Genetic markers of bone and joint health and physical capability in older adults: the HALCyon programme.

abstract：:Mesenchymal stem cells (MSC) are defined as plastic-adherent, clonal cells that are common progenitors for osteoblasts and adipocytes. An inverse relationship between bone and fat has been observed in several clinical conditions and has been suggested to be caused by re-directing MSC differentiation into one particula...

journal_title：Bone

authors： Post S,Abdallah BM,Bentzon JF,Kassem M

更新日期：2008-07-01 00:00:00

abstract：:Although osteoinductive ceramics can induce osteoblast differentiation in vitro and bone regeneration in vivo, their effects rely solely on the limited number of endogenous stem cells. More recently, ceramic carriers seeded with culture-expanded stem cells have been reported as implants capable of in vivo bone formati...

journal_title：Bone

authors： Chen S,Ryan DA,Dwyer MA,Cashman JR

更新日期：2014-10-01 00:00:00

abstract：:The correlation between bone mineral density and vertebral strength is not based on mechanical principles and thus the method cannot reflect the effects of subtle geometric features and densitometric inhomogeneities that may substantially affect vertebral strength. Finite element models derived from quantitative compu...

journal_title：Bone

authors： Crawford RP,Cann CE,Keaveny TM

更新日期：2003-10-01 00:00:00

abstract：:The SIBLINGs are a subfamily of the secreted calcium-binding phosphoproteins and comprise five small integrin-binding ligand N-linked glycoproteins [dentin matrix protein-1 (DMP1), secreted phosphoprotein-1 (SPP1) also called osteopontin (OPN), integrin-binding sialoprotein (IBSP) also called bone sialoprotein (BSP), ...

journal_title：Bone

authors： Whyte MP,Amalnath SD,McAlister WH,McKee MD,Veis DJ,Huskey M,Duan S,Bijanki VN,Alur S,Mumm S

更新日期：2020-03-01 00:00:00

abstract：:Both clinical and laboratory studies have shown that the chemotherapy drug, Methotrexate (MTX), has adverse short-term effects on bone. There are no studies that demonstrate the long-term response of bone to MTX. The purpose of this study was to determine the short- and long-term effects of MTX on bone volume, turnove...

journal_title：Bone

authors： Wheeler DL,Vander Griend RA,Wronski TJ,Miller GJ,Keith EE,Graves JE

更新日期：1995-02-01 00:00:00

abstract：BACKGROUND:Roux-en-Y gastric bypass (RYGB) is a common surgical procedure for treatment of morbid obesity. RYGB induces considerable and sustained weight loss, and remission of obesity related-comorbidities. While studies have suggested negative effects of RYGB on bone health, long-term data are lacking. We aimed to ev...

journal_title：Bone

authors： Blom-Høgestøl IK,Hewitt S,Chahal-Kummen M,Brunborg C,Gulseth HL,Kristinsson JA,Eriksen EF,Mala T

更新日期：2019-10-01 00:00:00

abstract：:Formoterol, a beta2-adrenergic agonist has been shown in ovariectomized rat models to have anabolic effects on bone. However, those studies did not determine whether the effect of formoterol was by a direct action on bone cells themselves or indirectly via anabolic action on muscle. To address the question of whether ...

journal_title：Bone

authors： Kellenberger S,Muller K,Richener H,Bilbe G

更新日期：1998-05-01 00:00:00

abstract：:How estrogen therapy influences bone metabolism in postmenopausal women has previously been studied using several approaches, including bone densitometry, measurement of biochemical markers of bone turnover, and histomorphometry. Taken together, these investigations suggest that conventional doses of estrogen protect ...

journal_title：Bone

authors： Tobias JH,Compston JE

更新日期：1999-02-01 00:00:00

abstract：:Hypertension and osteoporosis are two major chronic diseases affecting the elderly. A cross-sectional study of 3887 Chinese men (n = 1958) and women (n = 1929) was used to explore the association between angiotensin converting enzyme inhibitor (ACEI) use and bone mineral density (BMD). The participants were aged 65 ye...

journal_title：Bone

authors： Lynn H,Kwok T,Wong SY,Woo J,Leung PC

更新日期：2006-04-01 00:00:00

abstract：:Clinically, osteopenia or low bone mass has been observed in a variety of chronic inflammatory diseases, and elevated proinflammatory mediators have implicated this process. The purpose of this study was to develop an in vivo model of bone loss induced by chronic systemic inflammation. Time-release pellets designed to...

journal_title：Bone

authors： Smith BJ,Lerner MR,Bu SY,Lucas EA,Hanas JS,Lightfoot SA,Postier RG,Bronze MS,Brackett DJ

