Subregional areal bone mineral density (aBMD) is a better predictor of heterogeneity in trabecular microstructure of vertebrae in young and aged women than subregional trabecular bone score (TBS).

abstract：:Recent studies have shown that treatment with bisphosphonates could be effective against the myelomatous skeletal deterioration. However, the mechanisms of action of these drugs in multiple myeloma (MM) have been poorly studied. In the present study, 11 patients with MM and bone lesions were treated orally with 30 mg/...

journal_title：Bone

authors： Roux C,Ravaud P,Cohen-Solal M,de Vernejoul MC,Guillemant S,Cherruau B,Delmas P,Dougados M,Amor B

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND:Episodic flare-ups of fibrodysplasia ossificans progressiva (FOP) are characterized clinically by severe, often posttraumatic, connective tissue swelling and intramuscular edema, followed histologically by an intense and highly angiogenic fibroproliferative reaction. This early inflammatory and angiogenic fi...

journal_title：Bone

authors： Brennan TA,Lindborg CM,Bergbauer CR,Wang H,Kaplan FS,Pignolo RJ

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:Genesis of a cartilaginous scaffold is an obligate precursor to bone formation in heterotopic endochondral ossification (HEO). We tested the hypothesis that cartilage-derived retinoic acid-sensitive protein (CD-RAP) can serve as a plasma biomarker for the pre-osseous cartilaginous stage of HEO. Palovarotene,...

journal_title：Bone

authors： Lindborg CM,Brennan TA,Wang H,Kaplan FS,Pignolo RJ

更新日期：2018-04-01 00:00:00

abstract：:Metastatic bone disease has a major impact on the morbidity and mortality of breast cancer patients, and studies on bone metastasis biology have led to the development of the most widely used drugs for bone metastases treatment: zoledronate (Zol) and denosumab (Den). The aim of the present study was to assess the effe...

journal_title：Bone

authors： Liverani C,Mercatali L,Spadazzi C,La Manna F,De Vita A,Riva N,Calpona S,Ricci M,Bongiovanni A,Gunelli E,Zanoni M,Fabbri F,Zoli W,Amadori D,Ibrahim T

更新日期：2014-09-01 00:00:00

abstract：:In order to investigate the ultrastructure of bone resorptive cells in the two types of adult benign human osteopetrosis, iliac crest biopsies were obtained from 11 patients and 10 normal males, who served as a control group. Six patients had the radiological type I (4 women, 2 men, aged 23-58 years, mean = 36.5 years...

journal_title：Bone

authors： Bollerslev J,Marks SC Jr,Pockwinse S,Kassem M,Brixen K,Steiniche T,Mosekilde L

更新日期：1993-11-01 00:00:00

abstract：:Genetic mouse models are widely used for understanding human diseases but we know much less about the anatomical structure of the auditory ossicles in the mouse than we do about human ossicles. Furthermore, current studies have mainly focused on disease conditions such as osteomalacia and rickets in patients with hypo...

journal_title：Bone

authors： Lv K,Huang H,Yi X,Chertoff ME,Li C,Yuan B,Hinton RJ,Feng JQ

更新日期：2017-10-01 00:00:00

abstract：INTRODUCTION:The RANKL-OPG axis is a key regulator of osteoclastogenesis and bone turnover activity. Its contribution to bone resorption under altered mechanical states, however, has not been fully elucidated. Here we examined the role of OPG in regulating mechanically induced bone modeling in a rat model of orthodonti...

journal_title：Bone

authors： Dunn MD,Park CH,Kostenuik PJ,Kapila S,Giannobile WV

更新日期：2007-09-01 00:00:00

abstract：:Duchenne Muscular Dystrophy (DMD) is a progressive muscle disorder caused by genetic mutations of the dystrophin encoding gene. In the absence of functional dystrophin, DMD patients suffer from muscle inflammation and wasting, as well as compromised bone health with increased risk of fracture. The use of high dose glu...

journal_title：Bone

authors： Yoon SH,Grynpas M,Mitchell J

更新日期：2019-04-01 00:00:00

abstract：:Mineralization of the extracellular matrix of bone is an essential element of bone development, maintenance and repair. ALPL and ENPP1 genes and their products are known to be central in local regulation of bone mineralization. The present study investigates potential associations of ENPP1 and ALPL polymorphisms with ...

journal_title：Bone

authors： Ermakov S,Toliat MR,Cohen Z,Malkin I,Altmüller J,Livshits G,Nürnberg P

更新日期：2010-05-01 00:00:00

abstract：:Vitamin K is a cofactor for γ-glutamyl carboxylase, which is an essential enzyme for the γ-carboxylation of vitamin K-dependent proteins such as osteocalcin and matrix Gla protein. Although it has been suggested that vitamin K plays an important role in the improvement of bone metabolism, the relationship between diet...

