Does estrogen stimulate osteoblast function in postmenopausal women?

abstract：:Platelets play a key role in the replacement of the blood clot with granulation tissue during the early steps of bone regeneration. We hypothesized that activated platelets can neutralize locally produced reactive oxygen species, thereby protecting cells involved in granulation tissue formation. The potential of plate...

journal_title：Bone

authors： Kandler B,Maitz P,Fischer MB,Watzek G,Gruber R

更新日期：2005-04-01 00:00:00

abstract：:Cortical bone, the dominant component of the human skeleton by volume, plays a key role in protecting bones from fracture. We analyzed the cortical bone effects of teriparatide treatment in postmenopausal women with osteoporosis who had previously received long-term alendronate (ALN) therapy or were treatment naïve (T...

journal_title：Bone

authors： Ma YL,Zeng QQ,Chiang AY,Burr D,Li J,Dobnig H,Fahrleitner-Pammer A,Michalská D,Marin F,Pavo I,Stepan JJ

更新日期：2014-02-01 00:00:00

abstract：:Bone is a hierarchical, multiphasic and anisotropic structure which in addition possess piezoelectric properties. The generation of piezoelectricity in bone is a complex process which has been shown to play a key role both in bone adaptation and regeneration. In order to understand the complex biological, mechanical a...

journal_title：Bone

authors： Mohammadkhah M,Marinkovic D,Zehn M,Checa S

更新日期：2019-10-01 00:00:00

abstract：:Mutations in the GALNT3 gene result in familial tumoral calcinosis, characterized by persistent hyperphosphatemia and ectopic calcific masses in soft tissues. Since calcific masses often recur after surgical removal, a more permanent solution to the problem is required. Nicotinamide is reported to lower serum phosphat...

journal_title：Bone

authors： Reilly AM,Gray AK,Moe SM,Ichikawa S

更新日期：2014-10-01 00:00:00

abstract：:As the world's population ages, the occurrence of osteoporosis-related fractures is projected to increase. Low areal bone mineral density (aBMD), a well-known risk factor for fractures, may be influenced by physical activity (PA). In this cross-sectional study, we aimed to investigate potential associations between ob...

journal_title：Bone

authors： Johansson J,Nordström A,Nordström P

更新日期：2015-12-01 00:00:00

abstract：INTRODUCTION:The GH-IGF axis has profound effects on bone metabolism and may be important in the etiology of idiopathic osteoporosis. Serum IGF-I is often low in men with osteoporosis, which may be attributable to GH hypo-secretion or hepatic GH insensitivity. We studied the GH-IGF axis in depth to look for evidence to...

journal_title：Bone

authors： Patel MB,Arden NK,Masterson LM,Phillips DI,Swaminathan R,Syddall HE,Byrne CD,Wood PJ,Cooper C,Holt RI,Hertfordshire Cohort Study Group.

更新日期：2005-12-01 00:00:00

abstract：INTRODUCTION:Because osteoporotic patients are prone to fractures, it must be considered whether or not patients undergoing drug therapies should discontinue treatment after sustaining a non-vertebral fracture. This study has tested the effect of novel active vitamin D3 analog, 1alpha,25-dihydroxy-2beta(3-hydroxypropox...

journal_title：Bone

authors： Cao Y,Mori S,Mashiba T,Kaji Y,Manabe T,Iwata K,Miyamoto K,Komatsubara S,Yamamoto T

更新日期：2007-01-01 00:00:00

abstract：:Eldecalcitol (ELD), a 2β-hydroxypropyloxy derivative of 1α,25 (OH) 2D3, inhibits bone resorption more potently than alfacalcidol (ALF) while maintaining osteoblastic function in an ovariectomized (OVX) osteoporosis rat model. Alendronate (ALN), which is the most common bisphosphonate used for the treatment of osteopor...

journal_title：Bone

authors： Sugimoto M,Futaki N,Harada M,Kaku S

更新日期：2013-01-01 00:00:00

abstract：:Endochondral ossification in the growth plate of long bones involves cartilage mineralization, bone formation and the budding vasculature. Many of these processes take place in a complex and dynamic zone, the provisional ossification zone, of the growth plate. Here we investigate aspects of mineralization in 2D and 3D...

journal_title：Bone

authors： Haimov H,Shimoni E,Brumfeld V,Shemesh M,Varsano N,Addadi L,Weiner S

更新日期：2020-01-01 00:00:00

abstract：:Osteoclasts are specialized secretory cells of the myeloid lineage important for normal skeletal homeostasis as well as pathologic conditions of bone including osteoporosis, inflammatory arthritis and cancer metastasis. Differentiation of these multinucleated giant cells from precursors is controlled by the cytokine R...

journal_title：Bone

authors： Charles JF,Coury F,Sulyanto R,Sitara D,Wu J,Brady N,Tsang K,Sigrist K,Tollefsen DM,He L,Storm D,Aliprantis AO