更新日期：2006-03-01 00:00:00

abstract：:The enlargement of osteocyte lacunae via osteocytic osteolysis was previously detected in situations of increased calcium demand (e.g., lactation, vitamin D deficiency). However, it is unclear whether similar processes occur also in the growing infantile skeleton and how this is linked to the mineral distribution with...

journal_title：Bone

authors： Jandl NM,von Kroge S,Stürznickel J,Baranowsky A,Stockhausen KE,Mushumba H,Beil FT,Püschel K,Amling M,Rolvien T

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:There is evidence that the extent of vertebral bone marrow adiposity increases caudally along the vertebral column in children and adolescents. However, no studies have examined the lipid composition of bone marrow along the vertebral column, which may uniquely influence bone acquisition and metabolism durin...

journal_title：Bone

authors： Whitney DG,Devlin MJ,Alford AI,Caird MS

更新日期：2021-01-01 00:00:00

abstract：:Skeletal unloading in an animal hindlimb suspension model and microgravity experienced by astronauts or as a result of prolonged bed rest causes site-specific losses in bone mineral density of 1%-2% per month. This is accompanied by reductions in circulating levels of 1,25-(OH)(2)D(3), the active metabolite of vitamin...

journal_title：Bone

authors： Narayanan R,Smith CL,Weigel NL

更新日期：2002-09-01 00:00:00

abstract：:The aim of this study was to provide insight into the bone mineral status and biochemical markers of bone metabolism in a Chinese population from Shenyang, in the north of China, where hip fracture incidence is low. A total of 194 healthy men and women, aged 25-35 years and 65-75 years, were studied. Bone mineral dens...

journal_title：Bone

authors： Yan L,Prentice A,Zhou B,Zhang H,Wang X,Stirling DM,Laidlaw A,Han Y,Laskey A

更新日期：2002-02-01 00:00:00

abstract：:The effects of pregnancy and lactation on bone histomorphometry have been studied extensively in rats and dogs. However, these models differ greatly in reproductive physiology compared with women. The purpose of this study was to evaluate histomorphometric changes in iliac crest bone biopsies taken from cynomolgus mon...

journal_title：Bone

authors： Lees CJ,Jerome CP

更新日期：1998-05-01 00:00:00

abstract：:Aldehyde dehydrogenase 2 (ALDH2) is the enzyme that oxidizes the acetaldehyde produced by alcohol metabolism. This variant not only affects the response to alcohol but is also associated with several diseases, such as esophageal cancer, myocardial infarction, and particularly osteoporosis. In our previous study, we re...

journal_title：Bone

authors： Kosugi K,Tajima T,Menuki K,Okuma KF,Tokuda K,Fukuda H,Okada Y,Tsukamoto M,Yamanaka Y,Zenke Y,Sakai A

更新日期：2020-07-01 00:00:00

abstract：:The topological changes in vertebral cancellous bone were estimated in vertebrae from calcium-restricted ovariectomized Sinclair S-1 minipigs, a recently described animal model of cancellous osteopenia. Connectivity was estimated using unbiased stereological principles in disector pairs of sections from the first lumb...

journal_title：Bone

authors： Boyce RW,Ebert DC,Youngs TA,Paddock CL,Mosekilde L,Stevens ML,Gundersen HJ

更新日期：1995-06-01 00:00:00

abstract：:Paralysis of the masticatory muscles using botulinum toxin (BTX) is a common treatment for cosmetic reduction of the masseters as well as for conditions involving muscle spasm and pain. The effects of this treatment on mastication have not been evaluated, and claims that the treatment unloads the jaw joint and mandibl...

journal_title：Bone

authors： Rafferty KL,Liu ZJ,Ye W,Navarrete AL,Nguyen TT,Salamati A,Herring SW

更新日期：2012-03-01 00:00:00

abstract：:Loss of bone and muscle mass are two major clinical complications among the growing list of chronic diseases that primarily affect elderly individuals. Persistent low-grade inflammation, one of the major drivers of aging, is also associated with both bone and muscle dysfunction in aging. Particularly, chronic activati...

journal_title：Bone

authors： Davis HM,Essex AL,Valdez S,Deosthale PJ,Aref MW,Allen MR,Bonetto A,Plotkin LI

更新日期：2019-07-01 00:00:00

abstract：:Bone marrow mesenchymal stem cells (BMMSCs) provide the biological basis for bone reconstruction. Mechanical tension stimulation as a potent modulator is able to promote osteogenic capability of BMMSCs. Long non-coding RNAs (LncRNAs) as competing endogenous RNAs (ceRNAs) for microRNAs, are postulated to regulate the o...