journal_title：Bone

authors： Sogabe N,Maruyama R,Baba O,Hosoi T,Goseki-Sone M

更新日期：2011-05-01 00:00:00

abstract：:Ossification of the posterior longitudinal ligament of the spine (OPLL) is characterized by ectopic bone formation in the spinal ligaments. Mechanical stress, which acts on the posterior ligaments, is thought to be an important factor in the progression of OPLL. To elucidate this mechanism, we investigated the effects...

journal_title：Bone

authors： Tanno M,Furukawa KI,Ueyama K,Harata S,Motomura S

更新日期：2003-10-01 00:00:00

abstract：:The assessment of fracture risk often relies primarily on measuring bone mineral density, thereby accounting for only a single pathology: the loss of bone mass. However, bone's ability to resist fracture is a result of its biphasic composition and hierarchical structure that imbue it with high strength and toughness. ...

journal_title：Bone

authors： Abraham AC,Agarwalla A,Yadavalli A,Liu JY,Tang SY

更新日期：2016-06-01 00:00:00

abstract：:The study reports a theranostic nature of rno-miR-300 (miR300) in the osteoblast functioning, by influencing the signaling pathway(s), associated with osteoblast differentiation. Excessive expression of miR300 suppresses osteoblast functions. Smad3 served as a validated target for miR300, on homology-based computation...

journal_title：Bone

authors： Kaur T,John AA,Sharma C,Vashisht NK,Singh D,Kapila R,Kapila S

更新日期：2021-02-01 00:00:00

abstract：:Myostatin (GDF8) is a negative regulator of skeletal muscle growth and mice lacking myostatin show a significant increase in muscle mass and bone density compared to normal mice. In order to further define the role of myostatin in regulating bone mass we sought to determine if loss of myostatin function significantly ...

journal_title：Bone

authors： Hamrick MW,Shi X,Zhang W,Pennington C,Thakore H,Haque M,Kang B,Isales CM,Fulzele S,Wenger KH

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND:Eldecalcitol is an analog of 1,25-dihydroxyvitamin D(3) that improves bone mineral density; however, the effect of eldecalcitol on the risk of fractures is unclear. The objective of this study is to examine whether eldecalcitol is superior to alfacalcidol in preventing osteoporotic fractures. This trial is r...

journal_title：Bone

authors： Matsumoto T,Ito M,Hayashi Y,Hirota T,Tanigawara Y,Sone T,Fukunaga M,Shiraki M,Nakamura T

更新日期：2011-10-01 00:00:00

abstract：:Bisphosphonate (BP)-related osteonecrosis of the jaw, previously known as BRONJ, now referred to more broadly as medication-related osteonecrosis of the jaw (MRONJ), is a morbid condition that represents a significant risk for oncology patients who have received high dose intravenous (IV) infusion of a potent nitrogen...

journal_title：Bone

authors： Hokugo A,Kanayama K,Sun S,Morinaga K,Sun Y,Wu Q,Sasaki H,Okawa H,Evans C,Ebetino FH,Lundy MW,Sadrerafi K,McKenna CE,Nishimura I

更新日期：2019-06-01 00:00:00

abstract：:Osteoprogenitors present in cell populations derived from fetal or newborn rat and mouse calvaria differentiate in long term culture and form osteoblastic bone-forming colonies (bone nodules). Previous reports have indicated considerable differences between bone cell populations derived from these two species with reg...

journal_title：Bone

authors： Bellows CG,Ciaccia A,Heersche JN

更新日期：1998-08-01 00:00:00

abstract：OBJECTIVE:To establish a drill-hole defect model in osteoporotic mouse femur by comparing temporal cortical bone healing pattern between OVX-induced osteoporotic bone and sham-operated bone. METHODS:3-month-old female C57BL/6 mice were randomly divided into an ovariectomy group (OVX) and a sham-operated group (Sham). ...

journal_title：Bone

authors： He YX,Zhang G,Pan XH,Liu Z,Zheng LZ,Chan CW,Lee KM,Cao YP,Li G,Wei L,Hung LK,Leung KS,Qin L

更新日期：2011-06-01 00:00:00

abstract：:GM1 gangliosidosis is a lysosomal storage disorder caused by mutations in GLB1 encoding a lysosomal β-galactosidase. This disease is a continuum from the severe infantile form with rapid neurological decline to the chronic adult form, which is not life-limiting. The intermediate or type 2 form can be further classifie...

journal_title：Bone

authors： Ferreira CR,Regier DS,Yoon R,Pan KS,Johnston JM,Yang S,Spranger JW,Tifft CJ

更新日期：2020-02-01 00:00:00

abstract：:Glucocorticoids have marked effects on bone metabolism, and continued exposure of skeletal tissue to excessive amounts of these steroids results in osteoporosis. Therefore, in the present proteomic study, we characterized the potential effects of glucocorticoids on protein expression in human osteoblastic cells. Using...

