Effects of prostaglandin E2 on production of new cancellous bone in the axial skeleton of ovariectomized rats.

abstract：:Colony-stimulating factor-1 (CSF-1) induces osteoclast spreading that requires activation of c-Src and phosphatidyl inositol 3-kinase (PI3-K), both of which are recruited to activated c-Fms, the CSF-1 receptor. The present report provides evidence that the hemopoietic guanine nucleotide exchange factor (GEF), Vav, and...

journal_title：Bone

authors： Sakai H,Chen Y,Itokawa T,Yu KP,Zhu ML,Insogna K

更新日期：2006-12-01 00:00:00

abstract：:The effects of basic fibroblasts growth factor (bFGF) administered intravenously at dosages of 0.1 and 0.3 mg/kg per day for 7 days to growing rats are reported. Static and dynamic histomorphometry techniques were applied to the microradiographs and undecalcified ground sections of the proximal tibiae and tibial shaft...

journal_title：Bone

authors： Nagai H,Tsukuda R,Mayahara H

更新日期：1995-03-01 00:00:00

abstract：:Impaired fracture healing in patients with obesity-associated type 2 diabetes (T2D) is a significant unmet clinical problem that affects millions of people worldwide. However, the underlying causes are poorly understood. Additionally, limited clinical information is available on how pre-diabetic hyperglycemia in obese...

journal_title：Bone

authors： Khajuria DK,Soliman M,Elfar JC,Lewis GS,Abraham T,Kamal F,Elbarbary RA

更新日期：2020-08-01 00:00:00

abstract：:Global gene expression profiling has been used to study the molecular mechanisms of increased bone remodeling caused by PHPT. This disease is a model for chronic over-stimulation of target organs by PTH due to an inappropriate overproduction of the hormone. Hyperactivity of osteoblasts and osteoclasts lead to increase...

journal_title：Bone

authors： Reppe S,Stilgren L,Olstad OK,Brixen K,Nissen-Meyer LS,Gautvik KM,Abrahamsen B

更新日期：2006-07-01 00:00:00

abstract：:The assessment of fracture risk often relies primarily on measuring bone mineral density, thereby accounting for only a single pathology: the loss of bone mass. However, bone's ability to resist fracture is a result of its biphasic composition and hierarchical structure that imbue it with high strength and toughness. ...

journal_title：Bone

authors： Abraham AC,Agarwalla A,Yadavalli A,Liu JY,Tang SY

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:Studies in childhood suggest that both body composition and early postnatal growth are associated with bone mineral density (BMD). However, little is known of the relationships between longitudinal changes in fat (FM) and lean mass (LM) and bone development in pre-pubertal children. We therefore investigated...

journal_title：Bone

authors： Moon RJ,Cole ZA,Crozier SR,Curtis EM,Davies JH,Gregson CL,Robinson SM,Dennison EM,Godfrey KM,Inskip HM,Cooper C,Harvey NC,Southampton Women's Survey Study Group.

更新日期：2015-06-01 00:00:00

abstract：:Three siblings, aged 12, 4 and 2 years, presented at a Gambian clinic with bone deformities. Radiographs of knees and wrists confirmed the presence of florid rickets. The family (including 2 unaffected siblings and the mother) were investigated for hereditary rickets. The three affected siblings had biochemical featur...

journal_title：Bone

authors： Braithwaite V,Pettifor JM,Prentice A

更新日期：2013-03-01 00:00:00

abstract：:Bone can be viewed as a nano-fibrous composite with complex hierarchical structures. Its deformation and fracture behaviors depend on both the local structure and the type of stress applied. In contrast to the extensive studies on bone fracture under compression and tension, there is a lack of knowledge on the fractur...

journal_title：Bone

authors： Tang T,Ebacher V,Cripton P,Guy P,McKay H,Wang R

更新日期：2015-02-01 00:00:00

abstract：:Various substitution mutations in ALK2, a transmembrane serine/threonine kinase receptor for bone morphogenetic proteins (BMPs), have been identified in patients with genetic disorders such as fibrodysplasia ossificans progressiva (FOP), diffuse intrinsic pontine glioma (DIPG) and heart defects. In this study, we char...

journal_title：Bone

authors： Machiya A,Tsukamoto S,Ohte S,Kuratani M,Fujimoto M,Kumagai K,Osawa K,Suda N,Bullock AN,Katagiri T

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:Good bone and joint health is essential for the physical tasks of daily living and poorer indicators of physical capability in older adults have been associated with increased mortality rates. Genetic variants of indicators of bone and joint health may be associated with measures of physical capability. MET...

journal_title：Bone

authors： Alfred T,Ben-Shlomo Y,Cooper R,Hardy R,Cooper C,Deary IJ,Gunnell D,Harris SE,Kumari M,Martin RM,Sayer AA,Starr JM,Kuh D,Day IN,HALCyon study team.

