Abstract：
:The ligands that comprise the Transforming Growth Factor β superfamily highly govern the development of the embryonic growth plate. Members of this superfamily activate canonical TGFβ and/or BMP (Bone Morphogenetic Protein) signaling pathways. How these pathways interact with one another is an area of active investigation. These two signaling pathways have been described to negatively regulate one another through crosstalk involving Smad proteins, the primary intracellular effectors of canonical signaling. More recently, a mechanism for regulation of the BMP pathway through TGFβ and BMP receptor interactions has been described. Here in this review, we demonstrate examples of how TGFβ is a gatekeeper of BMP action in the developing growth plate at both the receptor and transcriptional levels.
journal_name
Bonejournal_title
Boneauthors
Wang W,Rigueur D,Lyons KMdoi
10.1016/j.bone.2020.115439subject
Has Abstractpub_date
2020-08-01 00:00:00pages
115439eissn
8756-3282issn
1873-2763pii
S8756-3282(20)30219-2journal_volume
137pub_type
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