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Elevated serum soluble CD200 and CD200R as surrogate markers of bone loss under bed rest conditions.

Abstract：

:CD200 is a transmembrane protein that belongs to the immunoglobulin family of proteins and is ubiquitously expressed on a variety of cell types. Upon interaction with its receptors (CD200Rs) expressed on myeloid-derived cells and T lymphocytes, an immunoregulatory signal is delivered to receptor-expressing cells. Previous studies have implicated a role for CD200:CD200R in the regulation of the expression of mRNA markers of osteoclastogenesis/osteoblastogenesis, following interaction of CD200 (on osteoblast precursors) with CD200R1 (on osteoclast precursors). Signaling of CD200R1 is hypothesized to attenuate osteoclastogenesis. We have investigated whether levels of soluble forms of CD200 and/or CD200R1 (sCD200, sCD200R1) are altered in volunteers undergoing 6° head down tilt bed rest to mimic conditions of microgravity known to be associated with preferential osteoclastogenesis and whether countermeasures, reported to be beneficial in attenuation of bone loss under microgravity conditions, would lead to altered sCD200 and sCD200R1 levels. Our data suggest that, as predicted, sCD200 levels fall under bed rest conditions while sCD200R1 levels rise. In subjects undergoing 30-minute per day continuous centrifugation protocols, as a countermeasure to attenuate changes which may lead to bone loss, these alterations in sCD200 and sCD200R1 levels seen under conditions of bed rest were abolished or attenuated. Our results suggest that measurement of sCD200 and/or sCD200R1 may prove a useful and rapid means of monitoring subjects at risk of bone loss and/or accessing the efficacy of treatment regimes designed to counter bone loss.

journal_name

Bone

journal_title

Bone

authors

Kos O,Hughson RL,Hart DA,Clément G,Frings-Meuthen P,Linnarsson D,Paloski WH,Rittweger J,Wuyts F,Zange J,Gorczynski RM

doi

10.1016/j.bone.2013.12.004

subject

Has Abstract

pub_date

2014-03-01 00:00:00

pages

33-40

eissn

8756-3282

issn

1873-2763

pii

S8756-3282(13)00492-4

journal_volume

60

pub_type

杂志文章,随机对照试验

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