更新日期：2013-01-01 00:00:00

abstract：:There are increasing evidences suggesting bone marrow adiposity tissue (MAT) plays a critical role in affecting both bone quantity and quality. However, very limited studies that have investigated the association between the composition of MAT and bone mineral density (BMD). The goal of this study was to quantify MAT ...

journal_title：Bone

authors： Li X,Shet K,Xu K,Rodríguez JP,Pino AM,Kurhanewicz J,Schwartz A,Rosen CJ

更新日期：2017-12-01 00:00:00

abstract：:Oral glucocorticoids (GC) preserve muscle strength and prolong walking in boys with Duchenne muscular dystrophy (DMD). Although vertebral fractures have been reported in boys taking GC, fracture rates for different GC regimes have not been investigated. The aim of this pragmatic longitudinal study was to compare growt...

journal_title：Bone

authors： Crabtree NJ,Adams JE,Padidela R,Shaw NJ,Högler W,Roper H,Hughes I,Daniel A,Mughal MZ

更新日期：2018-11-01 00:00:00

abstract：INTRODUCTION:The GH-IGF axis has profound effects on bone metabolism and may be important in the etiology of idiopathic osteoporosis. Serum IGF-I is often low in men with osteoporosis, which may be attributable to GH hypo-secretion or hepatic GH insensitivity. We studied the GH-IGF axis in depth to look for evidence to...

journal_title：Bone

authors： Patel MB,Arden NK,Masterson LM,Phillips DI,Swaminathan R,Syddall HE,Byrne CD,Wood PJ,Cooper C,Holt RI,Hertfordshire Cohort Study Group.

更新日期：2005-12-01 00:00:00

abstract：:Macrometastases in bone are preceded by bone marrow invasion of disseminated tumor cells. This study combined functional imaging parameters from FDG-PET/CT and MRI in a rat model of breast cancer bone metastases to a Model-averaged Neural Network (avNNet) for the detection of early metastatic disease and prediction of...

journal_title：Bone

authors： Ellmann S,Seyler L,Evers J,Heinen H,Bozec A,Prante O,Kuwert T,Uder M,Bäuerle T

更新日期：2019-03-01 00:00:00

abstract：:We report the establishment in vitro of three-dimensional (3D) cultures of human osteoblasts (hOB) derived from normal adults and supported uniquely by the extracellular matrix (ECM) they deposit. Osteoblasts were cultured in 3D cultures in vitro for up to 120 days. The 3D cultures, examined at 25, 31, and 48 days, ex...

journal_title：Bone

authors： Ferrera D,Poggi S,Biassoni C,Dickson GR,Astigiano S,Barbieri O,Favre A,Franzi AT,Strangio A,Federici A,Manduca P

更新日期：2002-05-01 00:00:00

abstract：:Bone is a composite biomaterial of mineral crystals, organic matrix, and water. Each contributes to bone quality and strength and may change independently, or together, with disease progression and treatment. Even so, there is a near ubiquitous reliance on ionizing x-ray-based approaches to measure bone mineral densit...

journal_title：Bone

authors： Surowiec RK,Ram S,Idiyatullin D,Goulet R,Schlecht SH,Galban CJ,Kozloff KM

更新日期：2021-02-01 00:00:00

abstract：:This review begins with an introduction to the malignant bone tumor, osteosarcoma [OS] and then moves to a discussion of the commonly used vectors for gene transfer. We first briefly highlight non-viral vectors including polymeric and liposomal delivery systems but concentrate predominantly on the 5 leading viral vect...

journal_title：Bone

authors： Witlox MA,Lamfers ML,Wuisman PI,Curiel DT,Siegal GP

更新日期：2007-04-01 00:00:00

abstract：:The present study describes the biological effects of risedronate, a pyridinyl bisphosphonate, on bone and assesses the safety and tolerability of risedronate when given at high doses, with or without calcium, to postmenopausal women with spinal osteoporosis. This single-center descriptive, double-blind, placebo-contr...

journal_title：Bone

authors： Zegels B,Eastell R,Russell RG,Ethgen D,Roumagnac I,Collette J,Reginster JY

更新日期：2001-01-01 00:00:00

abstract：OBJECTIVES:The present study was motivated by the fact that bone regeneration in the compromised vascular microenvironment of T2DM is challenging and the factors that determine the adverse bone regeneration outcomes are poorly understood. For this purpose the effect of T2DM on osteogenic and angiogenic healing potentia...

journal_title：Bone

authors： Caliaperoumal G,Souyet M,Bensidhoum M,Petite H,Anagnostou F

更新日期：2018-07-01 00:00:00

abstract：:During the 40 years since its discovery, calcitonin (CT) has been regarded primarily as an inhibitor of bone resorption and its therapeutic applications have been based on this property. A significant body of literature also indicates additional anabolic effects in animal and in vitro models. In a variety of bone loss...