journal_title：Bone

authors： Olkku A,Bodine PV,Linnala-Kankkunen A,Mahonen A

更新日期：2004-02-01 00:00:00

abstract：:Leptin has been suggested to mediate a variety of actions, including bone development, via its ubiquitously expressed receptor (Ob-Rb). In this study, we investigated the role of leptin in endochondral ossification at the growth plate. The growth plates of wild-type and ob/ob mice were analyzed. Effects of leptin on c...

journal_title：Bone

authors： Kishida Y,Hirao M,Tamai N,Nampei A,Fujimoto T,Nakase T,Shimizu N,Yoshikawa H,Myoui A

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND:Preterm infants are at risk for impaired bone mineralization and growth in length later in life due to inadequate nutritional intake in the early postnatal period. OBJECTIVE:To investigate whether increased nutritional supplementation of calcium, phosphate and protein in Very Low Birth Weight (VLBW) infants...

journal_title：Bone

authors： Christmann V,van der Putten ME,Rodwell L,Steiner K,Gotthardt M,van Goudoever JB,van Heijst AFJ

更新日期：2018-03-01 00:00:00

abstract：:Feral adult female cynomolgus monkeys were divided into three groups and treated for two years: (1) normal controls; (2) weak androgenic treatment (androstenedione+estrone); and (3) strong androgenic treatment (testosterone). The tibiae and the trabecular bone of femoral head from each group were tested mechanically. ...

journal_title：Bone

authors： Kasra M,Grynpas MD

更新日期：1995-09-01 00:00:00

abstract：:Bisphosphonates (BP), especially alendronate and risedronate, are the drugs most commonly used for osteoporosis treatment, being incorporated into the skeleton where they inhibit bone resorption and are thereafter slowly released during bone turnover. However, there are few data on the release of BP in patients who ha...

journal_title：Bone

authors： Peris P,Torra M,Olivares V,Reyes R,Monegal A,Martínez-Ferrer A,Guañabens N

更新日期：2011-10-01 00:00:00

abstract：:Disuse osteopenia and bone loss have been extensively reported in long duration space mission and long term bed rest. The pathology of the bone loss is similar to osteoporosis but highly confined to weight bearing bones. The current anabolic and/or anti-resorptive drugs have systemic effects and are costly over extend...

journal_title：Bone

authors： Uddin SM,Qin YX

更新日期：2015-06-01 00:00:00

abstract：:The potential of whole body vibration (WBV) to maintain or enhance musculoskeletal strength during ageing is of increasing interest, with both low and high magnitude WBV having been shown to maintain or increase bone mineral density (BMD) at the lumbar spine and femoral neck. The aim of this study was to determine how...

journal_title：Bone

authors： Spain L,Yang L,Wilkinson JM,McCloskey E

更新日期：2021-03-01 00:00:00

abstract：:Combat-related heterotopic ossification (HO) has emerged as a common and problematic complication of modern wartime extremity injuries, contributing to substantial patient morbidity and loss of function. We have previously reported that HO-forming patients exhibit a more pronounced systemic and local inflammatory resp...

journal_title：Bone

authors： Davis TA,Lazdun Y,Potter BK,Forsberg JA

更新日期：2013-09-01 00:00:00

abstract：:Mandibuloacral dysplasia (MAD) is a rare recessively inherited premature aging disease characterized by skeletal and metabolic anomalies. It is part of the spectrum of diseases called laminopathies and results from mutations in genes regulating the synthesis of the nuclear laminar protein, lamin A. Homozygous or compo...

journal_title：Bone

authors： Cunningham VJ,D'Apice MR,Licata N,Novelli G,Cundy T

更新日期：2010-09-01 00:00:00

abstract：:Bone marrow adipose tissue (BMAT) is preserved or increased in states of caloric restriction. Similarly, we found that BMAT in the tail vertebrae, but not the red marrow in the tibia, resists loss of neutral lipid with acute, 48-hour fasting in rats. The mechanisms underlying this phenomenon and its seemingly distinct...

journal_title：Bone

authors： Scheller EL,Khandaker S,Learman BS,Cawthorn WP,Anderson LM,Pham HA,Robles H,Wang Z,Li Z,Parlee SD,Simon BR,Mori H,Bree AJ,Craft CS,MacDougald OA

更新日期：2019-01-01 00:00:00

abstract：:Inflammation is an important part of the fracture repair process which requires osteogenic cells to interact with innate immune cells such as macrophages. All murine macrophages express the F4/80 cell surface marker but they may be further subdivided into two main phenotypes: M1 (proinflammatory) or M2 (anti-inflammat...

journal_title：Bone

authors： Hozain S,Cottrell J

更新日期：2020-09-01 00:00:00