Abstract：
:Bone is a hierarchical, multiphasic and anisotropic structure which in addition possess piezoelectric properties. The generation of piezoelectricity in bone is a complex process which has been shown to play a key role both in bone adaptation and regeneration. In order to understand the complex biological, mechanical and electrical interactions that take place during these processes, several computer models have been developed and used to test hypothesis on potential mechanisms behind experimental observations. This paper aims to review the available literature on computer modeling of bone piezoelectricity and its application to bone adaptation and healing. We first provide a brief overview of the fundamentals of piezoelectricity and bone piezoelectric effects. We then review how these properties have been used in computational models of bone adaptation and electromechanical behaviour of bone. In addition, in the last section, we summarize current limitations and potential directions for future work.
journal_name
Bonejournal_title
Boneauthors
Mohammadkhah M,Marinkovic D,Zehn M,Checa Sdoi
10.1016/j.bone.2019.07.024subject
Has Abstractpub_date
2019-10-01 00:00:00pages
544-555eissn
8756-3282issn
1873-2763pii
S8756-3282(19)30298-4journal_volume
127pub_type
杂志文章,评审相关文献
BONE文献大全abstract：OBJECTIVE:Autosomal recessive osteopetrosis (ARO) is a rare congenital disorder of defective bone resorption. The inability of osteoclasts to resorb bone compromises the development of bone marrow cavity, and ultimately, leads to defective hematopoiesis and death within the first decade. The only curative treatment cur...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2019.115144
更新日期：2020-01-01 00:00:00
abstract：:Bone resorption is a multistep process including osteoclast attachment, cytoskeletal reorganization, formation of four distinct plasma membrane domains, and matrix demineralization and degradation followed by cell detachment. The present study describes the intracellular mechanisms by which overexpression of cathepsin...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2008.11.019
更新日期：2009-04-01 00:00:00
abstract：:Bisphosphonates increase bone mass and reduce fracture risk, but their anti-resorptive action may lead to increases in fatigue microdamage. To investigate how bisphosphonate effects influence changes in bone volume and microdamage in the long term, a strain-adaptive model of bone remodeling and microdamage balance was...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2004.03.007
更新日期：2004-07-01 00:00:00
abstract：:Inhaled corticosteroids are the cornerstone of the modern therapy for asthma. In recent years, inhaled corticosteroids have been used in higher doses than previously. This has caused concern about possible osteoporotic side-effects. We studied bone mineral densities (BMDs) in 19 non-smoking women (mean age 53 years, r...
journal_title：Bone
pub_type： 临床试验,杂志文章
doi：10.1016/8756-3282(94)90309-3
更新日期：1994-11-01 00:00:00
abstract：:In an attempt to elucidate the biochemical defect in pseudoachondroplasia, proteoglycan metabolism was investigated in cartilage from a patient with the dominant form of this condition. Iliac-crest cartilage was radioactively labeled with 35S-sulfate and the newly synthesized proteoglycans examined for their hydrodyna...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/8756-3282(88)90118-4
更新日期：1988-01-01 00:00:00
abstract：BACKGROUND:Although 25-hydroxyvitamin D (25[OH]D) is commonly used to define vitamin D status, there is no consensus on the cutoff levels for vitamin D deficiency and insufficiency. In this study, we aimed to identify the 25(OH)D threshold that maximally suppressed parathyroid hormone (PTH) in Hong Kong Chinese populat...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2017.01.030
更新日期：2017-04-01 00:00:00
abstract：INTRODUCTION:Osteocalcin (OC) is the most abundant non-collagenous bone protein and is determinant for bone mineralization. We aimed to compare OC bone expression and serum factors related to its carboxylation in hip fragility fracture and osteoarthritis patients. We also aimed to identify which of these factors were a...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2012.08.129
更新日期：2012-12-01 00:00:00
abstract：:There are increasing evidences suggesting bone marrow adiposity tissue (MAT) plays a critical role in affecting both bone quantity and quality. However, very limited studies that have investigated the association between the composition of MAT and bone mineral density (BMD). The goal of this study was to quantify MAT ...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2017.08.014