journal_title：Bone

authors： Wu J,Zhao J,Sun L,Pan Y,Wang H,Zhang WB

更新日期：2018-03-01 00:00:00

abstract：:Chondrocytes are derived from mesenchymal stem cells, and play an important role in cartilage formation. Sex determining region Y box (Sox) family transcription factors are essential for chondrogenic differentiation, whereas the intracellular signal pathways of Sox activation have not been clearly elucidated. AMP-acti...

journal_title：Bone

authors： Bandow K,Kusuyama J,Kakimoto K,Ohnishi T,Matsuguchi T

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:Like osteonecrosis of the femoral head (ONFH), subchondral insufficiency fracture of the femoral head (SIF) causes femoral head collapse. However, little is known about the differences between the two diseases regarding the morphological features of the collapsed lesion. We tested the hypothesis that the mor...

journal_title：Bone

authors： Kawano K,Motomura G,Ikemura S,Yamaguchi R,Baba S,Xu M,Nakashima Y

更新日期：2020-12-01 00:00:00

abstract：:We believe that the assembled data are consistent with the presence of mRNA species and/or proteins in pagetic bone that are recognized by some paramyxovirus antibodies and nucleic acid probes. The evidence presented so far is insufficient to substantiate claims for the "unequivocal" presence of paramyxovirus sequence...

journal_title：Bone

authors： Ralston SH,Helfrich MH

更新日期：1999-05-01 00:00:00

abstract：:The effects of tumor-conditioned media (TCM) derived from cultured cells from an oncogenic hypophosphatemic osteomalacia (OHO) tumor on transformed human kidney cells were investigated. Dose-dependent cell detachment and aggregation occurred in kidney cells cultured in serum-free medium supplemented with TCM, but not ...

journal_title：Bone

authors： Rowe PS,Ong AC,Cockerill FJ,Goulding JN,Hewison M

更新日期：1996-02-01 00:00:00

abstract：:Disuse osteopenia and bone loss have been extensively reported in long duration space mission and long term bed rest. The pathology of the bone loss is similar to osteoporosis but highly confined to weight bearing bones. The current anabolic and/or anti-resorptive drugs have systemic effects and are costly over extend...

journal_title：Bone

authors： Uddin SM,Qin YX

更新日期：2015-06-01 00:00:00

abstract：:The risk of fragility fractures in elderly men is only partly explained by areal bone mineral density (aBMD) measured by dual X-ray absorptiometry (DXA). Several studies suggest the importance of bone morphology for the risk of fracture. The aim of this study was to assess the value of bone size and estimated structur...

journal_title：Bone

authors： Szulc P,Munoz F,Duboeuf F,Marchand F,Delmas PD

更新日期：2006-04-01 00:00:00

abstract：:The process of bone turnover displays variations over 24 h, with C-terminal cross-linked telopeptide of type 1 collagen (CTX) and osteocalcin exhibiting a nadir in the afternoon and a peak in the night. In contrast, N-terminal propeptide of type 1 procollagen (P1NP) did not display an apparent 24-hour rhythm. Other em...

journal_title：Bone

authors： van der Spoel E,Oei N,Cachucho R,Roelfsema F,Berbée JFP,Blauw GJ,Pijl H,Appelman-Dijkstra NM,van Heemst D

更新日期：2019-03-01 00:00:00

abstract：:To elucidate the histological events that follow administration of eldecalcitol, a second-generation of vitamin D analog currently awaiting approval as a drug for treatment of osteoporosis, we employed the ovariectomy (OVX) rat model. OVX rats received vehicle or 30ng/kg of eldecalcitol, and sham-operated animals rece...

journal_title：Bone

authors： de Freitas PH,Hasegawa T,Takeda S,Sasaki M,Tabata C,Oda K,Li M,Saito H,Amizuka N

更新日期：2011-09-01 00:00:00

abstract：:Trauma-induced heterotopic ossification is an intriguing phenomenon involving the inappropriate ossification of soft tissues within the body such as the muscle and ligaments. This inappropriate formation of bone is highly prevalent in those affected by blast injuries. Here, we developed a simplified cell culture model...

journal_title：Bone

authors： Logan NJ,Camman M,Williams G,Higgins CA

更新日期：2018-12-01 00:00:00

abstract：:Rare bone diseases account for 5% of all birth defects and can cause significant morbidity throughout patients' lives. Significant progress is being made to elucidate the pathophysiological mechanisms underlying these diseases. This paper summarizes presentation highlights of a workshop on Rare Skeletal Diseases conve...

journal_title：Bone

authors： Tosi LL,Warman ML

更新日期：2015-07-01 00:00:00