Abstract:
:Mineralocorticoid receptor (MR) antagonism may affect bone turnover via direct and indirect pathways involving parathyroid hormone, but randomized controlled trials are lacking. In a pre-specified analysis of the "Eplerenone in primary hyperparathyroidism" placebo-controlled, randomized trial (ISRCTN 33941607), effects of eight weeks MR-blockade with eplerenone on bone turnover markers in 97 patients with primary hyperparathyroidism were tested. Mean age was 67.5±9.5years, and 76 (78.4%) were females. In analysis of covariance with adjustment for baseline values, eplerenone had no significant effect on isoform 5b of the tartrate-resistant acid phosphatase (TRAP), beta-crosslaps, N-terminal propeptide of procollagen type 1 (P1NP), osteocalcin and bone-specific alkaline phosphatase. There was no significant cross-sectional correlation between plasma aldosterone concentration or the aldosterone-to-renin ratio and markers of bone turnover in multivariate linear regression models at baseline. These data provide first evidence from a randomized and placebo-controlled trial that short-term MR antagonism may not affect bone turnover, at least in patients with primary hyperparathyroidism.
journal_name
Bonejournal_title
Boneauthors
Verheyen N,Grübler MR,Meinitzer A,Trummer C,Schwetz V,Amrein K,Dimai HP,März W,Catena C,von Lewinski D,Voelkl J,Alesutan I,Fahrleitner-Pammer A,Brussee H,Pilz S,Tomaschitz Adoi
10.1016/j.bone.2017.08.030subject
Has Abstractpub_date
2017-12-01 00:00:00pages
212-217eissn
8756-3282issn
1873-2763pii
S8756-3282(17)30325-3journal_volume
105pub_type
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