journal_title：Bone

authors： Wallach S,Rousseau G,Martin L,Azria M

更新日期：1999-11-01 00:00:00

abstract：:Intracortical remodeling in the adult skeleton removes and replaces areas of compact bone that have sustained microdamage. Although studies have been performed in animal species in which there is an existing baseline of remodeling activity, laboratory rodents have been considered to have limited suitability as models ...

journal_title：Bone

authors： Bentolila V,Boyce TM,Fyhrie DP,Drumb R,Skerry TM,Schaffler MB

更新日期：1998-09-01 00:00:00

abstract：:The effect of clodronate on healing of the fracture of osteopenic bone was studied in rats. A total of 165 female rats (14 +/- 1 weeks, 216 +/- 2 g) were divided into five fracture groups (n = 30), and a neurectomized group (n = 15). Osteopenia (op) was induced by right sciatic neurectomy 4 weeks before the fracture. ...

journal_title：Bone

authors： Tarvainen R,Olkkonen H,Nevalainen T,Hyvönen P,Arnala I,Alhava E

更新日期：1994-11-01 00:00:00

abstract：:Micro- and nanoscale surface modifications have been the focus of multiple studies in the pursuit of accelerating bone apposition or osseointegration at the implant surface. Here, we evaluated histological and nanomechanical properties, and gene expression, for a microblasted surface presenting nanometer-scale texture...

journal_title：Bone

authors： Coelho PG,Takayama T,Yoo D,Jimbo R,Karunagaran S,Tovar N,Janal MN,Yamano S

更新日期：2014-08-01 00:00:00

abstract：:Bone healing is a complex multi-step process, which depends on the position and size of the lesion, and on the mechanical stability of the wounded area. To address more specifically the mechanisms involved in cortical bone healing, we created drill-hole defects in the cortex of mouse femur, a lesion that triggers intr...

journal_title：Bone

authors： Monfoulet L,Malaval L,Aubin JE,Rittling SR,Gadeau AP,Fricain JC,Chassande O

更新日期：2010-02-01 00:00:00

abstract：:Several animal studies have showed that gelatin may be effective for minimizing bone loss in OVX rats with established osteopenia. To gain insight into how cod bone gelatin administration affects bone loss after ovariectomy, studies were carried out focusing on bone quality and the molecular mechanisms. Eighty-four fe...

journal_title：Bone

authors： Han X,Xu Y,Wang J,Pei X,Yang R,Li N,Li Y

更新日期：2009-05-01 00:00:00

abstract：:Cylindrical trabecular bone specimens (d = 7 mm) were drilled in a vertical direction from the central part of the third vertebral body (L3) from 23 normal individuals aged 15-87 years (10 males and 13 females). The bone samples were embedded in methylmetacrylate and sawn in 400 microns thick sections with an arbitrar...

journal_title：Bone

authors： Mosekilde L

更新日期：1988-01-01 00:00:00

abstract：:Patients with coxarthrosis (cOA) have a reduced incidence of intracapsular femoral neck fracture, suggesting that cOA offers protection. The distribution of bone in the femoral neck was compared in cases of coxarthrosis and postmortem controls to assess the possibility that disease-associated changes might contribute ...

journal_title：Bone

authors： Jordan GR,Loveridge N,Bell KL,Power J,Dickson GR,Vedi S,Rushton N,Clarke MT,Reeve J

更新日期：2003-01-01 00:00:00

abstract：:CD200 is a transmembrane protein that belongs to the immunoglobulin family of proteins and is ubiquitously expressed on a variety of cell types. Upon interaction with its receptors (CD200Rs) expressed on myeloid-derived cells and T lymphocytes, an immunoregulatory signal is delivered to receptor-expressing cells. Prev...

journal_title：Bone

authors： Kos O,Hughson RL,Hart DA,Clément G,Frings-Meuthen P,Linnarsson D,Paloski WH,Rittweger J,Wuyts F,Zange J,Gorczynski RM

更新日期：2014-03-01 00:00:00

abstract：:Bone geometry plays a prominent role in bone strength. Cross-sectional studies have shown that advancing age is associated with increasing diameter of long bones, related to both periostal apposition and endosteal resorption. However, there are few data provided by prospective studies, especially concerning the change...

journal_title：Bone

authors： Briot K,Kolta S,Fechtenbaum J,Said-Nahal R,Benhamou CL,Roux C

更新日期：2010-08-01 00:00:00

abstract：:Solute transport in the lacunar-canalicular system (LCS) is essential for bone metabolism and mechanotransduction. Using the technique of fluorescence recovery after photobleaching (FRAP) we have been quantifying solute transport in the LCS of murine long bone as a function of loading parameters and molecular size. Ho...

journal_title：Bone

authors： Zhou X,Novotny JE,Wang L

更新日期：2009-10-01 00:00:00