Association of klotho gene polymorphism with bone density and spondylosis of the lumbar spine in postmenopausal women.

Abstract:

:Based on the fact that the klotho-deficient mouse exhibits multiple aging phenotypes, including osteopenia and subchondral sclerosis of joints, we explored the possibility of whether human klotho gene polymorphism is associated with two major age-related skeletal disorders: osteoporosis and spondylosis. Analysis of the CA repeat sequence downstream of the final exon of the klotho gene identified ten types of alleles in Japanese postmenopausal women (n = 377). We investigated the association of this microsatellite polymorphism with bone density and spondylosis score of the lumbar spine. None of the genotypes was associated with bone density in the overall population (n = 377; 754 alleles) nor in the subpopulation at not more than 10 years after menopause (20 years after menopause (n = 102; 204 alleles, p = 0.024). The type 7 allele was associated with high bone density in women more than 20 years after menopause (p = 0.042). The association study with spondylosis of postmenopausal women (n = 221) revealed that another distinct allele, type 8, was significantly associated with low spondylosis score at L-4/5 (p = 0.019) and L-5/S-1 (p = 0.048) levels in the subpopulation equal to or younger than the average age (

journal_name

Bone

journal_title

Bone

authors

Ogata N,Matsumura Y,Shiraki M,Kawano K,Koshizuka Y,Hosoi T,Nakamura K,Kuro-O M,Kawaguchi H

doi

10.1016/s8756-3282(02)00786-x

subject

Has Abstract

pub_date

2002-07-01 00:00:00

pages

37-42

issue

1

eissn

8756-3282

issn

1873-2763

pii

S875632820200786X

journal_volume

31

pub_type

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