menaquinone-4) supplementation on body composition and serum parameters in rats.

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    pub_type: 杂志文章


    authors: Sogabe N,Maruyama R,Baba O,Hosoi T,Goseki-Sone M

    更新日期:2011-05-01 00:00:00

  • Increased periosteal circumference remains present 12 months after an exercise intervention in preschool children.

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    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Specker B,Binkley T

    更新日期:2004-12-01 00:00:00

  • Extracellular calcium downregulates estrogen receptor alpha and increases its transcriptional activity through calcium-sensing receptor in breast cancer cells.

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    pub_type: 杂志文章


    authors: Journé F,Dumon JC,Kheddoumi N,Fox J,Laïos I,Leclercq G,Body JJ

    更新日期:2004-08-01 00:00:00

  • Trabecular microfracture and the influence of pyridinium and non-enzymatic glycation-mediated collagen cross-links.

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    authors: Hernandez CJ,Tang SY,Baumbach BM,Hwu PB,Sakkee AN,van der Ham F,DeGroot J,Bank RA,Keaveny TM

    更新日期:2005-12-01 00:00:00

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    pub_type: 杂志文章


    authors: Zhuo Y,Gauthier JY,Black WC,Percival MD,Duong LT

    更新日期:2014-10-01 00:00:00

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    pub_type: 杂志文章


    authors: Abraham AC,Agarwalla A,Yadavalli A,Liu JY,Tang SY

    更新日期:2016-06-01 00:00:00

  • Identification of the type II Na(+)-Pi cotransporter (Npt2) in the osteoclast and the skeletal phenotype of Npt2-/- mice.

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    authors: Gupta A,Tenenhouse HS,Hoag HM,Wang D,Khadeer MA,Namba N,Feng X,Hruska KA

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    authors: Hasserius R,Johnell O,Nilsson BE,Thorngren KG,Jonsson K,Mellström D,Redlund-Johnell I,Karlsson MK

    更新日期:2003-02-01 00:00:00

  • Genetic variation in the PTH pathway and bone phenotypes in elderly women: evaluation of PTH, PTHLH, PTHR1 and PTHR2 genes.

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    authors: Tenne M,McGuigan F,Jansson L,Gerdhem P,Obrant KJ,Luthman H,Akesson K

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  • Tetracycline/flurbiprofen combination therapy modulates bone remodeling in ovariectomized rats: preliminary observations.

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    pub_type: 杂志文章


    authors: Aoyagi M,Sasaki T,Ramamurthy NS,Golub LM

    更新日期:1996-12-01 00:00:00

  • Changes in marrow adipose tissue in relation to changes in bone parameters following estradiol replacement in adolescent and young adult females with functional hypothalamic amenorrhea.

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    pub_type: 杂志文章


    authors: Singhal V,Karzar NH,Bose A,Buckless C,Ackerman KE,Bredella MA,Klibanski A,Misra M

    更新日期:2021-01-06 00:00:00

  • Ultrashort echo time magnetic resonance imaging (UTE-MRI) of cortical bone correlates well with histomorphometric assessment of bone microstructure.

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    pub_type: 杂志文章


    authors: Jerban S,Ma Y,Wong JH,Nazaran A,Searleman A,Wan L,Williams J,Du J,Chang EY

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    pub_type: 杂志文章,评审


    authors: Tobias JH,Compston JE

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  • Spatial mapping of mineralization with manganese-enhanced magnetic resonance imaging.

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    pub_type: 杂志文章


    authors: Chesnick IE,Centeno JA,Todorov TI,Koenig AE,Potter K

    更新日期:2011-05-01 00:00:00

  • An ultrastructural study of the mitotic preosteoblasts in the primary spongiosa of the rat mandibular condyle.

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    pub_type: 杂志文章


    authors: Shibata S,Baba O,Sakamoto Y,Ohsako M,Yamashita Y,Ichijo T

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  • Comparative serum proteome expression of osteonecrosis of the femoral head in adults.

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    pub_type: 杂志文章


    authors: Wu RW,Wang FS,Ko JY,Wang CJ,Wu SL

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    pub_type: 杂志文章


    authors: Alford AI,Jacobs CR,Donahue HJ

    更新日期:2003-07-01 00:00:00

  • Growth of new bone guided by implants in a murine calvarial model.

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    pub_type: 杂志文章


    authors: Freilich M,M Patel C,Wei M,Shafer D,Schleier P,Hortschansky P,Kompali R,Kuhn L

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  • Comparison of force attenuation properties of four different hip protectors under simulated falling conditions in the elderly: an in vitro biomechanical study.

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    pub_type: 杂志文章


    authors: Kannus P,Parkkari J,Poutala J

    更新日期:1999-08-01 00:00:00

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    pub_type: 杂志文章,多中心研究


    authors: Gregson CL,Sayers A,Lazar V,Steel S,Dennison EM,Cooper C,Smith GD,Rittweger J,Tobias JH

    更新日期:2013-01-01 00:00:00

  • Osteal macrophages: a new twist on coupling during bone dynamics.

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    pub_type: 杂志文章,评审


    authors: Pettit AR,Chang MK,Hume DA,Raggatt LJ

    更新日期:2008-12-01 00:00:00

  • Different effects of age, adiposity and physical activity on the risk of ankle, wrist and hip fractures in postmenopausal women.

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    pub_type: 杂志文章


    authors: Armstrong ME,Cairns BJ,Banks E,Green J,Reeves GK,Beral V,Million Women Study Collaborators.

    更新日期:2012-06-01 00:00:00