更新日期：2012-11-01 00:00:00

abstract：OBJECTIVE:Type IIB procollagen is characteristic of cartilage, comprising 50% of the extracellular matrix. The NH(2)-propeptide of type IIB collagen, PIIBNP, can kill tumor cells via binding to integrins α(V)β(3) and α(V)β(5). As osteoclasts rely on α(V)β(3) integrins for function in bone erosion, we sought to determin...

journal_title：Bone

authors： Hayashi S,Wang Z,Bryan J,Kobayashi C,Faccio R,Sandell LJ

更新日期：2011-10-01 00:00:00

abstract：:Proteins are an essential part of essentially all biological processes, and there is enormous variation in protein forms and concentrations that is not reflected in DNA or RNA. Recently there have been rapid advances in the ability to measure protein sequence, modification and concentration, particularly with methods ...

journal_title：Bone

authors： Nielson CM,Jacobs JM,Orwoll ES

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:Currently, bone densitometry fails to identify nearly half of those elderly patients at immediate fracture risk. To improve clinical assessment of vertebral fracture risk, we aimed to determine how the DXA-based 2D parameter Trabecular Bone Score (TBS) relates to subregional variability in 3D trabecular micr...

journal_title：Bone

authors： Vom Scheidt A,Grisolia Seifert EF,Pokrant C,Püschel K,Amling M,Busse B,Milovanovic P

更新日期：2019-05-01 00:00:00

abstract：:Large segmental defects of the weight bearing long bones are very difficult to reconstruct. Current treatment options are afflicted with several limitations and disadvantages. We describe a novel approach to regenerate a segmental long bone defect in a patient using a multiple disc graft. Decellularized bovine trabecu...

journal_title：Bone

authors： Hesse E,Kluge G,Atfi A,Correa D,Haasper C,Berding G,Shin HO,Viering J,Länger F,Vogt PM,Krettek C,Jagodzinski M

更新日期：2010-05-01 00:00:00

abstract：:Spinal cord injury (SCI) causes profound bone loss due to muscle paralysis resulting in the inability to walk. Sclerostin, a Wnt signaling pathway antagonist produced by osteocytes, is a potent inhibitor of bone formation. Short-term studies in rodent models have demonstrated increased sclerostin in response to mechan...

journal_title：Bone

authors： Battaglino RA,Sudhakar S,Lazzari AA,Garshick E,Zafonte R,Morse LR

更新日期：2012-09-01 00:00:00

abstract：:There are increasing evidences suggesting bone marrow adiposity tissue (MAT) plays a critical role in affecting both bone quantity and quality. However, very limited studies that have investigated the association between the composition of MAT and bone mineral density (BMD). The goal of this study was to quantify MAT ...

journal_title：Bone

authors： Li X,Shet K,Xu K,Rodríguez JP,Pino AM,Kurhanewicz J,Schwartz A,Rosen CJ

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Like osteonecrosis of the femoral head (ONFH), subchondral insufficiency fracture of the femoral head (SIF) causes femoral head collapse. However, little is known about the differences between the two diseases regarding the morphological features of the collapsed lesion. We tested the hypothesis that the mor...

journal_title：Bone

authors： Kawano K,Motomura G,Ikemura S,Yamaguchi R,Baba S,Xu M,Nakashima Y

更新日期：2020-12-01 00:00:00

abstract：:Osteocytes, the most abundant cells in the cortical bone matrix, are thought to have mechanosensory and chemosensory regulatory roles. Marotti theorized that osteocytes signal to osteoblasts to recruit them into the osteocyte lineage. Martin extended this theory, assuming that osteocytes display a general inhibitory e...

journal_title：Bone

authors： Metz LN,Martin RB,Turner AS

更新日期：2003-11-01 00:00:00

abstract：:Skeletal unloading in an animal hindlimb suspension model and microgravity experienced by astronauts or as a result of prolonged bed rest causes site-specific losses in bone mineral density of 1%-2% per month. This is accompanied by reductions in circulating levels of 1,25-(OH)(2)D(3), the active metabolite of vitamin...

journal_title：Bone

authors： Narayanan R,Smith CL,Weigel NL

更新日期：2002-09-01 00:00:00

abstract：:Approximately 7.9 million fractures occur annually in the United States with 5-10% of these resulting in delayed or impaired healing. Nearly half of the trauma cost of $56 billion per year is used for the treatment of fractures. More importantly, fracture results in a substantial reduction in the quality of life. New ...

journal_title：Bone

authors： Bragdon B,Thinakaran S,Moseychuk O,Gurski L,Bonor J,Price C,Wang L,Beamer WG,Nohe A