更新日期：2017-12-01 00:00:00
abstract：:It is well known that porosity has an inverse relationship with the mechanical properties of bones. We examined cortical and trabecular porosity of antlers, and mineral composition, thickness and mechanical properties in the cortical wall. Samples belonged to two deer populations: a captive population of an experiment...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2011.10.026
更新日期：2012-01-01 00:00:00
abstract：INTRODUCTION:Angiogenesis is closely associated with bone formation, especially endochondral ossification. Angiopoietin 1 (Ang1) is a specific growth factor functioning to generate a stable and matured vasculature through the Tie2 receptor/PI3K/AKT pathway. Recently cartilage oligomeric matrix protein (COMP)-Ang1, an A...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2009.09.019
更新日期：2010-02-01 00:00:00
abstract：:The transcription factor nuclear factor E2 p45-related factor 2 (Nrf2) forms heterodimers with small musculoaponeurotic fibrosarcoma (Maf) proteins for the selective recognition of the antioxidant responsive element on target genes, followed by the regulation of gene expression of phase II detoxifying enzymes as well ...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2006.08.016
更新日期：2007-02-01 00:00:00
abstract：:Regeneration of bone defects caused by trauma, infection, tumours or inherent genetic disorders is a clinical challenge that usually necessitates bone grafting materials. Autologous bone or autograft is still considered the clinical "gold standard" and the most effective method for bone regeneration. However, limited ...
journal_title：Bone
pub_type： 杂志文章,评审
doi：10.1016/j.bone.2015.07.007
更新日期：2015-12-01 00:00:00
abstract：:Osteoarthritis (OA) is closely related to the function of several inflammatory cytokines. It has been reported that older age is associated with higher serum levels of the inflammatory cytokine IL-18. In the present study, we investigated the long-term role of serum IL-18 in cartilage loss in vivo using a new strain o...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2008.01.031
更新日期：2008-06-01 00:00:00
abstract：BACKGROUND:The treatment of complex bone loss scenarios remains challenging. This study evaluates the efficacy of ex vivo regional gene therapy using transduced human adipose-derived stem cells (ASCs) overexpressing bone morphogenetic protein-2 (BMP-2) to treat critical-sized bone defects. METHODS:Critical-sized femor...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2020.115524
更新日期：2020-09-01 00:00:00
abstract：:Osteonecrosis of the femoral head is a serious orthopedic problem. Moderate loads with knee loading promote bone formation, but their effects on osteonecrosis have not been investigated. Using a rat model, we examined a hypothesis that knee loading enhances vessel remodeling and bone healing through the modulation of ...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2015.09.012
更新日期：2015-12-01 00:00:00
abstract：:Osteocytes can participate in systemic mineral homeostasis through perilacunar maintenance and remodeling, where changes to osteocyte lacunar morphology may affect bone structural integrity, tissue strains, and osteocyte mechanosensitivity. Though aging is associated with both decreased bone quality and altered minera...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2018.01.018
更新日期：2018-05-01 00:00:00
abstract：:We previously reported that osteoclast formation in vitro, by coculture of mouse bone marrow and primary osteoblastic cells, occurs in two phases: proliferation of osteoclast progenitors followed by terminal differentiation into mature osteoclasts. Using this coculture system, we examined the effects of c-fos antisens...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/8756-3282(96)00076-2
更新日期：1996-06-01 00:00:00
abstract：OBJECTIVES:This study sought to identify the clinical and biochemical characteristics that would help distinguish hypophosphatasia (HPP) from other metabolic bone diseases in adult patients attending a metabolic bone clinic by comparing patients who have genetically confirmed HPP with a group of patients with low bone ...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2020.115795
更新日期：2021-03-01 00:00:00
abstract：:Eldecalcitol (ED-71), a 2β-hydroxypropyloxy derivative of 1α,25(OH)(2)D(3), inhibits bone resorption more potently than does alfacalcidol while maintaining osteoblastic function in an estrogen-deficient, high-turnover osteoporosis rat model. Alendronate (ALN) has been reported to increase bone mass by suppressing bone...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2012.02.005
更新日期：2012-05-01 00:00:00