更新日期：2011-11-01 00:00:00

abstract：:The skeletal consequences of streptozotocin-induced (STZ) diabetes in the rat are characterized by decreased bone formation and, consequently, reductions in bone mass. Given the ability of tetracyclines to inhibit the breakdown of connective tissue collagen in experimental diabetes (and in other diseases), we examined...

journal_title：Bone

authors： Bain S,Ramamurthy NS,Impeduglia T,Scolman S,Golub LM,Rubin C

更新日期：1997-08-01 00:00:00

abstract：:Ronacaleret is an orally-active calcium-sensing receptor (CaSR) antagonist that has the potential for therapeutic utility in the stimulation of PTH release, notably as a bone anabolic agent comparable to recombinant human PTH(1-34) (rhPTH(1-34)). A recent study has shown that, despite the ability to increase circulati...

journal_title：Bone

authors： Caltabiano S,Dollery CT,Hossain M,Kurtinecz MT,Desjardins JP,Favus MJ,Kumar R,Fitzpatrick LA

更新日期：2013-09-01 00:00:00

abstract：:Many clinical and experimental investigations address the influence of statins on bone formation and fracture healing. Simvastatin was shown to increase the expression of Bone morphogenetic protein (BMP-2), which is one of the most potent growth factors targeting bone formation. In this study, the effect of simvastati...

journal_title：Bone

authors： Pauly S,Luttosch F,Morawski M,Haas NP,Schmidmaier G,Wildemann B

更新日期：2009-09-01 00:00:00

abstract：:Bisphosphonates are one of the most well studied groups of medications and they are bone specific. This tissue specificity is a rare property for a drug introduced into clinical practice as long as 40 years ago. Over the years, the therapeutic boundaries of bisphosphonates were explored and their safety profile has wi...

journal_title：Bone

authors： Pazianas M,Abrahamsen B

更新日期：2011-07-01 00:00:00

abstract：:Immunosuppressant drugs are currently required by transplant recipients for the remainder of their lives, despite the many adverse effects associated with these therapies. Acute osteoporosis is one such effect, and a reproducible osteoporosis model has been established through the administration of the immunosuppressa...

journal_title：Bone

authors： Fukunaga J,Yamaai T,Yamachika E,Ishiwari Y,Tsujigiwa H,Sawaki K,Lee YJ,Ueno T,Kirino S,Mizukawa N,Takagi S,Nagai N,Sugahara T

更新日期：2004-03-01 00:00:00

abstract：:Peak bone mass (PBM) is an important determinant of osteoporosis. Circulating monocytes serve as early progenitors of osteoclasts and produce important molecules for bone metabolism. To search for genes functionally important for PBM variation, we performed a whole genome gene differential expression study of circulat...

journal_title：Bone

authors： Lei SF,Wu S,Li LM,Deng FY,Xiao SM,Jiang C,Chen Y,Jiang H,Yang F,Tan LJ,Sun X,Zhu XZ,Liu MY,Liu YZ,Chen XD,Deng HW

更新日期：2009-05-01 00:00:00

abstract：:The cathepsin K (CatK) inhibitor odanacatib (ODN) is currently being developed for the treatment of osteoporosis. In clinical trials, efficacy and resolution of effect of ODN treatment on bone turnover biomarkers and accrued bone mass have been demonstrated. Here, we examine the effects of continuing treatment and dis...

journal_title：Bone

authors： Zhuo Y,Gauthier JY,Black WC,Percival MD,Duong LT

更新日期：2014-10-01 00:00:00

abstract：:Sclerosteosis and van Buchem disease are two rare bone sclerosing dysplasias caused by genetic defects in the synthesis of sclerostin. In this article we review the demographic, clinical, biochemical, radiological, and histological characteristics of patients with sclerosteosis and van Buchem disease that led to a bet...

journal_title：Bone

authors： van Lierop AH,Appelman-Dijkstra NM,Papapoulos SE

更新日期：2017-03-01 00:00:00

abstract：:Mammalian bone sialoprotein (BSP) is a mineralized tissue-specific protein containing an RGD (arginine-glycine-aspartic acid) cell-attachment sequence and two distinct glutamic acid (glu)-rich regions, with each containing one contiguous glu sequence. These regions have been proposed to contribute to the attachment of...

journal_title：Bone

authors： Harris NL,Rattray KR,Tye CE,Underhill TM,Somerman MJ,D'Errico JA,Chambers AF,Hunter GK,Goldberg HA

更新日期：2000-12-01 00:00:00

abstract：:Alendronate has been shown to reduce bone turnover and increase bone mass. However, little is known about the duration of the effect on bone after treatment withdrawal. The aim of this study was to investigate the long-term effects on bone mineral density (BMD) and bone turnover of various alendronate regimens after t...

journal_title：Bone

authors： Bagger YZ,Tankó LB,Alexandersen P,Ravn P,Christiansen C

更新日期：2003-09-01 00:00:00