abstract：:The Euler number and the connectivity of an arbitrary object is defined, and it is illustrated why the connectivity of an n-dimensional object cannot be estimated in an (n-1)-dimensional section. The disector--principle for 3-D counting of the Euler--events is illustrated in cancellous bone. The correct handling for u...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/8756-3282(93)90144-y
更新日期：1993-05-01 00:00:00
abstract：:Cancellous microanatomy, bone remodelling, and hematopoietic tissue were studied in iliac crest and femoral neck biopsies taken intraoperatively in 102 consecutive patients with displaced intracapsular fractures. About half of the femoral biopsies had osteopenia, and most showed replacement of hematopoietic tissue by ...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/8756-3282(91)90047-m
更新日期：1991-01-01 00:00:00
abstract：:Postmenopausal osteoporosis is characterized by a reduction in the numbers of sinusoidal and arterial capillaries in the bone marrow and reduced bone perfusion suggesting a role of vascular component in the pathogenesis of osteoporosis. Previous studies have shown that bone formation and angiogenesis are positively co...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2011.12.003
更新日期：2012-03-01 00:00:00
abstract：:Bone geometry plays a prominent role in bone strength. Cross-sectional studies have shown that advancing age is associated with increasing diameter of long bones, related to both periostal apposition and endosteal resorption. However, there are few data provided by prospective studies, especially concerning the change...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2010.03.020
更新日期：2010-08-01 00:00:00
abstract：:Fracture risk and mechanical competence of bone are functions of bone mass and tissue quality, which in turn are dependent on the bone's mechanical environment. Male mice have a greater response to non-weight-bearing exercise than females, resulting in larger, stronger bones compared with control animals. The aim of t...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2006.12.002
更新日期：2007-04-01 00:00:00
abstract：INTRODUCTION:While the anti-resorptive effects of the bisphosphonates (BPs) are well documented, many questions remain about their mechanisms of action, particularly following long-term use. This study evaluated the effects of alendronate (Ale) treatment on TGF-β1 signaling in mesenchymal stem cells (MSCs) and osteocyt...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2012.10.017
更新日期：2013-01-01 00:00:00
abstract：OBJECTIVE:Osteoarthritis (OA) is a joint disease characterized by progressive degeneration of articular cartilage. Some features of OA, including chondrocyte hypertrophy and focal calcification of articular cartilage, resemble the endochondral ossification processes. Alterations in transforming growth factor β (TGFβ) s...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2018.07.008
更新日期：2018-11-01 00:00:00
abstract：:The conventional stereologic procedure for estimating bone surface densities in iliac crest biopsies gives biased estimates because bone substructure is anisotropic and the sectioning of the biopsies is intended to be parallel to the cylindrical axis of the iliac crest biopsy. It has recently been shown that random an...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/8756-3282(87)90126-8
更新日期：1987-01-01 00:00:00
abstract：INTRODUCTION:Parathyroid hormone (PTH) is a key regulator of calcium metabolism. Parathyroid hormone-like hormone (PTHrP) contributes to skeletal development through regulation of chondrocyte proliferation and differentiation during early bone growth. Both PTH and PTHrP act through the same receptor (PTHR1). A second r...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2007.12.005
更新日期：2008-04-01 00:00:00
abstract：:The role of drinking water fluoride content for prevention of osteoporosis remains controversial. Therefore, we analyzed the influence of drinking water fluoridation on the incidence of osteoporotic hip fractures and bone mineral density (BMD) in two different communities in eastern Germany: in Chemnitz, drinking wate...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/s8756-3282(97)00273-1
更新日期：1998-03-01 00:00:00
abstract：OBJECTIVE:To establish a drill-hole defect model in osteoporotic mouse femur by comparing temporal cortical bone healing pattern between OVX-induced osteoporotic bone and sham-operated bone. METHODS:3-month-old female C57BL/6 mice were randomly divided into an ovariectomy group (OVX) and a sham-operated group (Sham). ...
journal_title：Bone
pub_type： 杂志文章
doi：10.1016/j.bone.2011.03.720
更新日期：2011-06-01 00:00:00
